Efficacy of orally applied probiotic capsules for bacterial vaginosis and other vaginal infections: A double-blind, randomized, placebo-controlled study

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 168, Issue 1, 2013, Pages 75-79

  Vujic, Goran ^a   Jajac Knez, Alenka ^b   Despot Stefanovic, Vedrana ^b   Kuzmic Vrbanovic, Vedrana ^b  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b JADRAN Galenic Laboratory Ltd   (Croatia)

Author keywords

Bacterial vaginosis; Oral probiotics; Placebo controlled study

Indexed keywords

PLACEBO; PROBIOTIC AGENT;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FOLLOW UP; GARDNERELLA VAGINALIS; GYNECOLOGICAL EXAMINATION; HABIT; HUMAN; LACTOBACILLUS REUTERI; LACTOBACILLUS RHAMNOSUS; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PATIENT COMPLIANCE; PH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT INFECTION; RISK FACTOR; SEXUAL INTERCOURSE; SEXUALITY; SMOKING; TREATMENT DURATION; VAGINA DISCHARGE; VAGINA FLORA; VAGINITIS;

ADMINISTRATION, ORAL; ADULT; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LACTOBACILLUS; PROBIOTICS; VAGINA; VAGINOSIS, BACTERIAL;

EID: 84876927745     PISSN: 03012115     EISSN: 18727654     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2012.12.031     Document Type: Article

References (33)

1. U. Forsum, E. Holst, and P.G. Larsson Bacterial vaginosis - a microbiological and immunological enigma APMIS 113 2005 81 90
2. R.L. Sweet Gynecologic conditions and bacterial vaginosis: implications for the non-pregnant patient Infectious Diseases in Obstetrics and Gynecology 8 2000 184 190
3. R.B. Ness, S.L. Hillier, and K.E. Kip Bacterial vaginosis and risk of pelvic inflammatory disease Obstetrical and Gynecological Survey 60 2005 99 100
4. S. Guaschino, E. Ricci, and M. Franch Treatment of asymptomatic bacterial vaginosis to prevent pre term delivery: a randomized trial European Journal of Obstetrics, Gynecology, and Reproductive Biology 110 2003 149 152
5. H. Leitich, B. Bodner-Adler, M. Brunbauer, A. Kaider, C. Egarter, and P. Husslein Bacterial vaginosis as a risk factor for pre-term delivery: a meta analysis American Journal of Obstetrics and Gynecology 189 2003 139 147
6. L.O. Eckert, D.E. Moore, and D.L. Patton Relationship of vaginal bacteria and inflammation with conception and early pregnancy loss following in-vitro fertilization Infectious Diseases in Obstetrics and Gynecology 11 2003 11 17
7. J.D. Wilson, S.G. Ralph, and A.J. Rutherford Rates of bacterial vaginosis in women undergoing in vitro fertilisation for different types of infertility BJOG 109 2002 714 717
8. G.B. Hill, D.A. Eschenbach, and K.K. Holmes Bacteriology of the vagina Scandinavian Journal of Urology and Nephrology 86 Suppl 1984 23 29
9. S.J. Klebanoff, S.L. Hillier, D.A. Eschenbach, and A.M. Waltersdorph Control of the microbial flora of the vagina by H202 generating Lactobacilli Journal of Infectious Diseases 164 1991 94 100
10. D.A. Eschenbach, P.R. Davick, and B.L. Williams Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis Journal of Clinical Microbiology 27 1989 251 256
11. Anon. CDC sexually transmitted disease treatment guidelines 2006 Morbidity and Mortality Weekly Report 55 2006 50 52
12. J.M. Marrazzo Evolving issues in understanding and treating bacterial vaginosis Expert Review of Anti-Infective Therapy 2 2004 913 922
13. W.D. Hager, and R.P. Rapp Metronidazole Obstetrics and Gynecology Clinics of North America 19 1992 497 510
14. M.F. Trexler, T.G. Fraser, and M.P. Jones Fulminant pseudomembranous colitis caused by clindamycin phosphate vaginal cream American Journal of Gastroenterology 92 1997 2112 2113
15. C.S. Bradshaw, A.N. Morton, and J. Hocking High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence Journal of Infectious Diseases 193 2006 1478 1486
16. G. Reid, A.W. Bruce, and N. Fraser Oral probiotics can resolve urogenital infections FEMS Immunology and Medical Microbiology 30 2001 49 52
17. Report of a Joint FAO/WHO Expert Consultation on health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. American Córdoba Park Hotel, Córdoba, Argentina, 1-4 October 2001. http://www.who.int/foodsafety/publications/fs-management/en/ probiotics.pdf [accessed 11.02.08].
18. L. Morelli, D. Zonenenschain, M. Del Piano, and P. Cognein Utilization of the intestinal tract as a delivery system for urogenital probiotics Journal of Clinical Gastroenterology 38 2004 S107 S110
19. G. Reid, and J. Burton Use of lactobacillus to prevent infection by pathogenic bacteria Microbes and Infection 4 2002 319 324
20. M.E. Falagas, G.I. Betsi, and S. Athanasiou Probiotics for the treatment of women with bacterial vaginosis Clinical Microbiology and Infection 13 2007 657 664
21. R. Amsel, P.A. Totten, C.A. Spiegel, K.C. Chen, D. Eschenbach, and K.K. Holmes Nonspecific vaginitis: diagnostic criteria and microbial and epidemiologic associations American Journal of Medicine 74 1983 14 22
22. R.P. Nugent, M.A. Krohn, and S.L. Hillier Reliability of diagnosing bacterial vaginosis is improved by a standardized method of Gram stain interpretation Journal of Clinical Microbiology 29 1991 297 301
23. M. Saghaei Random allocation software for parallel group randomized trials BMC Medical Research Methodology 4 2004 26
24. K. Anukam, E. Osazuwa, and I. Ahonkhai Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC14: randomized double blind placebo controlled trial Microbes and Infection 8 2006 1450 1454
25. Hintze J. PASS 2008. Kaysville, Utah, USA, NCSS, LLC; 2008. www.ncss.com.
26. X.J. Zhang, Q. Shen, and G.Y. Wang Risk factors for reproductive tract infections among married women in rural areas of Anhui Province, China European Journal of Obstetrics, Gynecology, and Reproductive Biology 147 2009 187 191
27. D. Hellberg, S. Nilsson, and P.A. Mardh The diagnosis of bacterial vaginosis and vaginal flora changes Archives of Gynecology and Obstetrics 265 2001 11 15
28. W. Ya, C. Reifer, and L.E. Miller Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomized, placebo-controlled study American Journal of Obstetrics and Gynecology 203 2010 e1 e6 120
29. S. Boris, J. Suarez, and F. Vazquez Adherence of human vaginal Lactobacilli to vaginal epithelial cells and interaction with uropathogens Infection and Immunity 66 1998 1985 1989
30. K. Anukam, E. Osazuwa, G.I. Osemene, F. Ehigiagbe, A.W. Bruce, and G. Reid Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis Microbes and Infection 8 2006 2772 2776
31. R.C. Martinez, S.A. Franceschini, and M.C. Patta Improved treatment of vulvovaginal candidiasis with fluconazole plus probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 Letters in Applied Microbiology 48 2009 269 274
32. P. DeLucca, and D. Raghavarao Effect of investigator bias on the significance level of the Wilcoxon rank-sum test Biostatistics 1 2000 107 111
33. O.O. Oduyebo, R.I. Anorlu, and F.T. Ogunsola The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women Cochrane Database of Systematic Reviews 2009 CD006055