Current evidence of methotrexate efficacy in childhood chronic uveitis: A systematic review and meta-analysis approach

Rheumatology (United Kingdom)

Volumn 52, Issue 5, 2013, Pages 825-831

  Simonini, Gabriele ^a   Paudyal, Priyamvada ^b   Jones, Gareth T ^b   Cimaz, Rolando ^a   Macfarlane, Gary J ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Autoimmune chronic uveitis; Childhood; Methotrexate; Refractory uveitis

Indexed keywords

METHOTREXATE;

ARTICLE; AUTOIMMUNE DISEASE; CHILDHOOD DISEASE; DRUG EFFICACY; HUMAN; META ANALYSIS; PRIORITY JOURNAL; REMISSION; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME; UVEITIS; VISUAL ACUITY;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; EVIDENCE-BASED MEDICINE; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; METHOTREXATE; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; UVEITIS;

EID: 84876725716     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kes186     Document Type: Article

References (20)

1. Cunningham ET. Uveitis in children. Ocul Immunol Inflamm 2000;8:251-61.
2. Agle LMA, Vazquez-Cobian LB, Lehman TJA. Clinical trials in pediatric uveitis. Curr Rheum Rep 2003;5:477-81.
3. Simonini G, Cantarini L, Bresci C et al. Current therapeutic approaches to autoimmune chronic uveitis in children. Autoimmun Rev 2010;9:674-83.
4. Jabs DA, Nussemblatt RB, Rosembaum JT. Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 2005;140:509-16.
5. Kalinina Ayuso V, van de Winkel EL, Rothova A, de Boer JH. Relapse rate of uveitis post-methotrexate treatment in juvenile idiopathic arthritis. Am J Ophthalmol 2011;151:217-22.
6. Heiligenhaus A, Mingels A, Heinz C, Ganser G. Methotrexate for uveitis associated with juvenile idiopathic arthritis: value and requirement for additional anti-inflammatory medication. Eur J Ophthalmol 2007;17: 743-8.
7. Foeldvari I, Wierk A. Methotrexate is an effective treatment for chronic uveitis associated with juvenile idiopathic arthritis. J Rheumatol 2005;32:362-5.
8. Malik AR, Pavesio C. The use of low dose methotrexate in children with chronic anterior and intermediate uveitis. Br J Ophthalmol 2005;89:806-8.
9. Kaplan-Messas A, Barkana Y, Avni I, Neumann R. Methotrexate as a first-line corticosteroid-sparing therapy in a cohort of uveitis and scleritis. Ocul Immunol Inflamm 2003;11:131-9.
10. Gion N, Stavrou P, Foster CS. Immunomodulatory therapy for chronic tubulointerstitial nephritis-associated uveitis. Am J Ophthalmol 2000;129:764-8.
11. Samson CM, Waheed N, Baltatzis S, Foster CS. Methotrexate therapy for chronic noninfectious uveitis: analysis of a case series of 160 patients. Ophthalmology 2001;108:1134-9.
12. Shetty AK, Zganjar BE, Ellis GS Jr, Ludwig IH, Gedalia A. Low-dose methotrexate in the treatment of severe juvenile rheumatoid arthritis and sarcoid iritis. J Pediatr Ophthalmol Strabismus 1999;36:125-8.
13. Weiss AH, Wallace CA, Sherry DD. Methotrexate for resistant chronic uveitis in children with juvenile rheumatoid arthritis. J Pediatr 1998;133:266-8.
14. Zakka FR, Chang PY, Giuliari GP, Foster CS. Current trend in the management of ocular symptoms in Adamantiades-Beçhet's disease. Clin Opthalmol 2009;3: 567-9.
15. Yu ENY, Meniconi ME, Tufail F, Baltatzis S, Foster CS. Outocomes of treatment with immunomodulatory therapy in patients with corticosteroid-resistant juvenile idiopathic arthritis-associated chronic iridocyclitis. Ocul Immunol Inflam 2005;13:353-60.
16. Lyon F, Gale RP, Lightman S. Recent developments in the treatment of uveitis: an update. Expert Opin Investig Drugs 2009;18:609-16.
17. Jabs DA, Rosenbaum JT, Foster CS et al. Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel. Am J Ophthalmol 2000;130: 492-513.
18. Zierhut M, Doycheva D, Biester S et al. Therapy of uveitis in children. Int Ophthalmol Clin 2008;48:131-52.
19. Holzinger D, Frosch M. New treatment approaches in juvenile idiopathic arthritis. Int J Adv Rheumatol 2009;7: 1-7.
20. Sharma SM, Dick AD, Ramanan AV. Non-infectious pediatric uveitis: an update on immunomodulatory management. Paediatr Drugs 2009;11:229-41.