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Volumn 33, Issue 5, 2013, Pages 325-331

Role of interleukin-28B polymorphism as a predictor of sustained virological response in patients with chronic hepatitis C treated with triple therapy: A systematic review and meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

BOCEPREVIR; INTERLEUKIN 28B; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PLACEBO; RIBAVIRIN; TELAPREVIR;

EID: 84877049762     PISSN: 11732563     EISSN: 11791918     Source Type: Journal    
DOI: 10.1007/s40261-013-0074-0     Document Type: Review
Times cited : (27)

References (40)
  • 1
    • 84873522418 scopus 로고    scopus 로고
    • Global surveillance and control of Hepatitis C. Report of a WHO Consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium
    • WHO
    • WHO. Global surveillance and control of Hepatitis C. Report of a WHO Consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium. J Viral Liver. 1999;6(1):34-5.
    • (1999) J Viral Liver , vol.6 , Issue.1 , pp. 34-35
  • 2
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • 11583749 10.1016/S0140-6736(01)06102-5 1:CAS:528:DC%2BD3MXntF2qtb8%3D
    • Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet. 2001;358(9286):958-65.
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 3
    • 1542378867 scopus 로고    scopus 로고
    • Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: A randomized study of treatment duration and ribavirin dose
    • 14996676 10.7326/0003-4819-140-5-200403020-00010 1:CAS:528: DC%2BD2cXitlOktrg%3D
    • Hadziyannis SJ, Sette H Jr, Morgan TR, et al. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Intern Med. 2004;140(5):346-55.
    • (2004) Ann Intern Med , vol.140 , Issue.5 , pp. 346-355
    • Hadziyannis, S.J.1    Sette, Jr.H.2    Morgan, T.R.3
  • 4
    • 78650120447 scopus 로고    scopus 로고
    • Outcome of antiviral treatment in patients with chronic genotype 1 HCV hepatitis: A retrospective study in 507 patients
    • 20922189
    • Sporea I, Sirli R, Curescu M, et al. Outcome of antiviral treatment in patients with chronic genotype 1 HCV hepatitis: a retrospective study in 507 patients. J Gastrointestin Liver Dis. 2010;19(3):261-4.
    • (2010) J Gastrointestin Liver Dis , vol.19 , Issue.3 , pp. 261-264
    • Sporea, I.1    Sirli, R.2    Curescu, M.3
  • 5
    • 84870533049 scopus 로고    scopus 로고
    • High sustained virologic response rates in rapid virologic response patients in the large real-world PROPHESYS cohort confirm results from randomized clinical trials
    • 22706730 10.1002/hep.25892 1:CAS:528:DC%2BC38XhvVSmtb7E
    • Marcellin P, Cheinquer H, Curescu M, et al. High sustained virologic response rates in rapid virologic response patients in the large real-world PROPHESYS cohort confirm results from randomized clinical trials. Hepatology. 2012;56(6):2039-50.
    • (2012) Hepatology , vol.56 , Issue.6 , pp. 2039-2050
    • Marcellin, P.1    Cheinquer, H.2    Curescu, M.3
  • 6
    • 80053535445 scopus 로고    scopus 로고
    • Response to standard of care antiviral treatment in patients with HCV liver cirrhosis: A systematic review
    • 21961098
    • Bota S, Sporea I, Popescu A, et al. Response to standard of care antiviral treatment in patients with HCV liver cirrhosis: a systematic review. J Gastrointestin Liver Dis. 2011;20(3):293-8.
    • (2011) J Gastrointestin Liver Dis , vol.20 , Issue.3 , pp. 293-298
    • Bota, S.1    Sporea, I.2    Popescu, A.3
  • 7
    • 54349127407 scopus 로고    scopus 로고
    • Pegylated interferon and ribavirin combination therapy for chronic hepatitis C virus infection in patients with Child-Pugh A liver cirrhosis
    • 18615358 10.1080/00365520802245395 1:CAS:528:DC%2BD1cXht12isL%2FN
    • Syed E, Rahbin N, Weiland O, et al. Pegylated interferon and ribavirin combination therapy for chronic hepatitis C virus infection in patients with Child-Pugh A liver cirrhosis. Scand J Gastroenterol. 2008;43(11):1378-86.
