Trim21: A novel negative regulator in DNA sensor signaling

Cellular and Molecular Immunology

Volumn 10, Issue 3, 2013, Pages 190-192

  Yang, Bo ^a   Wang, Jie ^a   Sun, Bing ^a,b  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b INSTITUTE PASTEUR OF SHANGHAI   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DNA SENSOR; DOUBLE STRANDED DNA; MEMBRANE PROTEIN; PROTEIN DDX41; PROTEIN TRIM21; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; AUTOIMMUNE DISEASE; CELL SPECIFICITY; CYTOKINE PRODUCTION; DNA SEQUENCE; EARLY DIAGNOSIS; GENE SILENCING; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOPRECIPITATION; INNATE IMMUNITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VIRUS IMMUNITY;

ANIMALS; DEAD-BOX RNA HELICASES; DNA; HUMANS; IMMUNITY, INNATE; MICE; MODELS, IMMUNOLOGICAL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEOPROTEINS; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 84877626915     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2013.12     Document Type: Article

References (21)

1. Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007; 448: 501-505.
2. Chiu YH, Macmillan JB, Chen ZJ. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIGI pathway. Cell 2009; 138: 576-591.
3. Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V. RIG-Idependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol 2009; 10: 1065-1072.
4. Yang P, An H, Liu X, Wen M, Zheng Y, Rui Y et al. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol 2010; 11: 487-494.
5. Kim T, Pazhoor S, Bao M, Zhang Z, Hanabuchi S, Facchinetti V et al. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci USA 2010; 107: 15181-15186.
6. Zhang X, Brann TW, Zhou M, Yang J, Oguariri RM, Lidie KB et al. Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN. J Immunol 2011; 186: 4541-4545.
7. Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol 2010; 11: 997-1004.
8. Zhang Z, Yuan B, Bao M, Lu N, Kim T, Liu YJ. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol 2011; 12: 959-965.
9. Ishikawa H, Barber GN. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 2008; 455: 674-678.
10. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F et al. The adaptor protein MITA links virussensing receptors to IRF3 transcription factor activation. Immunity 2008; 29: 538-550.
11. Jin L,Waterman PM, Jonscher KR, Short CM, Reisdorph NA, Cambier JC. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals.Mol Cell Biol 2008; 28: 5014-5026.
12. Sun W, Li Y, Chen L, Chen H, You F, Zhou X et al. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci USA 2009; 106: 8653-8658.
13. Zhang Z, Bao M, Lu N, Weng L, Yuan B, Liu YJ. The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA. Nat Immunol 2013; 14: 172-178.
14. Higgs R, Ni Gabhann J, Ben Larbi N, Breen EP, Fitzgerald KA, Jefferies CA. The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. J Immunol 2008; 181: 1780-1786.
15. Yang K, Shi HX, Liu XY, Shan YF, Wei B, Chen S et al. TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response. J Immunol 2009; 182: 3782-3792.
16. Yoshimi R, Chang TH, Wang H, Atsumi T, Morse HC 3rd, Ozato K. Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. J Immunol 2009; 182: 7527-7538.
17. Pickart CM. Mechanisms underlying ubiquitination. Annu Rev Biochem 2001; 70: 503-533.
18. Woodward JJ, Iavarone AT, Portnoy DA. cdi-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response. Science 2010; 328: 1703-1705.
19. Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS et al. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol 2012; 13: 1155-1161.
20. Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, HyodoMet al. STING is a direct innate immune sensor of cyclic di-GMP. Nature 2011; 478: 515-518.
21. Kawasaki T, Kawai T, Akira S. Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity. Immunol Rev 2011; 243: 61-73.