Electronic nose technology for detection of invasive pulmonary aspergillosis in prolonged chemotherapy-induced neutropenia: A proof-of-principle study

Journal of Clinical Microbiology

Volumn 51, Issue 5, 2013, Pages 1490-1495

  De Heer, Koen ^a   Van Der Schee, Marc P ^a   Zwinderman, Koos ^b   Van Den Berk, Inge A H ^a   Visser, Caroline Elisabeth ^a   Van Oers, Rien ^a   Sterk, Peter J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTILEUKEMIC AGENT; ETOPOSIDE; FLUCONAZOLE; IFOSFAMIDE; METHOTREXATE; POSACONAZOLE; RITUXIMAB; VOLATILE ORGANIC COMPOUND; VORICONAZOLE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BREATH ANALYSIS; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIFFERENTIAL DIAGNOSIS; ELECTRONIC NOSE; FEMALE; FUNGUS CULTURE; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; LUNG ASPERGILLOSIS; LUNG DISEASE; MALE; NEUTROPENIA; NON INVASIVE PROCEDURE; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SPUTUM CULTURE; VALIDATION STUDY; WALDENSTROEM MACROGLOBULINEMIA; CHEMICALLY INDUCED; COMPLICATION; EXHALATION; INVASIVE PULMONARY ASPERGILLOSIS; MICROBIOLOGY; MIDDLE AGED; PRINCIPAL COMPONENT ANALYSIS; PROCEDURES;

ADULT; AGED; BREATH TESTS; COHORT STUDIES; ELECTRONIC NOSE; EXHALATION; FEMALE; HUMANS; INVASIVE PULMONARY ASPERGILLOSIS; MALE; MIDDLE AGED; NEUTROPENIA; PRINCIPAL COMPONENT ANALYSIS; PROSPECTIVE STUDIES; ROC CURVE; VOLATILE ORGANIC COMPOUNDS;

EID: 84876749771     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.02838-12     Document Type: Article

References (36)