    • (2008) Scand J Gastroenterol , vol.43 , Issue.11 , pp. 1378-1386
    • Syed, E.1    Rahbin, N.2    Weiland, O.3
  • 8
    • 77957854762 scopus 로고    scopus 로고
    • PegInterferon plus ribavirin and sustained virological response in HCV-related cirrhosis: Outcomes and factors predicting response
    • 20700116 10.1038/ajg.2010.294 1:CAS:528:DC%2BC3cXht1Grs7zK
    • Fernandez-Rodriguez C, Alonso S, Martinez SM, et al. PegInterferon plus ribavirin and sustained virological response in HCV-related cirrhosis: outcomes and factors predicting response. Am J Gastroenterol. 2010;105(10):2164-72.
    • (2010) Am J Gastroenterol , vol.105 , Issue.10 , pp. 2164-2172
    • Fernandez-Rodriguez, C.1    Alonso, S.2    Martinez, S.M.3
  • 9
    • 77949831342 scopus 로고    scopus 로고
    • Swiss Hepatitis C Cohort Study; Swiss HIV Cohort Study. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: A genome-wide association study
    • Rauch A, Kutalik Z, Descombes P, et al. Swiss Hepatitis C Cohort Study; Swiss HIV Cohort Study. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology. 2010;138(4):1338-45.
    • (2010) Gastroenterology , vol.138 , Issue.4 , pp. 1338-1345
    • Rauch, A.1    Kutalik, Z.2    Descombes, P.3
  • 10
    • 77957965687 scopus 로고    scopus 로고
    • ATAHC Study Group. Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection
    • Grebely J, Petoumenos K, Hellard M, et al. ATAHC Study Group. Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection. Hepatology. 2010;52(4):1216-24.
    • (2010) Hepatology , vol.52 , Issue.4 , pp. 1216-1224
    • Grebely, J.1    Petoumenos, K.2    Hellard, M.3
  • 11
    • 79955582363 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of the IL28B and sustained virologic response of patients with chronic hepatitis C to PEG-Interferon/ ribavirin therapy: A meta-analysis
    • 22087138 1:CAS:528:DC%2BC3MXjvV2rsLs%3D
    • Li S, Hu P, Zhang QQ, et al. Single nucleotide polymorphisms of the IL28B and sustained virologic response of patients with chronic hepatitis C to PEG-Interferon/ ribavirin therapy: a meta-analysis. Hepat Mon. 2011;11(3):163-72.
    • (2011) Hepat Mon , vol.11 , Issue.3 , pp. 163-172
    • Li, S.1    Hu, P.2    Zhang, Q.Q.3
  • 12
    • 84862513290 scopus 로고    scopus 로고
    • Meta-analysis: IL28B polymorphisms predict sustained viral response in HCV patients treated with pegylated interferon-α and ribavirin
    • 22591106 10.1111/j.1365-2036.2012.05131.x 1:CAS:528:DC%2BC38Xht1ygsbnK
    • Chen Y, Xu HX, Wang LJ, Liu XX, Mahato RI, Zhao YR. Meta-analysis: IL28B polymorphisms predict sustained viral response in HCV patients treated with pegylated interferon-α and ribavirin. Aliment Pharmacol Ther. 2012;36(2):91-103.
    • (2012) Aliment Pharmacol Ther , vol.36 , Issue.2 , pp. 91-103
    • Chen, Y.1    Xu, H.X.2    Wang, L.J.3    Liu, X.X.4    Mahato, R.I.5    Zhao, Y.R.6
  • 13
    • 79955669252 scopus 로고    scopus 로고
    • A new standard of care for the treatment of chronic HCV infection
    • 21468124 1:CAS:528:DC%2BC3MXlsFKit70%3D
    • Hofmann WP, Zeuzem S. A new standard of care for the treatment of chronic HCV infection. Nat Rev Gastroenterol Hepatol. 2011;8(5):257-64.
