Vitamin D and systemic lupus erythematosus: An update

Expert Review of Clinical Immunology

Volumn 9, Issue 5, 2013, Pages 453-463

  Mok, Chi Chiu ^a  

^a TUEN MUN HOSPITAL   (Hong Kong)

Author keywords

25 hydroxyvitamin D; deficiency; insufficiency; lupus; pathophysiology

Indexed keywords

25 HYDROXYVITAMIN D; CALCITRIOL; CHLOROQUINE; CYCLOSPORIN A; GLUCOCORTICOID; HYDROXYCHLOROQUINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 23; MACROPHAGE DERIVED CHEMOKINE; TACROLIMUS; VITAMIN D; VITAMIN D RECEPTOR;

ADAPTIVE IMMUNITY; APOPTOSIS; B LYMPHOCYTE DIFFERENTIATION; CELL PROLIFERATION; CYTOKINE PRODUCTION; HUMAN; IMMUNOMODULATION; INNATE IMMUNITY; INTESTINE ABSORPTION; MYELOID DENDRITIC CELL; PHAGOCYTOSIS; PHOTOSENSITIVITY; PROTEIN EXPRESSION; REVIEW; RISK FACTOR; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION;

HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; PREVALENCE; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84877268917     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1586/eci.13.19     Document Type: Review

References (84)

