Antilipolytic drug boosts glucose metabolism in prostate cancer

Nuclear Medicine and Biology

Volumn 40, Issue 4, 2013, Pages 524-528

  Andersen, Kim Francis ^a   Divilov, Vadim ^b   Koziorowski, Jacek ^a   Pillarsetty, NagaVaraKishore ^b   Lewis, Jason S ^b  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

18F FDG; Acipimox; Free fatty acid; Glucose; Metabolism; Prostate cancer

Indexed keywords

ACETIC ACID C 14; ACIPIMOX; ANDROGEN; FATTY ACID; FLUORODEOXYGLUCOSE F 18; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CANCER TISSUE; CASTRATION RESISTANT PROSTATE CANCER; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG UPTAKE; GAMMA COUNTER; GLUCOSE METABOLISM; IMAGE RECONSTRUCTION; LIQUID SCINTILLATION COUNTING; MOUSE; NONHUMAN; NUDE MOUSE; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PROSTATE CANCER; RADIATION MEASUREMENT; RADIOACTIVITY; SENSITIVITY AND SPECIFICITY; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; FLUORODEOXYGLUCOSE F18; GLUCOSE; HUMANS; HYPOLIPIDEMIC AGENTS; MALE; MICE; MICE, NUDE; POSITRON-EMISSION TOMOGRAPHY; PROSTATIC NEOPLASMS; PYRAZINES; TISSUE DISTRIBUTION;

EID: 84876727422     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2013.01.008     Document Type: Article

References (27)

1. Warburg O. Stoffweschel der Tumoren 1926, Verlag Springer, Berlin.
2. Crabtree H.G. Observations on the carbohydrate metabolism of tumours. Biochem J 1929, 23(3):536-545.
3. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963;13;1 (7285):785-9.
4. Knuuti M.J., Maki M., Yki-Jarvinen H., Voipio-Pulkki L.M., Harkonen R., Haaparanta M., et al. The effect of insulin and FFA on myocardial glucose uptake. J Mol Cell Cardiol 1995, 27(7):1359-1367.
5. Nuutila P., Koivisto V.A., Knuuti J., Ruotsalainen U., Teras M., Haaparanta M., et al. Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo. J Clin Invest 1992, 89(6):1767-1774.
6. Nuutila P., Knuuti M.J., Raitakari M., Ruotsalainen U., Teras M., Voipio-Pulkki L.M., et al. Effect of antilipolysis on heart and skeletal muscle glucose uptake in overnight fasted humans. Am J Physiol 1994, 267(6 Pt 1):E941-E946.
7. Thiebaud D., DeFronzo R.A., Jacot E., Golay A., Acheson K., Maeder E., et al. Effect of long chain triglyceride infusion on glucose metabolism in man. Metabolism 1982, 31(11):1128-1136.
8. Randle P.J., Newsholme E.A., Garland P.B. Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochem J 1964, 93(3):652-665.
9. Puhakainen I., Yki-Jarvinen H. Inhibition of lipolysis decreases lipid oxidation and gluconeogenesis from lactate but not fasting hyperglycemia or total hepatic glucose production in NIDDM. Diabetes 1993, 42(12):1694-1699.
10. US National Cancer Institute SEER database 2012, Ref Type: Online Source.
11. Chen C.D., Welsbie D.S., Tran C., Baek S.H., Chen R., Vessella R., et al. Molecular determinants of resistance to antiandrogen therapy. Nat Med 2004, 10(1):33-39.
12. Craft N., Chhor C., Tran C., Belldegrun A., DeKernion J., Witte O.N., et al. Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process. Cancer Res 1999, 59(19):5030-5036.
13. Effert P.J., Bares R., Handt S., Wolff J.M., Bull U., Jakse G. Metabolic imaging of untreated prostate cancer by positron emission tomography with 18fluorine-labeled deoxyglucose. J Urol 1996, 155(3):994-998.
14. Hofer C., Laubenbacher C., Block T., Breul J., Hartung R., Schwaiger M. Fluorine-18-fluorodeoxyglucose positron emission tomography is useless for the detection of local recurrence after radical prostatectomy. Eur Urol 1999, 36(1):31-35.
15. Liu I.J., Zafar M.B., Lai Y.H., Segall G.M., Terris M.K. Fluorodeoxyglucose positron emission tomography studies in diagnosis and staging of clinically organ-confined prostate cancer. Urology 2001, 57(1):108-111.
16. Melchior S.W., Brown L.G., Figg W.D., Quinn J.E., Santucci R.A., Brunner J., et al. Effects of phenylbutyrate on proliferation and apoptosis in human prostate cancer cells in vitro and in vivo. Int J Oncol 1999, 14(3):501-508.
17. Oyama N., Akino H., Suzuki Y., Kanamaru H., Sadato N., Yonekura Y., et al. The increased accumulation of [18F] fluorodeoxyglucose in untreated prostate cancer. Jpn J Clin Oncol 1999, 29(12):623-629.
18. Fricke E., Machtens S., Hofmann M., van den Hoff J., Bergh S., Brunkhorst T., et al. Positron emission tomography with 11C-acetate and 18F-FDG in prostate cancer patients. Eur J Nucl Med Mol Imaging 2003, 30(4):607-611.
19. Herrmann K., Schoder H., Eberhard S. FDG PET for the detection of recurrent/metastatic prostate carcinoma in patients with rising PSA after radical prostatectomy. J Nucl Med 2004, 45:359. Ref Type: Abstract.
20. Larson S.M., Morris M., Gunther I., Beattie B., Humm J.L., Akhurst T.A., et al. Tumor localization of 16beta-18F-fluoro-5alpha-dihydrotestosterone versus 18F-FDG in patients with progressive, metastatic prostate cancer. J Nucl Med 2004, 45(3):366-373.
21. Morris M.J., Akhurst T., Osman I., Nunez R., Macapinlac H., Siedlecki K., et al. Fluorinated deoxyglucose positron emission tomography imaging in progressive metastatic prostate cancer. Urology 2002, 59(6):913-918.
22. Nunez R., Macapinlac H.A., Yeung H.W., Akhurst T., Cai S., Osman I., et al. Combined 18F-FDG and 11C-methionine PET scans in patients with newly progressive metastatic prostate cancer. J Nucl Med 2002, 43(1):46-55.
23. Carballo-Jane E., Gerckens L.S., Luell S., Parlapiano A.S., Wolff M., Colletti S.L., et al. Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists. J Pharmacol Toxicol Methods 2007, 56(3):308-316.
24. Nuutinen J., Minn H., Bergman J., Haaparanta M., Ruotasalainen U., Laine H., et al. Uncoupling of fatty acid and glucose metabolism in malignant lymphoma: a PET study. Br J Cancer 1999, 80(3-4):513-518.
25. Medina M.A., Nuñez de Castro I. Glutaminolysis and glycolysis interactions in proliferant cells. Int J Biochem 1990, 22(7):681-683.
26. Schoder H., Larson S.M. Positron emission tomography for prostate, bladder, and renal cancer. Semin Nucl Med 2004, 34(4):274-292.
27. Kaarstad K., Bender D., Bentzen L., Munk O.L., Keiding S. Metabolic fate of 18F-FDG in mice bearing either SCCVII squamous cell carcinoma or C3H mammary carcinoma. J Nucl Med 2002, 43(7):940-947.