메뉴 건너뛰기




Volumn 73, Issue 3, 2013, Pages 279-291

Emtricitabine/tenofovir disoproxil fumarate: A review of its use in HIV-1 pre-exposure prophylaxis

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ADEFOVIR; ADEFOVIR DIPIVOXIL; ALANINE AMINOTRANSFERASE; CIDOFOVIR; CREATININE; EMTRICITABINE; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; PHOSPHATE; PLACEBO; TENOFOVIR DISOPROXIL;

EID: 84877116842     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-013-0024-4     Document Type: Review
Times cited : (32)

References (64)
  • 1
    • 79451471817 scopus 로고    scopus 로고
    • Accessed 4 Dec 2012
    • UNAIDS Report on the Global AIDS Epidemic: 2012. 2012. http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2012/ gr2012/20121120-AUAIDS-Global-Report-2012-en.pdf. Accessed 4 Dec 2012.
    • (2012) UNAIDS Report on the Global AIDS Epidemic: 2012
  • 2
    • 79961169980 scopus 로고    scopus 로고
    • HIV prevention in southern Africa: Why we must reassess our strategies?
    • 21668592 10.1111/j.1365-3156.2011.02807.x
    • Katsidzira L, Hakim JG. HIV prevention in southern Africa: why we must reassess our strategies? Trop Med Int Health. 2011;16(9):1120-30.
    • (2011) Trop Med Int Health , vol.16 , Issue.9 , pp. 1120-1130
    • Katsidzira, L.1    Hakim, J.G.2
  • 4
    • 48749117983 scopus 로고    scopus 로고
    • Estimation of HIV incidence in the United States
    • 18677024 10.1001/jama.300.5.520 1:CAS:528:DC%2BD1cXps1ygtrY%3D
    • Hall HI, Song R, Rhodes P, et al. Estimation of HIV incidence in the United States. JAMA. 2008;300(5):520-9.
    • (2008) JAMA , vol.300 , Issue.5 , pp. 520-529
    • Hall, H.I.1    Song, R.2    Rhodes, P.3
  • 5
    • 79961057113 scopus 로고    scopus 로고
    • Estimated HIV incidence in the United States, 2006-2009
    • 21826193 10.1371/journal.pone.0017502 1:CAS:528:DC%2BC3MXhtFWitLbP
    • Prejean J, Song R, Hernandez A, et al. Estimated HIV incidence in the United States, 2006-2009. PLoS ONE. 2011;6(8):e17502.
    • (2011) PLoS ONE , vol.6 , Issue.8 , pp. 17502
    • Prejean, J.1    Song, R.2    Hernandez, A.3
  • 6
    • 79961046007 scopus 로고    scopus 로고
    • HIV-2 infection surveillance: United States, 1987-2009
    • HIV-2 infection surveillance: United States, 1987-2009. MMWR. 2011;60(29):985-8.
    • (2011) MMWR , vol.60 , Issue.29 , pp. 985-988
  • 7
    • 84868333687 scopus 로고    scopus 로고
    • What primary care providers need to know about preexposure prophylaxis for HIV prevention: A narrative review
    • 22821365
    • Krakower D, Mayer KH. What primary care providers need to know about preexposure prophylaxis for HIV prevention: a narrative review. Ann Intern Med. 2012;157(7):490-7.
    • (2012) Ann Intern Med , vol.157 , Issue.7 , pp. 490-497
    • Krakower, D.1    Mayer, K.H.2
  • 8
    • 79960352907 scopus 로고    scopus 로고
    • HIV prevention transformed: The new prevention research agenda
    • 21763938 10.1016/S0140-6736(11)60877-5
    • Padian NS, McCoy SI, Karim SS, et al. HIV prevention transformed: the new prevention research agenda. Lancet. 2011;378(9787):269-78.
