메뉴 건너뛰기




Volumn 13, Issue 12, 2012, Pages 6311-6311

Impact of HER2 and PTEN simultaneous deregulation in non-small cell lung carcinoma: Correlation with biological behavior

Author keywords

Gene; HER2 neu; Non Small cell lung carcinoma; PTEN

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, HUMAN;

EID: 84877085810     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.12.6311     Document Type: Article
Times cited : (7)

References (37)
  • 1
    • 4544264923 scopus 로고    scopus 로고
    • Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers
    • Au NH, Cheang M, Huntsman DG, et al (2004). Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers. J Pathol, 204, 101-9.
    • (2004) J Pathol , vol.204 , pp. 101-109
    • Au, N.H.1    Cheang, M.2    Huntsman, D.G.3
  • 2
    • 84856071447 scopus 로고    scopus 로고
    • Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.
    • Bendell JC, Rodon J, Burris HA, et al (2012). Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. J Clin Oncol, 30, 282-90.
    • (2012) J Clin Oncol , vol.30 , pp. 282-290
    • Bendell, J.C.1    Rodon, J.2    Burris, H.A.3
  • 3
    • 3042701602 scopus 로고    scopus 로고
    • RRM and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer
    • Bepler G, Sharma S, Cantor A, et al (2004). RRM and PTEN as prognostic parameters for overalland disease-free survival in patients with non-small-cell lung cancer. J Clin Oncol, 22, 1878-85.
    • (2004) J Clin Oncol , vol.22 , pp. 1878-1885
    • Bepler, G.1    Sharma, S.2    Cantor, A.3
  • 4
    • 84860582939 scopus 로고    scopus 로고
    • Advances in treatment of lung cancer targeted therapy
    • Cagle PT, Chirieac LR (2012). Advances in treatment of lung cancer targeted therapy. Arch Pathol Lab Med, 136, 504-9.
    • (2012) Arch Pathol Lab Med , vol.136 , pp. 504-509
    • Cagle, P.T.1    Chirieac, L.R.2
  • 5
    • 7044249212 scopus 로고    scopus 로고
    • PTEN regulatory functions in tumor suppression and cell biology
    • Chu EC, Tarnawski AS (2004). PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit, 10, 235-41.
    • (2004) Med Sci Monit , vol.10 , pp. 235-241
    • Chu, E.C.1    Tarnawski, A.S.2
  • 6
    • 33745828702 scopus 로고    scopus 로고
    • EGF-ERBB signalling: towards the systems level
    • Citri A, Yarden Y (2006). EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol, 7, 505-16.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 505-516
    • Citri, A.1    Yarden, Y.2
  • 7
    • 0942287963 scopus 로고    scopus 로고
    • Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer
    • Gatzemeier U, Groth G, Butts C, et al (2004). Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer. Ann Oncol, 15, 19-27.
    • (2004) Ann Oncol , vol.15 , pp. 19-27
    • Gatzemeier, U.1    Groth, G.2    Butts, C.3
  • 8
    • 0037029712 scopus 로고    scopus 로고
    • Evaluation of HER-2/neu gene amplification and protein expression in nonsmall cell lung carcinomas
    • Hirsch FR, Varella-Garcia M, Franklin WA, et al (2002). Evaluation of HER-2/neu gene amplification and protein expression in nonsmall cell lung carcinomas. Br J Cancer, 86, 1449-56.
    • (2002) Br J Cancer , vol.86 , pp. 1449-1456
    • Hirsch, F.R.1    Varella-Garcia, M.2    Franklin, W.A.3
  • 10
    • 77955092315 scopus 로고    scopus 로고
    • PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers.
    • Jin G, Kim MJ, Jeon HS, et al (2010). PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers. Lung Cancer, 69, 279-83.
    • (2010) Lung Cancer , vol.69 , pp. 279-283
    • Jin, G.1    Kim, M.J.2    Jeon, H.S.3
  • 11
    • 0036127525 scopus 로고    scopus 로고
    • Promoter methylation and silencing of PTEN in gastric carcinoma
    • Kang YH, Lee HS, Kim WH (2002). Promoter methylation and silencing of PTEN in gastric carcinoma. Lab Invest, 82, 285-91.
    • (2002) Lab Invest , vol.82 , pp. 285-291
    • Kang, Y.H.1    Lee, H.S.2    Kim, W.H.3
  • 12
    • 78149470440 scopus 로고    scopus 로고
    • Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers
    • Lee SY, Kim MJ, Jin G, et al. (2010). Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers. J Thorac Oncol, 5, 1734-40.
    • (2010) J Thorac Oncol , vol.5 , pp. 1734-1740
    • Lee, S.Y.1    Kim, M.J.2    Jin, G.3
  • 13
    • 34249741939 scopus 로고    scopus 로고
    • PTEN and phosphorylated AKT expression and prognosis in early- and late-stage non-small cell lung cancer