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , Issue.5 , pp. 257-264
    • Hofmann, W.P.1    Zeuzem, S.2
  • 14
    • 77950817619 scopus 로고    scopus 로고
    • PROVE3 Study Team. Telaprevir for previously treated chronic HCV infection
    • McHutchison JG, Manns MP, Muir AJ, et al. PROVE3 Study Team. Telaprevir for previously treated chronic HCV infection. N Engl J Med. 2010; 362(14):1292-330.
    • (2010) N Engl J Med , vol.362 , Issue.14 , pp. 1292-1330
    • McHutchison, J.G.1    Manns, M.P.2    Muir, A.J.3
  • 15
    • 79957597421 scopus 로고    scopus 로고
    • Telaprevir: An NS3/4A Protease inhibitor for the treatment of chronic hepatitis C
    • 21558488 10.1345/aph.1P430 1:CAS:528:DC%2BC3MXntlKmsL0%3D
    • Smith LS, Nelson M, Naik S, Woten J. Telaprevir: an NS3/4A Protease inhibitor for the treatment of chronic hepatitis C. Ann Pharmacother. 2011;45(5):639-48.
    • (2011) Ann Pharmacother , vol.45 , Issue.5 , pp. 639-648
    • Smith, L.S.1    Nelson, M.2    Naik, S.3    Woten, J.4
  • 16
    • 79953173221 scopus 로고    scopus 로고
    • SPRINT-2 Investigators. Boceprevir for untreated chronic HCV genotype 1 infection
    • Poordad F, McCone J Jr, Bacon BR, et al. SPRINT-2 Investigators. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med. 2011;364(13):1195-206.
    • (2011) N Engl J Med , vol.364 , Issue.13 , pp. 1195-1206
    • Poordad, F.1    McCone Jr., J.2    Bacon, B.R.3
  • 17
    • 79251554986 scopus 로고    scopus 로고
    • Telaprevir is effective given every 8 or 12 hours with ribavirin and peginterferon alfa-2a or -2b to patients with chronic hepatitis C
    • 21034744 10.1053/j.gastro.2010.10.046 1:CAS:528:DC%2BC3MXhtlSks7w%3D
    • Marcellin P, Forns X, Goeser T, et al. Telaprevir is effective given every 8 or 12 hours with ribavirin and peginterferon alfa-2a or -2b to patients with chronic hepatitis C. Gastroenterology. 2011;140(2):459-68.
    • (2011) Gastroenterology , vol.140 , Issue.2 , pp. 459-468
    • Marcellin, P.1    Forns, X.2    Goeser, T.3
  • 18
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • 3802833 10.1016/0197-2456(86)90046-2 1:STN:280:DyaL2s7gsVamtA%3D%3D
    • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-88.
    • (1986) Control Clin Trials , vol.7 , Issue.3 , pp. 177-188
    • Dersimonian, R.1    Laird, N.2
  • 19
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • 9310563 10.1136/bmj.315.7109.629 1:STN:280:DyaK2svls1KjtA%3D%3D
    • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629-34.
    • (1997) BMJ , vol.315 , Issue.7109 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 20
    • 79957963815 scopus 로고    scopus 로고
    • IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin and telaprevir triple therapy in patients with genotype 1 hepatitis C
    • 21628662 10.1093/infdis/jir210 1:CAS:528:DC%2BC3MXntF2gt7k%3D
    • Chayama K, Nelson Hayes C, Abe H. IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin and telaprevir triple therapy in patients with genotype 1 hepatitis C. J Infect Dis. 2011;204(1):84-93.
