Emergence of methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of late-onset nosocomial pneumonia in intensive care patients in the USA

International Journal of Infectious Diseases

Volumn 17, Issue 6, 2013, Pages

  Pasquale, Timothy R ^a   Jabrocki, Bonnie ^a   Salstrom, Sara Jane ^a   Wiemken, Timothy L ^b   Peyrani, Paula ^b   Haque, Nadia Z ^c   Scerpella, Ernesto G ^d   Ford, Kimbal D ^d   Zervos, Marcus J ^c   Ramirez, Julio A ^b   File, Thomas M ^a,e  

^a AKRON CITY HOSPITAL   (United States)

^b University of Louisville School of Medicine   (United States)

^c HENRY FORD HEALTH SYSTEM   (United States)

^d PFIZER INC   (United States)

^e Northeastern Ohio Medical University   (United States)

Author keywords

CA MRSA; Community associated methicillin resistant Staphylococcus aureus; Community associated MRSA; Intensive care; MRSA; Nosocomial pneumonia

Indexed keywords

PANTON VALENTINE LEUKOCIDIN; VANCOMYCIN;

ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CHROMOSOME; CLINICAL FEATURE; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; GENE CASSETTE; GENOTYPE; HOSPITAL ACQUIRED PNEUMONIA; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; OBSERVATIONAL STUDY; ONSET AGE; PATHOGENESIS; RETROSPECTIVE STUDY; RISK FACTOR; UNITED STATES;

ADULT; AGED; BACTERIAL TYPING TECHNIQUES; COMMUNICABLE DISEASES, EMERGING; COMORBIDITY; CROSS INFECTION; FEMALE; GENOTYPE; HUMANS; INTENSIVE CARE UNITS; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MIDDLE AGED; PNEUMONIA, STAPHYLOCOCCAL; RETROSPECTIVE STUDIES; RISK FACTORS; STAPHYLOCOCCAL INFECTIONS; UNITED STATES;

EID: 84877107647     PISSN: 12019712     EISSN: 18783511     Source Type: Journal    
DOI: 10.1016/j.ijid.2012.12.013     Document Type: Article

References (40)

1. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005, 171:388-416. American Thoracic Society, Infectious Diseases Society of America.
2. Pujol M., Corbella X., Pena C., Pallares R., Dorca J., Verdaguer R., et al. Clinical and epidemiological findings in mechanically-ventilated patients with methicillin-resistant Staphylococcus aureus pneumonia. Eur J Clin Microbiol Infect Dis 1998, 17:622-628.
3. Tsuji B.T., Rybak M.J., Cheung C.M., Amjad M., Kaatz G.W. Community- and health care-associated methicillin-resistant Staphylococcus aureus: a comparison of molecular epidemiology and antimicrobial activities of various agents. Diagn Microbiol Infect Dis 2007, 58:41-47.
4. Morgan M.S. Diagnosis and treatment of Panton-Valentine leukocidin (PVL)-associated staphylococcal pneumonia. Int J Antimicrob Agents 2007, 30:289-296.
5. Maree C.L., Daum R.S., Boyle-Vavra S., Matayoshi K., Miller L.G. Community-associated methicillin-resistant Staphylococcus aureus isolates causing healthcare-associated infections. Emerg Infect Dis 2007, 13:236-242.
6. Popovich K.J., Weinstein R.A., Hota B. Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?. Clin Infect Dis 2008, 46:787-794.
7. Gonzalez B.E., Rueda A.M., Shelburne S.A., Musher D.M., Hamill R.J., Hulten K.G. Community-associated strains of methicillin-resistant Staphylococcus aureus as the cause of healthcare-associated infection. Infect Control Hosp Epidemiol 2006, 27:1051-1056.
8. Klevens R.M., Morrison M.A., Fridkin S.K., Reingold A., Petit S., Gershman K., et al. Community-associated methicillin-resistant Staphylococcus aureus and healthcare risk factors. Emerg Infect Dis 2006, 12:1991-1993.
9. Wang J.T., Wang J.L., Fan C.T., Chie W.C., Lai M.S., Lauderdale T.S., et al. Risk factors for mortality of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection: with investigation of the potential role of community-associated MRSA strains. J Infect 2010, 61:449-457.
10. Mangino J.E., Peyrani P., Ford K.D., Kett D.H., Zervos M.J., Welch V.L., et al. Development and implementation of a performance improvement project in adult intensive care units: overview of the Improving Medicine Through Pathway Assessment of Critical Therapy in Hospital-Acquired Pneumonia (IMPACT-HAP) study. Crit Care 2011, 15:R38. the IMPACT-HAP Study Group.
11. Centers for Disease Control and Prevention. National Healthcare Safety Network. Patient safety component manual. Device-associated module, ventilator-associated pneumonia (VAP) event. Atlanta, GA: CDC; 2011.
12. Knaus W.A., Draper E.A., Wagner D.P., Zimmerman J.E. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829.
13. Pugin J., Auckenthaler R., Mili N., Janssens J.P., Lew P.D., Suter P.M. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic 'blind' bronchoalveolar lavage fluid. Am Rev Respir Dis 1991, 143:1121-1129.
14. McDougal L.K., Steward C.D., Killgore G.E., Chaitram J.M., McAllister S.K., Tenover F.C. Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national database. J Clin Microbiol 2003, 41:5113-5120.
15. Singh A., Goering R.V., Simjee S., Foley S.L., Zervos M.J. Application of molecular techniques to the study of hospital infection. Clin Microbiol Rev 2006, 19:512-530.
16. Zhang K., McClure J.A., Elsayed S., Louie T., Conly J.M. Novel multiplex PCR assay for characterization and concomitant subtyping of staphylococcal cassette chromosome mec types I to V in methicillin-resistant Staphylococcus aureus. J Clin Microbiol 2005, 43:5026-5033.
17. Strommenger B., Cuny C., Werner G., Witte W. Obvious lack of association between dynamics of epidemic methicillin-resistant Staphylococcus aureus in central Europe and agr specificity groups. Eur J Clin Microbiol Infect Dis 2004, 23:15-19.
18. Lina G., Piémont Y., Godail-Gamot F., Bes M., Peter M.O., Gauduchon V., et al. Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis 1999, 29:1128-1132.
19. Wootton M., MacGowan A.P., Walsh T.R., Howe R.A. A multicenter study evaluating the current strategies for isolating Staphylococcus aureus strains with reduced susceptibility to glycopeptides. J Clin Microbiol 2007, 45:329-332.
20. Moore C.L., Osaki-Kiyan P., Perri M., Donabedian S., Haque N.Z., Chen A., Zervos M.J. USA600 (ST45) methicillin-resistant Staphylococcus aureus bloodstream infections in urban Detroit. J Clin Microbiol 2010, 48:2307-2310.
21. Trouillet J.L., Chastre J., Vuagnat A., Joly-Guillou M.L., Combaux D., Dombret M.C., et al. Ventilator associated pneumonia caused by potentially drug resistant bacteria. Am J Crit Care 1998, 157:531-539.
