Sensitization of upper airway mechanoreceptors as a new pharmacologic principle to treat obstructive sleep apnea: Investigations with AVE0118 in anesthetized pigs

Sleep

Volumn 36, Issue 5, 2013, Pages 699-708

  Wirth, Klaus J ^a   Steinmeyer, Klaus ^a   Ruetten, Hartmut ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Animal model; AVE0118; Mechanoreceptors; Negative pressure reflex; Obstructive sleep apnea

Indexed keywords

2' (4 METHOXYPHENYLACETAMIDOMETHYL) N [2 (3 PYRIDYL)ETHYL] 2 BIPHENYLCARBOXAMIDE; ACETAZOLAMIDE; CHLORALOSE; FLUOXETINE; LIDOCAINE; MIRTAZAPINE; NALOXONE; PAROXETINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; GENERAL ANESTHESIA; MECHANORECEPTOR; NEGATIVE PRESSURE VENTILATION; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY AIRFLOW; SLEEP DISORDERED BREATHING; TRACHEA PRESSURE; UPPER RESPIRATORY TRACT;

ANIMAL MODEL; AVE0118; MECHANORECEPTORS; NEGATIVE PRESSURE REFLEX; OBSTRUCTIVE SLEEP APNEA;

ADMINISTRATION, INTRANASAL; AIRWAY RESISTANCE; ANESTHETICS, INTRAVENOUS; ANIMALS; BIPHENYL COMPOUNDS; CHLORALOSE; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; MALE; MECHANORECEPTORS; POTASSIUM CHANNEL BLOCKERS; SLEEP APNEA, OBSTRUCTIVE; SWINE;

EID: 84877116546     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.2630     Document Type: Article

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