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Volumn 34, Issue 2, 2013, Pages 107-119

Mouse models of Prader-Willi Syndrome: A systematic review

Author keywords

Imprinting Center; Magel2; Mouse models; Necdin; Prader Willi Syndrome; Snord116

Indexed keywords

CHROMOSOME 15Q; DISEASE MODEL; GENE; GENE CLUSTER; GENE DELETION; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; GENE SILENCING; GENOME IMPRINTING; HUMAN; MAGEL2 GENE; NECDIN GENE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRADER WILLI SYNDROME; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SEQUENCE ANALYSIS; SNORD116 GENE; SNRPN GENE; SPECIES COMPARISON; SYSTEMATIC REVIEW; ANIMAL; CHROMOSOME 15; CHROMOSOME MAP; DEFICIENCY; GENETICS; KNOCKOUT MOUSE; MOUSE; MULTIGENE FAMILY; SYNTENY;

EID: 84877655322     PISSN: 00913022     EISSN: 10956808     Source Type: Journal    
DOI: 10.1016/j.yfrne.2013.01.002     Document Type: Review
Times cited : (64)

References (58)
  • 1
    • 0029795968 scopus 로고    scopus 로고
    • The stoned locus of Drosophila melanogaster produces a dicistronic transcript and encodes two distinct polypeptides
    • Andrews J., Smith M., Merakovsky J., Coulson M., Hannan F., Kelly L.E. The stoned locus of Drosophila melanogaster produces a dicistronic transcript and encodes two distinct polypeptides. Genetics 1996, 143:1699-1711.
    • (1996) Genetics , vol.143 , pp. 1699-1711
    • Andrews, J.1    Smith, M.2    Merakovsky, J.3    Coulson, M.4    Hannan, F.5    Kelly, L.E.6
  • 3
    • 35548982597 scopus 로고    scopus 로고
    • Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome
    • Bischof J.M., Stewart C.L., Wevrick R. Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome. Hum. Mol. Genet. 2007, 16:2713-2719.
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 2713-2719
    • Bischof, J.M.1    Stewart, C.L.2    Wevrick, R.3
  • 4
    • 0034931032 scopus 로고    scopus 로고
    • The SNRPN promoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice
    • Bressler J., Tsai T.F., Wu M.Y., Tsai S.F., Ramirez M.A., Armstrong D., Beaudet A.L. The SNRPN promoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice. Nat. Genet. 2001, 28:232-240.
    • (2001) Nat. Genet. , vol.28 , pp. 232-240
    • Bressler, J.1    Tsai, T.F.2    Wu, M.Y.3    Tsai, S.F.4    Ramirez, M.A.5    Armstrong, D.6    Beaudet, A.L.7
  • 5
    • 79956282385 scopus 로고    scopus 로고
    • Prader-Willi syndrome: obesity due to genomic imprinting
    • Butler M.G. Prader-Willi syndrome: obesity due to genomic imprinting. Curr. Genomics 2011, 12:204-215.
    • (2011) Curr. Genomics , vol.12 , pp. 204-215
    • Butler, M.G.1
  • 6
    • 0029907150 scopus 로고    scopus 로고
    • A 5-year-old white girl with Prader-Willi syndrome and a submicroscopic deletion of chromosome 15q11q13
    • Butler M.G., Christian S.L., Kubota T., Ledbetter D.H. A 5-year-old white girl with Prader-Willi syndrome and a submicroscopic deletion of chromosome 15q11q13. Am. J. Med. Genet. 1996, 65:137-141.
    • (1996) Am. J. Med. Genet. , vol.65 , pp. 137-141
    • Butler, M.G.1    Christian, S.L.2    Kubota, T.3    Ledbetter, D.H.4
  • 7
    • 0030726998 scopus 로고    scopus 로고
    • Prader-Willi syndrome
    • Cassidy S.B. Prader-Willi syndrome. J. Med. Genet. 1997, 34:917-923.
    • (1997) J. Med. Genet. , vol.34 , pp. 917-923
    • Cassidy, S.B.1
  • 12
    • 0033754151 scopus 로고    scopus 로고
    • Small evolutionarily conserved RNA, resembling C/D box small nucleolar RNA, is transcribed from PWCR1, a novel imprinted gene in the Prader-Willi deletion region, which Is highly expressed in brain
    • de los Santos T., Schweizer J., Rees C.A., Francke U. Small evolutionarily conserved RNA, resembling C/D box small nucleolar RNA, is transcribed from PWCR1, a novel imprinted gene in the Prader-Willi deletion region, which Is highly expressed in brain. Am. J. Hum. Genet. 2000, 67:1067-1082.
