Four-stage mechanistic model of dynamic platelet aggregation in a microfluidic chip

Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Volumn , Issue , 2012, Pages 1564-1566

  Combariza, Miguel E ^a   Tovar Lopez, Francisco J ^a   Nesbitt, Warwick S ^b   Yu, Xinghuo ^a   Mitchell, Arnan ^a  

^a RMIT UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Hemodynamics; Mechanistic model; Microfluidics; Non recirculating; Stenotic flow; Thrombus

Indexed keywords

BLOOD VESSELS; MICROFLUIDICS; PLATELETS;

CARDIO-VASCULAR DISEASE; CHEMICAL PATHWAYS; MECHANISTIC MODELING; MICROFLUIDIC CHIP; NON-RECIRCULATING; PLATELET AGGREGATION; STENOTIC FLOW; THROMBUS;

HEMODYNAMICS;

EID: 84876755929     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (4)

1. W. Nesbitt, E. Westein, F. Tovar-Lopez, E. Tolouei, A. Mitchell, J. Fu, J. Carberry, A. Fouras, and S. Jackson, "A shear gradient-dependent platelet aggregation mechanism drives thrombus formation, " Nature Medicine, vol. 15, pp. 665-673, (2009).
2. F. Tovar-Lopez, G. Rosengarten, E. Westein, K. Khoshmanesh, S. Jackson, A. Mitchell, and W. Nesbitt, "A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood, " Lab on a Chip, vol. 10, pp. 291-302, (2010).
3. K. Leiderman and A. L. Fogelson, "Grow with the flow: A spatial-temporal model of platelet deposition and blood coagulation under flow, " Mathematical Medicine and Biology, vol. 28, pp. 47-84, (2011).
4. D. M. Wootton, C. P. Markou, S. R. Hanson, and D. N. Ku, "A mechanistic model of acute platelet accumulation in thrombogenic stenoses, " Annals of Biomedical Engineering, vol. 29, pp. 321-329, (2001).