    • (2011) J Infect Dis , vol.204 , Issue.1 , pp. 84-93
    • Chayama, K.1    Nelson Hayes, C.2    Abe, H.3
  • 21
    • 84857919608 scopus 로고    scopus 로고
    • Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy
    • 21734353 10.1159/000328327 1:CAS:528:DC%2BC38Xjt1Omurg%3D
    • Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Sezaki H, Suzuki Y, et al. Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy. Intervirology. 2012;55(3):231-41.
    • (2012) Intervirology , vol.55 , Issue.3 , pp. 231-241
    • Akuta, N.1    Suzuki, F.2    Hirakawa, M.3    Kawamura, Y.4    Sezaki, H.5    Suzuki, Y.6
  • 22
    • 79151483121 scopus 로고    scopus 로고
    • Influence of ITPA polymorphisms on decrease of hemoglobin during treatment with pegylated interferon, ribavirin and telaprevir
    • 21246582 10.1002/hep.24058 1:CAS:528:DC%2BC3MXisVGis70%3D
    • Suzuki F, Suzuki Y, Akuta N, et al. Influence of ITPA polymorphisms on decrease of hemoglobin during treatment with pegylated interferon, ribavirin and telaprevir. Hepatology. 2011;53(2):415-21.
    • (2011) Hepatology , vol.53 , Issue.2 , pp. 415-421
    • Suzuki, F.1    Suzuki, Y.2    Akuta, N.3
  • 23
    • 84865494240 scopus 로고    scopus 로고
    • SPRINT-2 and RESPOND-2 Investigators. Factors that predict response of patients with hepatitis C virus infection to boceprevir
    • Poordad F, Bronowicki JP, Gordon SC, et al. SPRINT-2 and RESPOND-2 Investigators. Factors that predict response of patients with hepatitis C virus infection to boceprevir. Gastroenterology. 2012;143(3):608-18.
    • (2012) Gastroenterology , vol.143 , Issue.3 , pp. 608-618
    • Poordad, F.1    Bronowicki, J.P.2    Gordon, S.C.3
  • 24
    • 79960447952 scopus 로고    scopus 로고
    • Similar SVR rates in IL28B CC, CT or TT prior relapser, partial or null-responder patients treated with telaprevir/peginterferon/ribavirin: Retrospective analysis of the REALIZE study [abstract]
    • 10.1016/S0168-8278(11)60015-9
    • Pol S, Aerssens J, Zeuzem S, et al. Similar SVR rates in IL28B CC, CT or TT prior relapser, partial or null-responder patients treated with telaprevir/peginterferon/ribavirin: retrospective analysis of the REALIZE study [abstract]. J Hepatol. 2011;54(Suppl 1):S6.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1 , pp. 6
    • Pol, S.1    Aerssens, J.2    Zeuzem, S.3
  • 25
    • 79960720423 scopus 로고    scopus 로고
    • Telaprevir substantially improved SVR rates across all IL28B genotypes in the ADVANCE trial [abstract]
    • 10.1016/S0168-8278(11)61371-8
    • Jacobson IM, Catlett I, Marcellin P, et al. Telaprevir substantially improved SVR rates across all IL28B genotypes in the ADVANCE trial [abstract]. J Hepatol. 2011;54(Suppl 1):S542.
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1 , pp. 542
    • Jacobson, I.M.1    Catlett, I.2    Marcellin, P.3
  • 26
    • 77955691994 scopus 로고    scopus 로고
    • Amino acid substitution in hepatitis C virus core region and genetic variation near the Interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin
    • 20648473 10.1002/hep.23690 1:CAS:528:DC%2BC3cXhtV2ju7rK
    • Akuta N, Suzuki F, Hirakawa M, et al. Amino acid substitution in hepatitis C virus core region and genetic variation near the Interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin. Hepatology. 2010;52(2):421-9.
