AMLODIPINE PLUS BENAZEPRIL;
BENAZEPRIL PLUS HYDROCHLOROTHIAZIDE;
CHLORTALIDONE;
NEW DRUG;
BLOOD PRESSURE;
CLINICAL PRACTICE;
CLINICAL RESEARCH;
DRUG EFFICACY;
DRUG SAFETY;
FOOD AND DRUG ADMINISTRATION;
HEART INFARCTION;
HIGH RISK PATIENT;
HUMAN;
IN VITRO STUDY;
IN VIVO STUDY;
ISOLATED ORGAN;
MAXIMUM TOLERATED DOSE;
MULTICENTER STUDY (TOPIC);
NOTE;
POSTMARKETING SURVEILLANCE;
PRACTICE GUIDELINE;
PRESCRIPTION;
PRIORITY JOURNAL;
RANDOMIZED CONTROLLED TRIAL (TOPIC);
RISK FACTOR;
SYSTOLIC HYPERTENSION;
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Consumer Organizations
Inman WHW, ed., 2nd ed. Hingham, MA: MTP Press
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(2013)
9
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EMA Web site. Accessed January 14
EMA Web site. http://www.ema.europa.eu/ema/. Accessed January 14, 2013.
(2013)
10
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PMDA Web site. Accessed January 14
PMDA Web site. http://www.pmda.go.jp/english/index.html. Accessed January 14, 2013.
(2013)
11
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ICH Web site. Accessed January 9
ICH Web site. www.ich.org. Accessed January 9, 2013.
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12
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Jan 5; [Epub ahead of print].
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EMA. Guideline on clinical investigation of medicinal products in the treatment of hypertension. November Accessed January 16, 2013.
EMA. Guideline on clinical investigation of medicinal products in the treatment of hypertension. November 2010. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2010/12/WC500100191.pdf. Accessed January 16, 2013.
(2010)
17
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Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil
Bakris GL, Sica D, White WB, et al. Antihypertensive efficacy of hydrochlorothiazide vs chlorthalidone combined with azilsartan medoxomil. Am J Med. 2012;125:1229.e1-1229.e10.
Rationale and design of a randomized clinical trial on prevention of stroke in isolated systolic hypertension
The Systolic Hypertension in the Elderly Program (SHEP) Cooperative Research Group
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Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP)
SHEP Cooperative Research Group
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Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)
ALLHAT Collaborative Research Group
ALLHAT Collaborative Research Group. Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). JAMA. 2000; 283:1967-1975.
ACCOMPLISH Trial Investigators. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients
Jamerson K, Weber MA, Bakris GL, et al. ACCOMPLISH Trial Investigators. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med. 2008;359:2417-2428.
Institute of Medicine of the National Academies. Washington, DC: The National Academies Press;
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