Human mild traumatic brain injury decreases circulating branched-chain amino acids and their metabolite levels

Journal of Neurotrauma

Volumn 30, Issue 8, 2013, Pages 671-679

  Jeter, Cameron B ^a   Hergenroeder, Georgene W ^b   Ward, Norman H ^b   Moore, Anthony N ^b   Dash, Pramod K ^b  

^a UNIVERSITY OF TEXAS DENTAL BRANCH AT HOUSTON   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

biomarker; dietary supplementation; intracranial pressure; metabolism; mild traumatic brain injury

Indexed keywords

2 METHYLBUTYRYLCARNITINE; 2 OXOISOCAPROIC ACID; 2 OXOISOVALERIC ACID; BRANCHED CHAIN AMINO ACID; HYDROXYISOVALERYL CARNITINE; ISOBUTYRYLCARNITINE; ISOLEUCINE; LEUCINE; METHYLGLUTARYLCARNITINE; NEUROTRANSMITTER; PROPIONYLCARNITINE; SUCCINYLCARNITINE; TIGLYL CARNITINE; TRIGLYLCARNITINE; UNCLASSIFIED DRUG; VALINE;

ADOLESCENT; ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; BLOOD SAMPLING; BRAIN INJURY; CLINICAL ARTICLE; CONTROLLED STUDY; FALLING; GLASGOW COMA SCALE; HUMAN; PROGNOSIS; TRAFFIC ACCIDENT;

ADOLESCENT; ADULT; AMINO ACIDS, BRANCHED-CHAIN; AREA UNDER CURVE; BRAIN CONCUSSION; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; MALE; MASS SPECTROMETRY; MIDDLE AGED; ROC CURVE; YOUNG ADULT;

EID: 84876943390     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2012.2491     Document Type: Article

References (42)