1. Pike JW, Meyer MB. The vitamin D receptor: new paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D(3). Endocrinol. Metab. Clin. North Am. 39(2), 255-269 (2010
2. Adams JS, Hewison M. Update in vitamin D. J. Clin. Endocrinol. Metab. 95(2), 471-478 (2010
3. Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol. Metab. Clin. North Am. 39(2), 365-379 (2010
4. Adorini L, Penna G. Control of autoimmune diseases by the vitamin D endocrine system. Nat. Clin. Pract. Rheumatol. 4(8), 404-412 (2008
5. Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: modulator of the immune system. Curr. Opin. Pharmacol. 10(4), 482-496 (2010
6. Gombart AF. The vitamin D - antimicrobial peptide pathway and its role in protection against infection. Future Microbiol. 4(9), 1151-1165 (2009
7. Martineau AR, Wilkinson KA, Newton SM et al. IFN-γ- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. J. Immunol. 178(11), 7190-7198 (2007
8. Gauzzi MC, Purificato C, Donato K et al. Suppressive effect of 1α,25- dihydroxyvitamin D3 on type I IFN-mediated monocyte differentiation into dendritic cells: impairment of functional activities and chemotaxis. J. Immunol. 174(1), 270-276 (2005
9. Baeke F, Korf H, Overbergh L et al. The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation. J. Immunol. 186(1), 132-142 (2011
10. Bartels LE, Hvas CL, Agnholt J, Dahlerup JF, Agger R. Human dendritic cell antigen presentation and chemotaxis are inhibited by intrinsic 25-hydroxy vitamin D activation. Int. Immunopharmacol. 10(8), 922-928 (2010
11. Chen S, Sims GP, Chen XX, Gu YY, Chen S, Lipsky PE. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J. Immunol. 179(3), -1647 (2007)
12. Shirakawa AK, Nagakubo D, Hieshima K, Nakayama T, Jin Z, Yoshie O. 1,25- dihydroxyvitamin D3 induces CCR10 expression in terminally differentiating human B cells. J. Immunol. 180(5), -2795 (2008
13. Mok CC, Lau CS. Pathogenesis of systemic lupus erythematosus. J. Clin. Pathol. 56(7), 481-490 (2003
14. Katsiari CG, Liossis SN, Sfikakis PP. The pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus: a reappraisal. Semin. Arthritis Rheum. 39(6), 491-503 (2010
15. Fransen JH, van der Vlag J, Ruben J, Adema GJ, Berden JH, Hilbrands LB. The role of dendritic cells in the pathogenesis of systemic lupus erythematosus. Arthritis Res. Ther. 12(2), 207 (2010
16. Linker-Israeli M, Elstner E, Klinenberg JR, Wallace DJ, Koeffler HP. Vitamin D(3) and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC. Clin. Immunol. 99(1), 82-93 (2001
17. Ben-Zvi I, Aranow C, Mackay M et al. The impact of vitamin D on dendritic cell function in patients with systemic lupus erythematosus. PLoS One 5(2), e9193 (2010
18. Ritterhouse LL, Crowe SR, Niewold TB et al. Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Ann. Rheum. Dis. 70(9), 1569-1574 (2011
19. Pelajo CF, Lopez-Benitez JM, Miller LC. Vitamin D and autoimmune rheumatologic disorders. Autoimmun. Rev. 9(7), 507-510 (2010
20. Gatenby P, Lucas R, Swaminathan A. Vitamin D deficiency and risk for rheumatic diseases: an update. Curr. Opin. Rheumatol. 25(2), 184-191 (2013
21. Kamen DL, Cooper GS, Bouali H, Shaftman SR, Hollis BW, Gilkeson GS. Vitamin D deficiency in systemic lupus erythematosus. Autoimmun. Rev. 5(2), 114-117 (2006
22. Bonakdar ZS, Jahanshahifar L, Jahanshahifar F, Gholamrezaei A. Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus. Lupus 20(11), 1155-1160 (2011
23. Costenbader KH, Feskanich D, Holmes M, Karlson EW, Benito-Garcia E. Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women. Ann. Rheum. Dis. 67(4), 530-535 (2008
24. Hiraki LT, Munger KL, Costenbader KH, Karlson EW. Dietary intake of vitamin D during adolescence and risk of adult-onset systemic lupus erythematosus and rheumatoid arthritis. Arthritis Care Res. (Hoboken) 64(12), 1829-1836 (2012
25. Disanto G, Chaplin G, Morahan JM et al. Month of birth, vitamin D and risk of immune mediated disease: a case-control study. BMC Med. 10(1), 69 (2012
26. Singh A, Kamen DL. Potential benefits of vitamin D for patients with systemic lupus erythematosus. Dermatoendocrinol. 4(2), 146-151 (2012
27. Sumethkul K, Boonyaratavej S, Kitumnuaypong T et al. The predictive factors of low serum 25-hydroxyvitamin D and vitamin D deficiency in patients with systemic lupus erythematosus. Rheumatol. Int. doi:10.1007/s00296-012-2537-7 (2012) (Epub ahead of print
28. Casella CB, Seguro LP, Takayama L, Medeiros D, Bonfa E, Pereira RM. Juvenile onset systemic lupus erythematosus: a possible role for vitamin D in disease status and bone health. Lupus 21(12), 1335-1342 (2012
29. Mok CC, Birmingham DJ, Leung HW, Hebert LA, Song H, Rovin BH. Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis. Rheumatology (Oxford) 51(4), 644-652 (2012
30. Souto M, Coelho A, Guo C et al. Vitamin D insufficiency in Brazilian patients with SLE: prevalence, associated factors, and relationship with activity. Lupus 20(10), 1019-1026 (2011
