Effects of magnolol on impairment of learning and memory abilities induced by scopolamine in mice

Biological and Pharmaceutical Bulletin

Volumn 36, Issue 5, 2013, Pages 764-771

  Li, Yang Si ^a   Hong, Ying Fen ^a   He, Jiang ^a   Lin, Jian Xun ^a   Shan, Yi Long ^a   Fu, Dong Ying ^a   Chen, Zhi Peng ^a   Ren, Xin Ran ^b   Song, Zhi Hong ^a   Tao, Liang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Anti oxidation; Learning ability; Magnolol; Memory ability; Scopolamine

Indexed keywords

ACETYLCHOLINESTERASE; DONEPEZIL; MAGNOLOL; NITRIC OXIDE SYNTHASE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; BRAIN REGION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DRUG STRUCTURE; ENZYME ACTIVITY; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; LEARNING DISORDER; LIPID PEROXIDATION; MALE; MAZE TEST; MEMORY DISORDER; MOUSE; NERVE FIBER; NONHUMAN; OXIDATIVE STRESS; PASSIVE AVOIDANCE; TREATMENT RESPONSE;

ACETYLCHOLINE; ANIMALS; AVOIDANCE LEARNING; BIPHENYL COMPOUNDS; BRAIN; CHOLINERGIC NEURONS; LIGNANS; MALE; MALONDIALDEHYDE; MAZE LEARNING; MEMORY DISORDERS; MICE; NERVE FIBERS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE; ORGAN SIZE; SCOPOLAMINE HYDROBROMIDE; SUPEROXIDE DISMUTASE;

EID: 84876890714     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00880     Document Type: Article

References (24)

1. Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron, 44, 181-193 (2004).
2. Bigl V, Arendt T. Cholinergic neurons of the central nervous system: morphofunctional aspects. Acta Psychiatr. Scand. Suppl., 366 (S366), 7-13 (1991).
3. Mohapel P, Leanza G, Kokaia M, Lindvall O. Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning. Neurobiol. Aging, 26, 939-946 (2005).
4. Gökçek-Saraç Ç, Karakurt S, Adali O, Jakubowska-Doǧru E. Correlation between hippocampal levels of neural, epithelial and inducible NOS and spatial learning skills in rats. Behav. Brain Res., 235, 326-333 (2012).
5. Frölich L. The cholinergic pathology in Alzheimer's disease - Discrepancies between clinical experience and pathophysiological findings. J. Neural Transm., 109, 1003-1013 (2002).
6. Fibiger HC. Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence. Trends Neurosci., 14, 220-223 (1991).
7. Collerton D. Cholinergic function and intellectual decline in Alzheimer's disease. Neuroscience, 19, 1-28 (1986).
8. Chen YL, Lin KF, Shiao MS, Chen YT, Hong CY, Lin SJ. Magnolol, a potent antioxidant from Magnolia officinalis, attenuates intimal thickening and MCP-1 expression after balloon injury of the aorta in cholesterol-fed rabbits. Basic Res. Cardiol., 96, 353-363 (2001).
9. Shih HC, Wei YH, Lee CH. Magnolol alters the course of endotoxin tolerance and provides early protection against endotoxin challenge following sublethal hemorrhage in rats. Shock, 22, 358-363 (2004).
10. Matsui N, Takahashi K, Takeichi M, Kuroshita T, Noguchi K, Yamazaki K, Tagashira H, Tsutsui K, Okada H, Kido Y, Yasui Y, Fukuishi N, Fukuyama Y, Akagi M. Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice. Brain Res., 1305, 108-117 (2009).
11. Hou YC, Chao PD, Chen SY. Honokiol and magnolol increased hippocampal acetylcholine release in freely-moving rats. Am. J. Chin. Med., 28, 379-384 (2000).
12. Khaing Z, Kang D, Camelio AM, Schmidt CE, Siegel D. Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol. Bioorg. Med. Chem. Lett., 21, 4808-4812 (2011).
13. Myhrer T. Neurotransmitter systems involved in learning and memory in the rat: a meta-analysis based on studies of four behavioral tasks. Brain Res. Brain Res. Rev., 41, 268-287 (2003).
14. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods, 11, 47-60 (1984).
15. Schliebs R, Arendt T. The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. J. Neural Transm., 113, 1625-1644 (2006).
16. Hatip-Al-Khatib I, Takashi A, Egashira N, Iwasaki K, Fujiwara M. Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats. Brain Res., 1021, 169-176 (2004).
17. Georgiadou G, Pitsikas N. Repeated administration of the nitric oxide synthase inhibitor l-NAME differentially affects rats' recognition memory. Behav. Brain Res., 224, 140-144 (2011).
18. Rushaidhi M, Collie ND, Zhang H, Liu P. Agmatine selectively improves behavioural function in aged male Sprague-Dawley rats. Neuroscience, 218, 206-215 (2012).
19. Baluchnejadmojarad T, Roghani M. Chronic epigallocatechin-3-gallate ameliorates learning and memory deficits in diabetic rats via modulation of nitric oxide and oxidative stress. Behav. Brain Res., 224, 305-310 (2011).
20. Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. U.S.A., 90, 7951-7955 (1993).
21. Boissiere F, Faucheux B, Ruberg M, Agid Y, Hirsch EC. Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease. Exp. Neurol., 145, 245-252 (1997).
22. Mufson EJ, Ikonomovic MD, Styren SD, Counts SE, Wuu J, Leurgans S, Bennett DA, Cochran EJ, DeKosky ST. Preservation of brain nerve growth factor in mild cognitive impairment and Alzheimer disease. Arch. Neurol., 60, 1143-1148 (2003).
23. Shen ZX. CSF cholinesterase activity in demented and non-demented subjects. Neuroreport, 9, 483-488 (1998).
24. Knox LT, Jing Y, Fleete MS, Collie ND, Zhang H, Liu P. Scopolamine impairs behavioural function and arginine metabolism in the rat dentate gyrus. Neuropharmacology, 61, 1452-1462 (2011).