Microinjection of ghrelin in the nucleus accumbens core enhances locomotor activity induced by cocaine

Behavioural Brain Research

Volumn 248, Issue , 2013, Pages 7-11

  Jang, Ju Kyong ^a   Kim, Wha Young ^a   Cho, Bo Ram ^a   Lee, Jung Won ^a   Kim, Jeong Hoon ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Cocaine; Ghrelin; Locomotor activity; Nucleus accumbens core

Indexed keywords

COCAINE; DOPAMINE; GHRELIN; GHRELIN RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINE RELEASE; DRUG DEPENDENCE; DRUG MECHANISM; LOCOMOTION; MALE; MESOLIMBIC DOPAMINERGIC SYSTEM; MICROINJECTION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; SENSITIZATION;

ANIMALS; BEHAVIOR, ANIMAL; COCAINE; DOPAMINE; GHRELIN; MALE; MICROINJECTIONS; MOTOR ACTIVITY; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE-RELATED DISORDERS;

EID: 84877073814     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2013.03.049     Document Type: Article

References (35)

1. Kojima M., Hosoda H., Date Y., Makazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402:656-660.
2. Olszewski P.K., Schiöth H.B., Levine A.S. Ghrelin in the CNS: From hunger to a rewarding and memorable meal. Brain Research Reviews 2008, 58:160-170.
3. Ferrini F., Salio C., Lossi L., Merighi A. Ghrelin in central neurons. Current Neuropharmacology 2009, 7:37-49.
4. Dickson S.L., Egecioglu E., Landgren S., Skibicka K.P., Engel J.A., Jerlhag E. The role of the central ghrelin system in reward from food and chemical drugs. Molecular and Cellular Endocrinology 2011, 340:80-87.
5. Naleid A.M., Grace M.K., Cummings D.E., Levine A.S. Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens. Peptides 2005, 26:2274-2279.
6. Skibicka K.P., Hansson C., Alvarez-Crespo M., Friberg P.A., Dickson S.L. Ghrelin directly targets the ventral tegmental area to increase food motivation. Neuroscience 2011, 180:129-137.
7. Jerlhag E., Egecioglu E., Dickson S.L., Douhan A., Svensson L., Engel J.A. Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens. Addiction Biology 2007, 12:6-16.
8. Jerlhag E., Egecioglu E., Dickson S.L., Engel J.A. Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system. Addiction Biology 2010, 16:82-91.
9. Jerlhag E., Egecioglu E., Dickson S.L., Engel J.A. Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference. Psychopharmacology 2010, 211:415-422.
10. Wellman P.J., Davis K.W., Nation J.R. Augmentation of cocaine hyperactivity in rats by systemic ghrelin. Regulatory Peptides 2005, 125:151-154.
11. Wellman P.J., Hollas C.N., Elliott A.E. Systemic ghrelin sensitizes cocaine-induced hyperlocomotion in rats. Regulatory Peptides 2008, 146:33-37.
12. Abizaid A., Mineur Y.S., Roth R.H., Elsworth J.D., Sleeman M.W., Picciotto M.R., et al. Reduced locomotor responses to cocaine in ghrelin-deficient mice. Neuroscience 2011, 192:500-506.
13. Robinson T.E., Berridge K.C. The neural basis of drug craving: an incentive sensitization theory of addiction. Brain Research Reviews 1993, 18:247-291.
14. Vezina P. Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs. Neuroscience and Biobehavioral Reviews 2004, 151:99-120.
15. Cador M., Bjijou Y., Stinus L. Evidence of a complete independence of the neurobiological substrates of the induction and expression of behavioral sensitization to amphetamine. Neuroscience 1995, 65:385-395.
16. Zahm D. An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens. Neuroscience and Biobehavioral Reviews 2000, 24:85-105.
17. Sellings L.H.L., Clarke P.B.S. Segregation of amphetamine reward and locomotor stimulation between nucleus accumbens medial shell and core. Journal of Neuroscience 2003, 23:6295-6303.
