Itopride therapy for functional dyspepsia: A meta-analysis

World Journal of Gastroenterology

Volumn 18, Issue 48, 2012, Pages 7371-7377

  Huang, Xuan ^a   Lv, Bin ^a   Zhang, Shuo ^a   Fan, Yi Hong ^a   Meng, Li Na ^a  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Functional dyspepsia; Itopride; Meta analysis; Prokinetic agents; Randomized controlled trials

Indexed keywords

DOMPERIDONE; ITOPRIDE; MOSAPRIDE; PLACEBO;

ARTICLE; DRUG EFFICACY; DYSPEPSIA; EPIGASTRIC DISCOMFORT; GENETIC HETEROGENEITY; HUMAN; META ANALYSIS; PATIENT ASSESSMENT; POSTPRANDIAL STATE; RANDOMIZED CONTROLLED TRIAL (TOPIC); SATIETY; SCORING SYSTEM; THERAPY EFFECT; UNSPECIFIED SIDE EFFECT;

EID: 84877251297     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v18.i48.7371     Document Type: Article

References (29)

1. Miwa H, Ghoshal UC, Gonlachanvit S, Gwee KA, Ang TL, Chang FY, Fock KM, Hongo M, Hou X, Kachintorn U, Ke M, Lai KH, Lee KJ, Lu CL, Mahadeva S, Miura S, Park H, Rhee PL, Sugano K, Vilaichone RK, Wong BC, Bak YT. Asian consensus report on functional dyspepsia. J Neurogastroenterol Motil 2012; 18: 150-168
2. Kwan AC, Bao T, Chakkaphak S, Chang FY, Ke M, Law NM, Leelakusolvong S, Luo JY, Manan C, Park HJ, Piyaniran W, Qureshi A, Long T, Xu GM, Xu L, Yuen H. Validation of Rome II criteria for functional gastrointestinal disorders by factor analysis of symptoms in Asian patient sample. J Gastroenterol Hepatol 2003; 18: 796-802
3. Mahadeva S, Yadav H, Everett SM, Goh KL. Economic impact of dyspepsia in rural and urban malaysia: a populationbased study. J Neurogastroenterol Motil 2012; 18: 43-57
4. Mahadeva S, Goh KL. Burden of Dyspepsia in Rural and Urban Asia: Author's Reply. J Neurogastroenterol Motil 2012; 18: 230
5. Talley NJ, Tack J, Ptak T, Gupta R, Giguère M. Itopride in functional dyspepsia: results of two phase III multicentre, randomised, double-blind, placebo-controlled trials. Gut 2008; 57: 740-746
6. Hou XH, Li Q, Zhu L, Xie X, Chen JD. Correlation of gastric liquid emptying with various thresholds of sensation in healthy controls and patients with functional dyspepsia. Dig Dis Sci 2004; 49: 188-195
7. Quartero AO, de Wit NJ, Lodder AC, Numans ME, Smout AJ, Hoes AW. Disturbed solid-phase gastric emptying in functional dyspepsia: a meta-analysis. Dig Dis Sci 1998; 43: 2028-2033
8. Moayyedi P, Delaney BC, Vakil N, Forman D, Talley NJ. The efficacy of proton pump inhibitors in nonulcer dyspepsia: a systematic review and economic analysis. Gastroenterology 2004; 127: 1329-1337
9. Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, Stanghellini V. Functional gastroduodenal disorders. Gastroenterology 2006; 130: 1466-1479
10. Talley NJ, Vakil NB, Moayyedi P. American gastroenterological association technical review on the evaluation of dyspepsia. Gastroenterology 2005; 129: 1756-1780
11. Wysowski DK, Corken A, Gallo-Torres H, Talarico L, Rodriguez EM. Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions. Am J Gastroenterol 2001; 96: 1698-1703
12. Iwanaga Y, Kimura T, Miyashita N, Morikawa K, Nagata O, Itoh Z, Kondo Y. Characterization of acetylcholinesteraseinhibition by itopride. Jpn J Pharmacol 1994; 66: 317-322
13. Holtmann G, Talley NJ, Liebregts T, Adam B, Parow C. A placebo-controlled trial of itopride in functional dyspepsia. N Engl J Med 2006; 354: 832-840