    • (2011) Lancet , vol.378 , Issue.9787 , pp. 269-278
    • Padian, N.S.1    McCoy, S.I.2    Karim, S.S.3
  • 9
    • 81055125472 scopus 로고    scopus 로고
    • Interventions to prevent sexually transmitted infections, including HIV infection
    • 22080271 10.1093/cid/cir695
    • Marrazzo JM, Cates W. Interventions to prevent sexually transmitted infections, including HIV infection. Clin Infect Dis. 2011;53(Suppl. 3):S64-78.
    • (2011) Clin Infect Dis , vol.53 , Issue.SUPPL. 3
    • Marrazzo, J.M.1    Cates, W.2
  • 10
    • 84855616052 scopus 로고    scopus 로고
    • Panel on Antiretroviral Guidelines for Adults and Adolescents Department of Health and Human Services Accessed 10 Dec 2012
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. 2012. http://www.aidsinfo.nih.gov/ guidelines. Accessed 10 Dec 2012.
    • (2012) Guidelines for the Use of Antiretroviral Agents in HIV-1-infected Adults and Adolescents
  • 12
    • 79251646972 scopus 로고    scopus 로고
    • Interim guidance: Preexposure prophylaxis for the prevention of HIV infection in men who have sex with men
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. Interim guidance: preexposure prophylaxis for the prevention of HIV infection in men who have sex with men. MMWR. 2011;60(3):65-8.
    • (2011) MMWR , vol.60 , Issue.3 , pp. 65-68
  • 13
    • 84857476631 scopus 로고    scopus 로고
    • The British HIV Association/British Association for Sexual Health and HIV position statement on pre-exposure prophylaxis in the UK
    • 22362679 10.1258/ijsa.2011.051211 1:STN:280:DC%2BC383mtVSntQ%3D%3D
    • McCormack S, Fidler S, Fisher M, et al. The British HIV Association/British Association for Sexual Health and HIV position statement on pre-exposure prophylaxis in the UK. Int J STD AIDS. 2012;23(1):1-4.
    • (2012) Int J STD AIDS , vol.23 , Issue.1 , pp. 1-4
    • McCormack, S.1    Fidler, S.2    Fisher, M.3
  • 14
    • 84866461864 scopus 로고    scopus 로고
    • Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals [Update of Cochrane Database Syst Rev. 2009;(1):CD007189; PMID: 19160329]
    • Okwundu CI, Uthman OA, Okoromah CA. Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals [Update of Cochrane Database Syst Rev. 2009;(1):CD007189; PMID: 19160329]. Cochrane Database Syst Rev. 2012;7:CD007189.
    • (2012) Cochrane Database Syst Rev , vol.7
    • Okwundu, C.I.1    Uthman, O.A.2    Okoromah, C.A.3
  • 15
    • 84864996766 scopus 로고    scopus 로고
    • Interim guidance for clinicians considering the use of preexposure prophylaxis for the prevention of HIV infection in heterosexually active adults
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. Interim guidance for clinicians considering the use of preexposure prophylaxis for the prevention of HIV infection in heterosexually active adults. MMWR. 2012;61:586-9.
    • (2012) MMWR , vol.61 , pp. 586-589
  • 16
    • 84864507088 scopus 로고    scopus 로고
    • Preexposure prophylaxis for HIV - Where do we go from here?
    • 22784041 10.1056/NEJMe1207438 1:CAS:528:DC%2BC38XhtlSltrfO
    • Cohen MS, Baden LR. Preexposure prophylaxis for HIV - where do we go from here? N Engl J Med. 2012;367(5):459-61.
    • (2012) N Engl J Med , vol.367 , Issue.5 , pp. 459-461
    • Cohen, M.S.1    Baden, L.R.2
  • 17
    • 84864511894 scopus 로고    scopus 로고
    • Preexposure prophylaxis for HIV prevention: Recommend initiating PrEP
    • 10.1056/NEJMclde1207706
    • Karim SSA. Preexposure prophylaxis for HIV prevention: recommend initiating PrEP. N Engl J Med. 2012;367:462-5.
