Out of touch with reality? Social perception in first-episode schizophrenia

Social Cognitive and Affective Neuroscience

Volumn 8, Issue 4, 2013, Pages 394-403

  Ebisch, Sjoerd J H ^a   Salone, Anatolia ^a   Ferri, Francesca ^b   De Berardis, Domenico ^a,c   Romani, Gian Luca ^a   Ferro, Filippo M ^a   Gallese, Vittorio ^b,d  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c Department of Mental Health   (Italy)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

Disturbances of self experience; Functional magnetic resonance imaging (fMRI); Multisensoryintegration; Psychosis; Self other distinction

Indexed keywords

ADULT; ARTICLE; BRAIN CORTEX; FEMALE; HUMAN; MALE; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PERCEPTION; PHYSIOLOGY; SCHIZOPHRENIA; TOUCH; VISION;

ADULT; CEREBRAL CORTEX; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; SCHIZOPHRENIA; SOCIAL PERCEPTION; TOUCH; TOUCH PERCEPTION; VISUAL PERCEPTION; YOUNG ADULT;

EID: 84876829099     PISSN: 17495016     EISSN: 17495024     Source Type: Journal    
DOI: 10.1093/scan/nss012     Document Type: Article

References (108)

1. Addington, J., Penn, D., Woods, S.W., Addington, D., Perkins, D.O. (2008a). Social functioning in individuals at clinical high risk for schizophrenia. Schizophrenia Research, 99, 119-24.
2. Addington, J., Penn, D., Woods, S.W., Addington, D., Perkins, D.O. (2008b). Facial affect recognition in individuals at clinical high risk for schizophrenia. British Journal of Psychiatry, 192, 67-8.
3. Amminger, G.P., Schafer, M.R., Papageorgiou, K., et al. (2011). Emotion recognition in individuals at clinical high-risk for schizophrenia. Schizophrenia Bulletin. [Epub ahead of print].
4. Augustine, J.R. (1996). Circuitry and functional aspects of the insular lobe in primates including humans. Brain Research Reviews, 22, 229-44.
5. Avenanti, A., Bueti, D., Galati, G., Aglioti, S.M. (2005). Transcranial magnetic stimulation highlights the sensorimotor side of empathy for pain. Nature Neuroscience, 8, 955-60.
6. Banissy, M.J., Cohen, K.R., Maus, G.W., Walsh, V., Ward, J. (2009). Prevalence, characteristics and a neurocognitive model of mirror-touch synaesthesia. Experimental Brain Research, 198, 261-72.
7. Baron-Cohen, S., Wheelwright, S. (2004). The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. Journal of Autism and Developmental Disorders, 34, 163-75.
8. Bastiaansen, J.A., Thioux, M., Nanetti, L., van der Gaag, C., Ketelaars, C., Minderaa, R., et al. (2011). Age-related increase in inferior frontal gyrus activity and social functioning in autism spectrum disorder. Biological Psychiatry, 69, 832-8.
9. Batson, C.D., Fultz, J., Schoenrade, P.A., Paduano, A. (1987). Critical self-reflection and self-perceived altruism: when self-reward fails. Journal of Personality and Social Psychology, 53, 594-602.
10. Bellack, A.S., Green, M.F., Cook, J.A., et al. (2007). Assessment of community functioning in people with schizophrenia and other severe mental illnesses: a white paper based on an NIMH-sponsored workshop. Schizophrenia Bulletin, 33, 805-22.
11. Bentall, R.P., Baker, G.A., Havers, S. (1991). Reality monitoring and psychotic hallucinations. British Journal of Clinical Psychology, 30, 213-22.
12. Blakemore, S.J., Bristow, D., Bird, G., Frith, C., Ward, J. (2005). Somatosensory activations during the observation of touch and a case of vision-touch synaesthesia. Brain, 128, 1571-83.
