Male-Female Differences in Upregulation of Vasoconstrictor Responses in Human Cerebral Arteries

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Ahnstedt, Hilda ^a   Cao, Lei ^a   Krause, Diana N ^b   Warfvinge, Karin ^a   Säveland, Hans ^c   Nilsson, Ola G ^c   Edvinsson, Lars ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; MESSENGER RNA; SEROTONIN 1B RECEPTOR;

ADULT; ARTICLE; BRAIN ARTERY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; ORGAN CULTURE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; UPREGULATION; VASOCONSTRICTION;

ANGIOTENSIN II; CEREBRAL ARTERIES; ENDOTHELIN-1; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; MYOGRAPHY; ORGAN CULTURE TECHNIQUES; PROTEIN ISOFORMS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ENDOTHELIN A; RECEPTOR, SEROTONIN, 5-HT1B; RNA, MESSENGER; SEX FACTORS; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

EID: 84876914743     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062698     Document Type: Article

References (41)

1. Appelros P, Stegmayr B, Terent A, (2009) Sex differences in stroke epidemiology: a systematic review. Stroke 40: 1082-1090.
2. Forster A, Gass A, Kern R, Wolf ME, Ottomeyer C, et al. (2009) Gender differences in acute ischemic stroke: etiology, stroke patterns and response to thrombolysis. Stroke 40: 2428-2432.
3. Turtzo LC, McCullough LD, (2010) Sex-specific responses to stroke. Future Neurol 5: 47-59.
4. Kent DM, Price LL, Ringleb P, Hill MD, Selker HP, (2005) Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials. Stroke 36: 62-65.
5. Zuern CS, Lindemann S, Gawaz M, (2009) Platelet function and response to aspirin: gender-specific features and implications for female thrombotic risk and management. Semin Thromb Hemost 35: 295-306.
6. Hurn PD, Brass LM, (2003) Estrogen and stroke: a balanced analysis. Stroke 34: 338-341.
7. Liao S, Chen W, Kuo J, Chen C, (2001) Association of serum estrogen level and ischemic neuroprotection in female rats. Neurosci Lett 297: 159-162.
8. Arnold AP, (2009) Mouse models for evaluating sex chromosome effects that cause sex differences in non-gonadal tissues. J Neuroendocrinol 21: 377-386.
9. Du L, Bayir H, Lai Y, Zhang X, Kochanek PM, et al. (2004) Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. J Biol Chem 279: 38563-38570.
10. Vikman P, Edvinsson L, (2006) Gene expression profiling in the human middle cerebral artery after cerebral ischemia. Eur J Neurol 13: 1324-1332.
11. Edvinsson LI, Povlsen GK, (2011) Vascular plasticity in cerebrovascular disorders. J Cereb Blood Flow Metab 31: 1554-1571.
12. Ahnstedt H, Saveland H, Nilsson O, Edvinsson L, (2011) Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway. BMC Neurosci 12: 5.
13. Henriksson M, Stenman E, Vikman P, Edvinsson L, (2007) MEK1/2 inhibition attenuates vascular ETA and ETB receptor alterations after cerebral ischaemia. Exp Brain Res 178: 470-476.
14. Maddahi A, Edvinsson L, (2008) Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway. BMC Neurosci 9: 85.
15. Povlsen GK, Waldsee R, Ahnstedt H, Kristiansen KA, Johansen FF, et al. (2012) In vivo experimental stroke and in vitro organ culture induce similar changes in vasoconstrictor receptors and intracellular calcium handling in rat cerebral arteries. Exp Brain Res In Press.
16. Henriksson M, Xu CB, Edvinsson L, (2004) Importance of ERK1/2 in upregulation of endothelin type B receptors in cerebral arteries. Br J Pharmacol 142: 1155-1161.
17. Ansar S, Maddahi A, Edvinsson L, (2011) Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage. BMC Neurosci 12: 107.
18. Beg SA, Hansen-Schwartz JA, Vikman PJ, Xu CB, Edvinsson LI, (2006) ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat. J Cereb Blood Flow Metab 26: 846-856.
19. Mulvany MJ, Halpern W, (1977) Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41: 19-26.
20. Hogestatt ED, Andersson KE, Edvinsson L, (1983) Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels. Acta Physiol Scand 117: 49-61.
21. Nilsson T, Longmore J, Shaw D, Olesen IJ, Edvinsson L, (1999) Contractile 5-HT1B receptors in human cerebral arteries: pharmacological characterization and localization with immunocytochemistry. Br J Pharmacol 128: 1133-1140.
