The mechanical consequences of load bearing in the equine third metacarpal across speed and gait: The nonuniform distributions of normal strain, shear strain, and strain energy density

FASEB Journal

Volumn 27, Issue 5, 2013, Pages 1887-1894

  Rubin, Clinton T ^a   Seeherman, Howard ^b   Qin, Yi Xian ^a   Gross, Ted S ^c  

^a St Francis Hospital The Heart Center   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Bone adaptation; Bone remodeling; Cannon bone; Locomotion; Skeleton; Stress history; Vertebrate morphology

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BONE STRESS; CORTICAL BONE; DIAPHYSIS; FINITE ELEMENT ANALYSIS; GAIT; HOMEOSTASIS; LOCOMOTION; METACARPAL BONE; NONHUMAN; PHYSICAL PARAMETERS; PRIORITY JOURNAL; SHEAR STRESS; STRAIN ENERGY DENSITY; VELOCITY;

ANIMALS; BIOMECHANICS; FORELIMB; GAIT; HORSES; LOCOMOTION; METACARPAL BONES; SPRAINS AND STRAINS; STRESS, MECHANICAL; WEIGHT-BEARING;

ANIMALIA; EQUIDAE; VERTEBRATA;

EID: 84877141834     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-216804     Document Type: Article

References (36)

