Malnutrition may worsen the prognosis of critically ill children with hyperglycemia and hypoglycemia

Journal of Parenteral and Enteral Nutrition

Volumn 37, Issue 3, 2013, Pages 335-341

  Leite, Heitor Pons ^a   De Lima, Lúcio Flávio Peixoto ^a   De Oliveira Iglesias, Simone Brasil ^a   Pacheco, Juliana Cristina ^a   De Carvalho, Werther Brunow ^b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

blood glucose; intensive care units; malnutrition; mortality; pediatric; prognosis; risk factors

Indexed keywords

GLUCOSE; INSULIN;

ARTICLE; CHILD; CHILDHOOD DISEASE; CHILDHOOD MORTALITY; COHORT ANALYSIS; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DISEASE ASSOCIATION; EXPOSURE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INCIDENCE; INSULIN INFUSION; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; NUTRITIONAL STATUS; OBSERVATIONAL STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY;

ADOLESCENT; BLOOD GLUCOSE; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; FEMALE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIA; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; LENGTH OF STAY; MALE; MALNUTRITION; NUTRITIONAL STATUS; PROGNOSIS; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84876734113     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607112458124     Document Type: Article

References (36)

1. Van den Berghe G, Wouters PJ, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001 ; 345: 1359-1367
2. Razavi NL, Kitabchi AE, Wan JY, et al. Proinflammatory cytokines in response to insulin-induced hypoglycemic stress in healthy subjects. Metabolism. 2009 ; 58: 443-448
3. Hutton RA, Mikhailidis D, Dormandy KM, Ginsburg J. Platelet aggregation studies during transient hypoglycaemia: a potential method for evaluating platelet function. J Clin Pathol. 1979 ; 32 (5). 434-438 (Pubitemid 9207986)
4. Dandona P, Chaudhuri A, Dhindsa S. Proinflammatory and prothrombotic effects of hypoglycemia. Diabetes Care. 2010 ; 33: 1686-1687
5. Suh SW, Hamby AM, Swanson RA. Hypoglycemia, brain energetics, and hypoglycemic neuronal death. Glia. 2007 ; 55: 1280-1286 (Pubitemid 47235369)
6. Srinivasan V, Spinella PC, Drott HR, et al. Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatr Crit Care Med. 2004 ; 5: 329-336
7. Faustino EV, Apkon M. Persistent hyperglycemia in critically ill children. J Pediatr. 2005 ; 24: 437-451
8. Wintergerst KA, Buckibgham B, Gandrud L, et al. Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit. Pediatrics. 2006 ; 118: 173-179 (Pubitemid 46071160)
9. Yates AR, Dyke PC, Taeed R, et al. Hyperglycemia is a marker for poor outcome in the postoperative pediatric cardiac patient. Pediatr Crit Care Med. 2006 ; 7: 351-355 (Pubitemid 44048279)
10. Branco RG, Garcia PC, Piva JP, et al. Glucose level and risk of mortality in pediatric septic shock. Pediatr Crit Care Med. 2005 ; 6: 470-472 (Pubitemid 40980830)
11. Cochran A, Scaife ER, Hansen KW, Downey EC. Hyperglycemia and outcomes from pediatric traumatic brain injury. J Trauma. 2003 ; 55: 1035-1038 (Pubitemid 38044117)
12. Faustino EV, Clifford WB. Relationship between hypoglycemia and mortality in critically ill children. Pediatr Crit Care Med. 2010 ; 11: 690-698
13. Rake AJ, Srinivasan V, Nadkarni V, Kaptan R, Newth CJ. Glucose variability and survival in critically ill children: allostasis or harm?. Pediatr Crit Care Med. 2010 ; 11: 707-712
