Safety of antidepressants in adults aged under 65: Protocol for a cohort study using a large primary care database

BMC Psychiatry

Volumn 13, Issue , 2013, Pages

  Coupland, Carol ^a   Morriss, Richard ^a   Arthur, Antony ^b   Moore, Michael ^c   Hill, Trevor ^a   Hippisley Cox, Julia ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Antidepressants; Cohort; Depression; Safety

Indexed keywords

ANTIDEPRESSANT AGENT;

ADULT; AGE; ARTICLE; AUTOMUTILATION; DEPRESSION; DRUG ERUPTION; DRUG OVERDOSE; DRUG SAFETY; EPILEPSY; FALLING; FOLLOW UP; FRACTURE; HEART ARRHYTHMIA; HEART INFARCTION; HUMAN; INCIDENCE; MORTALITY; PRESCRIPTION; SIDE EFFECT; SUDDEN DEATH; SUICIDE; TRAFFIC ACCIDENT; TRANSIENT ISCHEMIC ATTACK; TREATMENT DURATION; UPPER GASTROINTESTINAL BLEEDING;

ADULT; ANTIDEPRESSIVE AGENTS; CAUSE OF DEATH; CLINICAL PROTOCOLS; DATABASES, FACTUAL; DEPRESSIVE DISORDER; FEMALE; HUMANS; MALE; MIDDLE AGED; PRIMARY HEALTH CARE; SELF-INJURIOUS BEHAVIOR; SUICIDE;

EID: 84877265084     PISSN: None     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/1471-244X-13-135     Document Type: Article

References (21)

1. Health and Social Care Information Centre, Prescribing and Primary Care Services Prescriptions Dispensed in the Community: England, Statistics for 2001 to 2011 https://catalogue.ic.nhs.uk/publications/prescribing/primary/pres-disp-com-eng-2001-11/pres-disp-com-eng-2001-11-rep.pdf, Health and Social Care Information Centre, Prescribing and Primary Care Services.
2. Health and Social Care Information Centre, Prescribing and Primary Care Prescription Cost Analysis England 2012, https://catalogue.ic.nhs.uk/publications/prescribing/primary/pres-cost-anal-eng-2012/pres-cost-anal-eng-2012-rep.pdf, Health and Social Care Information Centre, Prescribing and Primary Care.
3. Moore M, Yuen HM, Dunn N, Mullee MA, Maskell J, Kendrick T. Explaining the rise in antidepressant prescribing: a descriptive study using the general practice research database. BMJ 2009, 339:b3999. 10.1136/bmj.b3999, 2762496, 19833707.
4. Lockhart P, Guthrie B. Trends in primary care antidepressant prescribing 1995-2007: a longitudinal population database analysis. Br JGen Pract 2011, 61:e565-e572.
5. Arroll B, Elley CR, Fishman T, Goodyear-Smith FA, Kenealy T, Blashki G, Kerse N, MacGillivray S. Antidepressants versus placebo for depression in primary care. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews: Reviews 2009 Issue 3 2009, UK: John Wiley & Sons, Ltd Chichester.
6. Jick H, Kaye JA, Jick SS. Antidepressants and the risk of suicidal behaviors. JAMA 2004, 292(3):338-343. 10.1001/jama.292.3.338, 15265848.
7. Martinez C, Rietbrock S, Wise L, Ashby D, Chick J, Moseley J, Evans S, Gunnell D. Antidepressant treatment and the risk of fatal and non-fatal self harm in first episode depression: nested case-control study. BMJ 2005, 330(7488):389. 10.1136/bmj.330.7488.389, 549107, 15718538.
8. Stone M, Laughren T, Jones ML, Levenson M, Holland PC, Hughes A, Hammad TA, Temple R, Rochester G. Risk of suicidality in clinical trials of antidepressants in adults: analysis of proprietary data submitted to US Food and Drug Administration. BMJ 2009, 339:b2880. 10.1136/bmj.b2880, 2725270, 19671933.
9. Hippisley-Cox J, Pringle M, Hammersley V, Crown N, Wynn A, Meal A, Coupland C. Antidepressants as risk factor for ischaemic heart disease: case-control study in primary care. BMJ 2001, 323(7314):666-669. 10.1136/bmj.323.7314.666, 55927, 11566831.
10. Tata LJ, West J, Smith C, Farrington P, Card T, Smeeth L, Hubbard R. General population based study of the impact of tricyclic and selective serotonin reuptake inhibitor antidepressants on the risk of acute myocardial infarction. Heart 2005, 91(4):465-471. 10.1136/hrt.2004.037457, 1768803, 15772201.
11. Chen Y, Guo JJ, Li H, Wulsin L, Patel NC. Risk of cerebrovascular events associated with antidepressant use in patients with depression: A population-based, nested case-control study. Ann Pharmacother 2008, 42(2):177-184. 10.1345/aph.1K369, 18212255.
12. Dalton SO, Johansen C, Mellemkjaer L, Norgard B, Sorensen HT, Olsen JH. Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study. Arch Intern Med 2003, 163(1):59-64. 10.1001/archinte.163.1.59, 12523917.
13. Coupland C, Dhiman P, Barton G, Morriss R, Arthur A, Sach T, Hippisley-Cox J. A study of the safety and harms of antidepressant drugs for older people: a cohort study analysis using a large primary care database. Health Technol Assess 2011, 15(28). http://www.hta.ac.uk/fullmono/mon1528.pdf.
14. Abrams RC, Leon AC, Tardiff K, Marzuk PM, Li CS, Galea S. Antidepressant Use in elderly suicide victims in New york city: an analysis of 255 cases. J Clin Psychiatry 2009, 70(3):312-317. 10.4088/JCP.08m04243, 19210947.
15. Hubbard R, Farrington P, Smith C, Smeeth L, Tattersfield A. Exposure to tricyclic and selective serotonin reuptake inhibitor antidepressants and the risk of Hip fracture. Am J Epidemiol 2003, 158(1):77-84. 10.1093/aje/kwg114, 12835289.
16. Liu B, Anderson G, Mittmann N, To T, Axcell T, Shear N. Use of selective serotonin-reuptake inhibitors of tricyclic antidepressants and risk of hip fractures in elderly people. Lancet 1998, 351(9112):1303-1307. 10.1016/S0140-6736(97)09528-7, 9643791.
17. van Walraven C, Mamdani MM, Wells PS, Williams JI. Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study. BMJ 2001, 323(7314):655-658. 10.1136/bmj.323.7314.655, 55923, 11566827.
18. Coupland C, Dhiman P, Morriss R, Arthur A, Barton G, Hippisley-Cox J. Antidepressant use and risk of adverse outcomes in older people: population based cohort study. BMJ 2011, 343:d4551. 10.1136/bmj.d4551, 3149102, 21810886.
19. Altman DG, Andersen PK. Calculating the number needed to treat for trials where the outcome is time to an event. BMJ 1999, 319(7223):1492-1495. 10.1136/bmj.319.7223.1492, 1117211, 10582940.
20. Whitaker HJ, Farrington CP, Spiessens B, Musonda P. Tutorial in biostatistics: the self-controlled case series method. Stat Med 2006, 25(10):1768-1797. 10.1002/sim.2302, 16220518.
21. Whitaker H. The self controlled case series method. BMJ 2008, 337(aug28_2):a1069.