Prevention and treatment of venous thromboembolism in pregnancy in patients with hereditary antithrombin deficiency

International Journal of Women's Health

Volumn 5, Issue 1, 2013, Pages 233-241

  James, Andra H ^a   Konkle, Barbara A ^b,c   Bauer, Kenneth A ^d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b PUGET SOUND BLOOD CENTER   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Delivery; Heparin; Labor; Plasma derived concentrate; Thrombophilia; Thrombosis

Indexed keywords

ANTICOAGULANT AGENT; FRESH FROZEN PLASMA; HEPARIN; RECOMBINANT ANTITHROMBIN III; WARFARIN;

ADOLESCENT; ADULT; ANAMNESIS; ANTICOAGULATION; ANTITHROMBIN DEFICIENCY; ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; DEEP VEIN THROMBOSIS; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; HOSPITAL ADMISSION; HUMAN; INFERIOR CAVA VEIN OBSTRUCTION; LOADING DRUG DOSE; LUNG EMBOLISM; MAINTENANCE DRUG DOSE; PARTIAL THROMBOPLASTIN TIME; PRACTICE GUIDELINE; PREGNANCY; VENOUS THROMBOEMBOLISM;

EID: 84877288537     PISSN: None     EISSN: 11791411     Source Type: Journal    
DOI: 10.2147/IJWH.S43190     Document Type: Article

References (46)