18. Sellings L.H.L., McQuade L.E., Clarke P.B.S. Evidence for multiple sites within rat ventral striatum mediating cocaine-conditioned place preference and locomotor activation. Journal of Pharmacology and Experimental Therapeutics 2006, 317:1178-1187.
19. Ferrario C.R., Gorny G., Crombag H.S., Li Y., Kolb B., Robinson T.E. Neural and behavioral plasticity associated with the transition from controlled to escalated cocaine use. Biological Psychiatry 2005, 58:751-759.
20. Li Y., Acerbo M.J., Robinson T.E. The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbens. European Journal of Neuroscience 2004, 20:1647-1654.
21. Quarta D., Francesco C.D., Melotto S., Mangiarini L., Heidbreder C., Hedou G. Systemic administration of ghrelin increases extracellular dopamine in the shell, but not the core subdivision of the nucleus accumbens. Neurochemistry International 2009, 54:89-94.
22. Kaddis F.J., Wallace L.J., Uretsky N.K. AMPA/Kainate antagonists in the nucleus accumbens inhibit locomotor stimulatory response to cocaine and dopamine agonists. Pharmacology Biochemistry and Behavior 1993, 46:703-708.
23. Pap A., Bradberry C.W. Excitatory amino acid antagonists attenuate the effects of cocaine on extracellular dopamine in the nucleus accumbens. Journal of Pharmacology and Experimental Therapeutics 1995, 274:127-133.
24. Pellegrino L.J., Pellegrino A.S., Cushman A.J. A stereotaxic atlas of the rat brain 1979, Plenum Press, New York. 2nd ed.
25. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1997, Academic Press, New York. 3rd ed.
26. Guan X.M., Yu H., Palyha O.C., McKee K.K., Feighner S.D., Sirinathsinghji D.J.S., et al. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Molecular Brain Research 1997, 48:23-29.
27. Zigman J.M., Jones J.E., Lee C.E., Saper C.B., Elmquist J.K. Expression of ghrelin receptor mRNA in the rat and the mouse brain. Journal of Comparative Neurology 2006, 494:528-548.
28. Landgren S., Engel J.A., Hyytiä P., Zetterberg H., Blennow K., Jerlhag E. Expression the gene encoding the ghrelin receptor in rats selected for differential alcohol reference. Behavioural Brain Research 2011, 221:182-188.
29. Depoortere I., Thijs T., Peeters T. The contractile effect of the ghrelin receptor antagonist, D-Lys3-GHRP-6, in rat fundic strips is mediated through 5-HT receptors. European Journal of Pharmacology 2006, 537:160-165.
30. Taniguchi H., Ariga H., Zheng J., Ludwig K., Mantyh C., Pappas T.N., et al. Endogenous ghrelin and 5-HT regulate interdigestive gastrointestinal contractions in conscious rats. American Journal of Physiology. Gastrointestinal and Liver Physiology 2008, 295:G403-G411.
31. Pierce R.C., Kalivas P.W. Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine. Journal of Pharmacology and Experimental Therapeutics 1995, 275:1019-1029.
32. Kimmel H.L., Gong W., Dall Vechia S.E., Hunter R.G., Kuhar M.J. Intra-ventral tegmental area injection of rat cocaine and amphetamine-regulated transcript peptide 55-102 induces locomotor activity and promotes conditioned place preference. Journal of Pharmacology and Experimental Therapeutics 2000, 294:784-792.
33. Kim J-H., Creekmore E., Vezina P. Microinjection of CART peptide 55-102 into the nucleus accumbens blocks amphetamine-induced locomotion. Neuropeptides 2003, 37:369-373.
34. Soares J.B., Leite-Moreira A.F. Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. Peptides 2008, 29:1255-1270.
35. Chen C.Y., Chao Y., Chang F.Y., Chien E.J., Lee S.D., Doong M.L. Intracisternal des-acyl ghrelin inhibits food intake and non-nutrient gastric emptying in conscious rats. International Journal of Molecular Medicine 2005, 16:695-699.