Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor

Journal of Lipid Research

Volumn 54, Issue 5, 2013, Pages 1410-1420

  Zhang, Li ^a   Xu, Ming ^b   Scotti, Elena ^a   Chen, Zhijian J ^b   Tontonoz, Peter ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

E3 ubiquitinligase; Low density lipoprotein receptor; Lysosomal protein degradation; Proteasomal protein degradation

Indexed keywords

ARGININE; CYSTEINE; INTERLEUKIN 1BETA; LOW DENSITY LIPOPROTEIN RECEPTOR; LYSINE; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME E2;

ARTICLE; CELL FREE SYSTEM; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VITRO STUDY; LYSOSOME; MUTANT; MUTATIONAL ANALYSIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN TRANSPORT; RNA INTERFERENCE; UBIQUITINATION;

CELL-FREE SYSTEM; ENDOCYTOSIS; HEK293 CELLS; HUMANS; LIPOPROTEINS; LYSOSOMES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; RECEPTORS, LDL; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84876784016     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M035774     Document Type: Article

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