1. Heit JA, Kobbervig CE, James AH, Petterson TM, Bailey KR, Melton LJ 3rd. Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study. Ann Intern Med. 2005;143(10):697-706.
2. Pomp ER, Lenselink AM, Rosendaal FR, Doggen CJ. Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study. J Thromb Haemost. 2008;6(4): 632-637.
3. James AH, Jamison MG, Brancazio LR, Myers ER. Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. Am J Obstet Gynecol. 2006;194(5): 1311-1315.
4. Andersen BS, Steffensen FH, Sorensen HT, Nielsen GL, Olsen J. The cumulative incidence of venous thromboembolism during pregnancy and puerperium - an 11 year Danish population-based study of 63,300 pregnancies. Acta Obstet Gynecol Scand. 1998;77(2):170-173.
5. Gherman RB, Goodwin TM, Leung B, Byrne JD, Hethumumi R, Montoro M. Incidence, clinical characteristics, and timing of objectively diagnosed venous thromboembolism during pregnancy. Obstet Gynecol. 1999;94(5 Pt 1):730-734.
6. Lindqvist P, Dahlbäck B, Marŝál K. Thrombotic risk during pregnancy: a population study. Obstet Gynecol. 1999;94(4):595-599.
7. Simpson EL, Lawrenson RA, Nightingale AL, Farmer RD. Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database. BJOG. 2001; 108(1):56-60.
8. Jacobsen AF, Skjeldestad FE, Sandset PM. Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium - a register-based case-control study. Am J Obstet Gynecol. 2008;198(2):233. e1-e7.
9. Liu S, Rouleau J, Joseph KS, et al; Maternal Health Study Group of the Canadian Perinatal Surveillance System. Epidemiology of pregnancyassociated venous thromboembolism: a population-based study in Canada. J Obstet Gynaecol Can. 2009;31(7):611-620.
10. James AH, Tapson VF, Goldhaber SZ. Thrombosis during pregnancy and the postpartum period. Am J Obstet Gynecol. 2005;193(1):216-219.
11. De Stefano V, Simioni P, Rossi E, et al. The risk of recurrent venous thromboembolism in patients with inherited deficiency of natural anticoagulants antithrombin, protein C and protein S. Haematologica. 2006;91(5):695-698.
12. Dilley A, Austin H, El-Jamil M, et al. Genetic factors associated with thrombosis in pregnancy in a United States population. Am J Obstet Gynecol. 2000;183(5):1271-1277.
13. Gerhardt A, Scharf RE, Beckmann MW, et al. Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium. N Engl J Med. 2000;342(6):374-380.
14. Egeberg O. Thrombophilia caused by inheritable deficiency of blood antithrombin. Scand J Clin Lab Invest. 1965;17:92.
15. Patnaik MM, Moll S. Inherited antithrombin deficiency: a review. Haemophilia. 2008;14(6):1229-1239.
16. Hellgren M, Tengborn L, Abildgaard U. Pregnancy in women with congenital antithrombin III deficiency: experience of treatment with heparin and antithrombin. Gynecol Obstet Invest. 1982;14(2):127-141.
17. Conard J, Horellou MH, Van Dreden P, Lecompte T, Samama M. Thrombosis and pregnancy in congenital deficiencies in AT III, protein C or protein S: study of 78 women. Thromb Haemost. 1990;63(2):319-320.
18. Pabinger I, Schneider B. Thrombotic risk in hereditary antithrombin III, protein C, or protein S deficiency. A cooperative, retrospective study. Gesellschaft fur Thrombose- und Hamostaseforschung (GTH) Study Group on Natural Inhibitors. Arterioscler Thromb Vasc Biol. 1996; 16(6):742-748.
19. James A; Committee on Practice Bulletins - Obstetrics. Practice bulletin no 123: thromboembolism in pregnancy. Obstet Gynecol. 2011;118(3): 718-729.
20. Bates SM, Greer IA, Pabinger I, Sofaer S, Hirsh J; American College of Chest Physicians. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, 8th ed. Chest. 2008;133(Suppl 6):844S-886S.
21. Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos AM, Vandvik PO; American College of Chest Physicians. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(Suppl 2):e691S-e736S.
22. Jordan RE, Oosta GM, Gardner WT, Rosenberg RD. The kinetics of hemostatic enzyme-antithrombin interactions in the presence of low molecular weight heparin. J Biol Chem. 1980;255(21):10081-10090.
23. Wickerhauser M, Williams C, Mercer J. Development of large scale fractionation methods. VII. Preparation of antithrombin III concentrate. Vox Sang. 1979;36(5):281-293.
24. Finazzi G, Caccia R, Barbui T. Different prevalence of thromboembolism in the subtypes of congenital antithrombin III deficiency: review of 404 cases. Thromb Haemost. 1987;58(4):1094.
25. Tait RC, Walker ID, Islam SI, et al. Influence of demographic factors on antithrombin III activity in a healthy population. Br J Haematol. 1993;84(3):476-480.
26. Schwartz RS, Bauer KA, Rosenberg RD, Kavanaugh EJ, Davies DC, Bogdanoff DA. Clinical experience with antithrombin III concentrate in treatment of congenital and acquired deficiency of antithrombin. The Antithrombin III Study Group. Am J Med. 1989;87(3B):53S-60S.
27. Menache D, O'Malley JP, Schorr JB, et al. Evaluation of the safety, recovery, half-life, and clinical efficacy of antithrombin III (human) in patients with hereditary antithrombin III deficiency. Cooperative Study Group. Cooperative Study Group. Blood. 1990; 75(1):33-39.
28. Tiede A, Tait RC, Shaffer DW, et al. Antithrombin alfa in hereditary antithrombin deficient patients: A phase 3study of prophylactic intravenous administration in high risk situations. Thromb Haemost. 2008;99(3):616-622.
29. Sanson BJ, Friederich PW, Simioni P, et al. The risk of abortion and stillbirth in antithrombin-, protein C-, and protein S-deficient women. Thromb Haemost. 1996;75(3):387-388.
30. Friederich PW, Sanson BJ, Simioni P, et al. Frequency of pregnancyrelated venous thromboembolism in anticoagulant factor-deficient women: implications for prophylaxis. Ann Intern Med. 1996; 125(12):955-960.
31. Martinelli I, De Stefano V, Taioli E, Paciaroni K, Rossi E, Mannucci PM. Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium. Thromb Haemost. 2002;87(5):791-795.
32. Brandt P. Observations during the treatment of antithrombin-III deficient women with heparin and antithrombin concentrate during pregnancy, parturition, and abortion. Thromb Res. 1981;22(1-2):15-24.
33. Hellgren M, Nygårds EB. Long-term therapy with subcutaneous heparin during pregnancy. Gynecol Obstet Invest. 1982;13(2):76-89.
34. Michiels JJ, Stibbe J, Vellenga E, van Vliet HH. Prophylaxis of thrombosis in antithrombin III-deficient women during pregnancy and delivery. Eur J Obstet Gynecol Reprod Biol. 1984;18(3):149-153.
35. Samson D, Stirling Y, Woolf L, Howarth D, Seghatchian MJ, de Chazal R. Management of planned pregnancy in a patient with congenital antithrombin III deficiency. Br J Haematol. 1984;56(2): 243-249.
36. De Stefano V, Leone G, De Carolis S, et al. Management of pregnancy in women with antithrombin III congenital defect: report of four cases. Thromb Haemost. 1988;59(2):193-196.
37. Blondel-Hill E, Mant MJ. The pregnant antithrombin III deficient patient: management without antithrombin III concentrate. Thromb Res. 1992;65(2):193-198.
38. Kario K, Matsuo T, Kodama K, Matsuo M. Prophylactic antithrombin III administration during pregnancy immediately reduces the thrombin hyperactivity of congenital antithrombin III deficiency by forming thrombin-antithrombin III complexes. Thromb Res. 1992;66(5): 509-515.
39. Yamada T, Yamada H, Morikawa M, et al. Management of pregnancy with congenital antithrombin III deficiency: two case reports and a review of the literature. J Obstet Gynaecol Res. 2001;27(4):189-197.
40. Grandone E, De Stefano V, Rossi E, Cappucci F, Colaizzo D, Margaglione M. Antithrombotic prophylaxis during pregnancy in women with deficiency of natural anticoagulants. Blood Coagul Fibrinolysis. 2008;19(3):226-230.
41. Hidaka N, Hachisuga M, Tsukimori K, Onohara T, Maehara Y, Wake N. Intrapartum placement of an inferior vena cava filter for a woman with hereditary antithrombin III deficiency: its role in the prevention of fatal pulmonary embolism. J Obstet Gynaecol Res. 2008;34(1):95-99.
42. Sabadell J, Casellas M, Alijotas-Reig J, Arellano-Rodrigo E, Cabero L. Inherited antithrombin deficiency and pregnancy: maternal and fetal outcomes. Eur J Obstet Gynecol Reprod Biol. 2010;149(1):47-51.
43. Pamnani A, Rosenstein M, Darwich A, Wolfson A. Neuraxial anesthesia for labor and cesarean delivery in a parturient with hereditary antithrombin deficiency on recombinant human antithrombin infusion therapy. J Clin Anesth. 2010;22(6):450-453.
44. Sharpe CJ, Crowther MA, Webert KE, Donnery C. Cerebral venous thrombosis during pregnancy in the setting of type I antithrombin deficiency: case report and literature review. Transfus Med Rev. 2011; 25(1):61-65.
45. Kovac M, Miković Z, Rakirević L, et al. A successful outcome of pregnancy in a patient with congenital antithrombin deficiency. Vojnosanit Pregl. 2011;68(2):175-177.
46. Atryn (Recombinant) Highlights of Prescribing Information US. GTC Biotherapeutics, Inc. Framingham, MA, USA. November, 2010. Available at http://atryn.com/pdf/ATryn_PI_0409.pdf. Accessed April 21, 2013.