Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death

Cell Death and Disease

Volumn 4, Issue 4, 2013, Pages

  Moran, C ^a,b   Sanz Rodriguez, A ^a,c   Jimenez Pacheco, A ^a,c   Martinez Villareal, J ^a,c   McKiernan, R C ^a,c   Jimenez Mateos, E M ^a,c   Mooney, C ^a,c   Woods, I ^a   Prehn, J H M ^a,c   Henshall, D C ^a,c   Engel, T ^a,c  

^a Department of Physiology and Medical Physics ^*  (Ireland)

^b BEAUMONT HOSPITAL   (Ireland)

^c Centre for the Study of Neurological Disorders   (Ireland)

Author keywords

Apoptosis; BH3 only proteins; Neurons; Status epilepticus; Temporal lobe epilepsy

Indexed keywords

BCL 2 MODIFYING FACTOR PROTEIN; BH3 PROTEIN; GLUTAMATE RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; KAINIC ACID; MEMBRANE PROTEIN; PROTEIN BAX; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; BRAIN PROTECTION; BRAIN SIZE; CELL ADHESION; CELL DEATH; CELL STRESS; CONTROLLED STUDY; CYTOSKELETON; ELECTROENCEPHALOGRAPHY; EPILEPTIC STATE; EXTRACELLULAR MATRIX; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HISTOPATHOLOGY; IMMUNOREACTIVITY; MALE; MITOCHONDRION; MOLECULAR DYNAMICS; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRANSCRIPTION INITIATION; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; HIPPOCAMPUS; KAINIC ACID; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; PYRAZOLES; PYRIMIDINES; RNA, MESSENGER; SIGNAL TRANSDUCTION; STATUS EPILEPTICUS; TIME FACTORS; UP-REGULATION;

MUS;

EID: 84876900646     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.136     Document Type: Article

References (53)