    • (2010) Hepatology , vol.52 , Issue.2 , pp. 421-429
    • Akuta, N.1    Suzuki, F.2    Hirakawa, M.3
  • 27
    • 84867097675 scopus 로고    scopus 로고
    • 100% SVR in IL28B CC patients treated with 12 weeks of telaprevir, peginterferon and ribavirin in the PROVE2 trial [abstract]
    • 10.1016/S0168-8278(12)61106-4
    • Bronowicki JP, Hezode C, Bengtsson L, et al. 100% SVR in IL28B CC patients treated with 12 weeks of telaprevir, peginterferon and ribavirin in the PROVE2 trial [abstract]. J Hepatol. 2012;56(Suppl 2):S430.
    • (2012) J Hepatol , vol.56 , Issue.SUPPL. 2 , pp. 430
    • Bronowicki, J.P.1    Hezode, C.2    Bengtsson, L.3
  • 28
    • 79953176289 scopus 로고    scopus 로고
    • HCV RESPOND-2 Investigators. Boceprevir for previously treated chronic HCV genotype 1 infection
    • Bacon BR, Gordon SC, Lawitz E, et al. HCV RESPOND-2 Investigators. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med. 2011;364(13):1207-17.
    • (2011) N Engl J Med , vol.364 , Issue.13 , pp. 1207-1217
    • Bacon, B.R.1    Gordon, S.C.2    Lawitz, E.3
  • 29
    • 79959381354 scopus 로고    scopus 로고
    • REALIZE Study Team, et al. Telaprevir for retreatment of HCV infection
    • Zeuzem S, Andreone P, Pol S; REALIZE Study Team, et al. Telaprevir for retreatment of HCV infection. N Engl J Med. 2011;364(25):2417-28.
    • (2011) N Engl J Med , vol.364 , Issue.25 , pp. 2417-2428
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 30
    • 79959438789 scopus 로고    scopus 로고
    • ADVANCE Study Team. Telaprevir for previously untreated chronic hepatitis C virus infection
    • Jacobson IM, McHutchison JG, Dusheiko G, et al. ADVANCE Study Team. Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med. 2011;364(25):2405-16.
    • (2011) N Engl J Med , vol.364 , Issue.25 , pp. 2405-2416
    • Jacobson, I.M.1    McHutchison, J.G.2    Dusheiko, G.3
  • 31
    • 65449171953 scopus 로고    scopus 로고
    • PROVE2 Study Team. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    • Hézode C, Forestier N, Dusheiko G, et al. PROVE2 Study Team. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med. 2009;360(18):1839-50.
    • (2009) N Engl J Med , vol.360 , Issue.18 , pp. 1839-1850
    • Hézode, C.F.1
  • 32
    • 79952685977 scopus 로고    scopus 로고
    • Estimating the likelihood of sustained virological response in chronic hepatitis C therapy
    • 20849436 10.1111/j.1365-2893.2010.01372.x 1:STN:280: DC%2BC3MvkslShtQ%3D%3D
    • Mauss S, Hueppe D, John C, et al. Estimating the likelihood of sustained virological response in chronic hepatitis C therapy. J Viral Hepat. 2011;18(4):e81-90.
    • (2011) J Viral Hepat , vol.18 , Issue.4
    • Mauss, S.1    Hueppe, D.2    John, C.3
  • 33
    • 37649012154 scopus 로고    scopus 로고
    • Hepatic steatosis in chronic hepatitis C: Baseline host and viral characteristics and influence on response to therapy with peginterferon alpha-2a plus ribavirin
    • 1:STN:280:DC%2BD1c%2Fit1ahuw%3D%3D
    • Reddy KR, Govindarajan S, Marcellin P, et al. Hepatic steatosis in chronic hepatitis C: baseline host and viral characteristics and influence on response to therapy with peginterferon alpha-2a plus ribavirin. J Viral Hep. 2008;15(2):129-36.