22. Baker A.M., Meredith J.W., Haponik E.F. Pneumonia in intubated trauma patients: microbiology and outcomes. Am J Crit Care 1996, 153:343-349.
23. Giantsou E., Liratzopoulos N., Efraimidou E., Panopoulou M., Alepopoulou E., Kartali-Ktenidou S., et al. Both early-onset and late-onset ventilator-associated pneumonia are caused mainly by potentially multiresistant bacteria. Intensive Care Med 2005, 31:1488-1494.
24. Verhamme K.M., De Coster W., De Roo L., De Beenhouwer H., Nollet G., Verbeke J., et al. Pathogens in early-onset and late-onset intensive care unit-acquired pneumonia. Infect Control Hosp Epidemiol 2007, 28:389-397.
25. Seybold U., Kourbatova E.V., Johnson J.G., Halvosa S.J., Wang Y.F., King M.D., et al. Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections. Clin Infect Dis 2006, 42:647-656.
26. Nair N., Kourbatova E., Poole K., Huckabee C.M., Murray P., Huskins W.C., et al. Molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) among patients admitted to adult intensive care units: the STAR*ICU trial. Infect Control Hosp Epidemiol 2011, 32:1057-1063.
27. Wilmer A., Lloyd-Smith E., Romney M., Hoang L., Hull M., Champagne S. Methicillin-resistant Staphylococcus aureus strain USA300 is prevalent among hospital-onset cases in an urban Canadian setting. Infect Control Hosp Epidemiol 2011, 32:1227-1229.
28. Okuma K., Iwakawa K., Turnidge J.D., Grubb W.B., Bell J.M., O'Brien F.G., et al. Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J Clin Microbiol 2002, 40:4289-4294.
29. Hageman J.C., Uyeki T.M., Francis J.S., Jernigan D.B., Wheeler J.G., Bridges C.B., et al. Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season. Emerg Infect Dis 2006, 12:894-899.
30. Francis J.S., Doherty M.C., Lopatin U., Johnston C.P., Sinha G., Ross T., et al. Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes. Clin Infect Dis 2005, 40:100-107.
31. Vardakas K.Z., Matthaiou D.K., Falagas M.E. Incidence, characteristics and outcomes of patients with severe community acquired MRSA pneumonia. Eur Respir J 2009, 34:1148-1158.
32. Gillet Y., Vanhems P., Lina G., Bes M., Vandenesch F., Floret D., et al. Factors predicting mortality in necrotizing community-acquired pneumonia caused by Staphylococcus aureus containing Panton-Valentine leukocidin. Clin Infect Dis 2007, 45:315-321.
33. Labandeira-Rey M., Couzon F., Boisset S., Brown E.L., Bes M., Benito Y., et al. Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. Science 2007, 315:1130-1133.
34. Bae I.G., Tonthat G.T., Stryjewski M.E., Rude T.H., Reilly L.F., Barriere S.L., et al. Presence of genes encoding the Panton-Valentine leukocidin exotoxin is not the primary determinant of outcome in patients with complicated skin and skin structure infectious due to methicillin-resistant Staphylococcus aureus: results of a multinational trial. J Clin Microbiol 2009, 47:3952-3957.
35. Hota B., Lyles R., Rim J., Popovich K.J., Rice T., Aroutcheva A., et al. Predictors of clinical virulence in community-onset methicillin-resistant Staphylococcus aureus infections: the importance of USA300 and pneumonia. Clin Infect Dis 2011, 53:757-765. CDC Prevention Epicenters.
36. Peyrani P., Allen M., Wiemken T.L., Haque N.Z., Zervos M.J., Ford K.D., et al. Severity of disease and clinical outcomes in patients with hospital-acquired pneumonia due to methicillin-resistant Staphylococcus aureus strains not influenced by the presence of the Panton-Valentine Leukocidin gene. Clin Infect Dis 2011, 53:766-771. IMPACT-HAP Study Group.
37. Bubeck Wardenburg J., Palazzolo-Ballance A.M., Otto M., Schneewind O., DeLeo F.R. Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease. J Infect Dis 2008, 198:1166.
38. Choi E.Y., Huh J.W., Lim C.M., Koh Y., Kim S.H., Choi S.H., et al. Relationship between the MIC of vancomycin and clinical outcome in patients with MRSA nosocomial pneumonia. Intensive Care Med 2011, 37:639-647.
39. Haque N.Z., Zuniga L.C., Peyrani P., Reyes K., Lamerato L., Moore C.L., et al. Relationship of vancomycin minimum inhibitory concentration to mortality in patients with methicillin-resistant Staphylococcus aureus hospital-acquired, ventilator-associated, or health-care-associated pneumonia. Chest 2010, 138:1356-1362. IMPACT-HAP Study Group.
40. Wiemken T., Peyrani P., Arnold F.W., Ramirez J. The use of large databases to study pneumonia: what is their value?. Clin Chest Med 2011, 32:481-489.