    • (2000) Am. J. Hum. Genet. , vol.67 , pp. 1067-1082
    • de Los Santos, T.1    Schweizer, J.2    Rees, C.A.3    Francke, U.4
  • 14
    • 45849144806 scopus 로고    scopus 로고
    • SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice
    • Ding F., Li H.H., Zhang S., Solomon N.M., Camper S.A., Cohen P., Francke U. SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice. PLoS ONE 2008, 3:e1709.
    • (2008) PLoS ONE , vol.3
    • Ding, F.1    Li, H.H.2    Zhang, S.3    Solomon, N.M.4    Camper, S.A.5    Cohen, P.6    Francke, U.7
  • 15
    • 80051692364 scopus 로고    scopus 로고
    • A new deletion refines the boundaries of the murine Prader-Willi syndrome imprinting center
    • Dubose A.J., Smith E.Y., Yang T.P., Johnstone K.A., Resnick J.L. A new deletion refines the boundaries of the murine Prader-Willi syndrome imprinting center. Hum. Mol. Genet. 2011, 20:3461-3466.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 3461-3466
    • Dubose, A.J.1    Smith, E.Y.2    Yang, T.P.3    Johnstone, K.A.4    Resnick, J.L.5
  • 16
    • 84865617710 scopus 로고    scopus 로고
    • Analysis of endothelial protein C receptor gene and metabolic profile in Prader-Willi syndrome and obese subjects
    • Faienza M.F., Ventura A., Lauciello R., Crino A., Ragusa L., Cavallo L., Spera S., Grugni G. Analysis of endothelial protein C receptor gene and metabolic profile in Prader-Willi syndrome and obese subjects. Obesity 2012, 20:1866-1870.
    • (2012) Obesity , vol.20 , pp. 1866-1870
    • Faienza, M.F.1    Ventura, A.2    Lauciello, R.3    Crino, A.4    Ragusa, L.5    Cavallo, L.6    Spera, S.7    Grugni, G.8
  • 19
    • 0036724342 scopus 로고    scopus 로고
    • Evidence for the role of PWCR1/HBII-85 C/D box small nucleolar RNAs in Prader-Willi syndrome
    • Gallagher R.C., Pils B., Albalwi M., Francke U. Evidence for the role of PWCR1/HBII-85 C/D box small nucleolar RNAs in Prader-Willi syndrome. Am. J. Hum. Genet. 2002, 71:669-678.
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 669-678
    • Gallagher, R.C.1    Pils, B.2    Albalwi, M.3    Francke, U.4
  • 20
    • 0345062183 scopus 로고    scopus 로고
    • Disruption of the mouse necdin gene results in early post-natal lethality
    • Gerard M., Hernandez L., Wevrick R., Stewart C.L. Disruption of the mouse necdin gene results in early post-natal lethality. Nat. Genet. 1999, 23:199-202.
    • (1999) Nat. Genet. , vol.23 , pp. 199-202
    • Gerard, M.1    Hernandez, L.2    Wevrick, R.3    Stewart, C.L.4
  • 22
    • 1042267409 scopus 로고    scopus 로고
    • Prader-Willi syndrome: advances in genetics, pathophysiology and treatment
    • Goldstone A.P. Prader-Willi syndrome: advances in genetics, pathophysiology and treatment. Trends Endocrinol. Metab. 2004, 15:12-20.
    • (2004) Trends Endocrinol. Metab. , vol.15 , pp. 12-20
    • Goldstone, A.P.1
  • 23
    • 0033545993 scopus 로고    scopus 로고
    • An imprinted, mammalian bicistronic transcript encodes two independent proteins
    • Gray T.A., Saitoh S., Nicholls R.D. An imprinted, mammalian bicistronic transcript encodes two independent proteins. Proc. Natl. Acad. Sci. USA 1999, 96:5616-5621.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 5616-5621
    • Gray, T.A.1    Saitoh, S.2    Nicholls, R.D.3
  • 25
    • 0027522496 scopus 로고
    • Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart
    • Grimaldi K., Horn D.A., Hudson L.D., Terenghi G., Barton P., Polak J.M., Latchman D.S. Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart. Dev Biol 1993, 156:319-323.
