Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of advanced germline BRCA2 mutant prostate cancer

Annals of Oncology

Volumn 24, Issue 5, 2013, Pages 1416-1418

  Sandhu, S K ^a,b   Omlin, A ^a,b   Hylands, L ^a   Miranda, S ^a   Barber, L J ^a   Riisnaes, R ^a   Reid, A H ^a,b   Attard, G ^a,b   Chen, L ^a   Kozarewa, I ^a   Gevensleben, H ^a   Campbell, J ^a   Fenwick, K ^a   Assiotis, I ^a   Olmos, D ^a,b   Yap, T A ^a,b   Fong, P ^a,b   Tunariu, N ^b   Koh, D ^b   Molife, L R ^a,b   Kaye, S ^a,b   Lord, C J ^a   Ashworth, A ^a   De bono, J ^a,b   more..

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NIRAPARIB; OLAPARIB; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TRANSCRIPTION FACTOR ERG;

ADULT; ADVANCED CANCER; AGED; BONE METASTASIS; CANCER RESISTANCE; CASE REPORT; CASTRATION; DRUG BIOAVAILABILITY; DRUG DOSE ESCALATION; ERG GENE; GENE LOSS; GENE MUTATION; GENE REARRANGEMENT; GLEASON SCORE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; LETTER; MALE; MUTANT; PRIORITY JOURNAL; PROSTATE CANCER; PTEN GENE; SOFT TISSUE METASTASIS; TUMOR SUPPRESSOR GENE; VISCERAL METASTASIS;

EID: 84877104586     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdt074     Document Type: Letter

References (5)

1. Fong PC, Boss DS, Yap TA et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009; 361: 123-134.
2. Beltran H, Yelensky R, Frampton GM et al. Targeted next-generation sequencing of advanced prostate cancer Identifies potential therapeutic targets and disease heterogeneity. Eur Urol 2012 September 5 [epub ahead of print], doi: 10.1016/j.eururo.2012.08.053.
3. Brenner JC, Ateeq B, Li Y et al. Mechanistic rationale for inhibition of poly(ADPribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell 2011; 19: 664-678.
4. Schiewer MJ, Dicker AP, Brody JR et al. Dual roles of PARP-1 promote cancer growth and progression. Cancer Discov 2012; 2: 1134-1149.
5. Haffner MC, Aryee MJ, Toubaji A et al. Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements. Nat Genet 2010; 42: 668-675.