Effectiveness of artemether/lumefantrine for the treatment of uncomplicated plasmodium vivax and P. falciparum malaria in young children in papua New Guinea

Clinical Infectious Diseases

Volumn 56, Issue 10, 2013, Pages 1413-1420

  Senn, Nicolas ^a,b,c,d   Rarau, Patricia ^b   Manong, Doris ^b   Salib, Mary ^b   Siba, Peter ^b   Reeder, John C ^e   Rogerson, Stephen J ^c   Genton, Blaise ^a,d   Mueller, Ivo ^b,f,g  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH   (Papua New Guinea)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF BASEL   (Switzerland)

^e BURNET INSTITUTE   (Australia)

^f WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^g CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

Author keywords

artemether lumefantrine; effectiveness; malaria; vivax

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; PLACEBO;

ARTICLE; CHILD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG TREATMENT FAILURE; HUMAN; INFANT; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALARIA RAPID TEST; PAPUA NEW GUINEA; PLASMODIUM VIVAX MALARIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; TREATMENT OUTCOME;

AMODIAQUINE; ANTIMALARIALS; ARTEMISININS; CHILD, PRESCHOOL; ETHANOLAMINES; FLUORENES; HUMANS; INFANT; KAPLAN-MEIER ESTIMATE; MALARIA, FALCIPARUM; MALARIA, VIVAX; PAPUA NEW GUINEA; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84877290683     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cit068     Document Type: Article

References (24)

1. World Health Organization. Guidelines for the treatment of malaria. 2nd ed. Geneva, Switzerland: WHO, 2010.
2. Marfurt J, Mueller I, Sie A, et al. Low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against Plasmodium falciparum and P. vivax malaria in Papua New Guinea. Am J Trop Med Hyg 2007; 77:947-54.
3. Genton B, Baea K, Lorry K, Ginny M, Wines B, Alpers MP. Parasitological and clinical efficacy of standard treatment regimens against Plasmodium falciparum, P. vivax and P. malariae in Papua New Guinea. P N G Med J 2005; 48:141-50.
4. Karunajeewa HA, Mueller I, Senn M, et al. A trial of combination antimalarial therapies in children from Papua New Guinea. N Engl J Med 2008; 359:2545-57.
5. Baird JK. Resistance to therapies for infection by Plasmodium vivax. Clin Microbiol Rev 2009; 22:508-34.
6. Douglas N, Anstey NM, Angus B, Nosten F, Price R. Artemisinin combination therapy for vivax malaria. Lancet Infect Dis 2010; 10:405-16.
7. Lin E, Kiniboro B, Gray L, et al. Differential patterns of infection and disease with P. falciparum and P. vivax in young Papua New Guinean children. PLoS One 2010; 5:e9047.
8. Genton B, D'Acremont Vr, Rare L, et al. Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea. PLoS Med 2008; 5: e127.
9. Senn N, Rarau P, Stanisic DI, et al. Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial. PLoS Med 2012; 9:e1001195.
10. Krudsood S, Tangpukdee N, Muangnoicharoen S, et al. Clinical efficacy of chloroquine versus artemether-lumefantrine for Plasmodium vivax treatment in Thailand. Korean J Parasitol 2007; 45:111-4.
11. Ratcliff A, Siswantoro H, Kenangalem E, et al. Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison. Lancet 2007; 369:757-65.
12. Bassat Q. The use of artemether-lumefantrine for the treatment of uncomplicated Plasmodium vivax malaria. PLoS Negl Trop Dis 2011; 5: e1325.
13. Kasehagen LJ, Mueller I, McNamara DT, et al. Changing patterns of Plasmodium blood-stage infections in the Wosera region of Papua New Guinea monitored by light microscopy and high throughput PCR diagnosis. Am J Trop Med Hyg 2006; 75:588-96.
14. Senn N, Rarau P, Manong D, et al. Rapid diagnostic test-based management of Malaria: an effectiveness study in Papua New Guinean infants with Plasmodium falciparum and Plasmodium vivax malaria. Clin Infect Dis 2012; 54:644-51.
15. Kyabayinze DJ, Tibenderana JK, Odong GW, Rwakimari JB, Counihan H. Operational accuracy and comparative persistent antigenicity of HRP2 rapid diagnostic tests for Plasmodium falciparum malaria in a hyperendemic region of Uganda. Malar J 2008; 7:221.
16. Biswas S, Tomar D, Rao DN. Investigation of the kinetics of histidinerich protein 2 and of the antibody responses to this antigen, in a group of malaria patients from India. Ann Trop Med Parasitol 2005; 99:553-62.
17. Abba K, Deeks JJ, Olliaro P, et al. Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries. Cochrane Database Syst Rev 2011; 6:CD008122.
18. Mukhtar E, Gadalla N, El-zaki S-E, et al. A comparative study on the efficacy of artesunate plus sulphadoxine/pyrimethamine versus artemether-lumefantrine in eastern Sudan. Malar J 2007; 6:92.
19. Bell D, Wootton D, Mukaka M, et al. Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. Malar J 2009; 8:204.
20. Schoepflin S, Lin E, Kiniboro B, et al. Treatment with coartem (artemether-lumefantrine) in Papua New Guinea. Am J Trop Med Hyg 2010; 82:529-34.
21. Wells TN, Burrows JN, Baird JK. Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination. Trends Parasitol 2010; 26:145-51.
22. Betuela I, Bassat Q, Kiniboro B, et al. Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age. Antimicrob Agents Chemother 2012; 56:2146-9.
23. Shekalaghe SA, ter Braak R, Daou M, et al. In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals. Antimicrob Agents Chemother 2010; 54:1762-8.
24. Phyo AP, Lwin KM, Price RN, et al. Dihydroartemisinin-piperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: a randomized controlled trial. Clin Infect Dis 2011; 53:977-84.