메뉴 건너뛰기




Volumn 150, Issue 1, 2013, Pages 60-66

Hyperthermic isolated liver perfusion with melphalan and bevacizumab;Chimio-hyperthermie sur foie isolé perfusé avec du bévacizumab et du melfalan

Author keywords

Bevacizumab; Hepatocellular carcinoma; Isolated liver perfusion

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; MELPHALAN; MONOCLONAL ANTIBODY;

EID: 84877055352     PISSN: 18787886     EISSN: 18787878     Source Type: Journal    
DOI: 10.1016/j.jviscsurg.2012.10.018     Document Type: Article
Times cited : (2)

References (47)
  • 1
    • 0025019712 scopus 로고
    • Resection of hepatocellular carcinomas. Results in 72 European patients with cirrhosis
    • Franco, D., Capussotti, L., Smadja, C., et al. Resection of hepatocellular carcinomas. Results in 72 European patients with cirrhosis. Gastroenterology 98 (1990), 733–738.
    • (1990) Gastroenterology , vol.98 , pp. 733-738
    • Franco, D.1    Capussotti, L.2    Smadja, C.3
  • 2
    • 0025239635 scopus 로고
    • Hepatic resection for hepatocellular carcinoma
    • Tsuzuki, T., Sugioka, A., Ueda, M., et al. Hepatic resection for hepatocellular carcinoma. Surgery 107 (1990), 511–520.
    • (1990) Surgery , vol.107 , pp. 511-520
    • Tsuzuki, T.1    Sugioka, A.2    Ueda, M.3
  • 3
    • 80052875471 scopus 로고    scopus 로고
    • Liver transplantation for the treatment of hepatocellular carcinoma
    • Hanish, S.I., Knechtle, S.J., Liver transplantation for the treatment of hepatocellular carcinoma. Oncology (Williston Park) 25 (2011), 752–757.
    • (2011) Oncology (Williston Park) , vol.25 , pp. 752-757
    • Hanish, S.I.1    Knechtle, S.J.2
  • 4
    • 82955226150 scopus 로고    scopus 로고
    • Interventional therapies of unresectable liver metastases
    • Qian, J., Interventional therapies of unresectable liver metastases. J Cancer Res Clin Oncol 137 (2011), 1763–1772.
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 1763-1772
    • Qian, J.1
  • 6
    • 0033014829 scopus 로고    scopus 로고
    • Factors influencing survival of patients undergoing hepatectomy for colorectal metastases
    • Yamamoto, J., Shimada, K., Kosuge, T., Yamasaki, S., Sakamoto, M., Fukuda, H., Factors influencing survival of patients undergoing hepatectomy for colorectal metastases. Br J Surg 86 (1999), 332–337.
    • (1999) Br J Surg , vol.86 , pp. 332-337
    • Yamamoto, J.1    Shimada, K.2    Kosuge, T.3    Yamasaki, S.4    Sakamoto, M.5    Fukuda, H.6
  • 7
    • 0029881854 scopus 로고    scopus 로고
    • Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Francaise de Chirurgie
    • Nordlinger, B., Guiguet, M., Vaillant, J.C., et al. Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Francaise de Chirurgie. Cancer 77 (1996), 1254–1262.
    • (1996) Cancer , vol.77 , pp. 1254-1262
    • Nordlinger, B.1    Guiguet, M.2    Vaillant, J.C.3
  • 9
    • 80052284990 scopus 로고    scopus 로고
    • Radiofrequency ablation of liver tumors: Actual limitations and potential solutions in the future
    • Kunzli, B.M., Abitabile, P., Maurer, C.A., Radiofrequency ablation of liver tumors: Actual limitations and potential solutions in the future. World J Hepatol 3 (2011), 8–14.
