The potential value of phosphohistone-H3 mitotic index determined by digital image analysis in the assessment of pancreatic endocrine tumors in fine-needle aspiration cytology specimens

Acta Cytologica

Volumn 57, Issue 3, 2013, Pages 291-295

  Draganova Tacheva, Rossitza ^a   Bibbo, Marluce ^a   Birbe, Ruth ^a   Daskalakis, Constantine ^a   Solomides, Charalambos ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Digital image analysis; Endocrine tumors; Ki67 proliferation index; Pancreas; Phosphohistone H3 mitotic index

Indexed keywords

HISTONE H3; KI 67 ANTIGEN; PHOSPHOHISTONE H3; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; ASPIRATION CYTOLOGY; CANCER CELL; CANCER GRADING; COMPUTER ANALYSIS; DIGITAL IMAGING; FINE NEEDLE ASPIRATION CYTOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MITOSIS; PANCREAS ISLET CELL TUMOR; PRIORITY JOURNAL; RETROSPECTIVE STUDY;

EID: 84876800224     PISSN: 00015547     EISSN: 19382650     Source Type: Journal    
DOI: 10.1159/000350885     Document Type: Article

References (8)

1. Bosman FT, Carneiro F, Hruban RH, Theise ND (eds): WHO Classification of Tumours of the Digestive System, ed 4. Geneva, WHO, 2010.
2. Piani C, Franchi GM, Cappelletti C, Scavini M, Albarello L, Zerbi A, Giorgio Arcidiacono P, Bosi E, Manzoni MF: Cytological Ki-67 in pancreatic endocrine tumours: an opportunity for pre-operative grading. Endocr Relat Cancer 2008; 15: 175-181.
3. Jamali M, Chetty R: Predicting prognosis in gastroentero-pancreatic neuroendocrine tumors: an overview and the value of Ki-67 immunostaining. Endocr Pathol 2008; 19: 282-288.
4. Klimstra DS, Modlin IR, Adsay NV, Chetty R, Deshpande V, Gönen M, Jensen RT, Kidd M, Kulke MH, Lloyd RV, Moran C, Moss SF, Oberg K, O'Toole D, Rindi G, Robert ME, Suster S, Tang LH, Tzen CY, Washington MK, Wiedenmann B, Yao J: Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set. Am J Surg Pathol 2010; 34: 300-313.
5. Chatzipantelis P, Konstantinou P, Kaklamanos M, Apostolou G, Salla C: The role of cytomorphology and proliferative activity in predicting biologic behavior of pancreatic neuroendocrine tumors: a study by endoscopic ultrasound-guided fine-needle aspiration cytology. Cancer 2009; 117: 211-216.
6. Alexiev BA, Darwin PE, Goloubeva O, Ioffe OB: Proliferative rate in endoscopic ultrasound fine-needle aspiration of pancreatic endocrine tumors: correlation with clinical behavior. Cancer 2009; 117: 40-45.
7. Kim YJ, Ketter R, Steudel WI, Feiden W: Prognostic significance of the mitotic index using the mitosis marker anti-phosphohistone H3 in meningiomas. Am J Clin Pathol 2007; 128: 118-125.
8. Ong CW, Kim LG, Kong HH, Low LY, Wang TT, Supriya S, Kathiresan M, Soong R, Salto-Tellez M: Computer-assisted pathological immunohistochemistry scoring is more timeeffective than conventional scoring, but provides no analytical advantage. Histopathology 2010; 56: 523-529.