13. Blakemore, S.J., Smith, J., Steel, R., Johnstone, C.E., Frith, C.D. (2000). The perception of self-produced sensory stimuli in patients with auditory hallucinations and passivity experiences: evidence for a breakdown in self-monitoring. Psychological Medicine, 30, 1131-9.
14. Bleuler, E. (1911). Dementia Praecox oder Gruppe der Schizophrenien. In: Aschaffenburg, G., editor. Handbuch der Psychiatrie, Spezieller Teil, 4. Abteilung, 1. Hälfte. Leipzig: Deuticke. Translated by Zinkin, J., Lewis, N.D.C. (1950) in: Dementia Praecox or the Group of Schizophrenias. New York: International University Press.
15. Translated by Zinkin, J., Lewis, N.D.C. (1950) in: Dementia Praecox or the Group of Schizophrenias. New York: International University Press.
16. Bolognini, N., Rossetti, A., Maravita, A., Miniussi, C. (2011). Seeing touch in the somatosensory cortex: a TMS study of the visual perception of touch. Human Brain Mapping. doi: 10.1002/hbm.21172 [Epub ahead of print].
17. Botvinick, M., Cohen, J. (1998). Rubber hands "feel'touch that eyes see. Nature, 391, 756.
18. Bremmer, F., Schlack, A., Shah, N.J., et al. (2001). Polymodal motion processing in posterior parietal and premotor cortex: a human fMRI study strongly implies equivalencies between humans and monkeys. Neuron, 29, 287-96.
19. Buccino, G., Binkofski, F., Fink, G.R., et al. (2001). Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study. European Journal of Neuroscience, 13, 400-4.
20. Bufalari, I., Aprile, T., Avenanti, A., Di, R.F., Aglioti, S.M. (2007). Empathy for pain and touch in the human somatosensory cortex. Cerebral Cortex, 17, 2553-61.
21. Burns, J. (2006). The social brain hypothesis of schizophrenia. World Psychiatry, 5, 77-81.
22. Cardini, F., Costantini, M., Galati, G., Romani, G.L., Lòdavas, E., Serino, A. (2011). Viewing one's own face being touched modulates tactile perception: an fMRI study. Journal of Cognitive Neuroscience, 23, 503-13.
23. Cheng, Y., Lin, C.P., Liu, H.L., et al. (2007). Expertise modulates the perception of pain in others. Current Biology, 17, 1708-13.
24. Couture, S.M., Penn, D.L., Roberts, D.L. (2006). The functional significance of social cognition in schizophrenia: a review. Schizophrenia Bulletin, 32, S44-63.
25. Craig, A.D. (2002). How do you feel? Interoception: the sense of the physiological condition of the body. Nature Reviews Neuroscience, 3, 655-66.
26. Craig, A.D. (2009). How do you feel-now? The anterior insula and human awareness. Nature Reviews Neuroscience, 10, 59-70.
27. Critchley, H.D. (2005). Neural mechanisms of autonomic, affective, and cognitive integration. The Journal of Comparative Neurology, 493, 154-66.
28. Dayan, E., Casile, A., Levit-Binnun, N., Giese, M.A., Hendler, T., Flash, T. (2007). Neural representations of kinematic laws of motion: evidence for action-perception coupling. Proceedings of the National Academy of Science USA, 104, 20582-7.
29. de Waal, F.B. (2008). Putting the altruism back into altruism: the evolution of empathy. Annual Review of Psychology, 59, 279-300.
30. Derntl, B., Finkelmeyer, A., Toygar, T.K., et al. (2009). Generalized deficit in all core components of empathy in schizophrenia. Schizophrenia Research, 108, 197-206.
31. Dickey, C.C., Morocz, I.A., Minney, D., et al. (2010). Factors in sensory processing of prosody in schizotypal personality disorder: an fMRI experiment. Schizophrenia Research, 121, 75-89.
32. Downing, P.E., Chan, A.W., Peelen, M.V., Dodds, C.M., Kanwisher, N. (2010). Domain specificity in visual cortex. Cerebral Cortex, 16, 1453-61.