22. Nilsson T, Cantera L, Adner M, Edvinsson L (1997) Presence of contractile endothelin-A and dilatory endothelin-B receptors in human cerebral arteries. Neurosurgery 40: 346-351; discussion 351-343.
23. Hansen-Schwartz J, Hoel NL, Zhou M, Xu CB, Svendgaard NA, et al. (2003) Subarachnoid hemorrhage enhances endothelin receptor expression and function in rat cerebral arteries. Neurosurgery 52: 1188-1194.
24. Alexander SP, Mathie A, Peters JA, (2011) Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol 164Suppl 1: S1-324.
25. Ahnstedt H, Stenman E, Cao L, Henriksson M, Edvinsson L, (2012) Cytokines and growth factors modify the upregulation of contractile endothelin ET(A) and ET(B) receptors in rat cerebral arteries after organ culture. Acta Physiol (Oxf) 205: 266-278.
26. Hansen-Schwartz J, Nordstrom CH, Edvinsson L (2002) Human endothelin subtype A receptor enhancement during tissue culture via de novo transcription. Neurosurgery 50: 127-133; discussion 133-125.
27. Ansar S, Eftekhari S, Waldsee R, Nilsson E, Nilsson O, et al. (2013) MAPK signaling pathway regulate cerebrovascular receptor expression in human cerebral arteries. BMC Neurosci In press.
28. De Silva TM, Broughton BR, Drummond GR, Sobey CG, Miller AA, (2009) Gender influences cerebral vascular responses to angiotensin II through Nox2-derived reactive oxygen species. Stroke 40: 1091-1097.
29. Silva-Antonialli MM, Tostes RC, Fernandes L, Fior-Chadi DR, Akamine EH, et al. (2004) A lower ratio of AT1/AT2 receptors of angiotensin II is found in female than in male spontaneously hypertensive rats. Cardiovasc Res 62: 587-593.
30. Fu H, Hosomi N, Pelisch N, Nakano D, Liu G, et al. (2011) Therapeutic effects of postischemic treatment with hypotensive doses of an angiotensin II receptor blocker on transient focal cerebral ischemia. J Hypertens 29: 2210-2219.
31. Hosomi N, Nishiyama A, Ban CR, Naya T, Takahashi T, et al. (2005) Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. Neuroscience 134: 225-231.
32. Henriksson M, Stenman E, Edvinsson L, (2003) Intracellular pathways involved in upregulation of vascular endothelin type B receptors in cerebral arteries of the rat. Stroke 34: 1479-1483.
33. Tostes Passaglia RC, David FL, Fortes ZB, Nigro D, Scivoletto R, et al. (2000) Deoxycorticosterone acetate-salt hypertensive rats display gender-related differences in ET(B) receptor-mediated vascular responses. Br J Pharmacol 130: 1092-1098.
34. David FL, Montezano AC, Reboucas NA, Nigro D, Fortes ZB, et al. (2002) Gender differences in vascular expression of endothelin and ET(A)/ET(B) receptors, but not in calcium handling mechanisms, in deoxycorticosterone acetate-salt hypertension. Braz J Med Biol Res 35: 1061-1068.
35. Krause DN, Duckles SP, Pelligrino DA, (2006) Influence of sex steroid hormones on cerebrovascular function. J Appl Physiol 101: 1252-1261.
36. Geary GG, Krause DN, Duckles SP, (1998) Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries. Am J Physiol 275: H292-300.
37. Gonzales RJ, Ghaffari AA, Duckles SP, Krause DN, (2005) Testosterone treatment increases thromboxane function in rat cerebral arteries. Am J Physiol Heart Circ Physiol 289: H578-585.
38. Ospina JA, Duckles SP, Krause DN, (2003) 17beta-estradiol decreases vascular tone in cerebral arteries by shifting COX-dependent vasoconstriction to vasodilation. Am J Physiol Heart Circ Physiol 285: H241-250.
39. Mugge A, Barton M, Fieguth HG, Riedel M, (1997) Contractile responses to histamine, serotonin, and angiotensin II are impaired by 17 beta-estradiol in human internal mammary arteries in vitro. Pharmacology 54: 162-168.
40. Cheng DY, Gruetter CA, (1992) Chronic estrogen alters contractile responsiveness to angiotensin II and norepinephrine in female rat aorta. Eur J Pharmacol 215: 171-176.
41. Salom JB, Burguete MC, Perez-Asensio FJ, Torregrosa G, Alborch E, (2001) Relaxant effects of 17-beta-estradiol in cerebral arteries through Ca(2+) entry inhibition. J Cereb Blood Flow Metab 21: 422-429.