1. Fernstrom, J.D. (2005). Branched-chain amino acids and brain function. J. Nutr. 135, Suppl 6, 1539S-1546S. (Pubitemid 40791667)
2. Bergsneider, M., Hovda, D.A., Shalmon, E., Kelly, D.F., Vespa, P.M., Martin, N.A., Phelps, M.E., McArthur, D.L., Caron, M.J., Kraus, J.F., and Becker, D.P. (1997). Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J. Neurosurg. 86, 241-251. (Pubitemid 27130684)
3. Bergsneider, M., Hovda, D.A., Lee, S.M., Kelly, D.F., McArthur, D.L., Vespa, P.M., Lee, J.H., Huang, S.C., Martin, N.A., Phelps, M.E., and Becker, D.P. (2000). Dissociation of cerebral glucose metabolism and level of consciousness during the period of metabolic depression following human traumatic brain injury. J. Neurotrauma 17, 389-401. (Pubitemid 30327301)
4. Hovda, D.A., Lee, S.M., Smith, M.L., Von Stuck S., Bergsneider, M., Kelly, D., Shalmon, E., Martin, N., Caron, M., Mazziotta, J. et al. (1995). The neurochemical and metabolic cascade following brain injury: moving from animal models to man. J. Neurotrauma 12, 903-906.
5. Jiang, X.B., Ohno, K., Qian, L., Tominaga, B., Kuroiwa, T., Nariai, T., and Hirakawa, K. (2000). Changes in local cerebral blood flow, glucose utilization, and mitochondrial function following traumatic brain injury in rats. Neurol. Med. Chir. (Tokyo) 40, 16-29. (Pubitemid 30085637)
6. Yoshino, A., Hovda, D.A., Kawamata, T., Katayama, Y., and Becker, D.P. (1991). Dynamic changes in local cerebral glucose utilization following cerebral contusion in rats: evidence of a hyper-and subsequent hypometabolic state. Brain Res. 561, 106-119.
7. Aquilani, R., Iadarola, P., Contardi, A., Boselli, M., Verri, M., Pastoris, O., Boschi, F., Arcidiaco, P., and Viglio, S. (2005). Branched-chain amino acids enhance the cognitive recovery of patients with severe traumatic brain injury. Arch. Phys. Med. Rehabil. 86, 1729-1735. (Pubitemid 41354182)
8. Cole, J.T., Mitala, C.M., Kundu, S., Verma, A., Elkind, J.A., Nissim, I., and Cohen, A.S. (2010). Dietary branched chain amino acids ameliorate injury-induced cognitive impairment. Proc. Natl. Acad. Sci. U. S. A. 107, 366-371.
9. Aquilani, R., Boselli, M., Boschi, F., Viglio, S., Iadarola, P., Dossena, M., Pastoris, O., and Verri, M. (2008). Branched-chain amino acids may improve recovery from a vegetative or minimally conscious state in patients with traumatic brain injury: a pilot study. Arch. Phys. Med. Rehabil. 89, 1642-1647.
10. Vuille-Dit-Bille, R.N., Ha-Huy, R., and Stover, J.F. (2012). Changes in plasma phenylalanine, isoleucine, leucine, and valine are associated with significant changes in intracranial pressure and jugular venous oxygen saturation in patients with severe traumatic brain injury. Amino Acids 43,1287-1296.
11. Knaus, W.A., Draper, E.A., Wagner, D.P., and Zimmerman, J.E. (1985). APACHE II: a severity of disease classification system. Crit. Care Med. 13, 818-829. (Pubitemid 15250137)
12. Teasdale, G., and Jennett, B. (1974). Assessment of coma and impaired consciousness. A practical scale. Lancet 2, 81-84.
13. American Association for Automotive Medicine. (2001). The Abbreviated Injury Scale (AIS). 1990 revision Update 98 ed. AAAM: Des Plaines, IL.
14. Jeter, C.B., Hergenroeder, G.W., Ward, N.H.III, Moore, A.N., Dash, P.K. (2012). Human traumatic brain injury alters circulating L-arginine and its metabolite levels:possible link to cerebral blood flow, exracellular matrix remodeling, and energy status. J. Neurotrauma 29, 119-127.
15. Moche, l F., Charles, P., Seguin, F., Barritault, J., Coussieu, C., Perin, L., Le, B.Y., Gervais, C., Carcelain, G., Vassault, A., Feingold, J., Rabier, D., and Durr, A. (2007). Early energy deficit in Huntington disease: identification of a plasma biomarker traceable during disease progression. PLoS One 2, e647.
16. Piscopo, P., Crestini, A., Adduci, A., Ferrante, A., Massari, M., Popoli, P., Vanacore, N., and Confaloni, A. (2011). Altered oxidative stress profile in the cortex of mice fed an enriched branched-chain amino acids diet: possible link with amyotrophic lateral sclerosis? J. Neurosci. Res. 89, 1276-1283.
17. Brosnan, J.T., and Brosnan, M.E. (2006). Branched-chain amino acids: enzyme and substrate regulation. J. Nutr. 136, Suppl 1, 207S-211S. (Pubitemid 43156510)
18. Pardridge, W.M., and Choi, T.B. (1986). Neutral amino acid transport at the human blood-brain barrier. Fed. Proc. 45, 2073-2078. (Pubitemid 16065963)
19. Smith, Q.R., Momma, S., Aoyagi, M., and Rapoport, S.I. (1987). Kinetics of neutral amino acid transport across the blood-brain barrier. J. Neurochem. 49, 1651-1658. (Pubitemid 17161391)
20. Davis, J.M., Alderson, N.L., and Welsh, R.S. (2000). Serotonin and central nervous system fatigue: nutritional considerations. Am. J. Clin. Nutr. 72, Suppl 2, 573S-578S. (Pubitemid 30650057)