33. Eack, S.M., Mermon, D.E., Montrose, D.M., et al. (2010). Social cognition deficits among individuals at familial high risk for schizophrenia. Schizophrenia Bulletin, 36, 1081-8.
34. Ebisch, S.J., Ferri, F., Salone, A., et al. (2011). Differential involvement of somatosensory and interoceptive cortices during the observation of affective touch. Journal of Cognitive Neuroscience, 23, 1808-22.
35. Ebisch, S.J., Perrucci, M.G., Ferretti, A., Del Gratta, C., Romani, G.L., Gallese, V. (2008). The sense of touch: embodied simulation in a visuotactile mirroring mechanism for observed animate or inanimate touch. Journal of Cognitive Neuroscience, 20, 1611-23.
36. Eisenberg, N., Fabes, R.A., Miller, P.A., et al. (1989). Relation of sympathy and personal distress to prosocial behavior: a multimethod study. Journal of Personality and Social Psychology, 57, 55-66.
37. Farrer, C., Franck, N., Frith, C.D., et al. (2004). Neural correlates of action attribution in schizophrenia. Psychiatry Research, 131, 31-44.
38. Farrer, C., Franck, N., Georgieff, N., Frith, C.D., Decety, J., Jeannerod, M. (2003). Modulating the experience of agency: a positron emission tomography study. Neuroimage, 18, 324-33.
39. Fett, A.K., Viechtbauer, W., Dominguez, M.D., Penn, D.L., van Os, J., Krabbendam, L. (2011). The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neuroscience and Biobehavioral Reviews, 35, 573-88.
40. First, M.B., Spitzer, R.L., Williams, J.B.W., Gibbon, M. (1996a). Structured Clinical Interview for DSM IV Axis I Disorders-Research Version (SCID I, version 2.0). New York: Biometrics Research Department, New York State Psychiatric Institute.
41. First, M.B., Gibbon, M., Spitzer, R.L. (1996b). Structured Clinical Interview for DSM IV Axis II-Personality Disorders (SCID II, Version 2.0). New York: Biometrics Research Department, New York State Psychiatric Institute.
42. Fisher, M., McCoy, K., Poole, J.H., Vinogradov, S. (2008). Self and other in schizophrenia: a cognitive neuroscience perspective. American Journal of Psychiatry, 165, 1465-72.
43. Fogassi, L., Gallese, V., Fadiga, L., Luppino, G., Matelli, M., Rizzolatti, G. (1996b). Coding of peripersonal space in inferior premotor cortex (area F4). Journal of Neurophysiology, 76, 141-57.
44. Fogassi, L., Gallese, V., Fadiga, L., Rizzolatti, G. (1996a). Space coding in inferior premotor cortex (area F4): facts and speculations. In: Lacquaniti, F., Viviani, P., editors. NATO ASI Series: Multi-Sensory Control of Movement. Dordrecht: Kluwer, pp. 99-120.
45. Forman, S.D., Cohen, J.D., Fitzgerald, M., Eddy, W.F., Mintun, M.A., Noll, D.C. (1995). Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magnetic Resonance in Medicine, 33, 636-47.
46. Franck, N., Farrer, C., Georgieff, N., et al. (2001). Defective recognition of one's own actions in patients with schizophrenia. American Journal of Psychiatry, 158, 454-9.
47. Frith, C.D. (1987). The positive and negative symptoms of schizophrenia reflect impairments in the perception and initiation of action. Psychological Medicine, 17, 631-48.
48. Galati, G., Committeri, G., Sanes, J.N., Pizzamiglio, L. (2001). Spatial coding of visual and somatic sensory information in body-centred coordinates. European Journal of Neuroscience, 14, 737-46.
49. Gallese, V. (2003a). The manifold nature of interpersonal relations: the quest for a common mechanism. Philosophical Transactions of the Royal Society A, 358, 517-28.
