Environmental impact of medical prescriptions: Assessing the risks and hazards of persistence, bioaccumulation and toxicity of pharmaceuticals

Public Health

Volumn 127, Issue 4, 2013, Pages 312-317

  Deblonde, T ^a   Hartemann, P ^a  

^a INSERM   (France)

Author keywords

Environmental impact; Medical prescriptions; Risk assessment; Toxicity

Indexed keywords

ANTIBIOTIC AGENT; BIOCIDE; CONTRAST MEDIUM; CYTOSTATIC AGENT; DISINFECTANT AGENT; DRINKING WATER; DRUG RESIDUE; ESTROGEN;

ANTIBIOTICS; BIOACCUMULATION; DISINFECTION; DOSE-RESPONSE RELATIONSHIP; DRUG PRESCRIBING; ENVIRONMENTAL IMPACT; ENVIRONMENTAL IMPACT ASSESSMENT; HEALTH RISK; HEALTH WORKER; RISK ASSESSMENT; TOXICITY;

AQUATIC ENVIRONMENT; BIOACCUMULATION; BIODEGRADATION; ECOTOXICITY; ENVIRONMENTAL IMPACT; HAZARDOUS WASTE; HEALTH HAZARD; PRESCRIPTION; REVIEW; RISK ASSESSMENT; SWEDEN; WASTE WATER; WASTE WATER TREATMENT PLANT; WATER CONTAMINATION;

BIODEGRADATION, ENVIRONMENTAL; DRUG PRESCRIPTIONS; HAZARDOUS SUBSTANCES; HUMANS; RISK ASSESSMENT; SWEDEN;

SWEDEN;

EID: 84876962487     PISSN: 00333506     EISSN: 14765616     Source Type: Journal    
DOI: 10.1016/j.puhe.2013.01.026     Document Type: Review

References (31)

