Genetic biomarkers and exercise-related injuries: Current clinical applications?

British Journal of Sports Medicine

Volumn 47, Issue 9, 2013, Pages 530-532

  Schwellnus, M P ^a,b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b International Olympic Committee   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC MARKER;

ACHILLES TENDON; EXERCISE; FORECASTING; GENETIC MARKER; GENETICS; HUMAN; PERSONALIZED MEDICINE; PHYSIOLOGY; SPORT INJURY; SPORTS MEDICINE; TENDINITIS; TRENDS; ACCIDENT PREVENTION; EDITORIAL; GENETICS/SEX TESTING; INJURY; TENDON;

ACHILLES TENDON; ATHLETIC INJURIES; EXERCISE; FORECASTING; GENETIC MARKERS; HUMANS; INDIVIDUALIZED MEDICINE; SPORTS MEDICINE; TENDINOPATHY;

ACHILLES TENDON; GENETICS/SEX TESTING; INJURY PREVENTION; TENDONS;

EID: 84877694872     PISSN: 03063674     EISSN: 14730480     Source Type: Journal    
DOI: 10.1136/bjsports-2013-092515     Document Type: Editorial

References (17)

1. Mokone GG, Gajjar M, September AV, et al. The guanine-thymine dinucleotide repeat polymorphism within the tenascin-C gene is associated with Achilles tendon injuries. Am J Sports Med 2005;33:1016-21.
2. Mokone GG, Schwellnus MP, Noakes TD, et al. The COL5A1 gene and Achilles tendon pathology. Scand J Med Sci Sports 2006;16:19-26.
3. September AV, Cook J, Handley CJ, et al. Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations. Br J Sports Med 2009;43:357-65.
4. September AV, Nell EM, O'Connell K, et al. A pathway-based approach investigating the genes encoding interleukin-1beta, interleukin-6 and the interleukin-1 receptor antagonist provides new insight into the genetic susceptibility of Achilles tendinopathy. Br J Sports Med 2011;45:1040-7.
5. September AV, Posthumus M, van der Merwe L, et al. The COL12A1 and COL14A1 genes and Achilles tendon injuries. Int J Sports Med 2008;29:257-63.
6. Posthumus M, September AV, Schwellnus MP, et al. Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controls. J Sci Med Sport 2009;12:184-9.
7. Posthumus M, Collins M, Cook J, et al. Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology - a genetic association study. Rheumatology (Oxford) 2010;49:2090-7.
8. Nell EM, van der Merwe L, Cook J, et al. The apoptosis pathway and the genetic predisposition to Achilles tendinopathy. J Orthop Res 2012;30:1719-24.
9. Ziegler A, Koch A, Krockenberger K, et al. Personalized medicine using DNA biomarkers: a review. Hum Genet 2012;131:1627-38.
10. Lewis CM, Knight J. Introduction to genetic association studies. Cold Spring Harb Protoc 2012;2012:297-306.
11. Ioannidis JP, Boffetta P, Little J, et al. Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol 2008;37: 120-32.
12. Hirschhorn JN, Lohmueller K, Byrne E, et al. A comprehensive review of genetic association studies. Genet Med 2002;4:45-61.
13. Little J, Higgins JP, Ioannidis JP, et al. Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement. Hum Genet 2009;125:131-51.
14. Eskola PJ, Lemmela S, Kjaer P, et al. Genetic association studies in lumbar disc degeneration: a systematic review. PLoS ONE 2012;7:e49995.
15. September AV, Posthumus M, Collins M. Application of genomics in the prevention, treatment and management of Achilles tendinopathy and anterior cruciate ligament ruptures. Recent Pat DNA Gene Seq 2012;6:216-23.
16. Pitsiladis Y. Prevention of sports related injuries in athletes by genetic-screening: facts and fiction. Medicina Dello Sport 2012;65:348.
17. Laguette MJ, Abrahams Y, Prince S, et al. Sequence variants within the 30-UTR of the COL5A1 gene alters mRNA stability: implications for musculoskeletal soft tissue injuries. Matrix Biol 2011;30:338-45.