Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11

EMBO Reports

Volumn 14, Issue 5, 2013, Pages 441-449

  Farré, Jean Claude ^a   Burkenroad, Aaron ^a   Burnett, Sarah F ^a   Subramani, Suresh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Atg30; Atg32; mitophagy; pexophagy; phosphorylation

Indexed keywords

PROTEIN; PROTEIN ATG11; PROTEIN ATG19; PROTEIN ATG30; PROTEIN ATG32; PROTEIN ATG36; PROTEIN ATG8; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; MITOPHAGY; MOLECULAR BIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PEXOPHAGY; PHOSPHORYLATION; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; SACCHAROMYCES CEREVISIAE; SELECTIVE AUTOPHAGY;

AMINO ACID SEQUENCE; AUTOPHAGY; BINDING SITES; CONSENSUS SEQUENCE; GENE KNOCKOUT TECHNIQUES; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIAL DEGRADATION; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PICHIA; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, CELL SURFACE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; VESICULAR TRANSPORT PROTEINS;

PICHIA PASTORIS; SACCHAROMYCES CEREVISIAE;

EID: 84877579321     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2013.40     Document Type: Article

References (24)

1. Farre JC, Krick R, Subramani S, Thumm M (2009) Turnover of organelles by autophagy in yeast. Curr Opin Cell Biol 21: 522-530
2. Johansen T, Lamark T (2011) Selective autophagy mediated by autophagic adapter proteins. Autophagy 7: 279-296
3. Scott SV, Guan J, Hutchins MU, Kim J, Klionsky DJ (2001) Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway. Mol Cell 7: 1131-1141 (Pubitemid 32607348)
4. Farre JC, Manjithaya R, Mathewson RD, Subramani S (2008) PpAtg30 tags peroxisomes for turnover by selective autophagy. Dev Cell 14: 365-376
5. Kanki T, Wang K, Cao Y, Baba M, Klionsky DJ (2009) Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell 17: 98-109
6. Okamoto K, Kondo-Okamoto N, Ohsumi Y (2009) Mitochondriaanchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Dev Cell 17: 87-97
7. Motley AM, Nuttall JM, Hettema EH (2012) Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae. EMBO J 31: 2852-2868
8. Shintani T, Huang WP, Stromhaug PE, Klionsky DJ (2002) Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway. Dev Cell 3: 825-837 (Pubitemid 35460783)
9. Yorimitsu T, Klionsky DJ (2005) Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Mol Biol Cell 16: 1593-1605 (Pubitemid 40471933)
10. Noda NN, Ohsumi Y, Inagaki F (2010) Atg8-family interacting motif crucial for selective autophagy. FEBS Lett 584: 1379-1385
11. Suzuki K, Kubota Y, Sekito T, Ohsumi Y (2007) Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 12: 209-218 (Pubitemid 46152659)
12. Itakura E, Mizushima N (2010) Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins. Autophagy 6: 764-776
13. Aoki Y, Kanki T, Hirota Y, Kurihara Y, Saigusa T, Uchiumi T, Kang D (2011) Phosphorylation of Serine 114 on Atg32 mediates mitophagy. Mol Biol Cell 22: 3206-3217
14. Noda NN, Kumeta H, Nakatogawa H, Satoo K, Adachi W, Ishii J, Fujioka Y, Ohsumi Y, Inagaki F (2008) Structural basis of target recognition by Atg8/LC3 during selective autophagy. Genes Cells 13: 1211-1218
15. Wild P et al (2011) Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 333: 228-233
16. Nazarko TY, Farre JC, Subramani S (2009) Peroxisome size provides insights into the function of autophagy-related proteins. Mol Biol Cell 20: 3828-3839
17. Kim J et al (2001) Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole. J Cell Biol 153: 381-396 (Pubitemid 34280222)
18. Cheong H, Yorimitsu T, Reggiori F, Legakis JE, Wang CW, Klionsky DJ (2005) Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell 16: 3438-3453 (Pubitemid 40962611)
19. Kawamata T, Kamada Y, Kabeya Y, Sekito T, Ohsumi Y (2008) Organization of the pre-autophagosomal structure responsible for autophagosome formation. Mol. Biol Cell 19: 2039-2050
20. Kondo-Okamoto N et al (2012) Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy. J Biol Chem 287: 10631-10638
21. Chang CY, Huang WP (2007) Atg19 mediates a dual interaction cargo sorting mechanism in selective autophagy. Mol Biol Cell 18: 919-929
22. Manjithaya R, Jain S, Farre JC, Subramani S (2010) A yeast MAPK cascade regulates pexophagy but not other autophagy pathways. J Cell Biol 189: 303-310
23. Kanki T, Kang D, Klionsky DJ (2009) Monitoring mitophagy in yeast: the Om45-GFP processing assay. Autophagy 5: 1186-1189
24. Farre JC, Mathewson RD, Manjithaya R, Subramani S (2010) Roles of Pichia pastoris Uvrag in vacuolar protein sorting and the phosphatidylinositol 3-kinase complex in phagophore elongation in autophagy pathways. Autophagy 6: 86-99