    • (2012) N Engl J Med , vol.367 , pp. 462-465
    • Karim, S.S.A.1
  • 18
    • 84864511894 scopus 로고    scopus 로고
    • Preexposure prophylaxis for HIV prevention: Do not recommend initiating PrEP
    • 22784042 10.1056/NEJMclde1207706
    • Gray GE, Martinson N. Preexposure prophylaxis for HIV prevention: do not recommend initiating PrEP. N Engl J Med. 2012;367:462-5.
    • (2012) N Engl J Med , vol.367 , pp. 462-465
    • Gray, G.E.1    Martinson, N.2
  • 19
    • 84867675736 scopus 로고    scopus 로고
    • Preexposure prophylaxis for HIV prevention: Polling results
    • 23013053 10.1056/NEJMclde1211517
    • Colbert JA. Preexposure prophylaxis for HIV prevention: polling results. N Engl J Med. 2012;367:e22.
    • (2012) N Engl J Med , vol.367 , pp. 22
    • Colbert, J.A.1
  • 20
    • 84868324648 scopus 로고    scopus 로고
    • Truvada PrEP: Why i voted "yes
    • 22820485
    • Feinberg J. Truvada PrEP: why I voted "yes". Ann Intern Med. 2012;157(7):521-2.
    • (2012) Ann Intern Med , vol.157 , Issue.7 , pp. 521-522
    • Feinberg, J.1
  • 21
    • 84868321590 scopus 로고    scopus 로고
    • Voted "no" to Truvada PrEP
    • 22821402
    • Wood LV, Why I. voted "no" to Truvada PrEP. Ann Intern Med. 2012;157(7):519-20.
    • (2012) Ann Intern Med , vol.157 , Issue.7 , pp. 519-520
    • Wood, L.V.1    Why, I.2
  • 22
    • 66149100884 scopus 로고    scopus 로고
    • Emtricitabine/tenofovir disoproxil fumarate: In combination with a protease inhibitor in HIV-1 infection
    • 19441871 10.2165/00003495-200969070-00005 1:CAS:528:DC%2BD1MXosVarsbs%3D
    • Perry CM. Emtricitabine/tenofovir disoproxil fumarate: in combination with a protease inhibitor in HIV-1 infection. Drugs. 2009;69(7):843-57.
    • (2009) Drugs , vol.69 , Issue.7 , pp. 843-857
    • Perry, C.M.1
  • 23
    • 3242694930 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate: Clinical pharmacology and pharmacokinetics
    • 15217303 10.2165/00003088-200443090-00003 1:CAS:528:DC%2BD2cXmvVCksLo%3D
    • Kearney BP, Flaherty JF, Shah J. Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics. Clin Pharmacokinet. 2004;43(9):595-612.
    • (2004) Clin Pharmacokinet , vol.43 , Issue.9 , pp. 595-612
    • Kearney, B.P.1    Flaherty, J.F.2    Shah, J.3
  • 24
    • 22944463317 scopus 로고    scopus 로고
    • Emtricitabine: A review of its use in the management of HIV infection
    • 15977972 10.2165/00003495-200565100-00008 1:CAS:528:DC%2BD2MXpsFWks7k%3D
    • Frampton JE, Perry CM. Emtricitabine: a review of its use in the management of HIV infection. Drugs. 2005;65(10):1427-48.
    • (2005) Drugs , vol.65 , Issue.10 , pp. 1427-1448
    • Frampton, J.E.1    Perry, C.M.2
  • 25
    • 0043124520 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate
    • 12887265 10.2165/00003495-200363150-00006 1:CAS:528:DC%2BD3sXntFGhu78%3D
    • Chapman T, McGavin J, Noble S. Tenofovir disoproxil fumarate. Drugs. 2003;63(15):1597-608.
    • (2003) Drugs , vol.63 , Issue.15 , pp. 1597-1608
    • Chapman, T.1    McGavin, J.2    Noble, S.3
  • 26
    • 78651417113 scopus 로고    scopus 로고
    • Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection
    • 21118913 10.1093/jac/dkq447 1:CAS:528:DC%2BC3MXnsFajtg%3D%3D
    • Anderson PL, Kiser JJ, Gardner EM, et al. Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection. J Antimicrob Chemother. 2011;66(2):240-50.
