Prognostic impact of blood urea nitrogen changes during hospitalization in patients with acute heart failure syndrome

Circulation Journal

Volumn 77, Issue 5, 2013, Pages 1221-1228

  Miura, Masanobu ^a   Sakata, Yasuhiko ^a   Nochioka, Kotaro ^a   Takahashi, Jun ^a   Takada, Tsuyoshi ^a   Miyata, Satoshi ^a   Hiramoto, Tetsuya ^b   Inoue, Kan Ichi ^c   Tamaki, Kenji ^d   Shiba, Nobuyuki ^e   Shimokawa, Hiroaki ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Osaki Citizen Hospital   (Japan)

^c South Miyagi Medical Center   (Japan)

^d Iwate Prefectural Central Hospital   (Japan)

^e INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

Author keywords

Acute heart failure syndrome; Blood urea nitrogen; Neurohumoral activation; Renal dysfunction

Indexed keywords

CREATININE; FUROSEMIDE; SPIRONOLACTONE;

ACUTE HEART FAILURE; ADULT; ARTICLE; COHORT ANALYSIS; CONFIDENCE INTERVAL; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HAZARD RATIO; HOSPITALIZATION; HUMAN; KAPLAN MEIER METHOD; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PROGNOSIS; RETROSPECTIVE STUDY; SYSTOLIC BLOOD PRESSURE; UREA NITROGEN BLOOD LEVEL;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BLOOD PRESSURE; BLOOD UREA NITROGEN; FEMALE; GLOMERULAR FILTRATION RATE; HEART FAILURE; HOSPITALIZATION; HUMANS; JAPAN; KAPLAN-MEIER ESTIMATE; KIDNEY; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; REGISTRIES; RETROSPECTIVE STUDIES; RISK FACTORS; SYNDROME; SYSTOLE; TIME FACTORS;

EID: 84876774709     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-12-1390     Document Type: Article

References (24)

