Complete response of 7 years' duration after chemoradiotherapy followed by gefitinib in a patient with intramedullary spinal cord metastasis from lung adenocarcinoma

Journal of Thoracic Disease

Volumn 5, Issue 2, 2013, Pages

  Hata, Yoshinobu ^a   Takai, Yujiro ^a   Takahashi, Hiroshi ^a   Takagi, Keigo ^a   Isobe, Kazutoshi ^a   Hasegawa, Chikako ^a   Shibuya, Kazutoshi ^a   Goto, Hidenori ^a   Tamaki, Kazuyoshi ^a   Sato, Fumitomo ^a   Otsuka, Hajime ^a  

^a TOHO UNIVERSITY OMORI MEDICAL CENTER   (Japan)

Author keywords

EGFR; Gefitinib; Intramedullary spinal cord metastasis; Lung cancer; Magnetic resonance imaging; Positron emission tomography

Indexed keywords

CARBOPLATIN; CARCINOEMBRYONIC ANTIGEN; CISPLATIN; DOCETAXEL; GADOLINIUM; GEFITINIB; NAVELBINE; STEROID;

ADULT; ARTICLE; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CASE REPORT; CLINICAL FEATURE; CONTRAST ENHANCEMENT; DIAGNOSTIC IMAGING; DISEASE ASSOCIATION; DISEASE DURATION; DOSE RESPONSE; DOSIMETRY; DRUG MEGADOSE; HUMAN; IMAGE ANALYSIS; LUNG ADENOCARCINOMA; LUNG SURGERY; MALE; MEDICAL HISTORY; MULTIPLE CYCLE TREATMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; POSITRON EMISSION TOMOGRAPHY; SPINAL CORD METASTASIS; TREATMENT RESPONSE;

EID: 84876793256     PISSN: 20721439     EISSN: 20776624     Source Type: Journal    
DOI: 10.3978/j.issn.2072-1439.2012.12.09     Document Type: Article

References (15)

1. Kalayci M, Caǧavi F, Gül S, et al. Intramedullary spinal cord metastases: diagnosis and treatment - an illustrated review. Acta Neurochir (Wien) 2004;146:1347-54; discussion 1354.
2. Grem JL, Burgess J, Trump DL. Clinical features and natural history of intramedullary spinal cord metastasis. Cancer 1985;56:2305-14.
3. Mut M, Schiff D, Shaffrey ME. Metastasis to nervous system: spinal epidural and intramedullary metastases. J Neurooncol 2005;75:43-56.
4. Sung WS, Sung MJ, Chan JH, et al. Intramedullary Spinal Cord Metastases: A 20-Year Institutional Experience with a Comprehensive Literature Review. World Neurosurg 2012. [Epub ahead of print].
5. Detterbeck FC, Boffa DJ, Tanoue LT. The new lung cancer staging system. Chest 2009;136:260-71.
6. Connolly ES Jr, Winfree CJ, McCormick PC, et al. Intramedullary spinal cord metastasis: report of three cases and review of the literature. Surg Neurol 1996;46:329-37; discussion 337-8.
7. Schiff D, O'Neill BP. Intramedullary spinal cord metastases: clinical features and treatment outcome. Neurology 1996;47:906-12.
8. Grasso G, Meli F, Patti R, et al. Intramedullary spinal cord tumor presenting as the initial manifestation of metastatic colon cancer: case report and review of the literature. Spinal Cord 2007;45:793-6.
9. Findlay JM, Bernstein M, Vanderlinden RG, et al. Microsurgical resection of solitary intramedullary spinal cord metastases. Neurosurgery 1987;21:911-5.
10. Kaya RA, Dalkiliç T, Ozer F, et al. Intramedullary spinal cord metastasis: a rare and devastating complication of cancer-two case reports. Neurol Med Chir (Tokyo) 2003;43:612-5.
11. Ogino M, Ueda R, Nakatsukasa M, et al. Successful removal of solitary intramedullary spinal cord metastasis from colon cancer. Clin Neurol Neurosurg 2002;104:152-6.
12. Sutter B, Arthur A, Laurent J, et al. Treatment options and time course for intramedullary spinal cord metastasis. Report of three cases and review of the literature. Neurosurg Focus 1998;4:e3.
13. Raco A, Delfini R, Salvati M, et al. Intramedullary metastasis of unknown origin: a case report. Neurosurg Rev 1992;15:135-8.
14. Watanabe M, Nomura T, Toh E, et al. Intramedullary spinal cord metastasis: a clinical and imaging study of seven patients. J Spinal Disord Tech 2006;19:43-7.
15. Kalikaki A, Koutsopoulos A, Trypaki M, et al. Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC. Br J Cancer 2008;99:923-9.