Depleting NFAT1 expression inhibits the ability of invasion and migration of human lung cancer cells

Cancer Cell International

Volumn 13, Issue 1, 2013, Pages

  Liu, Ji fu ^a   Zhao, Shou hua ^a   Wu, Shan shan ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Invasion assay; Lung cancer; NFAT1; Pathogenesis; RNA interference

Indexed keywords

SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT1; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER SURGERY; CANCER TISSUE; CELL ADHESION; CELL ASSAY; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; METASTASIS; PROTEIN EXPRESSION; RNA INTERFERENCE; TUMOR INVASION; WOUND HEALING;

EID: 84877277934     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/1475-2867-13-41     Document Type: Article

References (17)

1. Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 2005, 5(6):472-484. 10.1038/nri1632, 15928679.
2. Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 1997, 15:707-747. 10.1146/annurev.immunol.15.1.707, 9143705.
3. Hogan PG, Chen L, Nardone J, Rao A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 2003, 17(18):2205-2232. 10.1101/gad.1102703, 12975316.
4. Graef IA, Chen F, Crabtree GR. NFAT signaling in vertebrate development. Curr Opin Genet Dev 2001, 11(5):505-512. 10.1016/S0959-437X(00)00225-2, 11532391.
5. Crabtree GR, Olson EN. NFAT signaling: choreographing the social lives of cells. Cell 2002, 109(Suppl):S67-S79.
6. Feske S, Okamura H, Hogan PG, Rao A. Ca2+/calcineurin signalling in cells of the immune system. Biochem Biophys Res Commun 2003, 311(4):1117-1132. 10.1016/j.bbrc.2003.09.174, 14623298.
7. Flanagan WM, Corthesy B, Bram RJ, Crabtree GR. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 1991, 352(6338):803-807. 10.1038/352803a0, 1715516.
8. Okamura H, Aramburu J, Garcia-Rodriguez C, Viola JP, Raghavan A, Tahiliani M, Zhang X, Qin J, Hogan PG, Rao A. Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol Cell 2000, 6(3):539-550. 10.1016/S1097-2765(00)00053-8, 11030334.
9. Shaw KT, Ho AM, Raghavan A, Kim J, Jain J, Park J, Sharma S, Rao A, Hogan PG. Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc Natl Acad Sci U S A 1995, 92(24):11205-11209. 10.1073/pnas.92.24.11205, 40600, 7479966.
10. Loh C, Shaw KT, Carew J, Viola JP, Luo C, Perrino BA, Rao A. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J Biol Chem 1996, 271(18):10884-10891. 10.1074/jbc.271.18.10884, 8631904.
11. Jain J, McCaffrey PG, Miner Z, Kerppola TK, Lambert JN, Verdine GL, Curran T, Rao A. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 1993, 365(6444):352-355. 10.1038/365352a0, 8397339.
12. Macian F, Lopez-Rodriguez C, Rao A. Partners in transcription: NFAT and AP-1. Oncogene 2001, 20(19):2476-2489. 10.1038/sj.onc.1204386, 11402342.
13. Morimoto T, Hasegawa K, Wada H, Kakita T, Kaburagi S, Yanazume T, Sasayama S. Calcineurin-GATA4 pathway is involved in beta-adrenergic agonist-responsive endothelin-1 transcription in cardiac myocytes. J Biol Chem 2001, 276(37):34983-34989. 10.1074/jbc.M005498200, 11435416.
14. Iniguez MA, Martinez-Martinez S, Punzon C, Redondo JM, Fresno M. An essential role of the nuclear factor of activated T cells in the regulation of the expression of the cyclooxygenase-2 gene in human T lymphocytes. J Biol Chem 2000, 275(31):23627-23635. 10.1074/jbc.M001381200, 10816557.
15. Yiu GK, Toker A. NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. J Biol Chem 2006, 281(18):12210-12217. 10.1074/jbc.M600184200, 16505480.
16. Flockhart RJ, Armstrong JL, Reynolds NJ, Lovat PE. NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma. Br J Cancer 2009, 101(8):1448-1455. 10.1038/sj.bjc.6605277, 2768445, 19724275.
17. Gaudineau B, Fougere M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S. Lipocalin 2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion. J Cell Sci 2012,