    • (2011) World J Hepatol , vol.3 , pp. 8-14
    • Kunzli, B.M.1    Abitabile, P.2    Maurer, C.A.3
  • 10
    • 14944385383 scopus 로고    scopus 로고
    • Predictors of survival after radiofrequency thermal ablation of colorectal cancer metastases to the liver: a prospective study
    • Berber, E., Pelley, R., Siperstein, A.E., Predictors of survival after radiofrequency thermal ablation of colorectal cancer metastases to the liver: a prospective study. J Clin Oncol 23 (2005), 1358–1364.
    • (2005) J Clin Oncol , vol.23 , pp. 1358-1364
    • Berber, E.1    Pelley, R.2    Siperstein, A.E.3
  • 11
    • 0034821968 scopus 로고    scopus 로고
    • Percutaneous radiofrequency ablation of hepatic metastases from colorectal cancer: long-term results in 117 patients
    • Solbiati, L., Livraghi, T., Goldberg, S.N., et al. Percutaneous radiofrequency ablation of hepatic metastases from colorectal cancer: long-term results in 117 patients. Radiology 221 (2001), 159–166.
    • (2001) Radiology , vol.221 , pp. 159-166
    • Solbiati, L.1    Livraghi, T.2    Goldberg, S.N.3
  • 12
    • 0030000098 scopus 로고    scopus 로고
    • Re: Reappraisal of hepatic arterial infusion in the treatment of non-resectable liver metastases from colorectal cancer
    • Anand, A., Anand, N., Anand, A., Re: Reappraisal of hepatic arterial infusion in the treatment of non-resectable liver metastases from colorectal cancer. J Natl Cancer Inst 88 (1996), 838–839.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 838-839
    • Anand, A.1    Anand, N.2    Anand, A.3
  • 13
    • 37649015497 scopus 로고    scopus 로고
    • Meta-analysis of hepatic arterial infusion for unresectable liver metastases from colorectal cancer: the end of an era?
    • Mocellin, S., Pilati, P., Lise, M., Nitti, D., Meta-analysis of hepatic arterial infusion for unresectable liver metastases from colorectal cancer: the end of an era?. J Clin Oncol 25 (2007), 5649–5654.
    • (2007) J Clin Oncol , vol.25 , pp. 5649-5654
    • Mocellin, S.1    Pilati, P.2    Lise, M.3    Nitti, D.4
  • 14
    • 85111264788 scopus 로고    scopus 로고
    • Fluoropyrimidine-HAI (hepatic arterial infusion) versus systemic chemotherapy (SCT) for unresectable liver metastases from colorectal cancer. Cochrane Database Syst Rev 2009:CD007823.
    • Mocellin S, Pasquali S, Nitti D. Fluoropyrimidine-HAI (hepatic arterial infusion) versus systemic chemotherapy (SCT) for unresectable liver metastases from colorectal cancer. Cochrane Database Syst Rev 2009:CD007823.
    • Mocellin, S.1    Pasquali, S.2    Nitti, D.3
  • 15
    • 46149110987 scopus 로고    scopus 로고
    • Isolated hepatic perfusion with 200 mg melphalan for advanced noncolorectal liver metastases
    • van Iersel, L.B., Hoekman, E.J., Gelderblom, H., et al. Isolated hepatic perfusion with 200 mg melphalan for advanced noncolorectal liver metastases. Ann Surg Oncol 15 (2008), 1891–1898.
    • (2008) Ann Surg Oncol , vol.15 , pp. 1891-1898
    • van Iersel, L.B.1    Hoekman, E.J.2    Gelderblom, H.3
  • 16
    • 77955239765 scopus 로고    scopus 로고
    • Management of isolated non-resectable liver metastases in colorectal cancer patients: a case-control study of isolated hepatic perfusion with melphalan versus systemic chemotherapy
    • van Iersel, L.B., Koopman, M., van de Velde, C.J., et al. Management of isolated non-resectable liver metastases in colorectal cancer patients: a case-control study of isolated hepatic perfusion with melphalan versus systemic chemotherapy. Ann Oncol 21 (2010), 1662–1667.