14. Hirshberg E, Larsen G, Van Duker H. Alterations in glucose homeostasis in the pediatric intensive care unit: hyperglycemia and glucose variability are associated with increased mortality and morbidity. Pediatr Crit Care Med. 2008 ; 9: 361-366
15. Eslami S, Taherzadeh Z, Schultz MJ, Abu-Hanna A. Glucose variability measures and their effect on mortality: a systematic review. Intensive Care Med. 2011 ; 37: 583-593
16. Haupt MT. Guidelines on critical care services and personnel: recommendations based on a system of categorization of three levels of care. Crit Care Med. 2003 ; 31: 2677-2683 (Pubitemid 37452849)
17. Hirshberg E, Lacroix J, Sward K, Willson D, Morris AH. Blood glucose control in critically ill adults and children: a survey on stated practice. Chest. 2008 ; 133: 1328-1335 (Pubitemid 351892987)
18. Mitrakou A, Ryan C, Veneman T, et al. Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol. 1991 ; 260: E67 - E74
19. J Pediatr Gastroenterol Nutr. 2005 ; 41: S28 - S32
20. Schoenfeld DA, Bernard GR. Statistical evaluation of days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome. Crit Care Med. 2002 ; 30: 1772-1777 (Pubitemid 34879589)
21. Slater A, Shann F, Pearson G. PIM 2: a revised version of the Paediatric Index of Mortality. Intensive Care Med. 2003 ; 29: 278-285 (Pubitemid 36384419)
22. Leteurtre S, Martinot A, Duhamel A, et al. Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet. 2003 ; 362: 192-197 (Pubitemid 36859934)
23. Development of a WHO growth references for school aged children and adolescents. Bull WHO. 2007 ; 85: 660-667
24. Seth A, Aneja S. Hyperglycemia in malnourished children with dehydrating gastroenteritis. Indian J Pediatr. 1995 ; 62: 353-355
25. Ronan A, Azad A, Rahman O, Phillips RE, Bennish ML. Hyperglycemia during childhood diarrhea. J Pediatr. 1997 ; 130: 45-51 (Pubitemid 27492718)
26. Das BK, Ramesh J, Agarwa JK, Mishra OP, Bhatt RP. Blood sugar and serum insulin response in protein-energy malnutrition. J Trop Pediatr. 1998 ; 44: 230-231
27. Zijlmans WC, van Kempen AA, Serlie MJ, Sauerwein HP. Glucose metabolism in children: influence of age, fasting, and infectious diseases. Metabolism. 2009 ; 58: 1356-1365
28. Bandsma RH, Spoelstra MN, Mari A. Impaired glucose absorption in children with severe malnutrition. J Pediatr. 2011 ; 158: 282-287
29. Bandsma RH, Mendel M, Spoelstra MN, et al. Mechanisms behind decreased endogenous glucose production in malnourished children. Pediatr Res. 2010 ; 68: 423-428
30. Osier FH, Berkley Ross JA, Sanderson F, Mohammed S, Newton CR. Abnormal blood glucose concentrations on admission to a rural Kenyan district hospital: prevalence and outcome. Arch Dis Child. 2003 ; 88: 621-625 (Pubitemid 36783045)
31. Siegelaar SE, Holleman F, Hoekstra JB, DeVries JH. Glucose variability: does it matter?. Endocr Rev. 2010 ; 31: 171-182
32. Van den Berghe G. How does blood glucose control with insulin save lives in intensive care?. J Clin Invest. 2004 ; 114: 1187-1195 (Pubitemid 40385286)
33. Golden MH, Ramdath D. Free radicals in the pathogenesis of kwashiorkor. Proc Nutr Soc. 1987 ; 46: 53-68
34. Evans P, Halliwell B. Micronutrients: oxidant/antioxidant status. Br J Nutr. 2001 ; 85: S67 - S74
35. Yung M, Wilkins B, Norton L, Slater A. Glucose control, organ failure, and mortality in pediatric intensive care. Pediatr Crit Care Med. 2008 ; 9: 147-152 (Pubitemid 351355025)
36. Kyle UG, Coss Bu JA, Kennedy CE, Jefferson LS. Organ dysfunction is associated with hyperglycemia in critically ill children. Intensive Care Med. 2010 ; 36: 312-320