31. Hamza RT, Awwad KS, Ali MK, Hamed AI. Reduced serum concentrations of 25-hydroxy vitamin D in Egyptian patients with systemic lupus erythematosus: relation to disease activity. Med. Sci. Monit. 17(12), CR711-CR718 (2011
32. López-Robles C, Rios-Fernández R, Callejas-Rubio JL, Ortego-Centeno N. Vitamin D deficiency in a cohort of patients with systemic lupus erythematosus from the south of Spain. Lupus 20(3), 330-331 (2011
33. Amital H, Szekanecz Z, Szücs G et al. Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D? Ann. Rheum. Dis. 69(6), -1157 (2010
34. Ruiz-Irastorza G, Gordo S, Olivares N, Egurbide MV, Aguirre C. Changes in vitamin D levels in patients with systemic lupus erythematosus: effects on fatigue, disease activity, and damage. Arthritis Care Res. (Hoboken) 62(8), 1160-1165 (2010
35. Cutillas-Marco E, Morales-Suárez-Varela M, Marquina-Vila A, Grant W. Serum 25-hydroxyvitamin D levels in patients with cutaneous lupus erythematosus in a Mediterranean region. Lupus 19(7), 810-814 (2010
36. Kim HA, Sung JM, Jeon JY, Yoon JM, Suh CH. Vitamin D may not be a good marker of disease activity in Korean patients with systemic lupus erythematosus. Rheumatol. Int. 31(9), 1189-1194 (2011
37. Szodoray P, Tarr T, Bazso A, Poor G, Szegedi G, Kiss E. The immunopathological role of vitamin D in patients with SLE: data from a single centre registry in Hungary. Scand. J. Rheumatol. 40(2), 122-126 (2011
38. Toloza SM, Cole DE, Gladman DD, Ibañez D, Urowitz MB. Vitamin D insufficiency in a large female SLE cohort. Lupus 19(1), 13-19 (2010
39. Wu PW, Rhew EY, Dyer AR et al. 25-hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus. Arthritis Rheum. 61(10), -1395 (2009
40. Borba VZ, Vieira JG, Kasamatsu T, Radominski SC, Sato EI, Lazaretti-Castro M. Vitamin D deficiency in patients with active systemic lupus erythematosus. Osteoporos. Int. 20(3), 427-433 (2009
41. Ruiz-Irastorza G, Egurbide MV, Olivares N, Martinez-Berriotxoa A, Aguirre C. Vitamin D deficiency in systemic lupus erythematosus: prevalence, predictors and clinical consequences. Rheumatology (Oxford) 47(6), 920-923 (2008
42. Cusack C, Danby C, Fallon JC et al. Photoprotective behaviour and sunscreen use: impact on vitamin D levels in cutaneous lupus erythematosus. Photodermatol. Photoimmunol. Photomed. 24(5), 260-267 (2008
43. Orbach H, Zandman-Goddard G, Amital H et al. Novel biomarkers in autoimmune diseases: prolactin, ferritin, vitamin D, and TPA levels in autoimmune diseases. Ann. NY Acad. Sci. 1109, 385-400 (2007
44. Fraser WD, Milan AM. Vitamin D assays: past and present debates, difficulties, and developments. Calcif. Tissue Int. 92(2), 118-127 (2013
45. Shoenfeld N, Amital H, Shoenfeld Y. The effect of melanism and vitamin D synthesis on the incidence of autoimmune disease. Nat. Clin. Pract. Rheumatol. 5(2), 99-105 (2009
46. Earthman CP, Beckman LM, Masodkar K, Sibley SD. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. Int. J. Obes. (Lond.) 36(3), 387-396 (2012
47. Reynolds JA, Haque S, Berry JL et al. 25-hydroxyvitamin D deficiency is associated with increased aortic stiffness in patients with systemic lupus erythematosus. Rheumatology (Oxford) 51(3), 544-551 (2012
48. Wright TB, Shults J, Leonard MB, Zemel BS, Burnham JM. Hypovitaminosis D is associated with greater body mass index and disease activity in pediatric systemic lupus erythematosus. J. Pediatr. 155(2), 260-265 (2009
49. Kamen DL. Vitamin D in lupus - new kid on the block? Bull. NYU Hosp. Jt Dis. 68(3), 218-222 (2010
50. Meier C, Kraenzlin ME. Antiepileptics and bone health. Ther. Adv. Musculoskelet. Dis. 3(5), 235-243 (2011
51. Mok CC, Tong KH, To CH, Siu YP, Au TC. Tacrolimus for induction therapy of diffuse proliferative lupus nephritis: an open-labeled pilot study. Kidney Int. 68(2), 813-817 (2005
52. Lee CT, Ng HY, Lien YH et al. Effects of cyclosporine, tacrolimus and rapamycin on renal calcium transport and vitamin D metabolism. Am. J. Nephrol. 34(1), 87-94 (2011
53. Grenet O, Bobadilla M, Chibout SD, Steiner S. Evidence for the impairment of the vitamin D activation pathway by cyclosporine A. Biochem. Pharmacol. 59(3), 267-272 (2000
54. Adams JS, Diz MM, Sharma OP. Effective reduction in the serum 1,25-dihydroxyvitamin D and calcium concentration in sarcoidosis-associated hypercalcemia with short-course chloroquine therapy. Ann. Intern. Med. 111(5), 437-438 (1989
55. Barré PE, Gascon-Barré M, Meakins JL, Goltzman D. Hydroxychloroquine treatment of hypercalcemia in a patient with sarcoidosis undergoing hemodialysis. Am. J. Med. 82(6), 1259-1262 (1987
56. O'Leary TJ, Jones G, Yip A, Lohnes D, Cohanim M, Yendt ER. The effects of chloroquine on serum 1,25-dihydroxyvitamin D and calcium metabolism in sarcoidosis. N. Engl. J. Med. 315(12), 727-730 (1986
