Penicillin to prevent recurrent leg cellulitis

New England Journal of Medicine

Volumn 368, Issue 18, 2013, Pages 1695-1703

  Thomas, Kim S ^a   Crook, Angela M ^c   Nunn, Andrew J ^c   Foster, Katharine A ^a   Mason, James M ^d   Chalmers, Joanne R ^a   Nasr, Ibrahim S ^e   Brindle, Richard J ^f   English, John ^b   Meredith, Sarah K ^c   Reynolds, Nicholas J ^g   De Berker, David ^f   Mortimer, Peter S ^c   Williams, Hywel C ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^d DURHAM UNIVERSITY   (United Kingdom)

^e ROYAL BERKSHIRE HOSPITAL   (United Kingdom)

^f BRISTOL ROYAL INFIRMARY   (United Kingdom)

^g NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PENICILLIN DERIVATIVE; PLACEBO;

ADULT; AGED; ARTICLE; CELLULITIS; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG COST; DRUG ERUPTION; DRUG FATALITY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HUMAN; IRELAND; KIDNEY FAILURE; LEG CELLULITIS; LENGTH OF STAY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; RECURRENT INFECTION; RISK REDUCTION; SEPSIS; SKIN MANIFESTATION; THRUSH; TREATMENT OUTCOME; UNITED KINGDOM;

EID: 84877289504     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1206300     Document Type: Article

References (21)

1. Cox NH. Oedema as a risk factor for multiple episodes of cellulitis/erysipelas of the lower leg: a series with community follow-up. Br J Dermatol 2006;155:947-50. (Pubitemid 44564503)
2. Thomas K, Crook A, Foster K, et al. Prophylactic antibiotics for the prevention of cellulitis (erysipelas) of the leg: results of the U.K. Dermatology Clinical Trials Network's PATCH II trial. Br J Dermatol 2012;166:169-78.
3. Jeng A, Beheshti M, Li J, Nathan R. The role of beta-hemolytic streptococci in causing diffuse, nonculturable cellulitis: a prospective investigation. Medicine (Baltimore) 2010;89:217-26.
4. Bernard P, Bedane C, Mounier M, Denis F, Catanzano G, Bonnetblanc JM. Streptococcal cause of erysipelas and cellulitis in adults: a microbiologic study using a direct immunofluorescence technique. Arch Dermatol 1989;125:779-82. (Pubitemid 19161120)
5. Damstra RJ, van Steensel MAM, Boomsma JHB, Nelemans P, Veraart JCJM. Erysipelas as a sign of subclinical primary lymphoedema: a prospective quantitative scintigraphic study of 40 patients with unilateral erysipelas of the leg. Br J Dermatol 2008;158:1210-5. (Pubitemid 351692855)
6. Soo JK, Bicanic TA, Heenan S, Mortimer PS. Lymphatic abnormalities demonstrated by lymphoscintigraphy after lower limb cellulitis. Br J Dermatol 2008;158:1350-3. (Pubitemid 351692850)
7. Levell NJ, Wingfield CG, Garioch JJ. Severe lower limb cellulitis is best diagnosed by dermatologists and managed with shared care between primary and secondary care. Br J Dermatol 2011;164:1326-8.
8. Guidelines on the management of cellulitis in adults. Belfast, Northern Ireland: Clinical Resource Efficiency Support Team, 2005 (http://www.acutemed. co.uk/docs/Cellulitis%20guidelines,%20CREST,%2005.pdf).
9. Consensus document on the management of cellulitis in lymphoedema. Oxfordshire, United Kingdom: British Lymphology Society, 2010 (http://www.thebls.com/docs/consensus.pdf).
10. Kremer M, Zuckerman R, Avraham Z, Raz R. Long-term antimicrobial therapy in the prevention of recurrent sort-tissue infections. J Infect 1991;22:37-40.
11. Sjöblom AC, Eriksson B, Jorup- Rönström C, Karkkonen K, Lindqvist M. Antibiotic prophylaxis in recurrent erysipelas. Infection 1993;21:390-3.
12. Chakroun M, Ben-Romdhane F, Battikh R, Souki A, Bouzouaia N. Benzathine penicillin prophylaxis in recurrent erysipelas. Med Mal Infect 1994;24:894-7. (In French.) (Pubitemid 24344274)
13. Cox NH, Colver GB, Paterson WD. Management and morbidity of cellulitis of the leg. J R Soc Med 1998;91:634-7. (Pubitemid 29017595)
14. Jorup-Rönström C, Britton S. Recurrent erysipelas: predisposing factors and costs of prophylaxis. Infection 1987;15:105-6. (Pubitemid 17051548)
15. Grambsch PM, Therneau TM. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 1994;81:515-26.
16. Prescription cost analysis - England, 2010. Leeds, United Kingdom: National Health and Social Care Information Centre, National Health Service, 2011 (http://www.ic.nhs.uk/pubs/prescostanalysis2010).
17. Unit costs of health and social care 2010. Kent, United Kingdom: Personal Social Services Research Unit University of Kent, 2010 (www.pssru.ac.uk/pdf/uc/ uc2010/uc2010.pdf).
18. National schedule of reference costs 2010-11 for NHS Trusts and PCTs. London: Department of Health, National Health Service, 2011 (http://www.dh.gov. uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/ DH-131140).
19. Barber JA, Thompson SG. Analysis of cost data in randomized trials: an application of the non-parametric bootstrap. Stat Med 2000;19:3219-36.
20. Dalal A, Eskin-Shwartz M, Mimouni D, et al. Interventions for the prevention of recurrent erysipelas and cellulitis. Cochrane Database Syst Rev 2012;4:CD009758.
21. Resistance surveillance website: bacteraemia search results. Birmingham, United Kingdom: British Society for Antimicrobial Chemotherapy, 2011 (http://www.bsacsurv.org/mrsweb/bacteraemia?organism=A&antimicrobial= All&year=All&country=All&summary=SIRSummary&formname= bsac-bacteraemia&submit=Search).