    • (2010) Ann Oncol , vol.21 , pp. 1662-1667
    • van Iersel, L.B.1    Koopman, M.2    van de Velde, C.J.3
  • 17
    • 67649158711 scopus 로고    scopus 로고
    • Analysis of factors associated with outcome in patients undergoing isolated hepatic perfusion for unresectable liver metastases from colorectal center
    • Alexander, H.R. Jr., Bartlett, D.L., Libutti, S.K., et al. Analysis of factors associated with outcome in patients undergoing isolated hepatic perfusion for unresectable liver metastases from colorectal center. Ann Surg Oncol 16 (2009), 1852–1859.
    • (2009) Ann Surg Oncol , vol.16 , pp. 1852-1859
    • Alexander, H.R.1    Bartlett, D.L.2    Libutti, S.K.3
  • 18
    • 59449096190 scopus 로고    scopus 로고
    • A phase I study of hyperthermic isolated hepatic perfusion with oxaliplatin in the treatment of unresectable liver metastases from colorectal cancer
    • Zeh, H.J. 3rd, Brown, C.K., Holtzman, M.P., Egorin, M.J., Holleran, J.L., A phase I study of hyperthermic isolated hepatic perfusion with oxaliplatin in the treatment of unresectable liver metastases from colorectal cancer. Ann Surg Oncol 16 (2009), 385–394.
    • (2009) Ann Surg Oncol , vol.16 , pp. 385-394
    • Zeh, H.J.1    Brown, C.K.2    Holtzman, M.P.3    Egorin, M.J.4    Holleran, J.L.5
  • 19
    • 0029803023 scopus 로고    scopus 로고
    • Biological rationale and clinical experience with hyperthermia
    • Engin, K., Biological rationale and clinical experience with hyperthermia. Control Clin Trials 17 (1996), 316–342.
    • (1996) Control Clin Trials , vol.17 , pp. 316-342
    • Engin, K.1
  • 20
    • 0020333904 scopus 로고
    • Interactions of hyperthermia and drugs: treatments and probes
    • Hahn, G.M., Li, G.C., Interactions of hyperthermia and drugs: treatments and probes. Natl Cancer Inst Monogr 61 (1982), 317–323.
    • (1982) Natl Cancer Inst Monogr , vol.61 , pp. 317-323
    • Hahn, G.M.1    Li, G.C.2
  • 22
    • 0036390101 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma (HCC) with systemic chemotherapy combining epirubicin, cisplatinum and infusional 5-fluorouracil (ECF regimen)
    • Boucher, E., Corbinais, S., Brissot, P., Boudjema, K., Raoul, J.L., Treatment of hepatocellular carcinoma (HCC) with systemic chemotherapy combining epirubicin, cisplatinum and infusional 5-fluorouracil (ECF regimen). Cancer Chemother Pharmacol 50 (2002), 305–308.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 305-308
    • Boucher, E.1    Corbinais, S.2    Brissot, P.3    Boudjema, K.4    Raoul, J.L.5
  • 23
    • 0036240629 scopus 로고    scopus 로고
    • Oral eniluracil/5-fluorouracil in patients with inoperable hepatocellular carcinoma
    • Benson, A.B. 3rd, Mitchell, E., Abramson, N., Klencke, B., Ritch, P., et al. Oral eniluracil/5-fluorouracil in patients with inoperable hepatocellular carcinoma. Ann Oncol 13 (2002), 576–581.
    • (2002) Ann Oncol , vol.13 , pp. 576-581
    • Benson, A.B.1    Mitchell, E.2    Abramson, N.3    Klencke, B.4    Ritch, P.5
  • 24
    • 0031424749 scopus 로고    scopus 로고
    • Epirubicin and etoposide combination chemotherapy to treat hepatocellular carcinoma patients: a phase II study
    • Bobbio-Pallavicini, E., Porta, C., Moroni, M., et al. Epirubicin and etoposide combination chemotherapy to treat hepatocellular carcinoma patients: a phase II study. Eur J Cancer 33 (1997), 1784–1788.