1. Castegnaro M., Hansel S. Les médicaments anticancéreux dans les effluents hospitaliers et domestiques. Environne Risques Santé 2006, 5:266-270.
2. Miège C., Choubert J.-M., Ribeiro L., Eusèbe M., Coquery M. Le devenir des résidus pharmaceutiques dans les stations d'épuration d'eaux usées. Une synthèse de la littérature. Techn Sci Méth 2009, 11:75-94.
3. Kim S.D., Cho J., Kim I.S., Vanderford B.J., Snyder S.A. Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking and waste waters. Wat Res 2007, 41:1013-1021.
4. European Commission EC 1907/2006 for registration, evaluation, authorisation and restriction of chemical substances 2007, European Parliament Council, Brussels.
5. European Commission Directive 98/8/EC of the European parliament and of the council concerning the placing of biocidal products on the market 1998, European Parliament Council, Brussels.
6. EMEA/CPMP Note for guidance on environmental risk assessment on medicinal products for human use. CHMP/SWP/4447/00 draft committee for proprietary medicinal products 2005, European Agency for the Evaluation of Medicinal Products, London.
7. Wennmalm A., Gunnarsson B. Pharmaceutical management through environmental product labeling in Sweden. Environ Int 2009, 35:775-777.
8. Carlsson C., Johansson A.K., Alvan G., Bergman K., Kühler T. Are pharmaceuticals potent environmental pollutants? Part I: environmental risk assessment of selected active pharmaceutical ingredients. Sci Total Environ 2006, 364:67-87.
9. Agerstrand M., Wester M., Ruden C. The Swedish environmental classification and information system for pharmaceuticals - an empirical investigation of the motivations, intentions and expectations underlying its development and implementation. Environ Int 2009, 35:778-786.
10. Risk Assessment Forum US EPA Proposed guidelines for ecological risk assessment 1996, USEPA/630/R-95/002B, USEPA, Washington, DC.
11. Presidential/Congressional Commission on Risk Assessment and Risk Management Framework for environmental health risk management. Final report 1997, USEPA, Washington.
12. Garric J., Ferrari B. Les substances pharmaceutiques dans les milieux aquatiques. Niveaux d'exposition et effets biologiques: que savons-nous?. Rev Sci l'Eau 2005, 18:307-330.
13. Matthiessen P., Sumpter J.P. Fish ecotoxicology. Effects of estrogenic substances in the aquatic environment 1998, 319-335. Fish Ecotoxicology. T. Braunbeck, D.E. Hinton, B. Streit (Eds.).
14. Auer C.M., Zeeman M., Nabholz J.V., Clements R.G. The US regulatory perspective. SAR QSAR Environ Res 1994, 2:21-38.
15. Lipnic R.L. Structure activity relationships. Fundamentals of aquatic toxicology 1995, 609-655. Taylor & Francis, London. G.M. Rand, S.R. Retrocelli (Eds.).
16. Sutter G.W., Gillet J.W., Norton S.B. Issue paper on characterization of exposure 1994, IUS EPA/630/R-94/009, Risk Assessment Forum, Washington DC, p. 4.1-4.64.
17. McMurry L.M., Oethinger M., Levy S.B. Triclosan targets lipid synthesis. Nature 1998, 394:531-532.
18. Russel A.D. Whiter triclosan?. J Antimicrob Chemother 2004, 53:693-695.
19. Saleh S., Haddadin R.N.S., Baillie S., Collier P.J. Triclosan - an update. Lett Appl Microbiol 2010, 52:87-95.
20. Scientific Committee on Consumer Protection S.C.C.P./1192/08 Opinion on triclosan Colipa n° P32 2008, Health & Consumer Protection Directorate General of the European Commission, Brussels.
21. Beire R.C., Duke S.E., Ziprin R.L., Harvey R.B., Hume M.E., Poole T.L., Scott H.M., Highfield L.D., Alali W.D., Andrews K., Anderson R.C., Nisbet D.J. Antibiotics and disinfectant susceptibility profiles of vancomycin-resistant Enterococcus faecium (VRE) isolated from community wastewater in Texas. Bull Envir Contam Toxicol 2008, 80:188-194.
22. Poole K. Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 2005, 56:20-51.
23. Zuccato E., Calamari D., Natangelo M., Fanelli R. Presence of therapeutic drugs in the environment. Lancet 2000, 355:1789-1790.
24. Hernando M.D., Mezcua M., Fernandez-Alba A.R., Barcelo D. Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. Talanta 2006, 69:334-342.
25. Catastini C., Mullot J.U., Boukari S., Mazellier P., Levi Y., Cervantes P., Ormsby J.N. Identification de molécules anticancéreuses dans les effluents hospitaliers de deux hôpitaux. Eur J Water Qual 2008, 39:171-180.
26. Commission internationale de la protection du Rhin Rapport d'évaluation: agents de contraste radiographique n° 187 2011, Commission Internationale de la Protection du Rhin in Allemagne (Coblence).
27. Environment Canada List of substances on the DSL that are persistent and inherently toxic to the environment 2010, CEPA Environmental Registry, Gatineau.
28. European Commission Classification, labelling and packaging regulation 2009, Annex VI, Table 3.2.Reg. 1272/2008, Brussels: European Parliament Council.
29. Canosa P., Morales S., Rodriguez I., Rubi E., Cela R., Gomez M. Aquatic degradation of triclosan and formation of toxic chlorophenols in presence of low concentrations of free chlorine. Anal Bioanal Chem 2005, 383:119-126.
30. Jackson J., Sutton R. Sources of endocrine-disrupting chemicals in urban wastewater, Oakland, CA. Sci Total Environ 2008, 405:153-160.
31. Ort C., Lawrence M.G., Reungoat J., Eaglesham G., Carter S., Keller J. Determining the fraction of pharmaceutical residues in wastewater originating from a hospital. Wat Res 2010, 44:605-615.