    • (1993) Dev Biol , vol.156 , pp. 319-323
    • Grimaldi, K.1    Horn, D.A.2    Hudson, L.D.3    Terenghi, G.4    Barton, P.5    Polak, J.M.6    Latchman, D.S.7
  • 26
    • 78650885904 scopus 로고    scopus 로고
    • The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index
    • Haqq A.M., Muehlbauer M.J., Newgard C.B., Grambow S., Freemark M. The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index. J. Clin. Endocrinol. Metab. 2011, 96:E225-E232.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96
    • Haqq, A.M.1    Muehlbauer, M.J.2    Newgard, C.B.3    Grambow, S.4    Freemark, M.5
  • 27
    • 0032231319 scopus 로고    scopus 로고
    • Imprinted expression of SNRPN in human preimplantation embryos
    • Huntriss J., Daniels R., Bolton V., Monk M. Imprinted expression of SNRPN in human preimplantation embryos. Am. J. Hum. Genet. 1998, 63:1009-1014.
    • (1998) Am. J. Hum. Genet. , vol.63 , pp. 1009-1014
    • Huntriss, J.1    Daniels, R.2    Bolton, V.3    Monk, M.4
  • 30
    • 33947650503 scopus 로고    scopus 로고
    • Analysis of candidate imprinted genes in PWS subjects with atypical genetics: a possible inactivating mutation in the SNURF/SNRPN minimal promoter
    • Maina E.N., Webb T., Soni S., Whittington J., Boer H., Clarke D., Holland A. Analysis of candidate imprinted genes in PWS subjects with atypical genetics: a possible inactivating mutation in the SNURF/SNRPN minimal promoter. J. Hum. Genet. 2007, 52:297-307.
    • (2007) J. Hum. Genet. , vol.52 , pp. 297-307
    • Maina, E.N.1    Webb, T.2    Soni, S.3    Whittington, J.4    Boer, H.5    Clarke, D.6    Holland, A.7
  • 31
    • 0035864916 scopus 로고    scopus 로고
    • Large-scale evaluation of imprinting status in the Prader-Willi syndrome region: an imprinted direct repeat cluster resembling small nucleolar RNA genes
    • Meguro M., Mitsuya K., Nomura N., Kohda M., Kashiwagi A., Nishigaki R., Yoshioka H., Nakao M., Oishi M., Oshimura M. Large-scale evaluation of imprinting status in the Prader-Willi syndrome region: an imprinted direct repeat cluster resembling small nucleolar RNA genes. Hum. Mol. Genet. 2001, 10:383-394.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 383-394
    • Meguro, M.1    Mitsuya, K.2    Nomura, N.3    Kohda, M.4    Kashiwagi, A.5    Nishigaki, R.6    Yoshioka, H.7    Nakao, M.8    Oishi, M.9    Oshimura, M.10
  • 32
    • 72049117629 scopus 로고    scopus 로고
    • Regionally reduced brain volume, altered serotonin neurochemistry, and abnormal behavior in mice null for the circadian rhythm output gene Magel2
    • Mercer R.E., Kwolek E.M., Bischof J.M., van Eede M., Henkelman R.M., Wevrick R. Regionally reduced brain volume, altered serotonin neurochemistry, and abnormal behavior in mice null for the circadian rhythm output gene Magel2. Am. J. Med. Genet. B Neuropsychiat. Genet. 2009, 150B:1085-1099.
    • (2009) Am. J. Med. Genet. B Neuropsychiat. Genet. , vol.150 B , pp. 1085-1099
    • Mercer, R.E.1    Kwolek, E.M.2    Bischof, J.M.3    van Eede, M.4    Henkelman, R.M.5    Wevrick, R.6
  • 33
    • 0034642301 scopus 로고    scopus 로고
    • Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome
    • Muscatelli F., Abrous D.N., Massacrier A., Boccaccio I., Le Moal M., Cau P., Cremer H. Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome. Hum. Mol. Genet. 2000, 9:3101-3110.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 3101-3110
    • Muscatelli, F.1    Abrous, D.N.2    Massacrier, A.3    Boccaccio, I.4    Le Moal, M.5    Cau, P.6    Cremer, H.7
  • 34
    • 0032076307 scopus 로고    scopus 로고
    • Imprinting in Prader-Willi and Angelman syndromes
    • Nicholls R.D., Saitoh S., Horsthemke B. Imprinting in Prader-Willi and Angelman syndromes. Trends Genet. 1998, 14:194-200.
    • (1998) Trends Genet. , vol.14 , pp. 194-200
    • Nicholls, R.D.1    Saitoh, S.2    Horsthemke, B.3
  • 37
    • 0029562967 scopus 로고
    • Chromosome engineering in mice
    • Ramirez-Solis R., Liu P., Bradley A. Chromosome engineering in mice. Nature 1995, 378:720-724.