    • Lim WT, Zhang WH, Miller CR, et al. (2007). PTEN and phosphorylated AKT expression and prognosis in early- and late-stage non-small cell lung cancer. Oncol Rep, 17, 853-7.
    • (2007) Oncol Rep , vol.17 , pp. 853-857
    • Lim, W.T.1    Zhang, W.H.2    Miller, C.R.3
  • 14
    • 78650459071 scopus 로고    scopus 로고
    • The role of human epidermal growth factor receptor 2 as a prognostic factor in lung cancer: a meta-analysis of published data
    • Liu L, Shao X, Gao W, et al. (2010). The role of human epidermal growth factor receptor 2 as a prognostic factor in lung cancer: a meta-analysis of published data. J Thorac Oncol, 5, 1922-32.
    • (2010) J Thorac Oncol , vol.5 , pp. 1922-1932
    • Liu, L.1    Shao, X.2    Gao, W.3
  • 16
    • 23444461754 scopus 로고    scopus 로고
    • PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
    • Marsit CJ, Zheng S, Aldape K, et al. (2005). PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration. Hum Pathol, 36, 768-76.
    • (2005) Hum Pathol , vol.36 , pp. 768-776
    • Marsit, C.J.1    Zheng, S.2    Aldape, K.3
  • 17
    • 0141921933 scopus 로고    scopus 로고
    • The role of HER-2/neu expression on the survival of patients with lung cancer: a systematic review of the literature
    • Meert AP, Martin B, Paesmans M, et al. (2003). The role of HER-2/neu expression on the survival of patients with lung cancer: a systematic review of the literature. Br J Cancer, 89, 959-65.
    • (2003) Br J Cancer , vol.89 , pp. 959-965
    • Meert, A.P.1    Martin, B.2    Paesmans, M.3
  • 18
    • 44249086425 scopus 로고    scopus 로고
    • Non-Small Cell Lung Cancer: Epidemiology, risk factors, treatment, and survivorship
    • Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA (2008). Non-Small Cell Lung Cancer: Epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc, 83, 584-94.
    • (2008) Mayo Clin Proc , vol.83 , pp. 584-594
    • Molina, J.R.1    Yang, P.2    Cassivi, S.D.3    Schild, S.E.4    Adjei, A.A.5
  • 19
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata Y, Lan KH, Zhou X, et al. (2004). PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell, 6, 117-27.
    • (2004) Cancer Cell , vol.6 , pp. 117-127
    • Nagata, Y.1    Lan, K.H.2    Zhou, X.3
  • 20
    • 0037211307 scopus 로고    scopus 로고
    • Correlation between encoded protein overexpression and copy number of the HER2 gene with survival in non-small cell lung cancer
    • Nakamura H, Saji H, Ogata A, et al. (2003). Correlation between encoded protein overexpression and copy number of the HER2 gene with survival in non-small cell lung cancer. Int J Cancer, 103, 61-6.
    • (2003) Int J Cancer , vol.103 , pp. 61-66
    • Nakamura, H.1    Saji, H.2    Ogata, A.3
  • 21
    • 79960894047 scopus 로고    scopus 로고
    • Molecular biomarkers in non-small-cell lung cancer: a retrospective analysis of data from the phase 3 FLEX study
    • O'Byrne KJ, Gatzemeier U, Bondarenko I, et al. (2011). Molecular biomarkers in non-small-cell lung cancer: a retrospective analysis of data from the phase 3 FLEX study. Lancet Oncol, 12, 795-805.
    • (2011) Lancet Oncol , vol.12 , pp. 795-805
    • O'Byrne, K.J.1    Gatzemeier, U.2    Bondarenko, I.3
  • 22
    • 0842290056 scopus 로고    scopus 로고
    • Loss of PTEN expression is not uncommon but lacks prognostic value in stage I NSCLC
    • Olaussen KA, Soria JC, Mřat L, et al. (2003). Loss of PTEN expression is not uncommon but lacks prognostic value in stage I NSCLC. Anticancer Res, 23, 4885-90.
    • (2003) Anticancer Res , vol.23 , pp. 4885-4890
    • Olaussen, K.A.1    Soria, J.C.2    Mřat, L.3
  • 23
    • 8644239447 scopus 로고    scopus 로고
    • Lack of prognostic implications of HER-2/neu abnormalities in 345 stage I non-small cell carcinomas (NSCLC) and 207 stage I-III neuroendocrine tumours (NET) of the lung
    • Pelosi G, Del CB, Dell'Orto P, et al. (2005). Lack of prognostic implications of HER-2/neu abnormalities in 345 stage I non-small cell carcinomas (NSCLC) and 207 stage I-III neuroendocrine tumours (NET) of the lung. Int J Cancer, 113, 101-8.
    • (2005) Int J Cancer , vol.113 , pp. 101-108
    • Pelosi, G.1    Del, C.B.2    Dell'Orto, P.3
  • 24
    • 78049431141 scopus 로고    scopus 로고
    • HER2 and chromosome 17 effect on patient outcome in the N9831 adjuvant trastuzumab trial
    • Perez EA, Reinholz MM, Hillman DW, et al. (2010). HER2 and chromosome 17 effect on patient outcome in the N9831 adjuvant trastuzumab trial. J Clin Oncol, 28, 4307-15.
    • (2010) J Clin Oncol , vol.28 , pp. 4307-4315
