-
1
-
-
77957350123
-
Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors
-
abstr.8503
-
Kefford R, Arkenau H, Brown MP, et al. Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors. J Clin Oncol 2010;28(Suppl.; abstr.8503): 611s.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
, pp. 611
-
-
Kefford, R.1
Arkenau, H.2
Brown, M.P.3
-
2
-
-
84876756447
-
-
accessed 1 Dec 2012
-
Catalogue of somatic mutation in cancer (COSMIC). http://www.sanger.ac. uk/cosmic (accessed 1 Dec 2012).
-
-
-
-
3
-
-
79953326958
-
Targeting BRAF in advanced melanoma: A first step toward manageable disease
-
Vultur A, Villanueva J, Herlyn M. Targeting BRAF in advanced melanoma: a first step toward manageable disease. Clin Cancer Res 2011;17: 1658-63.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1658-1663
-
-
Vultur, A.1
Villanueva, J.2
Herlyn, M.3
-
4
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
Hauschild A, Grob JJ, Demidov LV, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012;380: 358-65.
-
(2012)
Lancet
, vol.380
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
-
6
-
-
84874786489
-
Mechanisms of acquired resistance to ERK1/2 pathway inhibitors
-
May 7. doi: 10.1038/onc.2012.160. [Epub ahead of print].
-
Little AS, Smith PD, Cook SJ. Mechanisms of acquired resistance to ERK1/2 pathway inhibitors. Oncogene 2012 May 7. doi: 10.1038/onc.2012.160. [Epub ahead of print].
-
(2012)
Oncogene
-
-
Little, A.S.1
Smith, P.D.2
Cook, S.J.3
-
7
-
-
78650303507
-
Melanomas acquire resistance to BRAF(V600E) inhibition by RTK or N-RAS upregulation
-
Nazarian R, Shi HB, Wang Q, et al. Melanomas acquire resistance to BRAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 2010;468: 973-U377.
-
(2010)
Nature
, vol.468
-
-
Nazarian, R.1
Shi, H.B.2
Wang, Q.3
-
8
-
-
79960946383
-
Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition
-
Shi H, Kong X, Ribas A, et al. Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition. Cancer Res 2011;71: 5067-74.
-
(2011)
Cancer Res
, vol.71
, pp. 5067-5074
-
-
Shi, H.1
Kong, X.2
Ribas, A.3
-
9
-
-
78650303507
-
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
-
Nazarian R, Shi H, Wang Q, et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 2010;468: 973-7.
-
(2010)
Nature
, vol.468
, pp. 973-977
-
-
Nazarian, R.1
Shi, H.2
Wang, Q.3
-
10
-
-
14544284502
-
Risks and benefits of phase 1 oncology trials, 1991 through 2002
-
DOI 10.1056/NEJMsa042220
-
Horstmann E, McCabe MS, Grochow L, et al. Risks and benefits of phase 1 oncology trials, 1991 through 2002. N Engl J Med 2005;352: 895-904. (Pubitemid 40300298)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.9
, pp. 895-904
-
-
Horstmann, E.1
McCabe, M.S.2
Grochow, L.3
Yamamoto, S.4
Rubinstein, L.5
Budd, T.6
Shoemaker, D.7
Emanuel, E.J.8
Grady, C.9
-
11
-
-
80054790555
-
BRAF mutations in advanced cancers: Clinical characteristics and outcomes
-
El-Osta H, Falchook G, Tsimberidou A, et al. BRAF mutations in advanced cancers: clinical characteristics and outcomes. PLoS One 2011;6:e25806.
-
(2011)
PLoS One
, vol.6
-
-
El-Osta, H.1
Falchook, G.2
Tsimberidou, A.3
-
12
-
-
84863338519
-
PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations
-
Janku F, Wheler JJ, Westin SN, et al. PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol 2012;30: 777-82.