    • (1997) Eur J Cancer , vol.33 , pp. 1784-1788
    • Bobbio-Pallavicini, E.1    Porta, C.2    Moroni, M.3
  • 25
    • 0023765990 scopus 로고
    • Doxorubicin versus no antitumor therapy in inoperable hepatocellular carcinoma. A prospective randomized trial
    • Lai, C.L., Wu, P.C., Chan, G.C., Lok, A.S., Lin, H.J., Doxorubicin versus no antitumor therapy in inoperable hepatocellular carcinoma. A prospective randomized trial. Cancer 62 (1988), 479–483.
    • (1988) Cancer , vol.62 , pp. 479-483
    • Lai, C.L.1    Wu, P.C.2    Chan, G.C.3    Lok, A.S.4    Lin, H.J.5
  • 26
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet, J.M., Ricci, S., Mazzaferro, V., et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359 (2008), 378–390.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 27
    • 84856445882 scopus 로고    scopus 로고
    • An overview of evidence-based management of hepatocellular carcinoma: A meta-analysis
    • Salhab, M., Canelo, R., An overview of evidence-based management of hepatocellular carcinoma: A meta-analysis. J Cancer Res Ther 7 (2011), 463–475.
    • (2011) J Cancer Res Ther , vol.7 , pp. 463-475
    • Salhab, M.1    Canelo, R.2
  • 28
    • 7144255522 scopus 로고    scopus 로고
    • Treatment of unresectable hepatocellular carcinoma with lipiodol chemoembolization: a multicenter randomized trial, Groupe CHC
    • Pelletier, G., Ducreux, M., Gay, F., et al. Treatment of unresectable hepatocellular carcinoma with lipiodol chemoembolization: a multicenter randomized trial, Groupe CHC. J Hepatol 29 (1998), 129–134.
    • (1998) J Hepatol , vol.29 , pp. 129-134
    • Pelletier, G.1    Ducreux, M.2    Gay, F.3
  • 29
    • 85111293096 scopus 로고    scopus 로고
    • A comparison of lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. Groupe d'Etude et de Traitement du Carcinome Hepatocellulaire. N Engl J Med 1995;332:1256–61.
    • A comparison of lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. Groupe d'Etude et de Traitement du Carcinome Hepatocellulaire. N Engl J Med 1995;332:1256–61.
  • 30
    • 0025242359 scopus 로고
    • A randomized trial of hepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma
    • Pelletier, G., Roche, A., Ink, O., et al. A randomized trial of hepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma. J Hepatol 11 (1990), 181–184.
    • (1990) J Hepatol , vol.11 , pp. 181-184
    • Pelletier, G.1    Roche, A.2    Ink, O.3
  • 31
    • 0036237822 scopus 로고    scopus 로고
    • Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
    • Lo, C.M., Ngan, H., Tso, W.K., et al. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 35 (2002), 1164–1171.
    • (2002) Hepatology , vol.35 , pp. 1164-1171
    • Lo, C.M.1    Ngan, H.2    Tso, W.K.3
  • 32
    • 0037129704 scopus 로고    scopus 로고
    • Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial
    • Llovet, J.M., Real, M.I., Montana, X., et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 359 (2002), 1734–1739.
    • (2002) Lancet , vol.359 , pp. 1734-1739
    • Llovet, J.M.1    Real, M.I.2    Montana, X.3
  • 33
    • 0036061221 scopus 로고    scopus 로고
    • Efficacy and toxicity of intra-arterial cisplatin and etoposide for advanced hepatocellular carcinoma
    • Sangro, B., Rios, R., Bilbao, I., et al. Efficacy and toxicity of intra-arterial cisplatin and etoposide for advanced hepatocellular carcinoma. Oncology 62 (2002), 293–298.