    • (2011) J Antimicrob Chemother , vol.66 , Issue.2 , pp. 240-250
    • Anderson, P.L.1    Kiser, J.J.2    Gardner, E.M.3
  • 27
    • 0028791836 scopus 로고
    • Prevention of SIV infection in macaques by (R)-9-(2- phosphonylmethoxypropyl)adenine
    • 7502044 10.1126/science.270.5239.1197 1:CAS:528:DyaK2MXpsVyktLY%3D
    • Tsai CC, Follis KE, Sabo A, et al. Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science. 1995;270(5239):1197-9.
    • (1995) Science , vol.270 , Issue.5239 , pp. 1197-1199
    • Tsai, C.C.1    Follis, K.E.2    Sabo, A.3
  • 28
    • 33748988204 scopus 로고    scopus 로고
    • Chemoprophylaxis with tenofovir disoproxil fumarate provided partial protection against infection with simian human immunodeficiency virus in macaques given multiple virus challenges
    • 16960777 10.1086/507306 1:CAS:528:DC%2BD28XhtFSgt7zO
    • Subbarao S, Otten RA, Ramos A, et al. Chemoprophylaxis with tenofovir disoproxil fumarate provided partial protection against infection with simian human immunodeficiency virus in macaques given multiple virus challenges. J Infect Dis. 2006;194(7):904-11.
    • (2006) J Infect Dis , vol.194 , Issue.7 , pp. 904-911
    • Subbarao, S.1    Otten, R.A.2    Ramos, A.3
  • 29
    • 33748097643 scopus 로고    scopus 로고
    • Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus
    • 16810108 10.1097/01.qai.0000224972.60339.7c
    • Van Rompay KK, Kearney BP, Sexton JJ, et al. Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus. J Acquir Immune Defic Syndr. 2006;43(1):6-14.
    • (2006) J Acquir Immune Defic Syndr , vol.43 , Issue.1 , pp. 6-14
    • Van Rompay, K.K.1    Kearney, B.P.2    Sexton, J.J.3
  • 30
    • 0033947591 scopus 로고    scopus 로고
    • Prophylactic and therapeutic benefits of short-term 9-[2-(R)- (phosphonomethoxy)propyl]adenine (PMPA) administration to newborn macaques following oral inoculation with simian immunodeficiency virus with reduced susceptibility to PMPA
    • 10644348 10.1128/JVI.74.4.1767-1774.2000
    • Van Rompay KK, Miller MD, Marthas ML, et al. Prophylactic and therapeutic benefits of short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) administration to newborn macaques following oral inoculation with simian immunodeficiency virus with reduced susceptibility to PMPA. J Virol. 2000;74(4):1767-74.
    • (2000) J Virol , vol.74 , Issue.4 , pp. 1767-1774
    • Van Rompay, K.K.1    Miller, M.D.2    Marthas, M.L.3
  • 31
    • 0035882425 scopus 로고    scopus 로고
    • Two low doses of tenofovir protect newborn macaques against oral simian immunodeficiency virus infection
    • 11471100 10.1086/322781
    • Van Rompay KK, McChesney MB, Aguirre NL, et al. Two low doses of tenofovir protect newborn macaques against oral simian immunodeficiency virus infection. J Infect Dis. 2001;184(4):429-38.
    • (2001) J Infect Dis , vol.184 , Issue.4 , pp. 429-438
    • Van Rompay, K.K.1    McChesney, M.B.2    Aguirre, N.L.3
  • 32
    • 0032543742 scopus 로고    scopus 로고
    • Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection
    • 9662190 10.1097/00002030-199809000-00001
    • Van Rompay KK, Berardi CJ, Aguirre NL, et al. Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection. AIDS. 1998;12(9):F79-83.