    • (2008) J Viral Hep , vol.15 , Issue.2 , pp. 129-136
    • Reddy, K.R.1    Govindarajan, S.2    Marcellin, P.3
  • 34
    • 37249068019 scopus 로고    scopus 로고
    • Virological response in patients with hepatitis C virus genotype 1b and a high viral load: Impact of peginterferon-alpha-2a plus ribavirin dose reductions and host-related factors
    • 18081356 10.2165/00044011-200828010-00002 1:CAS:528:DC%2BD1cXhvVCmsLs%3D
    • Yamada G, Iino S, Okuno T, et al. Virological response in patients with hepatitis C virus genotype 1b and a high viral load: impact of peginterferon-alpha-2a plus ribavirin dose reductions and host-related factors. Clin Drug Investig. 2008;28(1):9-16.
    • (2008) Clin Drug Investig , vol.28 , Issue.1 , pp. 9-16
    • Yamada, G.1    Iino, S.2    Okuno, T.3
  • 35
    • 79958816097 scopus 로고    scopus 로고
    • Rapid virological response is the most important predictor of virological response across genotypes in patients with chronic hepatitis C virus infection
    • 21145856 10.1016/j.jhep.2010.10.032
    • Fried MW, Hadziyannis SJ, Shiffman ML, et al. Rapid virological response is the most important predictor of virological response across genotypes in patients with chronic hepatitis C virus infection. J Hepatol. 2011;55(1):69-75.
    • (2011) J Hepatol , vol.55 , Issue.1 , pp. 69-75
    • Fried, M.W.1    Hadziyannis, S.J.2    Shiffman, M.L.3
  • 36
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • 19684573 10.1038/nature08309 1:CAS:528:DC%2BD1MXpvFCrtbw%3D
    • Ge D, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 2009;461(7262):399-401.
    • (2009) Nature , vol.461 , Issue.7262 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.J.3
  • 37
    • 84855757818 scopus 로고    scopus 로고
    • The correlation of Il28B genotype with sustained virologic response in Romanian patients with chronic hepatitis C
    • 22368681 10.5812/kowsar.1735143X.4202
    • Sporea I, Popescu A, Curescu M, et al. The correlation of Il28B genotype with sustained virologic response in Romanian patients with chronic hepatitis C. Hepat Mon. 2011;11(12):975-9.
    • (2011) Hepat Mon , vol.11 , Issue.12 , pp. 975-979
    • Sporea, I.1    Popescu, A.2    Curescu, M.3
  • 38
    • 78650852060 scopus 로고    scopus 로고
    • The role of genetic markers in hepatitis C virus therapy: A major step to individualized care
    • 21205135 10.1111/j.1478-3231.2010.02389.x
    • McHutchison JG. The role of genetic markers in hepatitis C virus therapy: a major step to individualized care. Liver Int. 2011;31(Suppl 1):29-35.
    • (2011) Liver Int , vol.31 , Issue.SUPPL. 1 , pp. 29-35
    • McHutchison, J.G.1
  • 39
    • 19044361835 scopus 로고    scopus 로고
    • Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection
    • 15887125 10.1053/j.gastro.2005.01.059 1:CAS:528:DC%2BD2MXlt1CisL0%3D
    • Chen L, Borozan I, Feld J, et al. Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection. Gastroenterology. 2005;128(5):1437-44.
    • (2005) Gastroenterology , vol.128 , Issue.5 , pp. 1437-1444
    • Chen, L.1    Borozan, I.2    Feld, J.3
  • 40
    • 44349109098 scopus 로고    scopus 로고
    • Interferon signaling and treatment outcome in chronic hepatitis C
    • 18467494 10.1073/pnas.0707882105 1:CAS:528:DC%2BD1cXmt1Ghurw%3D
    • Sarasin-Filipowicz M, Oakeley EJ, Duong FH, et al. Interferon signaling and treatment outcome in chronic hepatitis C. Proc Natl Acad Sci U S A. 2008;105(19):7034-9.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.19 , pp. 7034-7039
    • Sarasin-Filipowicz, M.1    Oakeley, E.J.2    Duong, F.H.3


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