Is it possible to evaluate true prophylactic efficacy of antidepressants in severely ill patients with recurrent depression? Lessons from a placebo-controlled trial. the fifth trial of the Danish University Antidepressant Group (DUAG-5)

Journal of Affective Disorders

Volumn 148, Issue 2-3, 2013, Pages 286-290

  Licht, Rasmus W ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Antidepressive agents; Long term treatment; Placebo; Randomised clinical trial; Recurrent depression

Indexed keywords

CITALOPRAM; CLOMIPRAMINE; PLACEBO;

ADULT; ARTICLE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DEPRESSION; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; TREATMENT RESPONSE;

ANTIDEPRESSIVE AGENTS; CITALOPRAM; CLOMIPRAMINE; DENMARK; DEPRESSIVE DISORDER; DOUBLE-BLIND METHOD; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PLACEBOS; RECURRENCE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84877698472     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2012.12.009     Document Type: Article

References (21)

1. M. Bauer, P.C. Whybrow, J. Angst, M. Versiani, and H.J. Moller World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for biological treatment of unipolar depressive disorders, Part 1: Acute and continuation treatment of major depressive disorder World Journal of Biological Psychiatry 3 1 2002 5 43
2. M. Bauer, P.C. Whybrow, J. Angst, M. Versiani, and H.J. Moller World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for biological treatment of unipolar depressive disorders, Part 2: Maintenance treatment of major depressive disorder and treatment of chronic depressive disorders and subthreshold depressions World Journal of Biological Psychiatry 3 2 2002 69 86
3. P. Bech, L.F. Gram, E. Dein, O. Jacobsen, J. Vitger, and T.G. Bolwig Quantitative rating of depressive states Acta Psychiatrica Scandinavica 51 3 1975 161 170
4. Danish University Antidepressant Group, 1986. Citalopram: clinical effect profile in comparison with clomipramine. A controlled multicenter study. Danish University Antidepressant Group. Psychopharmacology Berl 90(1), 131-138.
5. Danish University Antidepressant Group Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. Danish University Antidepressant Group Journal of Affective Disorders. 18 4 1990 289 299
6. Danish University Antidepressant Group Moclobemide: a reversible MAO-A-inhibitor showing weaker antidepressant effect than clomipramine in a controlled multicenter study. Danish University Antidepressant Group Journal of Affective Disorders. 28 2 1993 105 116
7. Danish University Antidepressant Group Clomipramine dose-effect study in patients with depression: clinical end points and pharmacokinetics. Danish University Antidepressant Group (DUAG) Clinical Pharmacology & Therpeutics 66 2 1999 152 165
8. E. Frank, D.J. Kupfer, J.M. Perel, C. Cornes, D.B. Jarrett, A.G. Mallinger, M.E. Thase, A.B. McEachran, and V.J. Grochocinski Three year outcomes for maintenance therapies in recurrent depression Archives of General Psychiatry 47 1990 1093 1099
9. E. Frank, R.F. Prien, R.B. Jarrett, M.B. Keller, D.J. Kupfer, P.W. Lavori, A.J. Rush, and M.M. Weissman Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence Archives of General Psychiatry 48 9 1991 851 855
10. J.R. Geddes, S.M. Carney, C. Davies, T.A. Furukawa, D.J. Kupfer, E. Frank, and G.M. Goodwin Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review Lancet 361 9358 2003 653 661
11. L.F. Gram Acute and continuation therapy in unipolar depression: observations from the run-in phase of a maintenance trial Acta Psychiatrica Scandinavica 118 2 2008 123 129
12. M. Hamilton Development of a rating scale for primary depressive illness British Journal of Social and Clinical Psychology 6 4 1967 278 296
13. B. Hochstrasser, P.M. Isaksen, H. Koponen, L. Lauritzen, F.A. Mahnert, F. Rouillon, A.G. Wade, M. Andersen, S.F. Pedersen, J.C. Swart, and R. Nil Prophylactic effect of citalopram in unipolar, recurrent depression: placebo-controlled study of maintenance therapy British Journal of Psychiatry 178 2001 304 310
14. N. Kaymaz, O.J. van, A.J. Loonen, and W.A. Nolen Evidence that patients with single versus recurrent depressive episodes are differentially sensitive to treatment discontinuation: a meta-analysis of placebo-controlled randomized trials Journal of Clinical Psychiatry 69 9 2008 1423 1436
15. M.B. Keller, M.H. Trivedi, M.E. Thase, R.C. Shelton, S.G. Kornstein, C.B. Nemeroff, E.S. Friedman, A.J. Gelenberg, J.H. Kocsis, D.L. Dunner, R.M. Hirschfeld, A.J. Rothschild, J.M. Ferguson, A.F. Schatzberg, J.M. Zajecka, R.D. Pedersen, B. Yan, S. Ahmed, J. Musgnung, and P.T. Ninan The prevention of recurrent episodes of depression with venlafaxine for two years (PREVENT) study: outcomes from the 2-year and combined maintenance phases Journal of Clinical Psychiatry 68 8 2007 1246 1256
16. J.P. Lepine, V. Caillard, J.C. Bisserbe, S. Troy, J.M. Hotton, and P. Boyer A randomized, placebo-controlled trial of sertraline for prophylactic treatment of highly recurrent major depressive disorder American Journal of Psychiatry 161 5 2004 836 842
17. J.M. Rendell, and R.W. Licht Under-recruitment of patients for clinical trials: an illustrative example of a failed study Acta Psychiatrica Scandinavica 115 5 2007 337 339
18. A.F. Schatzberg, P. Blier, P.L. Delgado, M. Fava, P.M. Haddad, and R.C. Shelton Antidepressant discontinuation syndrome: consensus panel recommendations for clinical management and additional research Journal of Clinical Psychiatry 67 4 2006 27 30
19. World Health Organization The ICD-10 Classification of Mental and Behavioral Disorders. Clinical Desciptions and Diagnostic Guidelines 1992 World Health Organization Geneva
20. World Health Organization Schedules for Clinical Assessment in Neuropsychiatry: Version 2.0 1994 World Health Organization Geneva
21. Wulf, H.R. and Schlichting, P. Medstat. [2.12]. 1991. Albertslund, Denmark, Astra Group A/S.