    • (1998) AIDS , vol.12 , Issue.9
    • Van Rompay, K.K.1    Berardi, C.J.2    Aguirre, N.L.3
  • 33
    • 39849100140 scopus 로고    scopus 로고
    • Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir
    • 18254653 10.1371/journal.pmed.0050028
    • Garcia-Lerma JG, Otten RA, Qari SH, et al. Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir. PLoS Med. 2008;5(2):e28.
    • (2008) PLoS Med , vol.5 , Issue.2 , pp. 28
    • Garcia-Lerma, J.G.1    Otten, R.A.2    Qari, S.H.3
  • 34
    • 77952986105 scopus 로고    scopus 로고
    • Intermittent prophylaxis with oral Truvada protects macaques from rectal SHIV infection
    • Garcia-Lerma JG, Cong ME, Mitchell J, et al. Intermittent prophylaxis with oral Truvada protects macaques from rectal SHIV infection. Sci Transl Med. 2010;2(14):14ra4.
    • (2010) Sci Transl Med , vol.2 , Issue.14
    • Garcia-Lerma, J.G.1    Cong, M.E.2    Mitchell, J.3
  • 35
    • 79960433514 scopus 로고    scopus 로고
    • Protection against rectal transmission of an emtricitabine-resistant simian/human immunodeficiency virus SHIV162p3M184V mutant by intermittent prophylaxis with Truvada
    • 21632769 10.1128/JVI.00843-11 1:CAS:528:DC%2BC3MXpsVKqurg%3D
    • Cong ME, Youngpairoj AS, Zheng Q, et al. Protection against rectal transmission of an emtricitabine-resistant simian/human immunodeficiency virus SHIV162p3M184V mutant by intermittent prophylaxis with Truvada. J Virol. 2011;85(15):7933-6.
    • (2011) J Virol , vol.85 , Issue.15 , pp. 7933-7936
    • Cong, M.E.1    Youngpairoj, A.S.2    Zheng, Q.3
  • 36
    • 38849136442 scopus 로고    scopus 로고
    • Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice
    • 18198941 10.1371/journal.pmed.0050016
    • Denton PW, Estes JD, Sun Z, et al. Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med. 2008;5(1):e16.
    • (2008) PLoS Med , vol.5 , Issue.1 , pp. 16
    • Denton, P.W.1    Estes, J.D.2    Sun, Z.3
  • 37
    • 77952475729 scopus 로고    scopus 로고
    • Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice
    • 20098623 10.1371/journal.pone.0008829
    • Denton PW, Krisko JF, Powell DA, et al. Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice. PLoS ONE. 2010;5(1):e8829.
    • (2010) PLoS ONE , vol.5 , Issue.1 , pp. 8829
    • Denton, P.W.1    Krisko, J.F.2    Powell, D.A.3
  • 38
    • 84858626049 scopus 로고    scopus 로고
    • Preexposure prophylaxis with albumin-conjugated C34 peptide HIV-1 fusion inhibitor in SCID-hu Thy/Liv mice
    • 22252805 10.1128/AAC.05015-11 1:CAS:528:DC%2BC38XltV2qt74%3D
    • Stoddart CA, Nault G, Galkina SA, et al. Preexposure prophylaxis with albumin-conjugated C34 peptide HIV-1 fusion inhibitor in SCID-hu Thy/Liv mice. Antimicrob Agents Chemother. 2012;56(4):2162-5.
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.4 , pp. 2162-2165
    • Stoddart, C.A.1    Nault, G.2    Galkina, S.A.3
  • 39
    • 34249093503 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of emtricitabine and tenofovir disoproxil fumarate administered alone and in combination in healthy volunteers
    • 17519400 10.1177/0091270007300951 1:CAS:528:DC%2BD2sXmvF2jtrw%3D
    • Blum MR, Chittick GE, Begley JA, et al. Steady-state pharmacokinetics of emtricitabine and tenofovir disoproxil fumarate administered alone and in combination in healthy volunteers. J Clin Pharmacol. 2007;47(6):751-9.