21. Fernstrom, J.D. (1990). Aromatic amino acids and monoamine synthesis in the central nervous system: influence of the diet. J. Nutr. Biochem. 1, 508-517. (Pubitemid 20360410)
22. Cousins, D.A., Butts, K., and Young, A.H. (2009). The role of dopamine in bipolar disorder. Bipolar Disord. 11, 787-806.
23. de Groot, M.J., Hoeksma, M., Blau, N., Reijngoud, D.J., and van Spronsen, F.J. (2010). Pathogenesis of cognitive dysfunction in phenylketonuria: review of hypotheses. Mol. Genet. Metab. 99, Suppl 1, S86-S89.
24. van Os, J., and Kapur, S. (2009). Schizophrenia. Lancet 374, 635-645.
25. Sakai, R., Cohen, D.M., Henry, J.F., Burrin, D.G., and Reeds, P.J. (2004). Leucine-nitrogen metabolism in the brain of conscious rats: its role as a nitrogen carrier in glutamate synthesis in glial and neuronal metabolic compartments. J. Neurochem. 88, 612-622. (Pubitemid 38140206)
26. Morris, A.A. (2005). Cerebral ketone body metabolism. J. Inherit. Metab. Dis. 28, 109-121. (Pubitemid 40723878)
27. Vespa, P.M., McArthur, D., O'Phelan, K., Glenn, T., Etchepare, M., Kelly, D., Bergsneider, M., Martin, N.A., and Hovda, D.A. (2003). Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J. Cereb. Blood Flow Metab. 23, 865-877. (Pubitemid 36818694)
28. Roe, C.R., Millington, D.S., and Maltby, D.A. (1986). Identification of 3-methylglutarylcarnitine. A new diagnostic metabolite of 3-hydroxy-3- methylglutaryl-coenzyme A lyase deficiency. J. Clin. Invest. 77, 1391-1394. (Pubitemid 16047165)
29. Xu, G., Kwon, G., Marshall, C.A., Lin, T.A., Lawrence, J.C., Jr., and McDaniel, M.L. (1998). Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling. J. Biol. Chem. 273, 28178-28184. (Pubitemid 28496115)
30. Banks, W.A., and Kastin, A.J. (1998). Differential permeability of the blood-brain barrier to two pancreatic peptides: insulin and amylin. Peptides 19, 883-889. (Pubitemid 28312286)
31. Palovcik, R.A., Phillips, M.I., Kappy, M.S., and Raizada, M.K. (1984). Insulin inhibits pyramidal neurons in hippocampal slices. Brain Res. 309, 187-91. (Pubitemid 14067582)
32. Shibata, S., Liou, S.Y., Ueki, S., and Oomura, Y. (1986). Inhibitory action of insulin on suprachiasmatic nucleus neurons in rat hypothalamic slice preparations. Physiol. Behav. 36, 79-81. (Pubitemid 16149816)
33. O'Brien, R.M., and Granner, D.K. (1996). Regulation of gene expression by insulin. Physiol. Rev. 76, 1109-1161. (Pubitemid 26346818)
34. Hinzman, J.M., Thomas, T.C., Burmeister, J.J., Quintero, J.E., Huettl, P., Pomerleau, F., Gerhardt, G.A., and Lifshitz, J. (2010). Diffuse brain injury elevates tonic glutamate levels and potassium-evoked glutamate release in discrete brain regions at two days post-injury: an enzymebased microelectrode array study. J. Neurotrauma 27, 889-899.
35. Berry H.K., Brunner R.L., Hunt M.M., White P.P. (1990). Valine, isoleucine, and leucine. A new treatment for phenylketonuria. Am. J. Dis. Child 144, 539-543. (Pubitemid 20153407)
36. Richardson, M.A., Bevans, M.L., Read, L.L., Chao, H.M., Clelland, J.D., Suckow, R.F., Maher, T.J., and Citrome, L. (2003). Efficacy of the branched-chain amino acids in the treatment of tardive dyskinesia in men. Am. J. Psychiatry 160, 1117-1124. (Pubitemid 41070971)
37. Scarna, A., Gijsman, H.J., McTavish, S.F., Harmer, C.J., Cowen, P.J., and Goodwin, G.M. (2003). Effects of a branched-chain amino acid drink in mania. Br. J. Psychiatry 182, 210-213. (Pubitemid 36286733)
38. Montgomery, A.J., McTavish, S.F., Cowen, P.J., and Grasby, P.M. (2003). Reduction of brain dopamine concentration with dietary tyrosine plus phenylalanine depletion: an [11C]raclopride PET study. Am. J. Psychiatry 160, 1887-1889. (Pubitemid 41103327)
39. Gijsman, H.J., Scarna, A., Harmer, C.J., McTavish, S.B., Odontiadis, J., Cowen, P.J., and Goodwin, G.M. (2002). A dose-finding study on the effects of branch chain amino acids on surrogate markers of brain dopamine function. Psychopharmacology (Berl) 160, 192-197. (Pubitemid 34212245)
40. Murphy, M.G., Crocker, J.F., O'Regan, P., Lee, S.H., Geldenhuys, L., Dooley, K., Al-Khalidi, M., and Acott, P.D. (2007). Carnitine, acylcarnitine and amino acid profiles analyzed by tandem mass spectrometry in a surfactant/virus mouse model of acute hepatic encephalopathy. Chemosphere 68, 1692-1698. (Pubitemid 46891013)
41. Schadewaldt, P., Bodner-Leidecker, A., Hammen, H.W., and Wendel, U. (2001). Whole-body L-leucine oxidation in patients with variant form of maple syrup urine disease. Pediatr. Res. 49, 627-635. (Pubitemid 32390850)
42. van Calcar, S.C., Gleason, L.A., Lindh, H., Hoffman, G., Rhead, W., Vockley, G., Wolff, J.A., and Durkin, M.S. (2007). 2-methylbutyryl-CoA dehydrogenase deficiency in Hmong infants identified by expanded newborn screen. WMJ 106, 12-15. (Pubitemid 46294210)