Immune Regulation during Helminth Infections

PLoS Pathogens

Volumn 9, Issue 4, 2013, Pages

  Girgis, Natasha M ^a   Gundra, Uma Mahesh ^a   Loke, P'ng ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR ALPHA; INTERLEUKIN 5; INTERLEUKIN 9; LIPOPOLYSACCHARIDE; STAT6 PROTEIN; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; AUTOIMMUNITY; CELL HETEROGENEITY; EVOLUTION; HELMINTHIASIS; HOST RESISTANCE; HUMAN; IMMUNE SYSTEM; IMMUNOREGULATION; NONHUMAN; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TH2 CELL; VIRULENCE;

ANIMALS; AUTOIMMUNITY; HELMINTHIASIS; HELMINTHS; HUMANS; IMMUNOLOGIC FACTORS;

VERMES;

EID: 84876866769     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1003250     Document Type: Article

References (24)

1. Medzhitov R, Schneider DS, Soares MP, (2012) Disease tolerance as a defense strategy. Science 335: 936-941.
2. Little TJ, Shuker DM, Colegrave N, Day T, Graham AL, (2010) The coevolution of virulence: tolerance in perspective. PLoS Pathog 6: e1001006 doi:10.1371/journal.ppat.1001006.
3. Allen JE, Wynn TA, (2011) Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens. PLoS Pathog 7: e1002003 doi:10.1371/journal.ppat.1002003.
4. Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, et al. (2008) Helminth infections: the great neglected tropical diseases. J Clin Invest 118: 1311-1321.
5. Wiria AE, Djuardi Y, Supali T, Sartono E, Yazdanbakhsh M, (2012) Helminth infection in populations undergoing epidemiological transition: a friend or foe? Semin Immunopathol 34: 889-901.
6. McSorley HJ, Maizels RM, (2012) Helminth infections and host immune regulation. Clin Microbiol Rev 25: 585-608.
7. Babayan SA, Allen JE, Bradley JE, Geuking MB, Graham AL, et al. (2011) Wild immunology: converging on the real world. Ann N Y Acad Sci 1236: 17-29.
8. Graham AL, Hayward AD, Watt KA, Pilkington JG, Pemberton JM, et al. (2010) Fitness correlates of heritable variation in antibody responsiveness in a wild mammal. Science 330: 662-665.
9. Jouvin MH, Kinet JP, (2012) Trichuris suis ova: Testing a helminth-based therapy as an extension of the hygiene hypothesis. J Allergy Clin Immunol 130: 3-10.
10. Wolff MJ, Broadhurst MJ, Loke P, (2012) Helminthic therapy: improving mucosal barrier function. Trends Parasitol 28: 187-194.
11. Pulendran B, Artis D, (2012) New paradigms in type 2 immunity. Science 337: 431-435.
12. Artis D, Grencis RK, (2008) The intestinal epithelium: sensors to effectors in nematode infection. Mucosal Immunol 1: 252-264.
13. Allen JE, Maizels RM, (2011) Diversity and dialogue in immunity to helminths. Nat Rev Immunol 11: 375-388.
14. Taylor MD, van der Werf N, Maizels RM, (2012) T cells in helminth infection: the regulators and the regulated. Trends Immunol 33: 181-189.
15. Hussaarts L, van der Vlugt LE, Yazdanbakhsh M, Smits HH, (2011) Regulatory B-cell induction by helminths: implications for allergic disease. J Allergy Clin Immunol 128: 733-739.
16. Gordon S, Martinez FO, (2010) Alternative activation of macrophages: mechanism and functions. Immunity 32: 593-604.
17. Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, et al. (2012) Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent Type-2 immunity to helminth infection in mice. PLoS Pathog 8: e1002883 doi:10.1371/journal.ppat.1002883.
18. Correale J, Farez MF, (2011) The impact of environmental infections (parasites) on MS activity. Mult Scler 17: 1162-1169.
19. Harnett W, Harnett MM, (2010) Helminth-derived immunomodulators: can understanding the worm produce the pill? Nat Rev Immunol 10: 278-284.
20. Hewitson JP, Grainger JR, Maizels RM, (2009) Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity. Mol Biochem Parasitol 167: 1-11.
21. Elliott DE, Weinstock JV, (2011) Helminth-host immunological interactions: prevention and control of immune-mediated diseases. Ann N Y Acad Sci 1247: 83-96.
22. Cho I, Blaser MJ, (2012) The human microbiome: at the interface of health and disease. Nat Rev Genet 13: 260-270.
23. Broadhurst MJ, Ardeshir A, Kanwar B, Mirpuri J, Gundra UM, et al. (2012) Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon. PLoS Pathog 8: e1003000 doi:10.1371/journal.ppat.1003000.
24. Hooper LV, Littman DR, Macpherson AJ, (2012) Interactions between the microbiota and the immune system. Science 336: 1268-1273.