    • (2007) J Clin Pharmacol , vol.47 , Issue.6 , pp. 751-759
    • Blum, M.R.1    Chittick, G.E.2    Begley, J.A.3
  • 40
    • 79551697351 scopus 로고    scopus 로고
    • Oral preexposure anti-HIV prophylaxis for high-risk U.S. populations: Current considerations in light of new findings
    • 21284497 10.1089/apc.2010.0222
    • Myers GM, Mayer KH. Oral preexposure anti-HIV prophylaxis for high-risk U.S. populations: current considerations in light of new findings. AIDS Patient Care STDS. 2011;25(2):63-71.
    • (2011) AIDS Patient Care STDS , vol.25 , Issue.2 , pp. 63-71
    • Myers, G.M.1    Mayer, K.H.2
  • 41
    • 80052833501 scopus 로고    scopus 로고
    • Concentrations of tenofovir and emtricitabine in saliva: Implications for preexposure prophylaxis of oral HIV acquisition
    • 21788466 10.1128/AAC.00120-11
    • de Lastours V, Fonsart J, Burlacu R, et al. Concentrations of tenofovir and emtricitabine in saliva: implications for preexposure prophylaxis of oral HIV acquisition. Antimicrob Agents Chemother. 2011;55(10):4905-7.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.10 , pp. 4905-4907
    • De Lastours, V.1    Fonsart, J.2    Burlacu, R.3
  • 42
    • 83155177076 scopus 로고    scopus 로고
    • Penetration of tenofovir and emtricitabine in mucosal tissues: Implications for prevention of HIV-1 transmission
    • Patterson KB, Prince HA, Kraft E, et al. Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission. Sci Transl Med. 2011;3(112):112re4.
    • (2011) Sci Transl Med , vol.3 , Issue.112
    • Patterson, K.B.1    Prince, H.A.2    Kraft, E.3
  • 43
    • 84864505868 scopus 로고    scopus 로고
    • Antiretroviral prophylaxis for HIV prevention in heterosexual men and women
    • 22784037 10.1056/NEJMoa1108524 1:CAS:528:DC%2BC38XhtlSltrbK
    • Baeten JM, Donnell D, Ndase P, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012;367(5):399-410.
    • (2012) N Engl J Med , vol.367 , Issue.5 , pp. 399-410
    • Baeten, J.M.1    Donnell, D.2    Ndase, P.3
  • 44
    • 78650549662 scopus 로고    scopus 로고
    • Preexposure chemoprophylaxis for HIV prevention in men who have sex with men
    • 21091279 10.1056/NEJMoa1011205 1:CAS:528:DC%2BC3MXit1ansg%3D%3D
    • Grant RM, Lama JR, Anderson PL, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363(27):2587-99.
    • (2010) N Engl J Med , vol.363 , Issue.27 , pp. 2587-2599
    • Grant, R.M.1    Lama, J.R.2    Anderson, P.L.3
  • 45
    • 84864527306 scopus 로고    scopus 로고
    • Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana
    • 22784038 10.1056/NEJMoa1110711 1:CAS:528:DC%2BC38XhtlSltrbE
    • Thigpen MC, Kebaabetswe PM, Paxton LA, et al. Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med. 2012;367(5):423-34.
    • (2012) N Engl J Med , vol.367 , Issue.5 , pp. 423-434
    • Thigpen, M.C.1    Kebaabetswe, P.M.2    Paxton, L.A.3
  • 46
    • 84864507852 scopus 로고    scopus 로고
    • Preexposure prophylaxis for HIV infection among African women
    • 22784040 10.1056/NEJMoa1202614
    • Van Damme L, Corneli A, Ahmed K, et al. Preexposure prophylaxis for HIV infection among African women. N Engl J Med. 2012;367(5):411-22.
