Thrombosis during off pump LVAD placement in a patient with heparin induced thrombocytopenia using bivalirudin

Journal of Cardiothoracic Surgery

Volumn 8, Issue 1, 2013, Pages

  Awad, Hamdy ^a   Bryant, Richard ^a   Malik, Obaid ^b   Dimitrova, Galina ^a   Sai Sudhakar, Chittoor Bhaskar ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Bivalirudin; HeartMate II; Heparin induced thrombocytopenia; HITT; Left ventricular assist device; LVAD; Off pump; Pharmacology; Stasis

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN; HEPARIN; HIRUDIN DERIVATIVE; HIRULOG; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN;

ADVERSE EFFECTS; AGED; BLOOD CLOTTING; CASE REPORT; CHEMICALLY INDUCED; COMPLICATION; FEMALE; HEART ASSIST DEVICE; HEART VENTRICLE; HUMAN; THORAX SURGERY; THROMBOCYTOPENIA; THROMBOSIS;

AGED; ANTICOAGULANTS; ANTITHROMBINS; BLOOD COAGULATION; FEMALE; HEART VENTRICLES; HEART-ASSIST DEVICES; HEPARIN; HIRUDINS; HUMANS; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; THORACIC SURGICAL PROCEDURES; THROMBOCYTOPENIA; THROMBOSIS;

EID: 84876806305     PISSN: None     EISSN: 17498090     Source Type: Journal    
DOI: 10.1186/1749-8090-8-115     Document Type: Article

References (12)

1. Awad H, Dayem MAE, Heard J, Dimitrova G, Yu L, Sun BC. Initial experience with off-pump left ventricular assist device implantation in single center: retrospective analysis. J Cardiothorac Surg 2010, 5:123. 10.1186/1749-8090-5-123, 3016251, 21134285.
2. Koster A, Dyke CM, Aldea G, Smedira NG, McCarthy HL, Aronson S, Hetzer R, Avery E, Spiess B, Lincoff AM. Bivalirudin during cardiopulmonary bypass in patients with previous or acute heparin-induced thrombocytopenia and heparin antibodies: results of the CHOOSE-ON trial. Ann Thorac Surg 2007, 83:572-577. 10.1016/j.athoracsur.2006.09.038, 17257990.
3. Dyke CM, Aldea G, Koster A, Smedira N, Avery E, Aronson S, Spiess BD, Lincoff AM. Off-pump coronary artery bypass with bivalirudin for patients with heparin-induced thrombocytopenia or antiplatelet factor four/heparin antibodies. Ann Thorac Surg 2007, 84:836-839. 10.1016/j.athoracsur.2007.04.007, 17720385.
4. Sun BC, Firstenberg MS, Louis LB, Panza A, Crestanello JA, Sirak J, Sai-Sudhakar CB. Placement of long-term implantable ventricular assist devices without the use of cardiopulmonary bypass. J Heart Lung Transplant 2008, 27:718-721. 10.1016/j.healun.2008.03.020, 18582799.
5. Dyke CM, Smedira NG, Koster A. A comparison of bivalirudin to heparin with protamine reversal in patients undergoing cardiac surgery with cardiopulmonary bypass: the EVOLUTION-ON study. J Thorac Cardiovasc Surg 2006, 131:533-539. 10.1016/j.jtcvs.2005.09.057, 16515902.
6. Smedira NG, Dyke CM, Koster A. Anticoagulation with bivalirudin for off-pump coronary artery bypass grafting: the results of the EVOLUTION-OFF study. J Thorac Cardiovasc Surg 2006, 131:686-692. 10.1016/j.jtcvs.2005.10.049, 16515924.
7. Merry A, Raudkivi PJ, Middelton NG. Bivalirudin versus heparin and protamine in off-pump coronary artery bypass surgery. Ann Thorac Surg 2004, 77:925-931. 10.1016/j.athoracsur.2003.09.061, 14992900.
8. Czosnowski QA, Finks SW, Rogers KC. Bivalirudin for patients with heparin-induced thrombocytopenia undergoing cardiovascular surgery. Ann Pharmacother 2008, 42:1304-1309. 10.1345/aph.1K601, 18682541.
9. Wong JK, Tian Y, Shuttleworth P, Caffarelli AD, Reitz BA, Mora-Mangano CT. Case report: a thrombus in the venous reservoir while using bivalirudin in a patient with heparin-induced thrombocytopenia undergoing heart transplantation. Anesth Analg 2010, 111:609-612. 10.1213/ANE.0b013e3181e9ead3, 20686010.
10. Ranucci M. Bivalirudin and post-cardiotomy ECMO: a word of caution. Critical care (London, England) 2012, 16:427.
11. Nielsen VG, Steenwyk BL, Gurley WQ, Pereira SJ, Lell WA, Kirklin JK. Argatroban, bivalirudin, and lepirudin do not decrease clot propagation and strength as effectively as heparin-activated antithrombin in vitro. J Heart Lung Transplant 2006, 25:653-663. 10.1016/j.healun.2006.02.010, 16730571.
12. Salemi A, Agrawal YP, Fontes MA. An assay to monitor bivalirudin levels on cardiopulmonary bypass. Ann Thorac Surg 2011, 92:332-334. 10.1016/j.athoracsur.2010.12.064, 21718867.