1. Kazory A. Emergence of blood urea nitrogen as a biomarker of neurohormonal activation in heart failure. Am J Cardiol 2010; 106: 694-700.
2. Fonarow GC, Adams KF Jr, Abraham WT, Yancy CW, Boscardin WJ; ADHERE Scientific Advisory Committee, Study Group, and Investigators. Risk stratification for in-hospital mortality in acutely decompensated heart failure: Classification and regression tree analysis. JAMA 2005; 293: 572-580.
3. Chen CY, Yoshida A, Asakura M, Hasegawa T, Takahama H, Amaki M, et al. Serum blood urea nitrogen and plasma brain natriuretic peptide and low diastolic blood pressure predict cardiovascular morbidity and mortality following discharge in acute decompensated heart failure patients. Circ J 2012; 76: 2372-2379.
4. Aronson D, Mittleman MA, Burger AJ. Elevated blood urea nitrogen level as a predictor of mortality in patients admitted for decompensated heart failure. Am J Med 2004; 116: 466-473.
5. Smith GL, Shlipak MG, Havranek EP, Foody JM, Masoudi FA, Rathore SS, et al. Serum urea nitrogen, creatinine, and estimators of renal function: Mortality in older patients with cardiovascular disease. Arch Intern Med 2006; 166: 1134-1142.
6. Kinugasa Y, Kato M, Sugihara S, Hirai M, Kotani K, Ishida K, et al. A simple risk score to predict in-hospital death of elderly patients with acute decompensated heart failure: Hypoalbuminemia as an additional prognostic factor. Circ J 2009; 73: 2276-2281.
7. Filippatos G, Rossi J, Lloyd-Jones DM, Stough WG, Ouyang J, Shin DD, et al. Prognostic value of blood urea nitrogen in patients hospitalized with worsening heart failure: Insights from the Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Chronic Heart Failure (ACTIV in CHF) study. J Card Fail 2007; 13: 360-364.
8. Klein L, Massie BM, Leimberger JD, O'Connor CM, Piña IL, Adams KF Jr, et al; OPTIME-CHF Investigators. Hospitalization or changes in renal function during hospitalization for worsening heart failure predict post discharge survival: Results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF). Circ Heart Fail 2008; 1: 25-33.
9. McKee PA, Castelli WP, McNamara PM, Kannel WB. The natural history of congestive heart failure: The Framingham study. N Engl J Med 1971; 285: 1441-1446.
10. Imai E, Horio M, Nitta K, Yamagata K, Iseki K, Hara S, et al. Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease. Clin Exp Nephrol 2007; 11: 41-50.
11. Krumholz HM, Chen YT, Vaccarino V, Wang Y, Radford MJ, Bradford WD, et al. Correlates and impact on outcomes of worsening renal function in patients > or =65 years of age with heart failure. Am J Cardiol 2000; 85: 1110-1113.
12. Forman DE, Butler J, Wang Y, Abraham WT, O'Connor CM, Gottlieb SS, et al. Incidence, predictors at hospitalization, and impact of worsening renal function among patients hospitalized with heart failure. J Am Coll Cardiol 2004; 43: 61-67.
13. Cowie MR, Komajda M, Murray-Thomas T, Underwood J, Ticho B; POSH Investigators. Prevalence and impact of worsening renal function in patients hospitalized with decompensated heart failure: Results of the prospective outcomes study in heart failure (POSH). Eur Heart J 2006; 27: 1216-1222.
14. Aronson D, Burger AJ. The relationship between transient and persistent worsening renal function and mortality in patients with acute decompensated heart failure. J Card Fail 2010; 16: 541-547.
15. Gotsman I, Zwas D, Planer D, Admon D, Lotan C, Keren A. The significance of serum urea and renal function in patients with heart failure. Medicine (Baltimore) 2010; 89: 197-203.
16. Singh G, Peterson EL, Wells K, Williams LK, Lanfear DE. Comparison of renal predictors for in-hospital and postdischarge mortality after hospitalized heart failure. J Cardiovasc Med 2012; 13: 246-253.
17. Schrier RW. Blood urea nitrogen and serum creatinine: Not married in heart failure. Circ Heart Fail 2008; 1: 2-5.
18. Shirakabe A, Hata N, Kobayashi N, Shinada T, Tomita K, Tsurumi M, et al. Prognostic impact of acute kidney injury in patients with acute decompensated heart failure. Circ J 2013; 77: 687-696.
19. Gheorghiade M, Abraham WT, Albert NM, Greenberg BH, O'Connor CM, She L, et al; OPTIMIZE-HF Investigators and Coordinators. Systolic blood pressure at hospitalization, clinical characteristics, and outcomes in patients hospitalized with acute heart failure. JAMA 2006; 296: 2217-2226.
20. Voors AA, Davison BA, Felker GM, Ponikowski P, Unemori E, Cotter G, et al; Pre-RELAX-AHF study group. Early drop in systolic blood pressure and worsening renal function in acute heart failure: Renal results of Pre-RELAX-AHF. Eur J Heart Fail 2011; 13: 961-967.
21. Ito H, Nagatomo Y, Kohno T, Anzai T, Meguro T, Ogawa S, et al. Differential effects of carvedilol and metoprolol on renal function in patients with heart failure. Circ J 2010; 74: 1578-1583.
22. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al. 2009 Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the ACC/AHA Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation. J Am Coll Cardiol 2009; 53: e1-e90.
23. Adams KF Jr, Fonarow GC, Emerman CL, LeJemtel TH, Costanzo MR, Abraham WT, et al; ADHERE Scientific Advisory Committee and Investigators. Characteristics and outcomes of patients hospitalized for heart failure in the United States: Rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J 2005; 149: 209-216.
24. Nieminen MS, Brutsaert D, Dickstein K, Drexler H, Follath F, Harjola VP, et al; EuroHeart Survey Investigators; Heart Failure Association, European Society of Cardiology. EuroHeart Failure Survey II (EHFS II): A survey on hospitalized acute heart failure patients: Description of population. Eur Heart J 2006; 27: 2725-2736.