High fat/carbohydrate ratio but not total energy intake induces lower striatal dopamine D 2/3 receptor availability in diet-induced obesity

International Journal of Obesity

Volumn 37, Issue 5, 2013, Pages 754-757

  Van De Giessen, E ^a   La Fleur, S E ^a   Eggels, L ^a   De Bruin, K ^a   Van Den Brink, W ^a   Booij, J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

diet induced obesity; dopamine D2 3 receptor; energy intake; free choice high fat high sugar diet; saturated fat; striatum

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; LEPTIN;

ABDOMINAL FAT; ANIMAL EXPERIMENT; ARTICLE; CALORIC INTAKE; CARBOHYDRATE DIET; CONTROLLED STUDY; HUMAN; LIPID DIET; MALE; NONHUMAN; NUCLEUS ACCUMBENS; OBESITY; PRIORITY JOURNAL; RAT; SUGAR INTAKE;

ANIMALS; BENZAMIDES; BIOLOGICAL AVAILABILITY; CONTRAST MEDIA; CORPUS STRIATUM; DIET; DIET, HIGH-FAT; DIETARY CARBOHYDRATES; DIETARY FATS; DIETARY SUCROSE; DOPAMINE ANTAGONISTS; ENERGY INTAKE; FOOD HABITS; MALE; OBESITY; PYRROLIDINES; RANDOM ALLOCATION; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3;

RATTUS;

EID: 84877582760     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2012.128     Document Type: Article

References (19)

1. Johnson PM, Kenny PJ. Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci 2010; 13: 635-641.
2. Huang XF, Zavitsanou K, Huang X, Yu Y, Wang H, Chen F et al. Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity. Behav Brain Res 2006; 175: 415-419.
3. van de Giessen E, La Fleur SE, de Bruin CM, van den Brink W, Booij J. Free-choice and no-choice high fat diets affect striatal dopamine D2/3 receptor availability, caloric intake, and adiposity. Obesity (Silver Spring) 2012; e-pub ahead of print 6 February 2012; doi:10.1038/oby.2012.17.
4. Wang GJ, Volkow ND, Logan J, Pappas NR, Wong CT, Zhu W et al. Brain dopamine and obesity. Lancet 2001; 357: 354-357.
5. de Weijer BA, van de Giessen E, van Amelsvoort TA, Boot E, Braak B, Janssen IM et al. Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects. EJNMMI Res 2011; 1: 37.
6. Davis JF, Choi DL, Schurdak JD, Fitzgerald MF, Clegg DJ, Lipton JW et al. Leptin regulates energy balance and motivation through action at distinct neural circuits. Biol Psychiatry 2011; 69: 668-674.
7. La Fleur SE, van Rozen AJ, Luijendijk MC, Groeneweg F, Adan RA. A free-choice high-fat high-sugar diet induces changes in arcuate neuropeptide expression that support hyperphagia. Int J Obes (Lond) 2010; 34: 537-546.
8. Kalsbeek A, Fliers E, Romijn JA, La Fleur SE, Wortel J, Bakker O et al. The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels. Endocrinology 2001; 142: 2677-2685.
9. Crunelle CL, Miller ML, de Bruin K, van den Brink W, Booij J. Varenicline increases striatal dopamine D2/3 receptor binding in rats. Addict Biol 2009; 14: 500-502.
10. van de Giessen E, de Bruin K, La Fleur SE, van den Brink W, Booij J. Triple monoamine inhibitor tesofensine decreases food intake, body weight, and striatal dopamine D2/D3 receptor availability in diet-induced obese rats. Eur Neuropsychopharmacol 2012; 22: 290-299.
11. Lenoir M, Serre F, Cantin L, Ahmed SH. Intense sweetness surpasses cocaine reward. PLoS One 2007; 2: e698.
12. Hajnal A, Norgren R. Accumbens dopamine mechanisms in sucrose intake. Brain Res 2001; 904: 76-84.
13. Geiger BM, Haburcak M, Avena NM, Moyer MC, Hoebel BG, Pothos EN. Deficits of mesolimbic dopamine neurotransmission in rat dietary obesity. Neuroscience 2009; 159: 1193-1199.
14. Morris JK, Bomhoff GL, Gorres BK, Davis VA, Kim J, Lee PP et al. Insulin resistance impairs nigrostriatal dopamine function. Exp Neurol 2011; 231: 171-180.
15. Opland DM, Leinninger GM, Myers Jr. MG. Modulation of the mesolimbic dopamine system by leptin. Brain Res 2010; 1350: 65-70.
16. Odorizzi M, Max JP, Tankosic P, Burlet C, Burlet A. Dietary preferences of Brattleboro rats correlated with an overexpression of galanin in the hypothalamus. Eur J Neurosci 1999; 11: 3005-3014.
17. Akabayashi A, Koenig JI, Watanabe Y, Alexander JT, Leibowitz SF. Galanincontaining neurons in the paraventricular nucleus: a neurochemical marker for fat ingestion and body weight gain. Proc Natl Acad Sci USA 1994; 91: 10375-10379.
18. Adams AC, Clapham JC, Wynick D, Speakman JR. Feeding behaviour in galanin knockout mice supports a role of galanin in fat intake and preference. J Neuroendocrinol 2008; 20: 199-206.
19. Rada P, Mark GP, Hoebel BG. Galanin in the hypothalamus raises dopamine and lowers acetylcholine release in the nucleus accumbens: a possible mechanism for hypothalamic initiation of feeding behavior. Brain Res 1998; 798: 1-6.