5-Fluoro-[β-11C]-L-tryptophan is a functional analogue of 5-hydroxy-[β-11C]-L-tryptophan in vitro but not in vivo

Nuclear Medicine and Biology

Volumn 40, Issue 4, 2013, Pages 567-575

  Eriksson, Olof ^a   Selvaraju, Ramkumar ^a   Borg, Beatrice ^b   Asplund, Veronika ^a   Estrada, Sergio ^a   Antoni, Gunnar ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

5 HTP; 5 hydroxytryptophan; Fluoro tryptophan; FTRP; Neuroendocrine tumors

Indexed keywords

2 AMINO 2 NORBORNANECARBOXYLIC ACID; 5 FLUOROTRYPTOPHAN BETA C 11; 5 HYDROXYTRYPTOPHAN; 5 HYDROXYTRYPTOPHAN BETA C 11; CARBIDOPA; CARBOXYLIC ACID DERIVATIVE; ENZYME; FLUORINE 18; HARMINE; RADIOPHARMACEUTICAL AGENT; SEROTONIN; TETRABENAZINE; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LINE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MOUSE; MOUSE STRAIN; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIMATE; RAT; RAT STRAIN; SEROTONIN METABOLISM; SEROTONINERGIC SYSTEM; TUMOR XENOGRAFT;

ANIMALS; CARCINOMA, NEUROENDOCRINE; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; ISLETS OF LANGERHANS; MACACA FASCICULARIS; MICE; POSITRON-EMISSION TOMOGRAPHY; RADIOCHEMISTRY; RATS; TRYPTOPHAN;

EID: 84876700121     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2013.02.005     Document Type: Article

References (16)

1. Reibring L., Agren H., Hartvig P., Tedroff J., Lundqvist H., Bjurling P., et al. Uptake and utilization of [beta-11C]5-hydroxytryptophan in human brain studied by positron emission tomography. Psychiatry Res 1992, 45(4):215-225.
2. Lundquist P., Blomquist G., Hartvig P., Hagberg G.E., Torstenson R., Hammarlund-Udenaes M., et al. Validation studies on the 5-hydroxy-L-[beta-11C]-tryptophan/PET method for probing the decarboxylase step in serotonin synthesis. Synapse 2006, 59(8):521-531. 10.1002/syn.20268.
3. Orlefors H., Sundin A., Garske U., Juhlin C., Oberg K., Skogseid B., et al. Whole-body (11)C-5-hydroxytryptophan positron emission tomography as a universal imaging technique for neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and computed tomography. J Clin Endocrinol Metab 2005, 90(6):3392-3400. [pii]. 10.1210/jc.2004-1938.
4. Di Gialleonardo V., Signore A., Scheerstra E.A., Visser A.K., van Waarde A., Dierckx R.A., et al. 11C-Hydroxytryptophan uptake and metabolism in endocrine and exocrine pancreas. J Nucl Med 2012, [pii]. 10.2967/jnumed.112.104117.
5. de Heide L.J., Glaudemans A.W., Oomen P.H., Apers J.A., Totte E.R., van Beek A.P. Functional imaging in hyperinsulinemic hypoglycemia after gastric bypass surgery for morbid obesity. J Clin Endocrinol Metab 2012, 97(6):E963-E967. [pii]. 10.1210/jc.2011-3063.
6. Eriksson O., Espes D., Selvaraju R., Sörensen J., Lubberink M., Antoni G., et al. 2012, OP261.
7. Ohta Y., Kosaka Y., Kishimoto N., Wang J., Smith S.B., Honig G., et al. Convergence of the insulin and serotonin programs in the pancreatic beta-cell. Diabetes 2011, 60(12):3208-3216. [pii]. 10.2337/db10-1192.
8. Bjurling P., Watanabe Y., Tokushige M., Oda T., Långström B. Synthesis of B-11C-labelled L-tryptophan and 5-hydroxy-L-tryptophan using a multi-enzymatic reaction route. J Chem Soc Perkin Trans. 1989, 1(1):1331-1334.
9. Jager P.L., Chirakal R., Marriott C.J., Brouwers A.H., Koopmans K.P., Gulenchyn K.Y. 6-L-18F-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: basic aspects and emerging clinical applications. J Nucl Med 2008, 49(4):573-586. [pii]. 10.2967/jnumed.107.045708.
10. Hartvig P., Tedroff J., Lindner K.J., Bjurling P., Chang C.W., Tsukada H., et al. Positron emission tomographic studies on aromatic L-amino acid decarboxylase activity in vivo for L-dopa and 5-hydroxy-L-tryptophan in the monkey brain. J Neural Transm Gen Sect 1993, 94(2):127-135.
11. Eriksson B., Bergstrom M., Sundin A., Juhlin C., Orlefors H., Oberg K., et al. The role of PET in localization of neuroendocrine and adrenocortical tumors. Ann N Y Acad Sci 2002, 970:159-169.
12. Atkins H.L., Christman D.R., Fowler J.S., Hauser W., Hoyte R.M., Klopper J.F., et al. Organic radiopharmaceuticals labeled with isotopes of short half-life. V. 18 F-labeled 5- and 6-fluorotryptophan. J Nucl Med 1972, 13(10):713-719.
13. Kramer S.D., Mu L., Muller A., Keller C., Kuznetsova OF, Schweinsberg C., et al. 5-(2-18F-fluoroethoxy)-L-tryptophan as a substrate of system L transport for tumor imaging by PET. J Nucl Med 2012, 53(3):434-442. [pii]. 10.2967/jnumed.111.096289.
14. Bjurling P. Synthesis of 11C-labelled compounds using multi-enzymatic catalysis (doctoral thesis). Acta Universitatis Upsaliensis 1989;225.
15. Neels O.C., Koopmans K.P., Jager P.L., Vercauteren L., van Waarde A., Doorduin J., et al. Manipulation of [11C]-5-hydroxytryptophan and 6-[18F]fluoro-3,4-dihydroxy-L-phenylalanine accumulation in neuroendocrine tumor cells. Cancer Res 2008, 68(17):7183-7190. [pii]. 10.1158/0008-5472.CAN-08-0095.
16. Orlefors H., Sundin A., Lu L., Oberg K., Langstrom B., Eriksson B., et al. Carbidopa pretreatment improves image interpretation and visualisation of carcinoid tumours with 11C-5-hydroxytryptophan positron emission tomography. Eur J Nucl Med Mol Imaging 2006, 33(1):60-65. 10.1007/s00259-005-1891-z.