    • (1995) Nature , vol.378 , pp. 720-724
    • Ramirez-Solis, R.1    Liu, P.2    Bradley, A.3
  • 38
    • 0035234557 scopus 로고    scopus 로고
    • Genomic imprinting: parental influence on the genome
    • Reik W., Walter J. Genomic imprinting: parental influence on the genome. Nat. Rev. Genet. 2001, 2:21-32.
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 21-32
    • Reik, W.1    Walter, J.2
  • 39
    • 84859295289 scopus 로고    scopus 로고
    • Behavioural and cognitive profiles of mouse models for Prader-Willi syndrome
    • Relkovic, D., Isles, A.R., 2011. Behavioural and cognitive profiles of mouse models for Prader-Willi syndrome. Brain Res. Bull.
    • (2011) Brain Res. Bull.
    • Relkovic, D.1    Isles, A.R.2
  • 40
    • 0037335439 scopus 로고    scopus 로고
    • Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene necdin, results in congenital deficiency of central respiratory drive in neonatal mice
    • Ren J., Lee S., Pagliardini S., Gerard M., Stewart C.L., Greer J.J., Wevrick R. Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene necdin, results in congenital deficiency of central respiratory drive in neonatal mice. J. Neurosci. 2003, 23:1569-1573.
    • (2003) J. Neurosci. , vol.23 , pp. 1569-1573
    • Ren, J.1    Lee, S.2    Pagliardini, S.3    Gerard, M.4    Stewart, C.L.5    Greer, J.J.6    Wevrick, R.7
  • 41
    • 0346880102 scopus 로고    scopus 로고
    • Contextual fear conditioning regulates the expression of brain-specific small nucleolar RNAs in hippocampus
    • Rogelj B., Hartmann C.E., Yeo C.H., Hunt S.P., Giese K.P. Contextual fear conditioning regulates the expression of brain-specific small nucleolar RNAs in hippocampus. Eur. J. Neurosci. 2003, 18:3089-3096.
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 3089-3096
    • Rogelj, B.1    Hartmann, C.E.2    Yeo, C.H.3    Hunt, S.P.4    Giese, K.P.5
  • 42
    • 13144282733 scopus 로고    scopus 로고
    • Exclusion of the C/D box snoRNA gene cluster HBII-52 from a major role in Prader-Willi syndrome
    • Runte M., Varon R., Horn D., Horsthemke B., Buiting K. Exclusion of the C/D box snoRNA gene cluster HBII-52 from a major role in Prader-Willi syndrome. Hum. Genet. 2005, 116:228-230.
    • (2005) Hum. Genet. , vol.116 , pp. 228-230
    • Runte, M.1    Varon, R.2    Horn, D.3    Horsthemke, B.4    Buiting, K.5
  • 44
    • 78649454993 scopus 로고    scopus 로고
    • A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene
    • Schaller F., Watrin F., Sturny R., Massacrier A., Szepetowski P., Muscatelli F. A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene. Hum. Mol. Genet. 2010, 19:4895-4905.
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 4895-4905
    • Schaller, F.1    Watrin, F.2    Sturny, R.3    Massacrier, A.4    Szepetowski, P.5    Muscatelli, F.6
  • 46
    • 0030886796 scopus 로고    scopus 로고
    • Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern
    • Shemer R., Birger Y., Riggs A.D., Razin A. Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern. Proc. Natl. Acad. Sci. USA 1997, 94:10267-10272.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10267-10272
    • Shemer, R.1    Birger, Y.2    Riggs, A.D.3    Razin, A.4
  • 48
    • 27944457262 scopus 로고    scopus 로고
    • Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes
    • Stefan M., Claiborn K.C., Stasiek E., Chai J.H., Ohta T., Longnecker R., Greally J.M. Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes. BMC Genom. 2005, 6:157.
    • (2005) BMC Genom. , vol.6 , pp. 157
    • Stefan, M.1    Claiborn, K.C.2    Stasiek, E.3    Chai, J.H.4    Ohta, T.5    Longnecker, R.6    Greally, J.M.7
  • 49
    • 24944441699 scopus 로고    scopus 로고
    • Hormonal and metabolic defects in a prader-willi syndrome mouse model with neonatal failure to thrive
    • Stefan M., Ji H., Simmons R.A., Cummings D.E., Ahima R.S., Friedman M.I., Nicholls R.D. Hormonal and metabolic defects in a prader-willi syndrome mouse model with neonatal failure to thrive. Endocrinology 2005, 146:4377-4385.
