Increased unsaturation of lipids in cytoplasmic lipid droplets in DAOY cancer cells in response to cisplatin treatment

Metabolomics

Volumn 9, Issue 3, 2013, Pages 722-729

  Pan, Xiaoyan ^a,b   Wilson, Martin ^a,b   McConville, Carmel ^a   Arvanitis, Theodoros N ^a   Griffin, Julian L ^c   Kauppinen, Risto A ^d   Peet, Andrew C ^a,b,e  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b BIRMINGHAM CHILDREN S HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

1H NMR; Cisplatin; Isolation; Lipid droplets

Indexed keywords

CISPLATIN; FAT DROPLET; LINOLEIC ACID; OLEIC ACID; UNSATURATED FATTY ACID;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRUCTURE; DAOY CELL LINE; DNA FRAGMENTATION; DRUG EFFICACY; ENZYME INHIBITION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HUMAN CELL; LIPID ANALYSIS; LIPID METABOLISM; NEUROECTODERM TUMOR; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; TREATMENT RESPONSE;

EID: 84877633724     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-012-0483-8     Document Type: Article

References (24)

1. Bakshi, A., Mukherjee, D., Bakshi, A., Banerji, A. K., & Das, U. N. (2003). γ-Linolenic acid therapy of human gliomas. Nutrition, 19, 305-309. doi: 10. 1016/s0899-9007(02)00862-6.
2. Bayet-Robert, M., et al. (2010). Quantitative two-dimensional HRMAS 1H-NMR spectroscopy-based metabolite profiling of human cancer cell lines and response to chemotherapy. Magnetic Resonance in Medicine, 63, 1172-1183. doi: 10. 1002/mrm. 22303.
3. Boren, J., & Brindle, K. M. (2012). Apoptosis-induced mitochondrial dysfunction causes cytoplasmic lipid droplet formation. Cell Death and Differentiation,. doi: 10. 1038/cdd. 2012. 34.
4. Burns, C. P., & Spector, A. A. (1994). Biochemical effects of lipids on cancer therapy. The Journal of Nutritional Biochemistry, 5, 114-123.
5. Cockbain, A. J., Toogood, G. J., & Hull, M. A. (2012). Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer. Gut, 61, 135-149. doi: 10. 1136/gut. 2010. 233718.
6. Delikatny, E. J., Cooper, W. A., Brammah, S., Sathasivam, N., & Rideout, D. C. (2002). Nuclear magnetic resonance-visible lipids induced by cationic lipophilic chemotherapeutic agents are accompanied by increased lipid droplet formation and damaged mitochondria. Cancer Research, 62, 1394-1400.
7. Griffin, J. L., et al. (2003). Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death. Cancer Research, 63, 3195-3201.
8. Hakumaki, J. M., Poptani, H., Sandmair, A. M., Yla-Herttuala, S., & Kauppinen, R. A. (1999). 1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma: Implications for the in vivo detection of apoptosis. Nature Medicine, 5, 1323-1327. doi: 10. 1038/15279.
9. Herber, D. L., et al. (2010). Lipid accumulation and dendritic cell dysfunction in cancer. Nature Medicine, 16, 880-886.
10. Jakacki, R. I., et al. (2012). Outcome of children with metastatic medulloblastoma treated with carboplatin during craniospinal radiotherapy: A children's oncology group phase I/II study. Journal of Clinical Oncology. doi: 10. 1200/JCO. 2011. 40. 2792.
11. Kim, H. J., et al. (2012). Phase II study of palliative S-1 in combination with cisplatin as second-line chemotherapy for gemcitabine-refractory pancreatic cancer patients. Oncology Letters, 3, 1314-1318. doi: 10. 3892/ol. 2012. 637.
12. Mirbahai, L., et al. (2012). Lipid biomarkers of glioma cell growth arrest and cell death detected by 1H magic angle spinning MRS. NMR in Biomedicine. doi: 10. 1002/nbm. 2796.
13. Musacchio, T., Toniutti, M., Kautz, R., & Torchilin, V. P. (2009). 1H NMR detection of mobile lipids as a marker for apoptosis: The case of anticancer drug-loaded liposomes and polymeric micelles. Molecular Pharmaceutics, 6, 1876-1882. doi: 10. 1021/mp900164n.
14. Opstad, K. S., Bell, B. A., Griffiths, J. R., & Howe, F. A. (2008). An investigation of human brain tumour lipids by high-resolution magic angle spinning 1H MRS and histological analysis. NMR in Biomedicine, 21, 677-685.
15. Pan, X., et al. (2012). The lipid composition of isolated cytoplasmic lipid droplets from a human cancer cell line, BE(2)M17. Molecular BioSystems, 8, 1694-1700. doi: 10. 1039/C2MB05485J.
16. Quintero, M., Cabanas, M. E., & Arus, C. (2007). A possible cellular explanation for the NMR-visible mobile lipid (ML) changes in cultured C6 glioma cells with growth. BBA-Biochimica et Biophysica Acta, 1771, 31-44.
17. Scheim, D. E. (2009). Cytotoxicity of unsaturated fatty acids in fresh human tumor explants: Concentration thresholds and implications for clinical efficacy. Lipids in Health and Disease, 8, 54.
18. Schmitz, J. E., Kettunen, M. I., Hu, D. E., & Brindle, K. M. (2005). 1H MRS-visible lipids accumulate during apoptosis of lymphoma cells in vitro and in vivo. Magnetic Resonance in Medicine, 54, 43-50.
19. Shih, C. M., et al. (2005). Detection of apoptosis and necrosis in normal human lung cells using 1H NMR spectroscopy. Annals of the New York Academy of Sciences, 1042, 488-496. doi: 10. 1196/annals. 1338. 042.
20. Shulman, K., Haim, N., Wollner, M., Bernstein, Z., Abdah-Bortnyak, R., & Bar-Sela, G. (2012). Postoperative chemotherapy in gastric cancer, consisting of etoposide, doxorubicin and cisplatin, followed by radiotherapy with concomitant cisplatin: A feasibility study. Oncology Letters, 3, 1154-1158. doi: 10. 3892/ol. 2012. 617.
21. Tanida, S., et al. (2012). Mechanisms of cisplatin-induced apoptosis and of cisplatin sensitivity: Potential of BIN1 to act as a potent predictor of cisplatin sensitivity in gastric cancer treatment. International Journal of Surgical Oncology, 2012, 862879. doi: 10. 1155/2012/862879.
22. Weller, P. F., Ryeom, S. W., Picard, S. T., Ackerman, S. J., & Dvorak, A. M. (1991). Cytoplasmic lipid bodies of neutrophils: formation induced by cis-unsaturated fatty acids and mediated by protein kinase C. Journal of Cell Biology, 113, 137-146.
23. Xi, Y., & Rocke, D. M. (2008). Baseline correction for NMR spectroscopic metabolomics data analysis. BMC Bioinformatics, 9, 324.
24. Zietkowski, D., Payne, G. S., Nagy, E., Mobberley, M. A., Ryder, T. A., & Desouza, N. M. (2012). Comparison of NMR lipid profiles in mitotic arrest and apoptosis as indicators of paclitaxel resistance in cervical cell lines. Magnetic Resonance in Medicine, 68, 369-377. doi: 10. 1002/mrm. 23265.