Autoantibodies against Phospholipase A2 Receptor in Korean Patients with Membranous Nephropathy

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Oh, Yun Jung ^a,b   Yang, Seung Hee ^c   Kim, Dong Ki ^a   Kang, Shin Wook ^b   Kim, Yon Su ^a,c  

^a Seoul National University Hospital   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; PHOSPHOLIPASE A2 RECEPTOR;

ADULT; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ETHNIC GROUP; FEMALE; HUMAN; HYPOALBUMINEMIA; IDIOPATHIC DISEASE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KOREAN; MAJOR CLINICAL STUDY; MALE; MEMBRANOUS GLOMERULONEPHRITIS; PROTEINURIA; ASIAN; BIOPSY; BLOOD; DISEASE COURSE; FOLLOW UP; IMMUNOLOGY; KIDNEY; MIDDLE AGED; PATHOLOGY; RISK FACTOR; SOUTH KOREA; TREATMENT OUTCOME; WESTERN BLOTTING;

ASIAN CONTINENTAL ANCESTRY GROUP; AUTOANTIBODIES; BIOPSY; BLOTTING, WESTERN; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; GLOMERULONEPHRITIS, MEMBRANOUS; HUMANS; KIDNEY; MALE; MIDDLE AGED; RECEPTORS, PHOSPHOLIPASE A2; REPUBLIC OF KOREA; RISK FACTORS; TREATMENT OUTCOME;

EID: 84876844666     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062151     Document Type: Article

References (32)