    • (2005) Endocrinology , vol.146 , pp. 4377-4385
    • Stefan, M.1    Ji, H.2    Simmons, R.A.3    Cummings, D.E.4    Ahima, R.S.5    Friedman, M.I.6    Nicholls, R.D.7
  • 50
    • 79955554996 scopus 로고    scopus 로고
    • Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome
    • Stefan M., Simmons R.A., Bertera S., Trucco M., Esni F., Drain P., Nicholls R.D. Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome. Am. J. Physiol. Endocrinol. Metab. 2011, 300:E909-E922.
    • (2011) Am. J. Physiol. Endocrinol. Metab. , vol.300
    • Stefan, M.1    Simmons, R.A.2    Bertera, S.3    Trucco, M.4    Esni, F.5    Drain, P.6    Nicholls, R.D.7
  • 51
    • 0036318022 scopus 로고    scopus 로고
    • Necdin is required for terminal differentiation and survival of primary dorsal root ganglion neurons
    • Takazaki R., Nishimura I., Yoshikawa K. Necdin is required for terminal differentiation and survival of primary dorsal root ganglion neurons. Exp. Cell Res. 2002, 277:220-232.
    • (2002) Exp. Cell Res. , vol.277 , pp. 220-232
    • Takazaki, R.1    Nishimura, I.2    Yoshikawa, K.3
  • 52
    • 79951865949 scopus 로고    scopus 로고
    • Impaired hypothalamic regulation of endocrine function and delayed counterregulatory response to hypoglycemia in Magel2-null mice
    • Tennese A.A., Wevrick R. Impaired hypothalamic regulation of endocrine function and delayed counterregulatory response to hypoglycemia in Magel2-null mice. Endocrinology 2011, 152:967-978.
    • (2011) Endocrinology , vol.152 , pp. 967-978
    • Tennese, A.A.1    Wevrick, R.2
  • 53
    • 0032963667 scopus 로고    scopus 로고
    • Necdin-deficient mice do not show lethality or the obesity and infertility of Prader-Willi syndrome
    • Tsai T.F., Armstrong D., Beaudet A.L. Necdin-deficient mice do not show lethality or the obesity and infertility of Prader-Willi syndrome. Nat. Genet. 1999, 22:15-16.
    • (1999) Nat. Genet. , vol.22 , pp. 15-16
    • Tsai, T.F.1    Armstrong, D.2    Beaudet, A.L.3
  • 54
    • 0032837539 scopus 로고    scopus 로고
    • Paternal deletion from Snrpn to Ube3a in the mouse causes hypotonia, growth retardation and partial lethality and provides evidence for a gene contributing to Prader-Willi syndrome
    • Tsai T.F., Jiang Y.H., Bressler J., Armstrong D., Beaudet A.L. Paternal deletion from Snrpn to Ube3a in the mouse causes hypotonia, growth retardation and partial lethality and provides evidence for a gene contributing to Prader-Willi syndrome. Hum. Mol. Genet. 1999, 8:1357-1364.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 1357-1364
    • Tsai, T.F.1    Jiang, Y.H.2    Bressler, J.3    Armstrong, D.4    Beaudet, A.L.5
  • 55
    • 25444531466 scopus 로고    scopus 로고
    • The Prader-Willi syndrome murine imprinting center is not involved in the spatio-temporal transcriptional regulation of the Necdin gene
    • Watrin F., Le Meur E., Roeckel N., Ripoche M.A., Dandolo L., Muscatelli F. The Prader-Willi syndrome murine imprinting center is not involved in the spatio-temporal transcriptional regulation of the Necdin gene. BMC Genet. 2005, 6:1.
    • (2005) BMC Genet. , vol.6 , pp. 1
    • Watrin, F.1    Le Meur, E.2    Roeckel, N.3    Ripoche, M.A.4    Dandolo, L.5    Muscatelli, F.6
  • 58
    • 84865863393 scopus 로고    scopus 로고
    • Hypothalamic expression of snoRNA Snord116 is consistent with a link to the hyperphagia and obesity symptoms of Prader-Willi syndrome
    • Zhang, Q., Bouma, G.J., McClellan, K., Tobet, S., 2012. Hypothalamic expression of snoRNA Snord116 is consistent with a link to the hyperphagia and obesity symptoms of Prader-Willi syndrome. Int. J. Dev. Neurosci.
    • (2012) Int. J. Dev. Neurosci.
    • Zhang, Q.1    Bouma, G.J.2    McClellan, K.3    Tobet, S.4


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