1. Rubin, C. T., and Lanyon, L. E. (1984) Dynamic strain similarity in vertebrates; an alternative to allometric limb bone scaling. J. Theor. Biol. 107, 321-327
2. Frost, H. M. (1990) Skeletal structural adaptations to mechanical usage (SATMU): 1 Redefining Wolffs law: the bone modeling problem. Anat. Rec. 226, 403-413
3. Jones, H. H., Priest, J. D., Hayes, W. C., Tichenor, C. C., and Nagel, D. A. (1977) Humeral hypertrophy in response to exercise. J. Bone Joint Surg. Am. 59, 204-208
4. LeBlanc, A. D., Schneider, V. S., Evans, H. J., Engelbretson, D. A., and Krebs, J. M. (1990) Bone mineral loss and recovery after 17 weeks of bed rest. J. Bone Miner. Res. 5, 843-850
5. Lang, T., LeBlanc, A., Evans, H., Lu, Y., Genant, H., and Yu, A. (2004) Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J. Bone Miner. Res. 19, 1006-1012
6. Wolff, J. (1892) Das Gesetz der Transformation der Knochen (The Law of Bone Remodeling), Verlag von August Hirschwald, Berlin, Germany
7. Skedros, J. G., Mason, M. W., Nelson, M. C., and Bloebaum, R. D. (1996) Evidence of structural and material adaptation to specific strain features in cortical bone. Anat. Rec. 246, 47-63
8. Lanyon, L. E., and Smith, R. N. (1970) Bone strain in the tibia during normal quadrupedal locomotion. Acta Orthop. Scand. 41, 238-248
9. Rubin, C. T., and Lanyon, L. E. (1982) Limb mechanics as a function of speed and gait: a study of functional strains in the radius and tibia of horse and dog. J. Exp. Biol. 101, 187-211
10. Biewener, A. A. (1990) Biomechanics of mammalian terrestrial locomotion. Science 250, 1097-1103
11. Rybicki, E. F., and Mills, E. J. (1977) In vivo and analytical studies of forces and moments in equine long bones. J. Biomech. 10, 701-705
12. Gross, T. S., McLeod, K. J., and Rubin, C. T. (1992) Characterizing bone strain distributions in vivo using three triple rosette strain gages. J. Biomech. 25, 1081-1087
13. Adams, D. J., Spirt, A. A., Brown, T. D., Fritton, S. P., Rubin, C. T., and Brand, R. A. (1997) Testing the daily stress stimulus theory of bone adaptation with natural and experimentally controlled strain histories. J. Biomech. 30, 671-678
14. Fritton, S. P., McLeod, K. J., and Rubin, C. T. (2000) Quantifying the strain history of bone: spatial uniformity and selfsimilarity of low-magnitude strains. J. Biomech. 33, 317-325
15. Qin, Y. X., McLeod, K. J., Guilak, F., Chiang, F. P., and Rubin, C. T. (1996) Correlation of bony ingrowth to the distribution of stress and strain parameters surrounding a porous-coated implant. J. Orthop. Res. 14, 862-870
16. Currey, J. D. (1979) Mechanical properties of bone tissues with greatly differing functions. J. Biomech. 12, 313-319
17. Biewener, A. A., Swartz, S. M., and Bertram, J. E. (1986) Bone modeling during growth: dynamic strain equilibrium in the chick tibiotarsus. Calcified Tissue Int. 39, 390-395
18. Nunamaker, D. M., Butterweck, D. M., and Provost, M. T. (1990) Fatigue fractures in thoroughbred racehorses: relationships with age, peak bone strain, and training. J. Orth. Res. 8, 604-611
19. Biewener, A. A., Thomason, J., Goodship, A., and Lanyon, L. E. (1983) Bone stress in the horse forelimb during locomotion at different gaits: a comparison of two experimental methods. J. Biomech. 16, 565-576
20. Moreno, C. A., Main, R. P., and Biewener, A. A. (2008) Variability in forelimb bone strains during non-steady locomotor activities in goats. J. Exp. Biol. 211, 1148-1162
21. Nunamaker, D. M., Butterweck, D. M., and Black, J. (1991) In vitro comparison of thoroughbred and standardbred racehorses with regard to local fatigue failure of the third metacarpal bone. Am. J. Vet. Res. 52, 97-100
22. Burr, D. B., Milgrom, C., Fyhrie, D., Forwood, M., Nyska, M., Finestone, A., Hoshaw, S., Saiag, E., and Simkin, A. (1996) In vivo measurement of human tibial strains during vigorous activity. Bone 18, 405-410
23. Frost, H. M. (1992) Perspectives: bones mechanical usage windows. Bone Mineral 19, 257-271
24. Cowin, S. C. (1987) Bone remodeling of diaphyseal surfaces by torsional loads: theoretical predictions. J. Biomech. 20, 1111-1120
25. Beaupre, G. S., Orr, T. E., and Carter, D. R. (1990) An approach for time-dependent bone modeling and remodeling-application: a preliminary remodeling simulation. J. Orthop. Res. 8, 662-670
26. Van der Meulen, M. C., and Huiskes, R. (2002) Why mechanobiology?. A survey article. J. Biomech. 35, 401-414
27. Frost, H. M. (1986) Intermediary Organization of the Skeleton, CRC Press, Boca Raton, FL, USA
28. Lanyon, L. E. (1987) Functional strain in bone tissue as an objective, and controlling stimulus for adaptive bone remodelling. J. Biomech. 20, 1083-1093
29. Rubin, C., Turner, A. S., Bain, S., Mallinckrodt, C., and McLeod, K. (2001) Anabolism: Low mechanical signals strengthen long bones. Nature 412, 603-604
30. OConnor, J. A., Lanyon, L. E., and MacFie, H. (1982) The influence of strain rate on adaptive bone remodelling. J. Biomech. 15, 767-781
31. Weinbaum, S., Guo, P., and You, L. (2001) A new view of mechanotransduction and strain amplification in cells with microvilli and cell processes. Biorheology 38, 119-142
32. Gross, T. S., Edwards, J. L., McLeod, K. J., and Rubin, C. T. (1997) Strain gradients correlate with sites of periosteal bone formation. J. Bone Miner. Res. 12, 982-988
33. Rubin, C., Xu, G., and Judex, S. (2001) The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli. FASEB J. 15, 2225-2229
34. Bonewald, L. F. (2011) The amazing osteocyte. J. Bone Miner. Res. 26, 229-238
35. Rubin, C. T., and Lanyon, L. E. (1984) Regulation of bone formation by applied dynamic loads. J. Bone Joint Surg. 66, 397-402
36. Thompson, W. R., Rubin, C. T., and Rubin, J. (2012) Mechanical regulation of signaling pathways in bone. Gene 503, 179-193