50. Gallese, V. (2003b). The roots of empathy: the shared manifold hypothesis and the neural basis of intersubjectivity. Psychopathology, 36, 171-80.
51. Gallese, V., Keysers, C., Rizzolatti, G. (2004). A unifying view of the basis of social cognition. Trends in Cognitive Sciences, 8, 396-403.
52. Graziano, M.S. (2001). Is reaching eye-centered, body-centered, hand-centered, or a combination? Reviews in the Neurosciences, 12, 175-85.
53. Gusnard, D.A., Raichle, M.E. (2001). Searching for a baseline: functional imaging and the resting human brain. Nature Reviews Neuroscience, 2, 685-94.
54. Heatherton, T.F. (2011). Neuroscience of self and self-regulation. Annual Review of Psychology, 62, 363-90.
55. Horan, W.P., Kern, R.S., Shokat-Fadai, K., Sergi, M.J., Wynn, J.K., Green, M.F. (2009). Social cognitive skills training in schizophrenia: an initial efficacy study of stabilized outpatients. Schizophrenia Research, 107, 47-54.
56. Huang, J., Chan, R.C., Lu, X., Ma, Z., Li, Z., Gong, Q.Y. (2009). An exploratory study of the influence of conversation prosody on emotion and intention identification in schizophrenia. Brain Research, 1281, 58-63.
57. Huber, G. (1983). The concept of substrate-close basic symptoms and its significance for the theory and therapy of schizophrenic diseases. Nervenarzt, 54, 23-32.
58. Husserl, E. (1989). Ideas Pertaining to a Pure Phenomenology and to a Phenomenological Philosophy Second Book: Studies in the Phenomenology of Constitution. Dordrecht: Kluwer Academic Publishers.
59. Ihnen, G.H., Penn, D.L., Corrigan, P.W., Martin, J. (1998). Social perception and social skill in schizophrenia. Psychiatry Research, 80, 275-86.
60. Karnath, H.O., Baier, B., Nagele, T. (2005). Awareness of the functioning of one's own limbs mediated by the insular cortex? Journal of Neuroscience, 25, 7134-8.
61. Kay, S.R., Fiszbein, A., Opler, L.A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bulletin, 13, 261-76.
62. Keysers, C., Gazzola, V. (2009). Expanding the mirror: vicarious activity for actions, emotions, and sensations. Current Opinion in Neurobiology, 19, 666-71.
63. Keysers, C., Kaas, J.H., Gazzola, V. (2010). Somatosensation in social perception. Nature Reviews Neuroscience, 11, 417-28.
64. Keysers, C., Wicker, B., Gazzola, V., Anton, J.L., Fogassi, L., Gallese, V. (2004). A touching sight: SII/PV activation during the observation and experience of touch. Neuron, 42, 335-46.
65. Klosterkotter, J. (1992). The meaning of basic symptoms for the genesis of the schizophrenic nuclear syndrome. Japanese Journal of Psychiatry and Neurology, 46, 609-30.
66. Klosterkötter, J., Hellmich, M., Steinmeyer, E.M., Schultze-Lutter, F. (2001). Diagnosing schizophrenia in the initial prodromal phase. Archives of General Psychiatry, 58, 158-64.
67. Kohler, C.G., Bilker, W., Hagendoorn, M., Gur, R.E., Gur, R.C. (2000). Emotion recognition deficit in schizophrenia: association with symptomatology and cognition. Biological Psychiatry, 48, 127-36.
68. Lamm, C., Decety, J., Singer, T. (2011). Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain. Neuroimage, 54, 2492-502.
69. Lawrence, E.J., Shaw, P., Baker, D., Baron-Cohen, S., David, A.S. (2004). Measuring empathy: reliability and validity of the Empathy Quotient. Psychological Medicine, 34, 911-9.
70. Linden, S.C., Jackson, M.C., Subramanian, L., Wolf, C., Green, P., Healy, D., et al. (2010). Emotion-cognition interactions in schizophrenia: implicit and explicit effects of facial expression. Neuropsychologia, 48, 997-1002.
