IgA nephropathy with severe chronic renal failure: A randomized controlled trial of corticosteroids and azathioprine

Journal of Nephrology

Volumn 26, Issue 1, 2013, Pages 86-93

  Pozzi, Claudio ^a,b   Andrulli, Simeone ^a   Pani, Antonello ^c   Scaini, Patrizia ^d   Roccatello, Dario ^e   Fogazzi, Giambattista ^f   Pecchini, Paola ^d   Rustichelli, Roberto ^g   Finocchiaro, Pietro ^h   Del Vecchio, Lucia ^a   Locatelli, Francesco ^a  

^a A MANZONI HOSPITAL   (Italy)

^b Bassini Hospital   (Italy)

^c BROTZU HOSPITAL   (Italy)

^d Spedali Civili ^*  (Italy)

^e Center of Research on Immunopathology and Documentation on Rare Diseases   (Italy)

^f FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^g S MARIA NUOVA HOSPITAL   (Italy)

^h CNR   (Italy)

Author keywords

Azathioprine; Chronic kidney disease; Hypertension; IgA nephropathy; Proteinuria; Steroids

Indexed keywords

AZATHIOPRINE; METHYLPREDNISOLONE; PREDNISONE;

ADULT; ARTICLE; BLEEDING; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DEPRESSION; DIABETES MELLITUS; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HUMAN; HYPERTENSION; HYPERTRANSAMINASEMIA; IMMUNOGLOBULIN A NEPHROPATHY; INFECTION; LEUKOPENIA; LIVER DISEASE; MALE; MONOTHERAPY; MYALGIA; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SURVIVAL TIME; TREATMENT OUTCOME;

ADULT; ANGIOTENSIN RECEPTOR ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTI-INFLAMMATORY AGENTS; ANTIHYPERTENSIVE AGENTS; AZATHIOPRINE; CREATININE; DISEASE PROGRESSION; DRUG THERAPY, COMBINATION; FEMALE; GLOMERULONEPHRITIS, IGA; HUMANS; HYPERTENSION; IMMUNOSUPPRESSIVE AGENTS; KAPLAN-MEIER ESTIMATE; LONGITUDINAL STUDIES; MALE; METHYLPREDNISOLONE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDNISONE; PROPORTIONAL HAZARDS MODELS; PROTEINURIA; RENAL INSUFFICIENCY, CHRONIC; SEX FACTORS; TIME FACTORS;

EID: 84877093059     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/jn.5000110     Document Type: Article

References (20)

1. Koyama A, Igarashi M, Kobayashi M; Members and Coworkers of the Research Group on Progressive Renal Disease. Natural history and risk factors for immunoglobulin A nephropathy in Japan. Am J Kidney Dis. 1997;29(4):526-532.
2. D'Amico G. Natural history of idiopathic IgA nephropathy: role of clinical and histological prognostic factors. Am J Kidney Dis. 2000;36(2):227-237.
3. Donadio JV, Grande JP. IgA nephropathy. N Engl J Med. 2002;347(10):738-748.
4. D'Amico G, Ragni A, Gandini E, Fellin G. Typical and atypical natural history of IgA nephropathy in adult patients. Contrib Nephrol. 1993;104:6-13.
5. Schöll U, Wastl U, Risler T, et al. The "point of no return" and the rate of progression in the natural history of IgA nephritis. Clin Nephrol. 1999;52(5):285-292.
6. Komatsu H, Fujimoto S, Sato Y, et al. "Point of no return (PNR)" in progressive IgA nephropathy: significance of blood pressure and proteinuria management up to PNR. J Nephrol. 2005;18(6):690-695.
7. Pozzi C, Bolasco PG, Fogazzi GB, et al. Corticosteroids in IgA nephropathy: a randomised controlled trial. Lancet. 1999;353(9156):883-887.
8. Pozzi C, Andrulli S, Del Vecchio L, et al. Corticosteroid effectiveness in IgA nephropathy: long-term results of a randomized, controlled trial. J Am Soc Nephrol. 2004;15(1):157-163.
9. Locatelli F, Pozzi C, Del Vecchio L, et al. Combined treatment with steroids and azathioprine in IgA nephropathy: de sign of a prospective randomised multicentre trial. J Nephrol. 1999;12(5):308-311.
10. Pozzi C, Andrulli S, Pani A, et al. Corticosteroids and azathioprine vs corticosteroids alone in IgA nephropathy. J Am Soc Nephrol. 2010;21:1783-1790.
11. Churg J, Sobin LH. Renal disease: classification and atlas of glomerular disease. Tokyo: Igaku-Shoin; 1982.
12. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41.
13. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D; Modification of Diet in Renal Disease Study Group. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med. 1999;130(6):461-470.
14. Goumenos D, Ahuja M, Shortland JR, Brown CB. Can immunosuppressive drugs slow the progression of IgA nephropathy? Nephrol Dial Transplant. 1995;10(7):1173-1181.
15. Goumenos DS, Davlouros P, El Nahas AM, et al. Prednisolone and azathioprine in IgA nephropathy: a ten year follow-up study. Nephron Clin Pract. 2003;93:C47-C48.
16. Mitsuiki K, Harada A, Okura T, Higaki J. Histologically advanced IgA nephropathy treated successfully with prednisolone and cyclophosphamide. Clin Exp Nephrol. 2007;11(4): 297-303.
17. Roccatello D, Rossi D, Marletto F, et al. Long-term effects of methylprednisolone pulses and mycophenolate mofetil in IgA nephropathy patients at risk of progression. J Nephrol. 2011 Jun 28. [Epub ahead of print].
18. Ballardie FW, Roberts IS. Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy. J Am Soc Nephrol. 2002;13(1):142-148.
19. Manno C, Torres DD, Rossini M, Pesce F, Schena FP. Randomized controlled clinical trial of corticosteroids plus ACEinhibitors with long-term follow-up in proteinuric IgA nephropathy. Nephrol Dial Transplant. 2009;24(12):3694-3701.
20. Hou FF, Zhang X, Zhang GH, et al. Efficacy and safety of benazepril for advanced chronic renal insufficiency. N Engl J Med. 2006;354(2):131-140.