57. Huisman AM, White KP, Algra A et al. Vitamin D levels in women with systemic lupus erythematosus and fibromyalgia. J. Rheumatol. 28(11), 2535-2539 (2001
58. Mok CC, Birmingham DJ, Ho LY, Hebert LA, Song H, Rovin BH. Vitamin D deficiency as marker for disease activity and damage in systemic lupus erythematosus: a comparison with anti-dsDNA and anti-C1q. Lupus 21(1), 36-42 (2012
59. Reddy Vanga S, Good M, Howard PA, Vacek JL. Role of vitamin D in cardiovascular health. Am. J. Cardiol. 106(6), 798-805 (2010
60. Reis JP, von Mühlen D, Michos ED et al. Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis. Atherosclerosis 207(2), 585-590 (2009
61. de Boer IH, Kestenbaum B, Shoben AB, Michos ED, Sarnak MJ, Siscovick DS. 25-hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification. J. Am. Soc. Nephrol. 20(8), 1805-1812 (2009
62. Anderson JL, May HT, Horne BD et al.; Intermountain Heart Collaborative (IHC) Study Group. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Am. J. Cardiol. 106(7), 963-968 (2010
63. Kim DH, Sabour S, Sagar UN, Adams S, Whellan DJ. Prevalence of hypovitaminosis D in cardiovascular diseases (from the National Health and Nutrition Examination Survey 2001 to 2004). Am. J. Cardiol. 102(11), 1540-1544 (2008
64. Baz-Hecht M, Goldfine AB. The impact of vitamin D deficiency on diabetes and cardiovascular risk. Curr. Opin. Endocrinol. Diabetes. Obes. 17(2), 113-119 (2010
65. Martins D, Wolf M, Pan D et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch. Intern. Med. 167(11), -1165 (2007
66. Wang L, Song Y, Manson JE et al. Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies. Circ. Cardiovasc. Qual. Outcomes 5(6), 819-829 (2012
67. Zhao G, Ford ES, Li C, Croft JB. Serum 25-hydroxyvitamin D levels and all-cause and cardiovascular disease mortality among US adults with hypertension: the NHANES linked mortality study. J. Hypertens. 30(2), 284-289 (2012
68. Correia LC, Sodré F, Garcia G et al. Relation of severe deficiency of vitamin D to cardiovascular mortality during acute coronary syndromes. Am. J. Cardiol. 111(3), 324-327 (2013
69. Mok CC. Accelerated atherosclerosis, arterial thromboembolism, and preventive strategies in systemic lupus erythematosus. Scand. J. Rheumatol. 35(2), 85-95 (2006
70. Ravenell RL, Kamen DL, Spence JD et al. Premature atherosclerosis is associated with hypovitaminosis D and angiotensin-converting enzyme inhibitor non-use in lupus patients. Am. J. Med. Sci. 344(4), 268-273 (2012
71. Alele JD, Kamen DL. The importance of inflammation and vitamin D status in SLE-associated osteoporosis. Autoimmun. Rev. 9(3), 137-139 (2010
72. Yeap SS, Othman AZ, Zain AA, Chan SP. Vitamin D levels: its relationship to bone mineral density response and disease activity in premenopausal Malaysian systemic lupus erythematosus patients on corticosteroids. Int. J. Rheum. Dis. 15(1), 17-24 (2012
73. Bischoff HA, Borchers M, Gudat F et al. In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem. J. 33(1), 19-24 (2001
74. Prabhala A, Garg R, Dandona P. Severe myopathy associated with vitamin D deficiency in western New York. Arch. Intern. Med. 160(8), 1199-1203 (2000
75. Korenromp IH, Heijnen CJ, Vogels OJ, van den Bosch JM, Grutters JC. Characterization of chronic fatigue in patients with sarcoidosis in clinical remission. Chest 140(2), 441-447 (2011
76. Stockton KA, Kandiah DA, Paratz JD, Bennell KL. Fatigue, muscle strength and vitamin D status in women with systemic lupus erythematosus compared with healthy controls. Lupus 21(3), 271-278 (2012
77. Heaney RP, Recker RR, Grote J, Horst RL, Armas LA. Vitamin D(3) is more potent than vitamin D(2) in humans. J. Clin. Endocrinol. Metab. 96(3), E447-E452 (2011
78. Grossman JM, Gordon R, Ranganath VK et al. American College of Rheumatology recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. Arthritis Care Res. (Hoboken) 62(11), 1515-1526 (2010
79. Holick MF. Vitamin D deficiency. N. Engl. J. Med. 357(3), 266-281 (2007
80. Abou-Raya A, Abou-Raya S, Helmii M. The effect of vitamin D supplementation on inflammatory and hemostatic markers and disease activity in patients with systemic lupus erythematosus: a randomized placebo-controlled trial. J. Rheumatol. 40(3), 265-272 (2013
81. Terrier B, Derian N, Schoindre Y et al. Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation. Arthritis Res. Ther. 14(5), R221 (2012
82. Hartmann B, Heine G, Babina M et al. Targeting the vitamin D receptor inhibits the B cell-dependent allergic immune response. Allergy 66(4), 540-548 (2011
83. Sochorová K, Budinský V, Rozková D et al. Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells. Clin. Immunol. 133(1), 69-77 (2009
84. Laverny G, Penna G, Vetrano S et al. Efficacy of a potent and safe vitamin D receptor agonist for the treatment of inflammatory bowel disease. Immunol. Lett. 131(1), 49-58 (2010