Leptin, adiponectin, and short-term and long-term weight loss after a lifestyle intervention in obese children

Nutrition

Volumn 29, Issue 6, 2013, Pages 851-857

  Siegrist, Monika ^a   Rank, Melanie ^a   Wolfarth, Bernd ^a   Langhof, Helmut ^b   Haller, Bernhard ^a   Koenig, Wolfgang ^c   Halle, Martin ^a,d  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Rehabilitation Clinic Schönsicht   (Germany)

^c UNIVERSITY OF ULM   (Germany)

^d Munich Heart Alliance   (Germany)

Author keywords

Adipokines; Adolescents; Cardiometabolic risk; Inpatient weight loss program

Indexed keywords

ADIPONECTIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; TRIACYLGLYCEROL;

ADOLESCENT; ARTICLE; BEHAVIOR THERAPY; BLOOD PRESSURE MEASUREMENT; BODY MASS; CARDIOMETABOLIC RISK; CHILD HEALTH CARE; CONTROLLED STUDY; CORRELATIONAL STUDY; DIET THERAPY; EXERCISE; FEMALE; HOSPITAL PATIENT; HUMAN; LIFESTYLE MODIFICATION; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; OBESITY; PREDICTIVE VALUE; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; SEX DIFFERENCE; SHORT COURSE THERAPY; WEIGHT CHANGE; WEIGHT REDUCTION;

ADIPONECTIN; ADOLESCENT; BEHAVIOR THERAPY; BLOOD PRESSURE; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CHILD; CHOLESTEROL, HDL; EXERCISE; FEMALE; FOOD HABITS; HUMANS; INTERVENTION STUDIES; LEPTIN; LIFE STYLE; LINEAR MODELS; MALE; OBESITY; RISK FACTORS; TRIGLYCERIDES; WEIGHT LOSS;

EID: 84877621095     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2012.12.011     Document Type: Article

References (43)