71. Loken, L.S., Wessberg, J., Morrison, I., McGlone, F., Olausson, H. (2009). Coding of pleasant touch by unmyelinated afferents in humans. Nature Neuroscience, 12, 547-8.
72. Makin, T.R., Holmes, N.P., Zohary, E. (2007). Is that near my hand? Multisensory representation of peripersonal space in human intraparietal sulcus. Journal of Neuroscience, 27, 731-40.
73. Marjoram, D., Gardner, C., Burns, J., Miller, P., Lawrie, S.M., Johnstone, E.C. (2005). Symptomatology and social inference: a theory of mind study of schizophrenia and psychotic affective disorder. Cognitive Neuropsychiatry, 10, 347-59.
74. Menon, V., Uddin, L.Q. (2010). Saliency, switching, attention and control: a network model of insula function. Brain Structure and Function, 214, 655-67.
75. Meyer, K., Kaplan, J.T., Essex, R., Damasio, H., Damasio, A. (2011). Seeing touch is correlated with content-specific activity in primary somatosensory cortex. Cerebral Cortex, 21, 2113-21.
76. Minkowski, E. (1927). La schizophrénie. Psychopathologie des schizoïdes et des schizophrènes. Paris: Payot. Translated in part by Cutting, J. Reprinted (1986) in: The Clinical Roots of the Schizophrenia Concept (eds J. Cutting and M. Shepherd). Cambridge: Cambridge University Press.
77. Morgan, H.L., Turner, D.C., Corlett, P.R., et al. (2011). Exploring the impact of ketamine on the experience of illusory body ownership. Biological Psychiatry, 69, 35-41. 402 SCAN (2013) S. J.H. Ebisch et al.
78. Nichols, T., Brett, M., Andersson, J., Wager, T., Poline, J.B. (2005). Valid conjunction inference with the minimum statistic. Neuroimage, 25, 653-60.
79. Northoff, G. (2007). Psychopathology and pathophysiology of the self in depression - neuropsychiatric hypothesis. Journal of Affective Disorders, 104, 1-14.
80. Olausson, H., Lamarre, Y., Backlund, H., et al. (2002). Unmyelinated tactile afferents signal touch and project to insular cortex. Nature Neuroscience, 5, 900-4.
81. Parnas, J., Bovet, P., Zahavi, D. (2002). Schizophrenic autism: clinical phenomenology and pathogenetic implications. World Psychiatry, 1, 131-6.
82. Peelen, M.V., Downing, P.E. (2007). The neural basis of visual body perception. Nature Reviews Neuroscience, 8, 636-48.
83. Peled, A., Ritsner, M., Hirschmann, S., Geva, A.B., Modai, I. (2000). Touch feel illusion in schizophrenic patients. Biological Psychiatry, 48, 1105-8.
84. Phillips, M.L., Drevets, W.C., Rauch, S.L., Lane, R. (2003). Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biological Psychiatry, 54, 515-28.
85. Phillips, L.K., Seidman, L.J. (2008). Emotion processing in persons at risk for schizophrenia. Schizophrenia Bulletin, 34, 888-903.
86. Pihko, E., Nangini, C., Jousmaki, V., Hari, R. (2010). Observing touch activates human primary somatosensory cortex. European Journal of Neuroscience, 31, 1836-43.
87. Pinkham, A.E., Penn, D.L., Perkins, D.O., Lieberman, J. (2003). Implications for the neural basis of social cognition for the study of schizophrenia. American Journal of Psychiatry, 160, 815-24.
88. Pitcher, D., Garrido, L., Walsh, V., Duchaine, B.C. (2008). Transcranial magnetic stimulation disrupts the perception and embodiment of facial expressions. Journal of Neuroscience, 28, 8929-33.