    • (2002) Oncology , vol.62 , pp. 293-298
    • Sangro, B.1    Rios, R.2    Bilbao, I.3
  • 34
    • 0029052408 scopus 로고
    • The efficacy of continuous local arterial infusion of 5-fluorouracil and cisplatin through an implanted reservoir for severe advanced hepatocellular carcinoma
    • Toyoda, H., Nakano, S., Kumada, T., et al. The efficacy of continuous local arterial infusion of 5-fluorouracil and cisplatin through an implanted reservoir for severe advanced hepatocellular carcinoma. Oncology 52 (1995), 295–299.
    • (1995) Oncology , vol.52 , pp. 295-299
    • Toyoda, H.1    Nakano, S.2    Kumada, T.3
  • 35
    • 34247554921 scopus 로고    scopus 로고
    • Hepatic artery chemoembolization in 122 patients with metastatic carcinoid tumor: lessons learned
    • Bloomston, M., Al-Saif, O., Klemanski, D., et al. Hepatic artery chemoembolization in 122 patients with metastatic carcinoid tumor: lessons learned. J Gastrointest Surg 11 (2007), 264–271.
    • (2007) J Gastrointest Surg , vol.11 , pp. 264-271
    • Bloomston, M.1    Al-Saif, O.2    Klemanski, D.3
  • 36
    • 26444475764 scopus 로고    scopus 로고
    • Hepatic arterial embolization and chemoembolization for the treatment of patients with metastatic neuroendocrine tumors: variables affecting response rates and survival
    • Gupta, S., Johnson, M.M., Murthy, R., et al. Hepatic arterial embolization and chemoembolization for the treatment of patients with metastatic neuroendocrine tumors: variables affecting response rates and survival. Cancer 104 (2005), 1590–1602.
    • (2005) Cancer , vol.104 , pp. 1590-1602
    • Gupta, S.1    Johnson, M.M.2    Murthy, R.3
  • 37
    • 14644413806 scopus 로고    scopus 로고
    • Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas
    • Kouvaraki, M.A., Ajani, J.A., Hoff, P., et al. Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas. J Clin Oncol 22 (2004), 4762–4771.
    • (2004) J Clin Oncol , vol.22 , pp. 4762-4771
    • Kouvaraki, M.A.1    Ajani, J.A.2    Hoff, P.3
  • 38
    • 33644846851 scopus 로고    scopus 로고
    • Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors
    • Kulke, M.H., Stuart, K., Enzinger, P.C., et al. Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol 24 (2006), 401–406.
    • (2006) J Clin Oncol , vol.24 , pp. 401-406
    • Kulke, M.H.1    Stuart, K.2    Enzinger, P.C.3
  • 39
    • 49149114782 scopus 로고    scopus 로고
    • Activity of sunitinib in patients with advanced neuroendocrine tumors
    • Kulke, M.H., Lenz, H.J., Meropol, N.J., et al. Activity of sunitinib in patients with advanced neuroendocrine tumors. J Clin Oncol 26 (2008), 3403–3410.
    • (2008) J Clin Oncol , vol.26 , pp. 3403-3410
    • Kulke, M.H.1    Lenz, H.J.2    Meropol, N.J.3
  • 40
    • 10644270999 scopus 로고    scopus 로고
    • Isolated hepatic perfusion for the treatment of patients with advanced liver metastases from pancreatic and gastrointestinal neuroendocrine neoplasms
    • Grover, A.C., Libutti, S.K., Pingpank, J.F., Helsabeck, C., Beresnev, T., Alexander, H.R. Jr., Isolated hepatic perfusion for the treatment of patients with advanced liver metastases from pancreatic and gastrointestinal neuroendocrine neoplasms. Surgery 136 (2004), 1176–1182.