    • Perez, E.A.1    Reinholz, M.M.2    Hillman, D.W.3
  • 26
    • 13244259196 scopus 로고    scopus 로고
    • Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen
    • Shoman N, Klassen S, McFadden A, et al. (2005). Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen. Mod Pathol, 18, 250-9.
    • (2005) Mod Pathol , vol.18 , pp. 250-259
    • Shoman, N.1    Klassen, S.2    McFadden, A.3
  • 28
    • 33746866699 scopus 로고    scopus 로고
    • Her2-targeted therapies in non-small cell lung cancer
    • Swanton C, Futreal A, Eisen T (2006). Her2-targeted therapies in non-small cell lung cancer. Clin Cancer Res, 12, 4377-83.
    • (2006) Clin Cancer Res , vol.12 , pp. 4377-4383
    • Swanton, C.1    Futreal, A.2    Eisen, T.3
  • 29
    • 84855177600 scopus 로고    scopus 로고
    • The prognostic significance of HER2 overexpression in non-small cell lung cancer
    • Takenaka M, Hanagiri T, Shinohara S, et al. (2011). The prognostic significance of HER2 overexpression in non-small cell lung cancer. Anticancer Res, 31, 4631-6.
    • (2011) Anticancer Res , vol.31 , pp. 4631-4636
    • Takenaka, M.1    Hanagiri, T.2    Shinohara, S.3
  • 30
    • 10744231647 scopus 로고    scopus 로고
    • HER2 protein expression and gene alteration in stage I-IIIA non-small-cell lung cancer: a study of 140 cases using a combination of high throughput tissue microarray, immunohistochemistry, and fluorescent in situ hybridization
    • Tan D, Deeb G, Wang J, et al. (2003). HER2 protein expression and gene alteration in stage I-IIIA non-small-cell lung cancer: a study of 140 cases using a combination of high throughput tissue microarray, immunohistochemistry, and fluorescent in situ hybridization. Diagn Mol Pathol, 12, 201-11.
    • (2003) Diagn Mol Pathol , vol.12 , pp. 201-211
    • Tan, D.1    Deeb, G.2    Wang, J.3
  • 31
    • 31344479312 scopus 로고    scopus 로고
    • Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
    • Tang JM, He QY, Guo RX, et al. (2006). Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis. Lung Cancer, 51, 181-91.
    • (2006) Lung Cancer , vol.51 , pp. 181-191
    • Tang, J.M.1    He, Q.Y.2    Guo, R.X.3
  • 32
    • 37549070670 scopus 로고    scopus 로고
    • Evaluation of the prognostic role of a panel of biomarkers in stage IB-IIIA non-small cell lung cancer patients
    • Timotheadou E, Skarlos DV, Samantas E, et al. (2007). Evaluation of the prognostic role of a panel of biomarkers in stage IB-IIIA non-small cell lung cancer patients. Anticancer Res, 27, 4481-9.
    • (2007) Anticancer Res , vol.27 , pp. 4481-4489
    • Timotheadou, E.1    Skarlos, D.V.2    Samantas, E.3
  • 33
    • 34447306848 scopus 로고    scopus 로고
    • Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer
    • Valabrega G, Montemurro F, Aglietta M (2007). Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann Oncol, 18, 977-84.
    • (2007) Ann Oncol , vol.18 , pp. 977-984
    • Valabrega, G.1    Montemurro, F.2    Aglietta, M.3
  • 34
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel CL, Cobleigh MA, Tripathy D, et al. (2002). Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol, 20, 719-26.
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 35
    • 79958765919 scopus 로고    scopus 로고
    • PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib
    • Wang L, Zhang Q, Zhang J, et al. (2011). PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib. BMC Cancer, 11, 248.
    • (2011) BMC Cancer , vol.11 , pp. 248
    • Wang, L.1    Zhang, Q.2    Zhang, J.3
  • 36
    • 84862686050 scopus 로고    scopus 로고
    • mTOR and PTEN expression in non-small cell lung cancer: analysis by real-time fluorescence quantitative polymerase chain reaction and immunohistochemistry
    • Wang L, Yue W, Zhang L, et al. (2012). mTOR and PTEN expression in non-small cell lung cancer: analysis by real-time fluorescence quantitative polymerase chain reaction and immunohistochemistry. Surg Today, 42, 419-25.
    • (2012) Surg Today , vol.42 , pp. 419-425
    • Wang, L.1    Yue, W.2    Zhang, L.3
  • 37
    • 80053016843 scopus 로고    scopus 로고
    • Loss of PTEN expression is an independent poor prognostic factor in non-small cell lung cancer
    • Yoo SB, Xu X, Lee HJ, et al. (2011). Loss of PTEN expression is an independent poor prognostic factor in non-small cell lung cancer. Korean J Pathol, 45, 329-35.
    • (2011) Korean J Pathol , vol.45 , pp. 329-335
    • Yoo, S.B.1    Xu, X.2    Lee, H.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.