1. Groll AH, Shah PM, Mentzel C, Schneider M, Just-Nuebling G, Huebner K. 1996. Trends in the postmortem epidemiology of invasive fungal infections at a university hospital. J. Infect. 33:23-32.
2. Barth PJ, Rossberg C, Koch S, Ramaswamy A. 2000. Pulmonary aspergillosis in an unselected autopsy series. Pathol. Res. Pract. 196:73-80.
3. De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T, Pappas PG, Maertens J, Lortholary O, Kauffman CA, Denning DW, Patterson TF, Maschmeyer G, Bille J, Dismukes WE, Herbrecht R, Hope WW, Kibbler CC, Kullberg BJ, Marr KA, Munoz P, Odds FC, Perfect JR, Restrepo A, Ruhnke M, Segal BH, Sobel JD, Sorrell TC, Viscoli C, Wingard JR, Zaoutis T, Bennett JE. 2008. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin. Infect. Dis. 46: 1813-1821.
4. Rinaldi MG. 1991. Problems in the diagnosis of invasive fungal diseases. Rev. Infect. Dis. 13:493-495.
5. Leeflang MM, Debets-Ossenkopp YJ, Visser CE, Scholten RJ, Hooft L, Bijlmer HA, Reitsma JB, Bossuyt PM, Vandenbroucke-Grauls CM. 2008. Galactomannan detection for invasive aspergillosis in immunocompromized patients. Cochrane Database Syst. Rev. 4:CD007394. doi:10 .1002/14651858.CD007394.
6. Guo YL, Chen YQ, Wang K, Qin SM, Wu C, Kong JL. 2010. Accuracy of BAL galactomannan in diagnosing invasive aspergillosis: a bivariate metaanalysis and systematic review. Chest 138:817-824.
7. Robenshtok E, Gafter-Gvili A, Goldberg E, Weinberger M, Yeshurun M, Leibovici L, Paul M. 2007. Antifungal prophylaxis in cancer patients after chemotherapy or hematopoietic stem-cell transplantation: systematic review and meta-analysis. J. Clin. Oncol. 25:5471-5489.
8. Aisner J, Wiernik PH, Schimpff SC. 1977. Treatment of invasive asper-gillosis: relation of early diagnosis and treatment to response. Ann. Intern. Med. 86:539-543.
9. von Eiff M, Roos N, Schulten R, Hesse M, Zuhlsdorf M, van de Loo J. 1995. Pulmonary aspergillosis: early diagnosis improves survival. Respiration 62:341-347.
10. Pauling L, Robinson AB, Teranishi R, Cary P. 1971. Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. Proc. Natl. Acad. Sci. U. S. A. 68:2374-2376.
11. Fens N, Zwinderman AH, van der Schee MP, de Nijs SB, Dijkers E, Roldaan AC, Cheung D, Bel EH, Sterk PJ. 2009. Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma. Am. J. Respir. Crit. Care Med. 180:1076-1082.
12. Dragonieri S, Annema JT, Schot R, van der Schee MP, Spanevello A, Carratu P, Resta O, Rabe KF, Sterk PJ. 2009. An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD. Lung Cancer 64:166-170.
13. Thaler ER, Hanson CW. 2006. Use of an electronic nose to diagnose bacterial sinusitis. Am. J. Rhinol. 20:170-172.
14. Machado RF, Laskowski D, Deffenderfer O, Burch T, Zheng S, Mazzone PJ, Mekhail T, Jennings C, Stoller JK, Pyle J, Duncan J, Dweik RA, Erzurum SC. 2005. Detection of lung cancer by sensor array analyses of exhaled breath. Am. J. Respir. Crit. Care Med. 171:1286-1291.
15. Di Natale C, Macagnano A, Martinelli E, Paolesse R, D'Arcangelo G, Roscioni C, Finazzi-Agro A, D'Amico A. 2003. Lung cancer identification by the analysis of breath by means of an array of non-selective gas sensors. Biosens. Bioelectron. 18:1209-1218.
16. Peng G, Hakim M, Broza YY, Billan S, Abdah-Bortnyak R, Kuten A, Tisch U, Haick H. 2010. Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors. Br. J. Cancer 103:542-551.
17. Chambers ST, Syhre M, Murdoch DR, McCartin F, Epton MJ. 2009. Detection of 2-pentylfuran in the breath of patients with Aspergillus fumigatus. Med. Mycol. 47:468-476.
18. Syhre M, Scotter JM, Chambers ST. 2008. Investigation into the production of 2-pentylfuran by Aspergillus fumigatus and other respiratory pathogens in vitro and human breath samples. Med. Mycol. 46:209-215.
19. Lewis NS. 2004. Comparisons between mammalian and artificial olfaction based on arrays of carbon black-polymer composite vapor detectors. Acc. Chem. Res. 37:663-672.
20. Röck F, Barsan N, Weimar U. 2008. Electronic nose: current status and future trends. Chem. Rev. 108:705-725.
21. Wilson AD, Baietto M. 2011. Advances in electronic-nose technologies developed for biomedical applications. Sensors 11:1105-1176.
22. Friedrich MJ. 2009. Scientists seek to sniff out diseases: electronic "noses" may someday be diagnostic tools. JAMA 301:585-586.
23. Maertens J, Theunissen K, Verhoef G, Verschakelen J, Lagrou K, Verbeken E, Wilmer A, Verhaegen J, Boogaerts M, Van Eldere J. 2005. Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection: a prospective feasibility study. Clin. Infect. Dis. 41:1242-1250.
24. Dragonieri S, Schot R, Mertens BJ, Le Cessie S, Gauw SA, Spanevello A, Resta O, Willard NP, Vink TJ, Rabe KF, Bel EH, Sterk PJ. 2007. An electronic nose in the discrimination of patients with asthma and controls. J. Allergy Clin. Immunol. 120:856-862.
25. Broadhurst D, Kell DB. 2006. Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics 2:171-196.
26. Moens M, Smet A, Naudts B, Verhoeven J, Ieven M, Jorens P, Geise HJ, Blockhuys F. 2006. Fast identification of ten clinically important microorganisms using an electronic nose. Lett. Appl. Microbiol. 42:121-126.
27. Fend R, Kolk AH, Bessant C, Buijtels P, Klatser PR, Woodman AC. 2006. Prospects for clinical application of electronic-nose technology to early detection of Mycobacterium tuberculosis in culture and sputum. J. Clin. Microbiol. 44:2039-2045.
28. Dutta R, Hines EL, Gardner JW, Boilot P. 2002. Bacteria classification using Cyranose 320 electronic nose. Biomed. Eng. Online 1:4. doi:10.1186 /1475-925X-1-4.
29. Hockstein NG, Thaler ER, Lin Y, Lee DD, Hanson CW. 2005. Correlation of pneumonia score with electronic nose signature: a prospective study. Ann. Otol. Rhinol. Laryngol. 114:504-508.
30. Hockstein NG, Thaler ER, Torigian D, Miller WT, Jr, Deffenderfer O, Hanson CW. 2004. Diagnosis of pneumonia with an electronic nose: correlation of vapor signature with chest computed tomography scan findings. Laryngoscope 114:1701-1705.
31. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Moher D, Rennie D, de Vet Lijmer HCJG. 2003. The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Ann. Intern. Med. 138:W1-W12.
32. Fens N, Roldaan AC, van der Schee MP, Boksem RJ, Zwinderman AH, Bel EH, Sterk PJ. 2011. External validation of exhaled breath profiling using an electronic nose in the discrimination of asthma with fixed airways obstruction and chronic obstructive pulmonary disease. Clin. Exp. Allergy 41:1371-1378.
33. Gibson PG. 2006. Allergic bronchopulmonary aspergillosis. Semin. Respir. Crit. Care Med. 27:185-191.
34. Fens N, de Nijs SB, Peters S, Dekker T, Knobel HH, Vink TJ, Willard NP, Zwinderman AH, Krouwels FH, Janssen HG, Lutter R, Sterk PJ. 2011. Exhaled air molecular profiling in relation to inflammatory subtype and activity in COPD. Eur. Respir. J. 38:1301-1309.
35. Ibrahim B, Basanta M, Cadden P, Singh D, Douce D, Woodcock A, Fowler SJ. 2011. Non-invasive phenotyping using exhaled volatile organic compounds in asthma. Thorax 66:804-809.
36. Park SJ, Burdick MD, Brix WK, Stoler MH, Askew DS, Strieter RM, Mehrad B. 2010. Neutropenia enhances lung dendritic cell recruitment in response to Aspergillus via a cytokine-to-chemokine amplification loop. J. Immunol. 185:6190-6197.