1. Dietz W.H. Childhood weight affects adult morbidity and mortality. J Nutr 1998, 128(2 suppl):411S-414S.
2. Freedman D.S., Dietz W.H., Srinivasan S.R., Berenson G.S. Risk factors and adult body mass index among overweight children: The Bogalusa Heart Study. Pediatrics 2009, 123:750-757.
3. Friedman J.M. Obesity: Causes and control of excess body fat. Nature 2009, 459:340-342.
4. Rosen E.D., Spiegelman B.M. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006, 444:847-853.
5. de Graaf C., Blom W., Smeets P., Stafleu A., Hendriks H. Biomarkers of satiation and satiety. Am J Clin Nutr 2004, 79:946-961.
6. Donahoo W.T., Stob N.R., Ammon S., Levin N., Eckel R.H. Leptin increases skeletal muscle lipoprotein lipase and postprandial lipid metabolism in mice. Metabolism 2011, 60:438-443.
7. Halle M., Berg A., Garwers U., Grathwohl D., Knisel W., Keul J. Concurrent reductions of serum leptin and lipids during weight loss in obese men with type II diabetes. Am J Physiol 1999, 277:E277-E282.
8. Schäfer K., Halle M., Goeschen C., Dellas C., Pynn M., Loskutoff D.J., et al. Leptin promotes vascular remodeling and neointimal growth in mice. Arterioscler Thromb Vasc. Biol 2004, 24:112-117.
9. Koh K.K., Park S.M., Quon M.J. Leptin and cardiovascular disease: Response to therapeutic interventions. Circulation 2008, 117:3238-3249.
10. Wallace A.M., McMahon A.D., Packard C.J., Kelly A., Shepherd J., Gaw A., et al. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation 2001, 104:3052-3056.
11. Soderberg S., Colquhoun D., Keech A., Yallop J., Barnes E.H., Pollicino C., et al. Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: Results from the LIPID study. Int J Obes (Lond) 2009, 33:123-130.
12. Wolk R., Berger P., Lennon R.J., Brilakis E.S., Johnson B.D., Somers V.K. Plasma leptin and prognosis in patients with established coronary atherosclerosis. J Am Coll Cardiol 2004, 44:1819-1824.
13. Gil-Campos M., Canete R.R., Gil A. Adiponectin, the missing link in insulin resistance and obesity. Clin Nutr 2004, 23:963-974.
14. Spranger J., Kroke A., Mohlig M., Bergmann M.M., Ristow M., Boeing H., et al. Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003, 361:226-228.
15. Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001, 7:941-946.
16. Maziekas M.T., LeMura L.M., Stoddard N.M., Kaercher S., Martucci T. Follow up exercise studies in paediatric obesity: Implications for long term effectiveness. Br J Sports Med 2003, 37:425-429.
17. Gutin B., Ramsey L., Barbeau P., Cannady W., Ferguson M., Litaker M., et al. Plasma leptin concentrations in obese children: Changes during 4-mo periods with and without physical training. Am J Clin Nutr 1999, 69:388-394.
18. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995, 1:1155-1161.
19. Souza M.S., Cardoso A.L., Yasbek P., Faintuch J. Aerobic endurance, energy expenditure, and serum leptin response in obese, sedentary, prepubertal children and adolescents participating in a short-term treadmill protocol. Nutrition 2004, 20:900-904.
20. Venner A.A., Lyon M.E., Doyle-Baker P.K. Leptin: A potential biomarker for childhood obesity?. Clin Biochem 2006, 39:1047-1056.
21. Silva F.M., de Almeida J.C., Feoli A.M. Effect of diet on adiponectin levels in blood. Nutr Rev 2011, 69:599-612.
22. Cambuli V.M., Musiu M.C., Incani M., Paderi M., Serpe R., Marras V., et al. Assessment of adiponectin and leptin as biomarkers of positive metabolic outcomes after lifestyle intervention in overweight and obese children. J Clin Endocrinol. Metab 2008, 93:3051-3057.
23. Reinehr T., Kleber M., de S.G., Andler W. Leptin concentrations are a predictor of overweight reduction in a lifestyle intervention. Int J Pediatr Obes 2009, 4:215-223.
24. Torgerson J.S., Carlsson B., Stenlof K., Carlsson L.M., Bringman E., Sjostrom L. A low serum leptin level at baseline and a large early decline in leptin predict a large 1-year weight reduction in energy-restricted obese humans. J Clin Endocrinol Metab 1999, 84:4197-4203.
25. Niskanen L.K., Haffner S., Karhunen L.J., Turpeinen A.K., Miettinen H., Uusitupa M.I. Serum leptin in obesity is related to gender and body fat topography but does not predict successful weight loss. Eur J Endocrinol 1997, 137:61-67.
26. Di Stefano G., Bini V., Papi F., Celi F., Contessa G., Berioli M.G., et al. Leptin serum concentrations predict the responsiveness of obese children and adolescents to weight excess reduction program. Int J Obes Relat Metab Disord 2000, 24:1586-1591.
27. Cole T.J., Bellizzi M.C., Flegal K.M., Dietz W.H. Establishing a standard definition for child overweight and obesity worldwide: International survey. BMJ 2000, 320:1240-1243.
28. Kromeyer-Hauschild K., Wabitsch M., Kunze D., Geller F., Geis H.C., Hesse V., et al. Perzentile für den Body Mass Index für das Kindes- und Jugendalter unter Heranziehung verschiedener deutscher Stichproben. Monatsschr Kinderheilk 2001, 149:807-818.
29. Cole T.J. The LMS method for constructing normalized growth standards. Eur J Clin Nutr 1990, 44:45-60.
30. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004, 114(2 Suppl 4th Report):555-576. National High Blood Pressure Education Program Working Group on High Blood in Children and Adolescents.
31. Tanner J. Growth and Adolescence 1962, Blackwell, Oxford.
32. Rank M., Siegrist M., Wilks D.C., Haller B., Wolfarth B., Langhof H., et al. Long-term effects of an inpatient weight-loss program in obese children and the role of genetic predisposition-Rationale and design of the LOGIC-trial. BMC Pediatr 2012, 12:30.
33. Cole T.J., Faith M.S., Pietrobelli A., Heo M. What is the best measure of adiposity change in growing children: BMI, BMI %, BMI z-score or BMI centile?. Eur J Clin Nutr 2005, 59:419-425.
34. Zimmet P., Alberti K.G., Kaufman F., Tajima N., Silink M., Arslanian S., et al. The metabolic syndrome in children and adolescents-An IDF consensus report. Pediatr Diabetes 2007, 8:299-306.
35. AGA recommendations. Leitlinien der Arbeitsgemeinschaft Adipositas im Kindesalter. Available at 2008. Accessed February 10, 2010. http://www.adipositas-gesellschaft.de/daten/Leitlinie-AGA-S2-2008.pdf.
36. Kettaneh A., Heude B., Romon M., Oppert J.M., Borys J.M., Balkau B., et al. High plasma leptin predicts an increase in subcutaneous adiposity in children and adults. Eur Clin Nutr 2007, 61:719-726.
37. Byrnes S.E., Baur L.A., Bermingham M., Brock K., Steinbeck K. Leptin and total cholesterol are predictors of weight gain in pre-pubertal children. Int J Obes Relat Metab Disord 1999, 23:146-150.
38. Folsom A.R., Jensen M.D., Jacobs D.R., Hilner J.E., Tsai A.W., Schreiner P.J. Serum leptin and weight gain over 8 years in African American and Caucasian young adults. Obes Res 1999, 7:1-8.
39. Hodge A.M., de Court, Dowse G.K., Zimmet P.Z., Collier G.R., Gareeboo H., et al. Do leptin levels predict weight gain?-A 5-year follow-up study in Mauritius. Mauritius Non-communicable Disease Study Group. Obes Res 1998, 6:319-325.
40. Ahima R.S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E., et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996, 382:250-252.
41. Celi F., Bini V., Papi F., Contessa G., Santilli E., Falorni A. Leptin serum levels are involved in the relapse after weight excess reduction in obese children and adolescents. Diabetes Nutr Metab 2003, 16:306-311.
42. Murer S.B., Knopfli B.H., Aeberli I., Jung A., Wildhaber J., Wildhaber-Brooks J., et al. Baseline leptin and leptin reduction predict improvements in metabolic variables and long-term fat loss in obese children and adolescents: A prospective study of an inpatient weight-loss program. Am J Clin Nutr 2011, 93:695-702.
43. Riestra P., Garcia-Anguita A., Lasuncion M.A., Cano B., de O.M., Garces C. Relationship of adiponectin with metabolic syndrome components in pubertal children. Atherosclerosis 2011, 216:467-470.