    • (2004) Surgery , vol.136 , pp. 1176-1182
    • Grover, A.C.1    Libutti, S.K.2    Pingpank, J.F.3    Helsabeck, C.4    Beresnev, T.5    Alexander, H.R.6
  • 41
    • 33846562484 scopus 로고    scopus 로고
    • Correlation between melphalan pharmacokinetics and hepatic toxicity following hyperthermic isolated liver perfusion for unresectable metastatic disease
    • Mocellin, S., Pilati, P., Da Pian, P., et al. Correlation between melphalan pharmacokinetics and hepatic toxicity following hyperthermic isolated liver perfusion for unresectable metastatic disease. Ann Surg Oncol 14 (2007), 802–809.
    • (2007) Ann Surg Oncol , vol.14 , pp. 802-809
    • Mocellin, S.1    Pilati, P.2    Da Pian, P.3
  • 42
    • 44849096794 scopus 로고    scopus 로고
    • Isolated hepatic melphalan perfusion of colorectal liver metastases: outcome and prognostic factors in 154 patients
    • van Iersel, L.B., Gelderblom, H., Vahrmeijer, A.L., et al. Isolated hepatic melphalan perfusion of colorectal liver metastases: outcome and prognostic factors in 154 patients. Ann Oncol 19 (2008), 1127–1134.
    • (2008) Ann Oncol , vol.19 , pp. 1127-1134
    • van Iersel, L.B.1    Gelderblom, H.2    Vahrmeijer, A.L.3
  • 43
  • 44
    • 10744222925 scopus 로고    scopus 로고
    • Reductive surgery plus percutaneous isolated hepatic perfusion for multiple advanced hepatocellular carcinoma
    • Ku, Y., Iwasaki, T., Tominaga, M., et al. Reductive surgery plus percutaneous isolated hepatic perfusion for multiple advanced hepatocellular carcinoma. Ann Surg 239 (2004), 53–60.
    • (2004) Ann Surg , vol.239 , pp. 53-60
    • Ku, Y.1    Iwasaki, T.2    Tominaga, M.3
  • 45
    • 4043127317 scopus 로고    scopus 로고
    • Isolated hypoxic hepatic perfusion with orthograde or retrograde flow in patients with irresectable liver metastases using percutaneous balloon catheter techniques: a phase I and II study
    • van Etten, B., Brunstein, F., van, I.M.G., et al. Isolated hypoxic hepatic perfusion with orthograde or retrograde flow in patients with irresectable liver metastases using percutaneous balloon catheter techniques: a phase I and II study. Ann Surg Oncol 11 (2004), 598–605.
    • (2004) Ann Surg Oncol , vol.11 , pp. 598-605
    • van Etten, B.1    Brunstein, F.2    van, I.M.G.3
  • 46
    • 20644434717 scopus 로고    scopus 로고
    • Phase I study of hepatic arterial melphalan infusion and hepatic venous hemofiltration using percutaneously placed catheters in patients with unresectable hepatic malignancies
    • Pingpank, J.F., Libutti, S.K., Chang, R., et al. Phase I study of hepatic arterial melphalan infusion and hepatic venous hemofiltration using percutaneously placed catheters in patients with unresectable hepatic malignancies. J Clin Oncol 23 (2005), 3465–3474.
    • (2005) J Clin Oncol , vol.23 , pp. 3465-3474
    • Pingpank, J.F.1    Libutti, S.K.2    Chang, R.3
  • 47
    • 41549166543 scopus 로고    scopus 로고
    • Isolated hypoxic hepatic perfusion with retrograde outflow in patients with irresectable liver metastases; a new simplified technique in isolated hepatic perfusion
    • Verhoef, C., de Wilt, J.H., Brunstein, F., et al. Isolated hypoxic hepatic perfusion with retrograde outflow in patients with irresectable liver metastases; a new simplified technique in isolated hepatic perfusion. Ann Surg Oncol 15 (2008), 1367–1374.
    • (2008) Ann Surg Oncol , vol.15 , pp. 1367-1374
    • Verhoef, C.1    de Wilt, J.H.2    Brunstein, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.