1. Wasserstein AG, (1997) Membranous glomerulonephritis. J Am Soc Nephrol 8: 664-674.
2. Couser WG, Steinmuller DR, Stilmant MM, Salant DJ, Lowenstein LM, (1978) Experimental glomerulonephritis in the isolated perfused rat kidney. J Clin Invest 62: 1275-1287.
3. Van Damme BJ, Fleuren GJ, Bakker WW, Vernier RL, Hoedemaeker PJ, (1978) Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis. Lab Invest 38: 502-510.
4. Glassock RJ, (2010) The pathogenesis of idiopathic membranous nephropathy: a 50-year odyssey. Am J Kidney Dis 56: 157-167.
5. Beck LH Jr, Bonegio RG, Lambeau G, Beck DM, Powell DW, et al. (2009) M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 361: 11-21.
6. Hofstra JM, Beck LH Jr, Beck DM, Wetzels JF, Salant DJ, (2011) Anti-phospholipase A receptor antibodies correlate with clinical status in idiopathic membranous nephropathy. Clin J Am Soc Nephrol 6: 1286-1291.
7. Qin W, Beck LH Jr, Zeng C, Chen Z, Li S, et al. (2011) Anti-phospholipase A2 receptor antibody in membranous nephropathy. J Am Soc Nephrol 22: 1137-1143.
8. Beck LH, Jr., Fervenza FC, Beck DM, Bonegio RG, Malik FA, et al. (2011) Rituximab-Induced Depletion of Anti-PLA2R Autoantibodies Predicts Response in Membranous Nephropathy. J Am Soc Nephrol.
9. Beck LH Jr, Salant DJ, (2010) Membranous nephropathy: recent travels and new roads ahead. Kidney Int 77: 765-770.
10. Hoxha E, Harendza S, Zahner G, Panzer U, Steinmetz O, et al. (2011) An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis. Nephrol Dial Transplant 26: 2526-2532.
11. Hoxha E, Kneissler U, Stege G, Zahner G, Thiele I, et al. (2012) Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy. Kidney Int.
12. Stanescu HC, Arcos-Burgos M, Medlar A, Bockenhauer D, Kottgen A, et al. (2011) Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. N Engl J Med 364: 616-626.
13. Tomura S, Kashiwabara H, Tuchida H, Shishido H, Sakurai S, et al. (1984) Strong association of idiopathic membranous nephropathy with HLA-DR2 and MT1 in Japanese. Nephron 36: 242-245.
14. Hiki Y, Kobayashi Y, Itoh I, Kashiwagi N, (1984) Strong association of HLA-DR2 and MT1 with idiopathic membranous nephropathy in Japan. Kidney Int 25: 953-957.
15. Abe S, Amagasaki Y, Konishi K, Kato E, Iyori S, et al. (1986) Idiopathic membranous glomerulonephritis: aspects of geographical differences. J Clin Pathol 39: 1193-1198.
16. Reichert LJ, Koene RA, Wetzels JF, (1998) Prognostic factors in idiopathic membranous nephropathy. Am J Kidney Dis 31: 1-11.
17. Pei Y, Cattran D, Greenwood C, (1992) Predicting chronic renal insufficiency in idiopathic membranous glomerulonephritis. Kidney Int 42: 960-966.
18. Cattran DC, Pei Y, Greenwood CM, Ponticelli C, Passerini P, et al. (1997) Validation of a predictive model of idiopathic membranous nephropathy: its clinical and research implications. Kidney Int 51: 901-907.
19. Cattran D, (2005) Management of membranous nephropathy: when and what for treatment. J Am Soc Nephrol 16: 1188-1194.
20. Levey AS, Coresh J, Balk E, Kausz AT, Levin A, et al. (2003) National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 139: 137-147.
21. Lee CS, Cha RH, Lim YH, Kim H, Song KH, et al. (2010) Ethnic coefficients for glomerular filtration rate estimation by the Modification of Diet in Renal Disease study equations in the Korean population. J Korean Med Sci 25: 1616-1625.
22. Prunotto M, Carnevali ML, Candiano G, Murtas C, Bruschi M, et al. (2010) Autoimmunity in membranous nephropathy targets aldose reductase and SOD2. J Am Soc Nephrol 21: 507-519.
23. Doi T, Mayumi M, Kanatsu K, Suehiro F, Hamashima Y, (1984) Distribution of IgG subclasses in membranous nephropathy. Clin Exp Immunol 58: 57-62.
24. Oliveira DB, (1998) Membranous nephropathy: an IgG4-mediated disease. Lancet 351: 670-671.
25. Hofstra JM, Debiec H, Short CD, Pelle T, Kleta R, et al. (2012) Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy. J Am Soc Nephrol 23: 1735-1743.
26. Bruschi M, Carnevali ML, Murtas C, Candiano G, Petretto A, et al. (2011) Direct characterization of target podocyte antigens and auto-antibodies in human membranous glomerulonephritis: Alfa-enolase and borderline antigens. J Proteomics 74: 2008-2017.
27. Wakui H, Imai H, Komatsuda A, Miura AB, (1999) Circulating antibodies against alpha-enolase in patients with primary membranous nephropathy (MN). Clin Exp Immunol 118: 445-450.
28. Gitlits VM, Toh BH, Sentry JW, (2001) Disease association, origin, and clinical relevance of autoantibodies to the glycolytic enzyme enolase. J Investig Med 49: 138-145.
29. Ponticelli C, Altieri P, Scolari F, Passerini P, Roccatello D, et al. (1998) A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. J Am Soc Nephrol 9: 444-450.
30. Jha V, Ganguli A, Saha TK, Kohli HS, Sud K, et al. (2007) A randomized, controlled trial of steroids and cyclophosphamide in adults with nephrotic syndrome caused by idiopathic membranous nephropathy. J Am Soc Nephrol 18: 1899-1904.
31. Cattran DC, Appel GB, Hebert LA, Hunsicker LG, Pohl MA, et al. (2001) Cyclosporine in patients with steroid-resistant membranous nephropathy: a randomized trial. Kidney Int 59: 1484-1490.
32. Alexopoulos E, Papagianni A, Tsamelashvili M, Leontsini M, Memmos D, (2006) Induction and long-term treatment with cyclosporine in membranous nephropathy with the nephrotic syndrome. Nephrol Dial Transplant 21: 3127-3132.