Eculizumab for salvage treatment of refractory antibody-mediated rejection in kidney transplant patients: Case reports

Transplantation Proceedings

Volumn 45, Issue 3, 2013, Pages 1022-1025

  Kocak, B ^a   Arpali, E ^a   Demiralp, E ^a   Yelken, B ^a   Karatas, C ^a   Gorcin, S ^a   Gorgulu, N ^a   Uzunalan, M ^a   Turkmen, A ^a   Kalayoglu, M ^a  

^a MEMORIAL HOSPITAL   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; BASILIXIMAB; COMPLEMENT COMPONENT C4D; CREATININE; ECULIZUMAB; HEMOGLOBIN; HLA ANTIBODY; HLA B13 ANTIGEN; HLA DR4 ANTIGEN; IMMUNOGLOBULIN; MYCOPHENOLIC ACID; PREDNISOLONE; RITUXIMAB; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE KIDNEY TUBULE NECROSIS; ACUTE PANCREATITIS; ADULT; ANTIBODY MEDIATED REJECTION; ANURIA; CASE REPORT; CHRONIC KIDNEY FAILURE; CONFERENCE PAPER; CREATININE BLOOD LEVEL; DESENSITIZATION; DISEASE SEVERITY; DRUG WITHDRAWAL; FEMALE; FEVER; GLOMERULOPATHY; HEMODIALYSIS; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HUMAN; HYPERTENSION; IMMUNOASSAY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY CORTEX NECROSIS; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; KIDNEY TUBULE NECROSIS; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOPENIA; MEDICAL HISTORY; PLASMAPHERESIS; POSTOPERATIVE PERIOD; PREOPERATIVE CARE; PRIORITY JOURNAL; SALVAGE THERAPY; SINGLE DRUG DOSE; STEROID THERAPY; T LYMPHOCYTE; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA; URINE VOLUME; VASCULITIS;

ADULT; ANTIBODIES, MONOCLONAL, HUMANIZED; FEMALE; GRAFT REJECTION; HUMANS; KIDNEY TRANSPLANTATION; SALVAGE THERAPY;

EID: 84876868259     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2013.02.062     Document Type: Conference Paper

References (11)

1. J.M. Burns, L.D. Cornell, D.K. Perry Alloantibody levels and acute humoral rejection early after positive crossmatch kidney transplantation Am J Transplant 8 12 2008 2684 2694
2. C.J. Sonnenday, D.S. Warren, M. Cooper Plasmapheresis, CMV hyperimmune globulin, and anti-CD20 allow ABO-incompatible renal transplantation without splenectomy Am J Transplant 4 8 2004 1315 1322 (Pubitemid 39013579)
3. Y.T. Becker, B.N. Becker, J.D. Pirsch Rituximab as treatment for refractory kidney transplant rejection Am J Transplant 4 6 2004 996 1001 (Pubitemid 38745599)
4. K. Hadaya, S. Ferrari-Lacraz, D. Fumeaux Eculizumab in acute recurrence of thrombotic microangiopathy after renal transplantation Am J Transplant 11 11 2011 2523 2527
5. V. Chatelet, V. Frémeaux-Bacchi, T. Lobbedez Safety and long-term efficacy of eculizumab in a renal transplant patient with recurrent atypical hemolytic-uremic syndrome Am J Transplant 9 11 2009 2644 2645
6. M.D. Stegall, T. Diwan, S. Raghavaiah Terminal complement inhibition decreases antibody-mediated rejection in sensitized renal transplant recipients Am J Transplant 11 11 2011 2405 2413
7. R.A. Montgomery, A.A. Zachary Transplanting patients with a positive donor-specific crossmatch: a single center's perspective Pediatr Transplant 8 6 2004 535 542 (Pubitemid 40052349)
8. M.D. Stegall, M.F. Chedid, L.D. Cornell The role of complement in antibody-mediated rejection in kidney transplantation Nat Rev Nephrol 8 11 2012 670 678
9. J.E. Locke, C.M. Magro, A.L. Singer The use of antibody to complement protein C5 for salvage treatment of severe antibody-mediated rejection Am J Transplant 9 1 2009 231
10. P. Hillmen, N.S. Young, J. Schubert The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria N Engl J Med 355 12 2006 1233 1243 (Pubitemid 44427447)
11. F. González-Roncero, M. Suñer, G. Bernal Eculizumab treatment of acute antibody-mediated rejection in renal transplantation: case reports Transplant Proc 44 9 2012 2690 2694