Is platelet transfusion efficient to restore platelet reactivity in patients who are responders to aspirin and/or clopidogrel before emergency surgery?

Journal of Trauma and Acute Care Surgery

Volumn 74, Issue 5, 2013, Pages 1367-1369

  Taylor, Guillaume ^a   Osinski, Diane ^a   Thevenin, Aude ^a   Devys, Jean Michel ^a  

^a Fondation Adolphe De Rothschild   (France)

Author keywords

aspirin; clopidogrel; emergency surgery.; Platelet transfusion; Verify Now

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; PURINERGIC P2Y12 RECEPTOR;

ARTICLE; CASE STUDY; CLINICAL ARTICLE; EMERGENCY SURGERY; HUMAN; NEUROSURGERY; OBSERVATIONAL STUDY; PLATELET REACTIVITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTE TRANSFUSION; TREATMENT RESPONSE;

ASPIRIN; BLOOD PLATELETS; HEMORRHAGE; HUMANS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET TRANSFUSION; PROSPECTIVE STUDIES; TICLOPIDINE; WOUNDS AND INJURIES;

EID: 84877068364     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31828cca61     Document Type: Article

References (10)

1. Creutzfeldt CJ, Weinstein JR, Longstreth WT Jr, Becker KJ, McPharlin TO, Tirschwell DL. Prior antiplatelet therapy, platelet infusion therapy, and outcome after intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2009;18(3):221-228.
2. Downey DM, Monson B, Butler KL, Fortuna GR Jr, Saxe JM, Dolan JP, Markert RJ, McCarthy MC. Does platelet administration affect mortality in elderly head-injured patients taking antiplatelet medications? Am Surg. 2009;75(11):1100-1103.
3. Vilahur G, Choi BG, Zafar MU, Viles-Gonzalez JF, Vorchheimer DA, Fuster V, Badimon JJ. Normalization of platelet reactivity in clopidogreltreated subjects. J Thromb Haemost. 2007;5(1):82-90.
4. de Gans K, de Haan RJ, Majoie CB, Koopman MM, Brand A, Dijkgraaf MG, Vermeulen M, Roos YB. PATCH: platelet transfusion in cerebral haemorrhage: study protocol for a multicentre, randomised, controlled trial. BMC Neurol. 2012;10:19.
5. Washington CW, Schuerer DJE, Grubb RL. Platelet transfusion: an unnecessary risk for mild traumatic brain injury patients on antiplatelet therapy. J Trauma. 2011;71(2):358-363.
6. Michelson AD. Methods for the measurement of platelet function. Am J Cardiol. 2009;103(suppl 3):20A-26A.
7. Naidech AM, Jovanovic B, Liebling S, Garg RK, Bassin SL, Bendok BR, Bernstein RA, Alberts MJ, Batjer HH. Reduced platelet activity is associated with early clot growth and worse 3-month outcome after intracerebral hemorrhage. Stroke. 2009;40(7):2398-2401.
8. Weber AA, Braun M, Hohlfeld T, Schwippert B, Tschope D, Schror K. Recovery of platelet function after discontinuation of clopidogrel treatment in healthy volunteers. Br J Clin Pharmacol. 2001;52(3):333-336.
9. Bouman HJ, Schomig E, van Werkum JW, Velder J, Hackeng CM, Hirschhauser C, Waldmann C, Schmalz HG, ten Berg JM, Taubert D. Paraoxonase-1 is a major determinant of clopidogrel efficacy. Nat Med. 2011;17(1):110-116.
10. Bansal V, Fortlage D, Lee J, Doucet J, Potenza B, Coimbra R. A new clopidogrel (Plavix) point-of-care assay: rapid determination of antiplatelet activity in trauma patients. J Trauma. 2011;70(1):65-70.