89. Poldrack, R.A. (2007). Region of interest analysis for fMRI. Social Cognitive and Affective Neuroscience, 2, 67-70.
90. Rizzolatti, G., Fogassi, L., Gallese, V. (2002). Motor and cognitive functions of the ventral premotor cortex. Current Opinion in Neurobiology, 12, 149-54.
91. Rizzolatti, G., Scandolara, C., Matelli, M., Gentilucci, M. (1981a). Afferent properties of periarcuate neurons in macaque monkeys. I. Somatosensory responses. Behavioural Brain Research, 2, 125-46.
92. Rizzolatti, G., Scandolara, C., Matelli, M., Gentilucci, M. (1981b). Afferent properties of periarcuate neurons in macaque monkeys. II. Visual responses. Behavioural Brain Research, 2, 147-63.
93. Roux, P., Christophe, A., Passerieux, C. (2010). The emotional paradox: dissociation between explicit and implicit processing of emotional prosody in schizophrenia. Neuropsychologia, 48, 3642-9.
94. Saper, C.B. (2002). The central autonomic nervous system: conscious visceral perception and autonomic pattern generation. Annual Review of Neuroscience, 25, 433-69.
95. Sass, L.A., Parnas, J. (2003). Schizophrenia, consciousness, and the self. Schizophrenia Bulletin, 29, 427-44.
96. Schaefer, M., Xu, B., Flor, H., Cohen, L.G. (2009). Effects of different viewing perspectives on somatosensory activations during observation of touch. Human Brain Mapping, 30, 2722-30.
97. Schultze-Lutter, F. (2009). Subjective symptoms of schizophrenia in research and the clinic: the basic symptom concept. Schizophrenia Bulletin, 35, 5-8.
98. Schultze-Lutter, F., Addington, J., Ruhrmann, S., Klosterkötter, J. (2007). Strumento di valutazione per la propensione alla schizofrenia. Versione per adulti. Trad. Giuliano Aiello. Rome: Giovanni Fioriti Editore s.r.l. Translated by Aiello G. (2011). Rome: Giovanni Fioriti Editore s.r.l.
99. Serino, A., Canzoneri, E., Avenanti, A. (2011). Fronto-parietal areas necessary for a multisensory representation of peripersonal space in humans: an rTMS study. Journal of Cognitive Neuroscience, 23, 2956-67.
100. Shean, G., Murphy, A., Meyer, J. (2005). Social cognition and symptom dimensions. The Journal of Nervous and Mental Disease, 193, 751-5.
101. Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R.J., Frith, C.D. (2004). Empathy for pain involves the affective but not sensory components of pain. Science, 303, 1157-62.
102. Taylor, K.S., Seminowicz, D.A., Davis, K.D. (2009). Two systems of resting state connectivity between the insula and cingulate cortex. Human Brain Mapping, 30, 2731-45.
103. Tsakiris, M., Hesse, M.D., Boy, C., Haggard, P., Fink, G.R. (2007). Neural signatures of body ownership: a sensory network for bodily self-consciousness. Cerebral Cortex, 17, 2235-44.
104. van der Meer, L., Costafreda, S., Aleman, A., David, A.S. (2010). Self-reflection and the brain: a theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia. Neuroscience and Biobehavioral Reviews, 34, 935-46.
105. Vinogradov, S., Luks, T.L., Schulman, B.J., Simpson, G.V. (2008). Deficit in a neural correlate of reality monitoring in schizophrenia patients. Cerebral Cortex, 18, 2532-9.
106. Vogt, B.A. (2005). Pain and emotion interactions in subregions of the cingulate gyrus. Nature Reviews Neuroscience, 6, 533-44.
107. Voss, M., Moore, J., Hauser, M., Gallinat, J., Heinz, A., Haggard, P. (2010). Altered awareness of action in schizophrenia: a specific deficit in predicting action consequences. Brain, 133, 3104-12.
108. Wood, R., Gallese, V., Cattaneo, L. (2010). Visuotactile empathy within the primary somatosensory cortex revealed by short-latency afferent inhibition. Neuroscience Letters, 473, 28-31.