-
(2012)
J Clin Oncol
, vol.30
, pp. 777-782
-
-
Janku, F.1
Wheler, J.J.2
Westin, S.N.3
-
13
-
-
33751184938
-
Detection of BRAF V600E mutation in colorectal cancer: Comparison of automatic sequencing and real-time chemistry methodology
-
DOI 10.2353/jmoldx.2006.060070
-
Benlloch S, Paya A, Alenda C, et al. Detection of BRAF V600E mutation in colorectal cancer: comparison of automatic sequencing and real-time chemistry methodology. J Mol Diagn 2006;8: 540-3. (Pubitemid 44774151)
-
(2006)
Journal of Molecular Diagnostics
, vol.8
, Issue.5
, pp. 540-543
-
-
Benlloch, S.1
Paya, A.2
Alenda, C.3
Bessa, X.4
Andreu, M.5
Jover, R.6
Castells, A.7
Llor, X.8
Aranda, F.I.9
Massuti, B.10
-
14
-
-
84866879524
-
Detecting BRAF mutations in formalin-fixed melanoma: Experiences with two state-of-the-art techniques
-
Schoenewolf NL, Dummer R, Mihic-Probst D, et al. Detecting BRAF mutations in formalin-fixed melanoma: experiences with two state-of-the-art techniques. Case Rep Oncol 2012;5: 280-9.
-
(2012)
Case Rep Oncol
, vol.5
, pp. 280-289
-
-
Schoenewolf, N.L.1
Dummer, R.2
Mihic-Probst, D.3
-
15
-
-
84867555830
-
Multisite analytic performance studies of a real-time polymerase chain reaction assay for the detection of BRAF V600E mutations in formalin-fixed paraffin-embedded tissue specimens of malignant melanoma
-
Anderson S, Bloom KJ, Vallera DU, et al. Multisite analytic performance studies of a real-time polymerase chain reaction assay for the detection of BRAF V600E mutations in formalin-fixed paraffin-embedded tissue specimens of malignant melanoma. Arch Pathol Lab Med 2012;136: 1385-91.
-
(2012)
Arch Pathol Lab Med
, vol.136
, pp. 1385-1391
-
-
Anderson, S.1
Bloom, K.J.2
Vallera, D.U.3
-
16
-
-
84866522096
-
High-resolution melting analysis as a sensitive prescreening diagnostic tool to detect KRAS, BRAF, PIK3CA, and AKT1 mutations in formalin-fixed, paraffin-embedded tissues
-
Ney JT, Froehner S, Roesler A, et al. High-resolution melting analysis as a sensitive prescreening diagnostic tool to detect KRAS, BRAF, PIK3CA, and AKT1 mutations in formalin-fixed, paraffin-embedded tissues. Arch Pathol Lab Med 2012;136: 983-92.
-
(2012)
Arch Pathol Lab Med
, vol.136
, pp. 983-992
-
-
Ney, J.T.1
Froehner, S.2
Roesler, A.3
-
17
-
-
84871619722
-
Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma
-
Long GV, Wilmott JS, Capper D, et al. Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma. Am J Surg Pathol 2013;37: 61-5.
-
(2013)
Am J Surg Pathol
, vol.37
, pp. 61-65
-
-
Long, G.V.1
Wilmott, J.S.2
Capper, D.3
-
18
-
-
84871390702
-
Intratumoral molecular heterogeneity in a BRAF-mutant, BRAF inhibitor-resistant melanoma: A case illustrating the challenges for personalized medicine
-
Wilmott JS, Tembe V, Howle JR, et al. Intratumoral molecular heterogeneity in a BRAF-mutant, BRAF inhibitor-resistant melanoma: a case illustrating the challenges for personalized medicine. Mol Cancer Ther 2012;11: 2704-8.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 2704-2708
-
-
Wilmott, J.S.1
Tembe, V.2
Howle, J.R.3
-
19
-
-
84866789813
-
Overwhelming response to Dabrafenib in a patient with double BRAF mutation (V600E; V600M) metastatic malignant melanoma
-
Ponti G, Tomasi A, Pellacani G. Overwhelming response to Dabrafenib in a patient with double BRAF mutation (V600E; V600M) metastatic malignant melanoma. J Hematol Oncol 2012;5: 60.
-
(2012)
J Hematol Oncol
, vol.5
, pp. 60
-
-
Ponti, G.1
Tomasi, A.2
Pellacani, G.3
|