14. Zhou LY, Li BC, Lin SL, Li AY, Dong XY, Li ZS, Yuan YZ, Yu ZL, Liu XG, Wang HJ, Zheng YR. A Multi-centre Clinical Trial on Itopride Hydrochloride for Treatment of Functional Dyspepsia. Zhongguo Linchuang Yaolixue Zazhi 2000; 16: 403-407
15. Sun J, Zhang CL, Chu Y, Yuan YZ, Li ZS, Liu XG, Luo HS. A multi-center, double-blind, randomized and controlled trial of itopride hydrochloride in treatment of functional dyspepsia. Shanghai Yixue 2003; 26: 227-229
16. Mo JZ, Li DG, Jiang JH, Jiang YB, Wang XP, Gong ZH, Cao ZJ. A multi-center clinical trial of itopride hydrochloride in the treatment of functional dyspepsia. Zhongguo Xinyao Zazhi 2003; 12: 467-469
17. Chen X, Hu NZ, Xie HJ, Li BK, Xu JM. Effect of itopride hydrochloride on functional dyspepsia. Zhongguo Linchuang Yaolixue Zazhi 2004; 20: 25-29.
18. Amarapurkar DN, Rane P. Randomised, double-blind, comparative study to evaluate the efficacy and safety of ganaton (itopride hydrochloride) and mosapride citrate in the management of functional dyspepsia. J Indian Med Assoc 2004; 102: 735-77, 760
19. Zhu CQ, Mao YM, Zeng MD, Dong SX, Xu GM, Wang GS, Li YM, Cai JT. A clinical study of hydrochloride itopride in the treatment of functional dyspepsia. Zhongguo Yaoke Daxue Xuebao 2005; 6: 580-583
20. Li YH, Gong PL, Hou XH, Chen J, Liu NZ, Tian DA, Tang FA, Feng CW, Yang YX, Li HB. Itopride in treatment of 104 patients with functional dyspepsia: a randomized, doubleblind controlled clinical trial. Zhongguo Xinyao Yu Linchuang Zazhi 2005; 7: 524-528
21. Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GN. Functional gastroduodenal disorders. Gut 1999; 45(Suppl 2): II37-II42
22. Veldhuyzen van Zanten SJ, Jones MJ, Verlinden M, Talley NJ. Efficacy of cisapride and domperidone in functional (nonulcer) dyspepsia: a meta-analysis. Am J Gastroenterol 2001; 96: 689-696
23. Hiyama T, Yoshihara M, Matsuo K, Kusunoki H, Kamada T, Ito M, Tanaka S, Chayama K, Haruma K. Treatment of functional dyspepsia with serotonin agonists: a meta-analysis of randomized controlled trials. J Gastroenterol Hepatol 2007; 22: 1566-1570
24. Choung RS, Talley NJ, Peterson J, Camilleri M, Burton D, Harmsen WS, Zinsmeister AR. A double-blind, randomized, placebo-controlled trial of itopride (100 and 200 mg three times daily) on gastric motor and sensory function in healthy volunteers. Neurogastroenterol Motil 2007; 19: 180-187
25. Suzuki H, Nishizawa T, Hibi T. Therapeutic strategies for functional dyspepsia and the introduction of the Rome III classification. J Gastroenterol 2006; 41: 513-523
26. Mushiroda T, Douya R, Takahara E, Nagata O. The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate. Drug Metab Dispos 2000; 28: 1231-1237
27. Veldhuyzen Van Zanten SJ. Pitfalls in designing trials of functional dyspepsia: the ascent and demise of itopride. Gut 2008; 57: 723-724
28. Mahadeva S, Raman MC, Ford AC, Follows M, Axon AT, Goh KL, Moayyedi P. Gastro-oesophageal reflux is more prevalent in Western dyspeptics: a prospective comparison of British and South-East Asian patients with dyspepsia. Aliment Pharmacol Ther 2005; 21: 1483-1490
29. Mahadeva S, Yadav H, Rampal S, Everett SM, Goh KL. Ethnic variation, epidemiological factors and quality of life impairment associated with dyspepsia in urban Malaysia. Aliment Pharmacol Ther 2010; 31: 1141-1151