Self-nanoemulsifying drug delivery systems of valsartan: Preparation and in-vitro characterization

International Journal of Drug Delivery

Volumn 4, Issue 2, 2012, Pages

  Rajinikanth, P S ^a   Keat, Neo Woei ^a   Garg, Sanjay ^b  

^a INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Enhancement of dissolution; Nanoemulsion; Poorly soluble drug; Self emulsifying drug delivery system; Valsartan

Indexed keywords

DRUG CARRIER; LABRASOL; MACROGOL 400; POLYSORBATE 20; VALSARTAN; MACROGOL;

ARTICLE; CENTRIFUGATION; CONTROLLED STUDY; DISSOLUTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; EMULSION; FREEZING; HEATING; IN VITRO STUDY; NANOEMULSION; PARTICLE SIZE; TRANSMISSION ELECTRON MICROSCOPY; TURBIDITY; ZETA POTENTIAL; COOLING; DRUG SYNTHESIS; FREEZE THAWING; THERMODYNAMICS;

EID: 84877330592     PISSN: None     EISSN: 09754415     Source Type: Journal    
DOI: 10.5138/ijdd.v4i2.477     Document Type: Article

References (25)

1. Zaid AN et al. Formulation and bioequivalence of two Valsartan tablets after a single dose administration. Scientia Pharmaceutica 2011; 79: 123-135.
2. Novitch M. The United States Pharmacopoeia: The National Formulary Asian Edition. Tata Press Limited. USA: 1994.
3. Siddiqui N et al. Pharmacacological and pharmaceutical profile of Valsartan: A Review. Journal of Appl Pharmal Sci. 2011; 01 (04): 12-19.
4. Saydam M, Takka S. Bioavailability file: Valsartan. FABAD J Pharm Sci 2007; 32: 185-196.
5. DrugBank: Open Data Drug & Drug Target. 2007. Available from: http://www.drugbank.ca/drugs/DB00177
6. Patel SN et al. Self-emulsifying drug delivery system. J Global Tech 2010; 2(2): 29-37.
7. Tang J, Sun J, He ZG. Self-Emulsifying Drug Delivery Systems: Strategy for improving oral delivery of poorly soluble drugs. Current Drug Therapy 2007; 2: 85-93.
8. Date AA, Desai N, Dixit R & Nagarsenker M. Self-nanoemulsifying Drug Delivery Systems: Formulation insights, applications and advances. Nanomedicine 2010; 5(10).
9. Nielsen FS, Petersen KB & Müllertz A. Bioavailability of Probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state. Eur J Pharm Biopharm 2008; 69: 553-62.
10. Kumar GP, Rambhau D, Aapte SS. Oral bioavailability enhancement of Carbamazepine in healthy human volunteers. J Pharm Research 2011 Jan 13rd; 4(2): 361-5.
11. Taha EI, Al-Saidan S, Samy AM, Khan MA. Preparation and in vitro characterization of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate. Intr J Pharm 2004; 11(285)109-19.
12. Mahmood EA, Bendas ER, Mohamed MI. Preparation and evaluation of self-nanoemulsifying tablets of Carvedilol. AAPS 2009 Feb 24; 10(1):9192-7.
13. Jeevana JB & Sreelakshmi K. Design and evaluation of self-nanoemulsifying drug delivery system of Flutamide. J Young Pharm 2011; 3(1): 4-8.
14. Dixit AR, Rajput SJ & Patel SG. Preparation and bioavailability assessment of SMEDDS containing Valsartan. AAPS 2010 Feb; 11(1):314-21
15. Patel AR, Vavia PR. Preparation and in vivo evaluation of SMEDDS (Self-Microemulsifying Drug Delivery System) containing Fenofibrate. AAPS Journal 2007; 9(3): 344-352.
16. Gupta AK et al. Preparation and in-vitro evaluation of self-emulsifying drug delivery system of antihypertensive drug Valsartan. Intr J Pharma and Life Sciences March 2011; 2(3): 633-639.
17. Parambi DGT, Mathew M, Ganesan V. A validated stability indicating HPLC method for the determination of Valsartan in tablet dosage forms. Journal of Applied Pharmaceutical Science. June 2011; 01(04): 97-99.
18. Dey S et al. Development and validation of a UV-Vis Spectrophotometric method for the estimation and degradation monitoring of Cefradroxil in bulk and pharmaceutical dosage forms. International Journal of Chemistry Research. May 2010; 1(1): 29-35.
19. Shafiq-un-Nabi S et al. Formulation development and optimization using nanoemulsion technique: A technical note. AAPS PharmSciTech 2007; 8(2): Article 28.
20. Griffin WC. Calculation of HLB values of non-ionic surfactants. J. Soc. Cosmet. Chem. (1954): 259.
21. Pasquali RC, Taurozzi MP & Bregni C. Some considerations about the hydrophilic-lipophilic balance system. Int. J. Pharm 2008 May 22; 356(1-2): 44-51.
22. Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev 1997; 25: 47-58.
23. Particle Sciences Drug Development Services. Emulsion stability and testing. Tehnical Brief 2011 Volume 2. [cited 2011 July 30]. Available from: http://www.particlesciences.com/docs/technical_briefs/TB_2011_2.pdf
24. Colloidal Dynamics. The zeta potential. [cited 2011 July 27]. Available from: http://www.coloidal-dynamics.com/docs/CDElTUT1.pdf
25. Mason TG, Wilking JN, Meleson K, Chang CB & Graves SM. Nanoemulsions: Formation, structure and physical properties. J. Phys: Condens. Matter 18 (2006) R635-R666.