1. Barnes AP, Polleux F. Establishment of axon-dendrite polarity in developing neurons. Annu Rev Neurosci 2009; 32: 347-381.
2. Gao FB. Molecular and cellular mechanisms of dendritic morphogenesis. Curr Opin Neurobiol 2007; 17: 525-532.
3. Jan YN, Jan LY. The control of dendrite development. Neuron 2003; 40: 229-242.
4. Miller FD, Kaplan DR. On Trk for retrograde signaling. Neuron 2001; 32: 767-770.
5. Whitford KL, Dijkhuizen P, Polleux F, Ghosh A. Molecular control of cortical dendrite development. Annu Rev Neurosci 2002; 25: 127-149.
6. Ernsberger U. Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia. Cell Tissu Res 2009; 336: 349-384.
7. McAllister AK. Neurotrophins and neuronal differentiation in the central nervous system. Cell Mol Life Sci 2001; 58: 1054-1060.
8. Tucker KL, Meyer M, Barde YA. Neurotrophins are required for nerve growth during development. Nat Neurosci 2001; 4: 29-37.
9. Huang EJ, Reichardt LF. Trk receptors: Roles in neuronal signal transduction. Annu Rev Biochem 2003; 72: 609-642.
10. Diarra A, Geetha T, Potter P, Babu Jr. Signaling of the neurotrophin receptor p75 in relation to Alzheimer's disease. Biochem Biophys Res Commun 2009; 390: 352-356.
11. Minichiello L. TrkB signalling pathways in LTP and learning. Nat Rev Neurosci 2009; 10: 850-860; Review
12. Manser E, Leung T, Salihuddin H, Tan L, Lim L. A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature 1993; 363: 364-367.
13. Satoh T, Kato J, Nishida K, Kaziro Y. Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation. FEBS Lett 1996; 386: 230-234.
14. Linseman DA, Heidenreich KA, Fisher SK. Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway. J Biol Chem 2001; 276: 5622-5628.
15. Yang W, Lin Q, Zhao J, Guan JL, Cerione RA. The nonreceptor tyrosine kinase ACK2, a specific target for Cdc42 and a negative regulator of cell growth and focal adhesion complexes. J Biol Chem 2001; 276: 43987-43993.
16. Yokoyama N, Miller WT. Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, autophosphorylation, and interaction with Hck. J Biol Chem 2003; 278: 47713-47723.
17. Kiyono M, Kato J, Kataoka T, Kaziro Y, Satoh T. Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1. J Biol Chem 2000; 275: 29788-29793.
18. Kato J, Kaziro Y, Satoh T. Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation. Biochem Biophys Res Commun 2000; 268: 141-147.
19. Yokoyama N, Lougheed J, Miller WT. Phosphorylation of WASP by the Cdc42 associated kinase ACK1: Dual hydroxyamino acid specificity in a tyrosine kinase. J Biol Chem 2005; 280: 42219-42226.
20. Eisenmann KM, McCarthy JB, Simpson MA, Keely PJ, Guan JL, Tachibana K et al. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. Nat Cell Biol 1999; 1: 507-513.
21. Galisteo ML, Yang Y, Urena J, Schlessinger J. Activation of the nonreceptor proteintyrosine kinase Ack by multiple extracellular stimuli. Proc Natl Acad Sci USA 2006; 103: 9796-9801.
22. Kato-Stankiewicz J, Ueda S, Kataoka T, Kaziro Y, Satoh T. Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2 dependent manner. Biochem Biophys Res Commun 2001; 284: 470-477.
23. Yang W, Lin Q, Guan JL, Cerione RA. Activation of the Cdc42-associated tyrosine kinase-2 (ACK-2) by cell adhesion via integrin beta1. J Biol Chem 1999; 274: 8524-8530.
24. La Torre A, del Rio JA, Soriano E, Urena JM. Expression pattern of ACK1 tyrosine kinase during brain development in the mouse. Gene Expr Patterns 2006; 6: 886-892.
25. Urena JM, La Torre A, Martinez A, Lowenstein E, Franco N, Winsky-Sommerer R et al. Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain. J Comp Neurol 2005; 490: 119-132.
26. Watson FL, Heerssen HM, Moheban DB, Lin MZ, Sauvageot CM, Bhattacharyya A et al. Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex. J Neurosci 1999; 19: 7889-7900.
27. Kryl D, Yacoubian T, Haapasalo A, Castren E, Lo D, Barker PA. Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells. J Neurosci 1999; 19: 5823-5833.
28. Podlesniy P, Kichev A, Pedraza C, Saurat J, Encinas M, Perez B et al. Pro-NGF from Alzheimer's disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75NTR and apoptosis. Am J Pathol 2006; 169: 119-131.
29. Greene LA, Tischler AS. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 1976; 73: 2424-2428.
30. Schmidt G, Wittinghofer A. Priming of PC12 cells for semiquantitative microinjection studies involving Ras. FEBS Lett 2000; 474: 184-188.
31. McAllister AK, Katz LC, Lo DC. Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth. Neuron 1997; 18: 767-778.
32. Nguyen T, Di Giovanni S. NFAT signaling in neural development and axon growth. Int J Dev Neurosci 2008; 26: 141-145.
33. Arévalo JC, Chao MV. Axonal growth: Where neurotrophins meet Wnts. Curr Opin Cell Biol 2005; 17: 112-115.
34. Mott HR, Owen D, Nietlispach D, Lowe PN, Manser E, Lim L et al. Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK. Nature 1999; 399: 384-388.
35. MacDonald JI, Verdi JM, Meakin SO. Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3. J Mol Neurosci 1999; 13: 141-158.
36. Robinson KN, Manto K, Buchsbaum RJ, MacDonald JI, Meakin SO. Neurotrophindependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA. J Biol Chem 2005; 280: 225-235.
37. Heckman CA, Urban JM, Cayer M, Li Y, Boudreau N, Barnes J et al. Novel p21-activated kinase-dependent protrusions characteristically formed at the edge of transformed cells. Exp Cell Res 2004; 295: 432-447.
38. Worby C, Margolis B. Positive versus negative signaling of LET-23: Regulation through the adaptor protein, SEM-5. Sci STKE 2000; 2000: Pe2.
39. Shen F, Lin Q, Gu Y, Childress C, Yang W. Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation. Mol Biol Cell 2007; 18: 732-742.
40. Read DE, Gorman AM. Involvement of Akt in neurite outgrowth. Cell Mol Life Sci 2009; 66: 2975-2984.
41. da Silva JS, Dotti CG. Breaking the neuronal sphere: Regulation of the actin cytoskeleton in neuritogenesis. Nat Rev Neurosci 2002; 3: 694-704.
42. Katoh H, Aoki J, Ichikawa A, Negishi M. p160 RhoA-binding kinase ROKalpha induces neurite retraction. J Biol Chem 1998; 273: 2489-2492.
43. Kozma R, Sarner S, Ahmed S, Lim L. Rho family GTPases and neuronal growth cone remodelling: Relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid. Mol Cell Biol 1997; 17: 1201-1211.
44. Suo L, Lu H, Ying G, Capecchi MR, Wu Q. Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase. Mol Cell Biol 2012; 4: 362-376.
45. Luo L. Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. Annu Rev Cell Dev Biol 2002; 18: 601-635.
46. Bramham CR, Wells DG. Dendritic mRNA: Transport, translation and function. Nat Rev Neurosci 2007; 8: 776-789.
47. Flavell SW, Greenberg ME. Signaling mechanisms linking neuronal activity to ne expression and plasticity of the nervous system. Annu Rev Neurosci 2008; 31: 563-590.
48. Poo MM. Neurotrophins as synaptic modulators. Nat Rev Neurosci. 2001; 2: 24-32.
49. Schubert V, Da Silva JS, Dotti CG. Localized recruitment and activation of RhoA underlies dendritic spine morphology in a glutamate receptor-dependent manner. J Cell Biol 2006; 172: 453-467.
50. Harlow E, Lane D. Antibodies. A laboratory manual. Cold Spring Harbor Laboratory Ed.: New York, 1988.
51. Peiró S, Comella JX, Enrich C, Martin-Zanca D, Rocamora N. PC12 cells have caveolae that contain TrkA. J Biol Chem 2000; 275: 37846-37852.
52. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning. A Laboratory Manual. 2nd edn. Cold Spring Harbor Laboratory Press, Plainview, New York, 1989.
53. Gao WQ, Liu XL, Hatten ME. The weaver gene encodes a nonautonomous signal for CNS neuronal differentiation. Cell 1992; 68: 841-854.