    • (2012) N Engl J Med , vol.367 , Issue.5 , pp. 411-422
    • Van Damme, L.1    Corneli, A.2    Ahmed, K.3
  • 47
    • 84872429566 scopus 로고    scopus 로고
    • Tenofovir disoproxil fumarate drug levels indicate PrEP use is strongly correlated with HIV-1 protective effects: Kenya and Uganda [abstract no. 30]
    • Seattle (WA); 5-8 Mar
    • Donnell D, Baeten J, Hendrix C, et al. Tenofovir disoproxil fumarate drug levels indicate PrEP use is strongly correlated with HIV-1 protective effects: Kenya and Uganda [abstract no. 30]. 19th Conference on Retroviruses and Opportunistic Infections, Seattle (WA); 5-8 Mar 2012.
    • (2012) 19th Conference on Retroviruses and Opportunistic Infections
    • Donnell, D.1    Baeten, J.2    Hendrix, C.3
  • 50
    • 85081776265 scopus 로고    scopus 로고
    • Accessed 17 Oct 2012
    • Q&A: the VOICE HIV prevention study. 2011. http://www.niaid.nih.gov/ news/qa/pages/voiceqa.aspx. Accessed 17 Oct 2012.
    • (2011) Q&A: The VOICE HIV Prevention Study
  • 51
    • 84862853260 scopus 로고    scopus 로고
    • Effects of FTC/TDF on bone mineral density in seronegative men from 4 continents: DEXA results of the global iPrEx study [abstract no. 94LB]
    • Boston (MA); 27 Feb-2 Mar
    • Mulligan K, Glidden DV, Gonzales P, et al. Effects of FTC/TDF on bone mineral density in seronegative men from 4 continents: DEXA results of the global iPrEx study [abstract no. 94LB]. 18th Conference on Retroviruses and Opportunistic Infections, Boston (MA); 27 Feb-2 Mar 2011.
    • (2011) 18th Conference on Retroviruses and Opportunistic Infections
    • Mulligan, K.1    Glidden, D.V.2    Gonzales, P.3
  • 52
    • 84865701068 scopus 로고    scopus 로고
    • Preexposure prophylaxis for HIV infection
    • 22820712 10.1001/jama.2012.9885 1:CAS:528:DC%2BC38XhsFamsbfL
    • Steinbrook R. Preexposure prophylaxis for HIV infection. JAMA. 2012;308(9):865-6.
    • (2012) JAMA , vol.308 , Issue.9 , pp. 865-866
    • Steinbrook, R.1
  • 53
    • 84865687603 scopus 로고    scopus 로고
    • Ethical challenges of preexposure prophylaxis for HIV
    • 22847147 10.1001/2012.jama.10158 1:CAS:528:DC%2BC38XhsFamsbfE
    • Jay JS, Gostin LO. Ethical challenges of preexposure prophylaxis for HIV. JAMA. 2012;308(9):867-8.
    • (2012) JAMA , vol.308 , Issue.9 , pp. 867-868
    • Jay, J.S.1    Gostin, L.O.2
  • 54
    • 84861623364 scopus 로고    scopus 로고
    • Antiretroviral prophylaxis for HIV prevention reaches a key milestone
    • 22608193 10.1016/S0140-6736(12)60786-7
    • Karim SSA, Karim QA. Antiretroviral prophylaxis for HIV prevention reaches a key milestone. Lancet. 2012;379(9831):2047-8.
    • (2012) Lancet , vol.379 , Issue.9831 , pp. 2047-2048
    • Karim, S.S.A.1    Karim, Q.A.2
  • 55
    • 81855160859 scopus 로고    scopus 로고
    • Cohen MS (2011) Pre-exposure prophylaxis and antiretroviral resistance: HIV prevention at a cost?
    • 21976467 10.1093/cid/cir684 1:CAS:528:DC%2BC3MXhsVOis7%2FI
    • Hurt CB, Eron JJ Jr. Cohen MS (2011) Pre-exposure prophylaxis and antiretroviral resistance: HIV prevention at a cost? Clin Infect Dis. 2011;53(12):1265-70.
    • (2011) Clin Infect Dis , vol.53 , Issue.12 , pp. 1265-1270
    • Hurt, C.B.1    Eron, Jr.J.J.2
  • 56
    • 84860014826 scopus 로고    scopus 로고
    • Unraveling the divergent results of pre-exposure prophylaxis trials for HIV prevention
    • 22333749 10.1097/QAD.0b013e3283522272
    • van der Straten A, Van Damme L, Haberer JE, et al. Unraveling the divergent results of pre-exposure prophylaxis trials for HIV prevention. AIDS. 2012;26(7):F13-9.
    • (2012) AIDS , vol.26 , Issue.7
    • Van Der Straten, A.1    Van Damme, L.2    Haberer, J.E.3
  • 57
    • 77955930318 scopus 로고    scopus 로고
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    • 20643915 10.1126/science.1193748 1:CAS:528:DC%2BC3cXhtV2hsr%2FI
    • Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329(5996):1168-74.
    • (2010) Science , vol.329 , Issue.5996 , pp. 1168-1174
    • Abdool Karim, Q.1    Abdool Karim, S.S.2    Frohlich, J.A.3
  • 59
    • 62449261120 scopus 로고    scopus 로고
    • HIV preexposure prophylaxis in the United States: Impact on lifetime infection risk, clinical outcomes, and cost-effectiveness
    • 19193111 10.1086/597095
    • Paltiel AD, Freedberg KA, Scott CA, et al. HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness. Clin Infect Dis. 2009;48(6):806-15.
    • (2009) Clin Infect Dis , vol.48 , Issue.6 , pp. 806-815
    • Paltiel, A.D.1    Freedberg, K.A.2    Scott, C.A.3
  • 60
    • 65649140248 scopus 로고    scopus 로고
    • Modeling the impact of HIV chemoprophylaxis strategies among men who have sex with men in the United States: HIV infections prevented and cost-effectiveness
    • 18753932 10.1097/QAD.0b013e32830e00f5
    • Desai K, Sansom SL, Ackers ML, et al. Modeling the impact of HIV chemoprophylaxis strategies among men who have sex with men in the United States: HIV infections prevented and cost-effectiveness. AIDS. 2008;22(14):1829-39.
    • (2008) AIDS , vol.22 , Issue.14 , pp. 1829-1839
    • Desai, K.1    Sansom, S.L.2    Ackers, M.L.3
  • 61
    • 84859771317 scopus 로고    scopus 로고
    • The cost-effectiveness of preexposure prophylaxis for HIV prevention in the United States in men who have sex with men
    • 22508731
    • Juusola JL, Brandeau ML, Owens DK, et al. The cost-effectiveness of preexposure prophylaxis for HIV prevention in the United States in men who have sex with men. Ann Intern Med. 2012;156(8):541-50.
    • (2012) Ann Intern Med , vol.156 , Issue.8 , pp. 541-550
    • Juusola, J.L.1    Brandeau, M.L.2    Owens, D.K.3
  • 62
    • 78349313028 scopus 로고    scopus 로고
    • The risk of HIV drug resistance following implementation of pre-exposure prophylaxis
    • 20847692 10.1097/QCO.0b013e32833ff1e6
    • van de Vijver DAMC, Boucher CAB. The risk of HIV drug resistance following implementation of pre-exposure prophylaxis. Curr Opin Infect Dis. 2010;23(6):621-7.
    • (2010) Curr Opin Infect Dis , vol.23 , Issue.6 , pp. 621-627
    • Van De Vijver, D.1    Boucher, C.A.B.2
  • 63
    • 82455205791 scopus 로고    scopus 로고
    • Optimal uses of antiretrovirals for prevention in HIV-1 serodiscordant heterosexual couples in South Africa: A modelling study
    • 22110407 10.1371/journal.pmed.1001123
    • Hallett TB, Baeten JM, Heffron R, et al. Optimal uses of antiretrovirals for prevention in HIV-1 serodiscordant heterosexual couples in South Africa: a modelling study. PLoS Med. 2011;8(11):e1001123.
    • (2011) PLoS Med , vol.8 , Issue.11 , pp. 1001123
    • Hallett, T.B.1    Baeten, J.M.2    Heffron, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.